CN114617948A

CN114617948A - Qiangli Madelia Doudai preparation and raw material composition, preparation method and application thereof

Info

Publication number: CN114617948A
Application number: CN202111509230.7A
Authority: CN
Inventors: 尹强; 尹海龙; 穆丹丹; 孙黎; 刘秋云; 周琴; 邓新新; 李超杰; 马小燕; 王丽敏; 宋菲; 张鹏
Original assignee: Xinjiang Uygur Pharmaceutical Co ltd
Current assignee: Xinjiang Uygur Pharmaceutical Co ltd
Priority date: 2021-12-10
Filing date: 2021-12-10
Publication date: 2022-06-14

Abstract

The invention discloses a Qiangli Made Li Aya special preparation, a raw material composition thereof, a preparation method and application. The raw material composition of the brute force madrid-force arayate preparation comprises an active ingredient A, an active ingredient B and refined honey; the active ingredient A consists of the following components: 30 parts of dried ginger, 30 parts of pepper, 30 parts of long pepper, 30 parts of cinnamon, 30 parts of emblic leafflower fruit, 30 parts of fructus terminaliae billericae meat, 30 parts of whiteflower leadword root, 30 parts of radix stephaniae tetrandrae, 30 parts of rhizoma bletillae, 30 parts of milk peach, 30 parts of white skin pine nut kernel, 30 parts of chamomile and 15 parts of chamomile seed; the active component B is 60-120 parts of raisin fluid extract; the QIANGLIMADELI ABAI YATE is in the form of honeyed paste or honeyed pill. The powerful Madelia-Dolabea preparation has stable quality, good safety, convenient administration and good patient compliance; can be used for treating mild cognitive dysfunction.

Description

Qiangli Madelia Dolabei preparation and raw material composition, preparation method and application thereof

Technical Field

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a Qiangli Madeli and Dolabei preparation, and a raw material composition, a preparation method and application thereof.

Background

The Strong Made Tuli Ayate Mi Gao is recorded in the drug Standard of Ministry of health of the people's republic of China (vitamin drug booklet), the Standard number is WS₃BW-0196-98. The standard method comprises collecting 1000g of red raisin, decocting in water for 2 times (1 hr each time), mixing decoctions, filtering, and concentrating the filtrate into fluid extract with density of 1.20. The original process parameters are not clear in water addition amount, and the preparation method is relatively simple in description. In addition, the honey paste is a semisolid viscous paste because of the more traditional dosage form, and each timeThe dosage can be determined by the patient by feeling, and the conditions of inaccurate dosage, inconvenient administration, bad taste and poor adaptability exist.

The powerful Madeduli ayaki special honey paste has the main functions of strengthening the body, relieving pain, tonifying the kidney and nourishing the brain, and is used for treating hemiplegia, joint osteodynia, dementia, tongue heaviness, soreness of waist, impotence, tooth looseness and the like. According to the literature report, the brute force madrepo-aristobal has a protective effect on the SD rat focal cerebral ischemia model, but no report is found on the aspect of treating mild cognitive dysfunction.

Mild Cognitive Impairment (MCI) refers to a group of clinical conditions that have significant memory impairment or mild other cognitive impairment, but do not affect daily life, ranging between normal aging and mild dementia. The impairment of dementia includes multiple cognitive domains, the most important and essential being memory. In addition to memory, dementia impairs other cognitive functions, such as spatial disorders, disorders of language understanding and expression, disorders of executive functioning, etc.; in addition, dementia affects the patient's ability to work professionally, socially, and daily living, sometimes with psychobehavioral abnormalities. Thus, dementia is a far more widespread and severe clinical condition than mild cognitive impairment.

Therapeutic agents for cognitive dysfunction have not been able to determine their efficacy and safety at present because the emphasis of the previous research has been on dementia, and therefore, the drugs developed are all for the treatment of dementia. Cognitive dysfunction was not mentioned on schedule until after the 90's of the last century. At present, the method for treating mild cognitive dysfunction mainly comprises drug therapy accompanied with rehabilitation exercise, wherein the drugs mainly comprise a cerebral circulation improving agent, a cerebral metabolism improving agent, a cholinesterase inhibitor and the like, and mainly comprise western drugs, but the period of taking the drugs is long, the cost is high, and the damage to the liver is serious.

