CN114616241A - 基于铁蛋白重链亚基的药物载体 - Google Patents
基于铁蛋白重链亚基的药物载体 Download PDFInfo
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- CN114616241A CN114616241A CN202080050897.2A CN202080050897A CN114616241A CN 114616241 A CN114616241 A CN 114616241A CN 202080050897 A CN202080050897 A CN 202080050897A CN 114616241 A CN114616241 A CN 114616241A
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- ferritin
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Abstract
涉及生物医药领域。具体而言，涉及基于铁蛋白重链亚基的药物载体。更具体地，涉及铁蛋白重链亚基的突变体多肽、包含所述多肽的融合蛋白、包含所述多肽的笼状蛋白，以及它们作为药物载体的应用。
Description
PCT国内申请，说明书已公开。
Claims (39)
- PCT国内申请，权利要求书已公开。
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| CN2019106302099 | 2019-07-12 | ||
| CN201910631186 | 2019-07-12 | ||
| CN201910630209 | 2019-07-12 | ||
| PCT/CN2020/101312 WO2021008454A1 (zh) | 2019-07-12 | 2020-07-10 | 基于铁蛋白重链亚基的药物载体 |
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| CN116897162A (zh) * | 2021-02-25 | 2023-10-17 | 昆山新蕴达生物科技有限公司 | 铁蛋白重链亚基突变体及其应用 |
| CN113181375A (zh) * | 2021-05-13 | 2021-07-30 | 北京市神经外科研究所 | 一种纳米药物及其制备方法 |
| CN117547618A (zh) * | 2022-03-04 | 2024-02-13 | 南京纳么美科技有限公司 | 内腔装载小核酸药物的铁蛋白纳米笼载体及应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104059156A (zh) * | 2014-06-25 | 2014-09-24 | 华东理工大学 | 一种包含生物活性短肽-铁蛋白重链亚基的蛋白纳米粒子及其制备方法 |
| CN106922149A (zh) * | 2014-09-30 | 2017-07-04 | 西纳生物技术有限公司 | 融合蛋白、由多个所述融合蛋白的单体组成的纳米颗粒及其用途 |
| WO2019087155A1 (en) * | 2017-11-06 | 2019-05-09 | Thena Biotech S.r.l. | Fusion-proteins based on human ferritin and protease-cleavable peptides and their use as chemotherapeutics carriers |
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| WO2008048288A2 (en) * | 2005-11-09 | 2008-04-24 | Montana State University | Novel nanoparticles and use thereof |
| CN108503704A (zh) * | 2017-02-27 | 2018-09-07 | 昆山新蕴达生物科技有限公司 | 穿越血脑屏障的纳米药物载体 |
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2020
- 2020-07-10 WO PCT/CN2020/101312 patent/WO2021008454A1/zh active Application Filing
- 2020-07-10 CN CN202080050897.2A patent/CN114616241A/zh active Pending
Patent Citations (3)
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| CN104059156A (zh) * | 2014-06-25 | 2014-09-24 | 华东理工大学 | 一种包含生物活性短肽-铁蛋白重链亚基的蛋白纳米粒子及其制备方法 |
| CN106922149A (zh) * | 2014-09-30 | 2017-07-04 | 西纳生物技术有限公司 | 融合蛋白、由多个所述融合蛋白的单体组成的纳米颗粒及其用途 |
| WO2019087155A1 (en) * | 2017-11-06 | 2019-05-09 | Thena Biotech S.r.l. | Fusion-proteins based on human ferritin and protease-cleavable peptides and their use as chemotherapeutics carriers |
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| 杨彩云等: "铁蛋白表面修饰及其应用", 化学进展, vol. 28, no. 1, pages 91 - 102 * |
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