Disclosure of Invention

The invention aims to solve the technical problems that a Qiangli Madelia Adia special preparation is inconvenient to take, poor in patient compliance, unstable in quality and the like in the prior art, and provides a Qiangli Madelia Adia special preparation and a raw material composition, a preparation method and application thereof. The mad-earth-force agate special preparation provided by the invention has stable quality, good safety, convenient taking and good patient compliance; can be used for treating mild cognitive dysfunction.

The invention solves the technical problems through the following technical scheme:

the invention provides a raw material composition of a Qiangli Ma De Tu Ayate preparation, which comprises an active component A, an active component B and refined honey in parts by mass; wherein the active ingredient A consists of the following components: 30 parts of dried ginger, 30 parts of pepper, 30 parts of long pepper, 30 parts of cinnamon, 30 parts of emblic leafflower fruit, 30 parts of fructus terminaliae billericae meat, 30 parts of whiteflower leadword root, 30 parts of radix stephaniae tetrandrae, 30 parts of rhizoma bletillae, 30 parts of milk peach, 30 parts of white skin pine nut kernel, 30 parts of chamomile and 15 parts of chamomile seed; the active component B is 60-120 parts of raisin fluid extract;

when the Qiangli Ma-De-Tu-Ayate preparation is a Qiangli Ma-De-Tu-Ayate honeyed pill, the dosage of the refined honey is 50-80%; when the Qiangli Ma De Tu Te preparation is Qiangli Ma De Tu Te Mel paste, the amount of the refined honey is 300% -400%; wherein the percentage is the mass percentage of the active component A.

In the present invention, the amount of said refined honey affects the processability of the raw material composition, such as the instrumental suitability, formability and reproducibility. The amount of the refined honey in the invention can make the raw material composition have good processing performance. When the Qianglaida Dolabite preparation is Qianglaida Dolabite honeyed pill, the refined honey is preferably used in an amount of 60%. When the Qiangli Madeli-Dolabite preparation is Qiangli Madeli-Dolabite honey paste, the refined honey is preferably used in an amount of 350%.

In the present invention, the refined honey may be refined from honey by a method conventional in the art. The honey can be conventional honey in pharmacopoeia of people's republic of China 2020 edition.

Preferably, the relative density of the refined honey is 1.35-1.40.

In the invention, the raisin fluid extract can be obtained by decocting raisin by adopting a conventional method in the field.

Preferably, the preparation method of the raisin liquid extract comprises the following steps: decocting raisin in water for 3 times, 6 times water for the first time, 5 times water for the second time, and 4 times water for the third time, each time for 1 hr, mixing decoctions, filtering, and concentrating to obtain the final product. The optimized scheme refines the technological parameters of the raisin liquid extract and ensures the stable quality of the raisin liquid extract.

In the invention, the raisin fluid extract is preferably a red raisin fluid extract, and more preferably a trivia fluid extract. The red grape dry fluid extract is prepared by preparing red grapes into red grapes and further preparing the red grape dry fluid extract.

Preferably, the relative density of the raisin extract is 1.20-1.25.

Preferably, the active ingredient B is 90 parts of raisin fluid extract.

In the present invention, when the madreporte preparation is a madreporte honey paste, the raw material composition preferably further includes a preservative. In the present invention, the preservative may be a conventional preservative in the pharmacopoeia of the people's republic of China, 2020 edition four.

Further preferably, the preservative is selected from one of benzoic acid or sodium benzoate. Further preferably, the preservative is sodium benzoate; the dosage of the sodium benzoate is preferably 0.15 percent, and the percentage is the mass percentage of the total amount of the active ingredient A, the active ingredient B and the refined honey.

From the aspect of vitamins, the bletilla striata in the active component A of the raw material composition has the effects of tonifying yang, producing sperm, nourishing heart and producing blood, and is mainly used for treating convulsion, paralysis, dementia and the like of a human body; the chamomile has the effects of relieving muscle cramp, diminishing inflammation, improving eyesight, tonifying brain and strengthening tendons; the plumbago zeylanica is bitter in taste and slightly warm in taste, and has the effects of dispelling wind, relieving pain, removing blood stasis and relieving swelling; the milk peach has the effects of treating mental asthenia, hypopsia and the like; radix Aristolochiae Fangchi is bitter, pungent and cold in taste, enters bladder and lung channels, has the effects of dispelling pathogenic wind, relieving pain, clearing heat and promoting diuresis, and is mainly used for treating damp-heat body pain, edema of lower limbs, dysuresia and rheumatic arthralgia; cinnamon is pungent and sweet in flavor and large in nature and heat in nature, enters kidney, spleen, heart and liver channels, and has the effects of tonifying fire and yang, guiding fire to the origin, dispelling cold and relieving pain, and warming and dredging channels and collaterals. The whole prescription can not only expel cold in vivo, but also make pathogenic qi externally reach, block the source of abnormal body fluid and block the development of illness. Has effects of strengthening vital qi, nourishing brain and invigorating kidney.

The invention also provides a preparation method of the Qiangli Ma De Li Ayate preparation, which adopts the raw material composition of the Qiangli Ma De Li Ayate preparation to prepare the Qiangli Ma De Li Ayate preparation.

In the present invention, preferably, the preparation method of the brute force maderamide preparation comprises the following steps:

s1, mixing and crushing the active ingredient A, and sieving to obtain medicinal powder;

s2, uniformly mixing the raisin fluid extract, the refined honey and the medicinal powder to obtain an intermediate product of the powerful Maderelia preparation;

s3, preparing the intermediate product of the Qianglaida-Madelia-Dolaba preparation into the Qianglaida-Madelia preparation.

Preferably, in step S1, the sieving is 80-100 mesh sieving.

Preferably, in step S2, the refined honey is added to the raisin extract, and the mixture is mixed uniformly, and then the medicinal powder is added and further mixed uniformly.

Preferably, when the raw material composition of the brute force madaitia preparation further includes a preservative, in step S2, the fluid extract, the refined honey, the medicinal powder, and the preservative are uniformly mixed.

In step S3, the intermediate product of the brute-force mad-force aristode preparation may be prepared into the brute-force mad-force aristode preparation according to a conventional preparation method of the brute-force mad-force aristode preparation.

When the brute force mad-hei preparation is the brute force mad-hei paste, preferably, in step S3, the intermediate product of the brute force mad-hei preparation is further mixed by a colloid mill to obtain the brute force mad-hei-l preparation.

When the brute force mad-free aristolic acid preparation is brute force mad-free aristolic acid honey pills, preferably, in step S3, the intermediate product of the brute force mad-free aristolic acid preparation is refined into a soft material, the soft material is made into pill strips, the pill strips are made into pills, and the pills are dried to obtain the brute force mad-free aristolic acid honey pills.

Wherein the soft material can be refined in a conventional medicine refining machine in the field.

Wherein, after the drying, a coating step is preferably further included. The coating may be carried out using procedures conventional in the art. The weight gain of the coating is preferably 2-4%, for example 3%.

The invention also provides a brute force madrid-force agate preparation which is prepared according to the preparation method of the brute force madrid-force agate preparation;

the QIANGLIMA MOLI JIA YA is QIANGLIMA MOLI JIA MIAN or QIANGLIMA MOLI JIA MIAN.

When the brute force mad-mah-jo-hao-bo preferably comprises a coating.

The invention also provides application of the Qiangli Madelia Ayata preparation in preparation of a medicine for treating mild cognitive dysfunction. The Qiangli Madelia preparation is preferably the Qiangli Madelia preparation.

On the basis of the common knowledge in the field, the above preferred conditions can be combined randomly to obtain the preferred embodiments of the invention.

The reagents and starting materials used in the present invention are commercially available.

The positive progress effects of the invention are as follows:

1. the invention unexpectedly finds that the Qiangli Madele Aryata preparation can be used for treating mild cognitive dysfunction, effectively improving the memory of patients and improving the life quality of the patients.

2. The Qiangli Made Li Ayate preparation, in particular to Qiangli Made Li Ayate honeyed pills, has the following advantages: firstly, the dissolving and releasing medicine is slow, and the effect is durable; secondly, the quality of the medicine is controllable, the quality stability is high, the medicine is safe and reliable, and no toxic or side effect exists; the medicine is convenient to take and has good patient compliance; is suitable for long-time administration, and has high adaptability to patients with mild cognitive dysfunction who need long-time administration.

3. The pharmaceutical composition disclosed by the invention is simple in preparation method, mature in process, natural in raw materials and stable in quality, and is suitable for industrial production.

Drawings

Fig. 1 is a flow chart of the preparation of the brute force mad-earth-force agate honey paste in example 1 of the present invention.

Fig. 2 is a flow chart of a preparation process of the brute force mad-force agate honeyed pill in example 2 and comparative example 1 of the present invention.

Detailed Description

The invention is further illustrated by the following examples, which are not intended to limit the invention thereto. The experimental methods without specifying specific conditions in the following examples were selected according to the conventional methods and conditions, or according to the commercial instructions.

Example 1

The raw material composition of the powerful Maderelia Atlantic honey paste comprises an active ingredient A, an active ingredient B, refined honey and sodium benzoate in parts by mass; the active ingredient A consists of the following components: 30 parts of dried ginger, 30 parts of pepper, 30 parts of long pepper, 30 parts of cinnamon, 30 parts of emblic leafflower fruit, 30 parts of fructus terminaliae billericae meat, 30 parts of whiteflower leadword root, 30 parts of radix stephaniae tetrandrae, 30 parts of rhizoma bletillae, 30 parts of milk peach, 30 parts of white skin pine nut kernel, 30 parts of chamomile and 15 parts of chamomile seed; the active component B is 90 parts of trivia dry fluid extract; the mass percentage of the refined honey in the active component A is 350%; the dosage of sodium benzoate is 0.15% of the total amount of the medicinal powder, the trivia grape dry fluid extract and the refined honey.

Wherein the refined honey is prepared from Mel, and has relative density of 1.35-1.40.

The preparation method of the trivia raisin extract comprises the following steps: adding water into triumol raisin, decocting for 3 times, the first time is 6 times of water, the second time is 5 times of water, the third time is 4 times of water, each time lasts for 1 hour, combining the decoctions, filtering and concentrating to obtain a fluid extract with the relative density of 1.20-1.25.

The preparation process of the Qiangli Madeli-Tuli-Ayaite honey paste prepared from the raw material composition is shown in figure 1, and the preparation process specifically comprises the following steps:

s1, mixing and crushing the active ingredient A into fine powder, and sieving the fine powder by a 100-mesh sieve to obtain medicinal powder;

s2, adding refined honey and sodium benzoate into the dry fluid extract of trivia grape, mixing, slowly adding the medicinal powder, and further mixing to obtain intermediate product of QIANGLIMA' ERAI preparation, marked as intermediate product a;

s3, further mixing the intermediate product a with a colloid mill to obtain QIANGLIMADETULI ASHITE MIGAO F1.

Example 2

The raw material composition of the Qiangli Ma-Tu-Ayate honeyed pill comprises an active ingredient A, an active ingredient B and refined honey in parts by mass; the active ingredient A consists of the following components: 30 parts of dried ginger, 30 parts of pepper, 30 parts of long pepper, 30 parts of cinnamon, 30 parts of emblic leafflower fruit, 30 parts of fructus terminaliae billericae meat, 30 parts of whiteflower leadword root, 30 parts of radix stephaniae tetrandrae, 30 parts of rhizoma bletillae, 30 parts of milk peach, 30 parts of white skin pine nut kernel, 30 parts of chamomile and 15 parts of chamomile seed; the active component B is 90 parts of trivia dry fluid extract; the mass percentage of the refined honey in the active component A is 60%.

The preparation method of the honey and the trivia raisins in this example is the same as that of example 1.

The preparation process of the brute force madder-mear-asia honeyed pill by adopting the raw material composition is shown in figure 2, and the preparation process specifically comprises the following steps:

s1, mixing and crushing the active component A into fine powder, and sieving the fine powder by a 100-mesh sieve to obtain medicinal powder;

s2, adding refined honey into the trivia dry fluid extract, mixing, slowly adding the medicinal powder, and further mixing to obtain an intermediate product of the powerful Madereli Ayate preparation, which is marked as an intermediate product b;

s3, refining the intermediate product b into soft materials, making the soft materials into pill strips, making the pill strips into pills, drying and coating to obtain the powerful Made local Ayate honeyed pills F2.

Wherein the weight gain of the coating is 3%. In the step, the soft material has moderate hardness, the adaptability of the instrument is good, and the prepared pill is basically round.

Comparative example 1

Except for the amount of the refined honey, the raw material composition of the brute force maderamide preparation of the comparative example is the same as that of example 2, wherein the refined honey accounts for 90% by mass of the active ingredient a.

The raw material composition is adopted to prepare the Qiangli Ma De Tu Ayate honeyed pill according to the method of the embodiment 2. In the step S3, the soft material is soft, the adaptability of the instrument is poor, and the gear of the instrument is easy to be adhered during the pill making process; the pill has low roundness.

Effect example 1

Taking the intermediate product b in the example 2, the dark avoidance experiment of the model mouse with the aging caused by the traditional Chinese medicine preparation of scopolamine is carried out, and the method is as follows:

1. laboratory animal

Healthy ICR mouse male mice, the weight of which is 20 +/-2 g, are purchased from the disease prevention and control center in Hubei province, are placed in quiet environment with proper temperature and humidity and good ventilation after being separated into cages, freely drink water and reasonably eat food, and the experiment is started 7 days after the mice are adapted to the environment.

2. Required material

The test drugs are: taking the intermediate product b, preparing a suspension with a required concentration by using water, wherein the preparation concentration is 40.4625mg/mL, and the administration doses are respectively as follows: 4.0463mg/20g in the low dose group, 8.0925mg/20g in the medium dose group, and 12.1388mg/20g in the high dose group.

Control drugs: nanchong (Donepezil Hydrochloride Tablets, national Standard H20040751, 5 mg/tablet, available from san Jitang pharmaceutical Co., Ltd., Guizhou) is prepared into a suspension of the desired concentration with water immediately before use.

3. Experimental methods

Dividing 60 ICR mice into six groups according to a random digital table method, wherein each group comprises 10 mice, and the groups respectively comprise a blank control group (distilled water is fed in the gavage), a model group (scopolamine drug is fed in the gavage), a low dose group (low dose test drug is fed in the gavage), a medium dose group (medium dose test drug is fed in the gavage), a high dose group (high dose test drug is fed in the gavage), and a positive control group (Nuchong is fed in the gavage), the mice in the blank group and the medium dose group are intragastrically administered with 8.0925mg/20g each day, the mice in the model group are intragastrically administered with 1.17ug/20g each day, the mice in the positive control group are intragastrically administered with 6.5ug/20g each day, the mice in the low dose group are intragastrically administered with 4.0463mg/20g each day, and the mice in the high dose group are intragastrically administered with 12.1388mg/20g each day.

Twice daily for 25 consecutive days; and forty-five minutes after the second intragastric administration on day 22, injecting normal saline into mice of a blank control group, and injecting 1.17ug/20g of scopolamine (prepared into corresponding concentration by normal saline) into abdominal cavities of a model group, a low dose group, a medium dose group, a high dose group and a positive control group.

On the 22 nd day of administration, the first memory test of the darkening-prevention experiment of the model mouse with the aging caused by scopolamine was carried out fifteen minutes after the injection of scopolamine (the normal saline injection of the blank control group mouse). The mouse head is put into a bright room with a hole on the back, and after the mouse head is adapted to the environment for three minutes, a timer is started. The time recorded by the timer when the mouse enters the opening to reach the dark room and is subjected to an error is taken as the latency. The experiment was trained on mice for 5min and the number of errors in mice within 5min was recorded. The second trial was performed on day 25 of dosing, which was the same as day 22, and the latency of each mouse and the number of errors that occurred within 5min were recorded.

4. Results of the experiment

The results of the experiment are shown in table 1.

TABLE 1 results of the darkening-prevention test in each group of mice (

n＝60)

Note: p <0.05 compared to the blank control group.

The results show that when the mice are injected with scopolamine drugs by the model group, the passive avoidance conditioned reflex of the mice can be prolonged, and the time for making errors for the first time is reduced, and the error occurrence frequency is increased. Compared with a model group and a positive control group, the latency of a low-dose group, a medium-dose group and a high-dose group is obviously prolonged, and the error occurrence frequency is obviously reduced. The preparation of the invention is proved to have certain effect on improving memory. Wherein the high dose group changes more significantly than the low dose group, and the medium dose group changes more significantly than the high dose group. The result shows that the brute force madreporite preparation provided by the invention is effective in treating mild cognitive dysfunction, wherein the treatment effect of the medium dosage is more prominent.

Effect example 2

The intermediate b of example 2 was used to perform the mouse Morris water maze test as follows:

1. experimental animals: the same effect as in example 1 was obtained.

2. The required materials are as follows: the same effect as in example 1 was obtained.

3. Experimental methods

Dividing 60 ICR mice into six groups according to a random digital table method, wherein each group comprises 10 mice, and the groups respectively comprise a blank control group (distilled water is fed in the gavage), a model group (scopolamine drug is fed in the gavage), a low dose group (low dose test drug is fed in the gavage), a medium dose group (medium dose test drug is fed in the gavage), a high dose group (high dose test drug is fed in the gavage), and a positive control group (Nuchong is fed in the gavage), wherein, the mice in the blank group and the medium dose group are intragastrically administered with 8.0925mg/20g every day with the corresponding drugs, the mice in the model group are intragastrically administered with 1.17ug/20g every day with the corresponding drugs, the mice in the positive control group are intragastrically administered with 6.5ug/20g every day with the corresponding drugs, the mice in the low dose group are intragastrically administered with 4.0463mg/20g every day with the corresponding drugs, and the mice in the high dose group are intragastrically administered with 12.1388mg/20g every day with the corresponding drugs; twice daily for 25 consecutive days.

The water maze experiment was started on day 20. And performing second intragastric administration one hour before training, injecting physiological saline into mice in a blank control group after half an hour of administration, and injecting 1.17ug/20g of scopolamine into abdominal cavities of the mice in a model group, a low dose group, a medium dose group, a high dose group and a positive control group. 10 minutes after injection, the water maze experiment was started. The mice were placed in the operating room half an hour in advance and were made familiar with the experimental environment. Injecting warm water (22-25 ℃) into the water pool to enable the liquid level to be about 1cm lower than the platform, drawing the curtain together, putting the mouse back to the platform into the water pool, enabling the mouse to independently find the platform within 150s and automatically climb up for 3 times, staying for 10s, if the mouse does not find the platform, manually placing the mouse on the platform and staying for 25s, and repeating for three times.

Day 21-24: warm water (22-25 ℃) was poured into the tank to bring the surface of the liquid above 1cm of the platform, and then the ink was poured into the tank to cover the platform. The periphery of the pool is pasted with marks with different colors to divide the pool into four quadrants, and the middle points of the four quadrants and the center point of the pool are taken as platform placing positions respectively. The mouse is placed from the farthest distance away from the platform back to the platform, the ability of the mouse to find the platform is trained, the time for finding the platform is recorded, and the ability of the mouse to find the platform at the rest different platform placement positions is exercised. Training was continued for six days, twice a day, and the average of the two times was taken as the final training result. The dosing was continued during the training period, as on day 20.

On day 25 of dosing, the mice were placed at the farthest distance from the platform, the platform was removed to account for the space exploration of the different quadrants of the mice, and the experimental results of the number of times the mice crossed the platform within 150s were recorded. The administration method was the same as on day 20.

3. Results of the experiment

The results of the experiment are shown in table 2.

TABLE 2 Water maze positioning navigation and search results for each group of mice: (

n＝60)

Note: compared to the model group, # P < 0.05.

The results show that the platform finding time of the mouse injected with the scopolamine drug in the model group is prolonged, compared with the model group and the positive control group, the platform finding time of the low-dose group, the medium-dose group and the high-dose group is obviously shortened, and the frequency of the platform is obviously increased, which shows that the preparation provided by the invention has a treatment effect on the memory disorder part in mild cognitive dysfunction. Wherein the high dose group changes more significantly than the low dose group, and the medium dose group changes more significantly than the high dose group. The result shows that the brute force madreporite preparation provided by the invention is effective in treating mild cognitive dysfunction, wherein the treatment effect of the medium dosage is more prominent.

The above examples are illustrative of only a few embodiments of the present invention, and are described in detail and detail, but the scope of the present invention includes but is not limited to these embodiments, and any optimization and modification based on the change of the component ratio is within the scope of the present invention.

Claims

1. A raw material composition of a Qiangli Ma-De-Moli-Ayaite preparation comprises an active component A, an active component B and refined honey in parts by mass; wherein the active ingredient A consists of the following components: 30 parts of dried ginger, 30 parts of pepper, 30 parts of long pepper, 30 parts of cinnamon, 30 parts of emblic leafflower fruit, 30 parts of fructus terminaliae billericae meat, 30 parts of white lead, 30 parts of radix stephaniae tetrandrae, 30 parts of rhizoma bletillae, 30 parts of milk peach, 30 parts of white bark pine nut kernel, 30 parts of chamomile and 15 parts of chamomile seed; the active component B is 60-120 parts of raisin fluid extract;

when the Qiangli Ma De Tu Ayate preparation is a Qiangli Ma De Tu Ayate honeyed pill, the dosage of the refined honey is 50-80%; when the Qiangli Ma-De-Tu-Ayate preparation is Qiangli Ma-De-Tu-Ayate honey paste, the consumption of the refined honey is 300-400%; wherein the percentage is the mass percentage of the active component A.

2. The raw material composition of the doxycycline hyacinthine preparation according to claim 1, wherein the doxycycline hyacinthine preparation is a doxycycline hyacinthine honeyed pill, and the amount of the refined honey is 60%; or the Qiangli Ma-De-Tu-Ayate preparation is Qiangli Ma-De-Tu-Ayate honey paste, and the consumption of the refined honey is 350%;

and/or the relative density of the refined honey is 1.35-1.40.

3. The raw material composition of the brute-force madeira preparation according to claim 1, wherein the active ingredient B is 90 parts of a raisin fluid extract;

and/or the preparation method of the raisin fluid extract comprises the following steps: decocting raisin in water for 3 times, 6 times of water for the first time, 5 times of water for the second time, and 4 times of water for the third time, each time for 1 hr, mixing decoctions, filtering, and concentrating to obtain the final product;

and/or the raisin fluid extract is red raisin fluid extract, preferably trivia raisin fluid extract;

and/or the relative density of the raisin extract is 1.20-1.25.

4. The raw material composition of brute force mad-weed-yagar preparation according to claim 1, wherein when the brute force mad-weed-yagar preparation is brute force mad-weed-paste, the raw material composition of brute force mad-weed-preparation further comprises a preservative; preferably, the preservative is selected from one of benzoic acid or sodium benzoate; further preferably, the preservative is sodium benzoate, and the dosage of the sodium benzoate is preferably 0.15%, and the percentage is the mass percentage of the total amount of the active ingredient A, the active ingredient B and the refined honey.

5. A method for preparing a brute force mad-weed preparation, which comprises preparing a brute force mad-weed preparation from a raw material composition of the brute force mad-weed preparation according to any one of claims 1 to 4.

6. The process for the preparation of the brute force mad-weed preparation according to claim 5, characterized in that it comprises the following steps:

7. The method for preparing the Qiangli Madduli Ayaite preparation according to claim 6, wherein in step S1, the sieving is 80-100 mesh sieving;

and/or, in step S2, adding the refined honey into the raisin extract, mixing uniformly, adding the medicinal powder, and further mixing uniformly;

and/or, when the raw material composition of the brute force madrepore preparation further comprises a preservative, in step S2, the fluid extract, the refined honey, the medicinal powder and the preservative are uniformly mixed.

8. The method of claim 6, wherein in step S3, the intermediate products of the Qiangluma Tulipa preparation are further mixed by colloid mill to obtain Qiangluma Tulipa honey paste;

or in step S3, the intermediate product of the Qiangli Ma Tu Ayate preparation is refined into soft material, the soft material is made into pill strips, the pill strips are made into pills, and the pills are dried to obtain Qiangli Ma Tu Ayate honeyed pills; wherein, after the drying, a coating step is preferably further included.

9. A brute-force madrid-force agate preparation, prepared according to the method for preparing a brute-force madrid-force agate preparation of any one of claims 5 to 8;

the QIANGLIMA MADELI ABATE preparation is QIANGLIMA MADELI ABATE Mel paste or QIANGLIMA MADELI ABATE Mel pill.

10. An application of QIANGLIMADETULI ADATA preparation in preparing medicine for treating mild cognitive dysfunction is provided.