CN114605254A - 一种粗l-乳酸的精制纯化方法及其纯化装置 - Google Patents
一种粗l-乳酸的精制纯化方法及其纯化装置 Download PDFInfo
- Publication number
- CN114605254A CN114605254A CN202210525606.1A CN202210525606A CN114605254A CN 114605254 A CN114605254 A CN 114605254A CN 202210525606 A CN202210525606 A CN 202210525606A CN 114605254 A CN114605254 A CN 114605254A
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- Prior art keywords
- lactic acid
- percent
- short
- light phase
- distillation
- Prior art date
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- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 title claims abstract description 335
- 238000000034 method Methods 0.000 title claims abstract description 37
- 238000007670 refining Methods 0.000 title claims abstract description 26
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 147
- 239000004310 lactic acid Substances 0.000 claims abstract description 71
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 71
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 26
- 238000010438 heat treatment Methods 0.000 claims abstract description 25
- 238000001704 evaporation Methods 0.000 claims abstract description 24
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 23
- 235000013305 food Nutrition 0.000 claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 21
- 238000005292 vacuum distillation Methods 0.000 claims abstract description 20
- 239000000758 substrate Substances 0.000 claims abstract description 17
- 238000004821 distillation Methods 0.000 claims abstract description 16
- 238000004587 chromatography analysis Methods 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 238000000526 short-path distillation Methods 0.000 claims description 29
- 230000008020 evaporation Effects 0.000 claims description 16
- 230000008569 process Effects 0.000 claims description 8
- 238000000746 purification Methods 0.000 claims description 8
- 230000003287 optical effect Effects 0.000 claims description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 6
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 6
- 150000002505 iron Chemical class 0.000 claims description 6
- 238000004042 decolorization Methods 0.000 claims description 5
- 229960000448 lactic acid Drugs 0.000 description 61
- 238000004519 manufacturing process Methods 0.000 description 13
- 229920000747 poly(lactic acid) Polymers 0.000 description 6
- 239000004626 polylactic acid Substances 0.000 description 6
- 238000004891 communication Methods 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 238000000605 extraction Methods 0.000 description 4
- 238000000855 fermentation Methods 0.000 description 4
- 230000004151 fermentation Effects 0.000 description 4
- 238000011161 development Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 229930182843 D-Lactic acid Natural products 0.000 description 2
- JVTAAEKCZFNVCJ-UWTATZPHSA-N D-lactic acid Chemical compound C[C@@H](O)C(O)=O JVTAAEKCZFNVCJ-UWTATZPHSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229940022769 d- lactic acid Drugs 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 239000010985 leather Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000007639 printing Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- KVZLHPXEUGJPAH-UHFFFAOYSA-N 2-oxidanylpropanoic acid Chemical compound CC(O)C(O)=O.CC(O)C(O)=O KVZLHPXEUGJPAH-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- -1 printing Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
- C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/47—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/10—Process efficiency
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (10)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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CN2021112805105 | 2021-11-01 | ||
CN202111280510.5A CN114276233A (zh) | 2021-11-01 | 2021-11-01 | 一种粗l-乳酸的精制纯化方法及其纯化装置 |
Publications (2)
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CN114605254A true CN114605254A (zh) | 2022-06-10 |
CN114605254B CN114605254B (zh) | 2022-08-23 |
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CN202111280510.5A Pending CN114276233A (zh) | 2021-11-01 | 2021-11-01 | 一种粗l-乳酸的精制纯化方法及其纯化装置 |
CN202210525606.1A Active CN114605254B (zh) | 2021-11-01 | 2022-05-16 | 一种粗l-乳酸的精制纯化方法及其纯化装置 |
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CN202111280510.5A Pending CN114276233A (zh) | 2021-11-01 | 2021-11-01 | 一种粗l-乳酸的精制纯化方法及其纯化装置 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN115322088A (zh) * | 2022-07-18 | 2022-11-11 | 吉峰久业生物科技(天津)有限公司 | L-乳酸成品100%含量的工业大生产提取工艺 |
Families Citing this family (1)
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CN114276232A (zh) * | 2021-10-28 | 2022-04-05 | 欧尚元(天津)有限公司 | 一种超纯级乳酸的制备方法及其制备装置 |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1270953A (zh) * | 2000-03-20 | 2000-10-25 | 湖北省广水市民族化工有限公司 | 乳酸的短程暨分子蒸馏精制工艺 |
US20020004610A1 (en) * | 2000-05-23 | 2002-01-10 | Eric Dubois | Process for the preparation of lactic acid by evaporative crystallisation |
CN101007756A (zh) * | 2006-01-25 | 2007-08-01 | 上海同杰良生物材料有限公司 | 一种制取高纯度l-乳酸的工艺方法 |
CN101234960A (zh) * | 2008-03-04 | 2008-08-06 | 江苏道森生物化学有限公司 | 一种利用离心分子蒸馏技术制备高纯度乳酸的方法 |
CN101607887A (zh) * | 2008-06-16 | 2009-12-23 | 中国科学院过程工程研究所 | 发酵法清洁生产乳酸的方法 |
CN103724183A (zh) * | 2013-12-16 | 2014-04-16 | 河南金丹乳酸科技股份有限公司 | 利用分子蒸馏技术工业化生产乳酸的方法 |
CN104178438A (zh) * | 2014-08-01 | 2014-12-03 | 湖北艾尔生物科技有限公司 | 一株适合于糖蜜发酵生产高纯度l-乳酸的德式乳酸杆菌及发酵方法和应用 |
CN104263765A (zh) * | 2014-09-10 | 2015-01-07 | 湖北艾尔生物科技有限公司 | 一种直接发酵生产l-乳酸钠的方法及发酵培养基配方 |
CN107382713A (zh) * | 2017-08-30 | 2017-11-24 | 沈阳金博地生态环保科技有限公司 | 一种提纯乳酸的工艺 |
CN111269107A (zh) * | 2020-04-09 | 2020-06-12 | 安徽固德生物工程有限公司 | 一种l-乳酸提纯精制方法 |
-
2021
- 2021-11-01 CN CN202111280510.5A patent/CN114276233A/zh active Pending
-
2022
- 2022-05-16 CN CN202210525606.1A patent/CN114605254B/zh active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1270953A (zh) * | 2000-03-20 | 2000-10-25 | 湖北省广水市民族化工有限公司 | 乳酸的短程暨分子蒸馏精制工艺 |
US20020004610A1 (en) * | 2000-05-23 | 2002-01-10 | Eric Dubois | Process for the preparation of lactic acid by evaporative crystallisation |
CN101007756A (zh) * | 2006-01-25 | 2007-08-01 | 上海同杰良生物材料有限公司 | 一种制取高纯度l-乳酸的工艺方法 |
CN101234960A (zh) * | 2008-03-04 | 2008-08-06 | 江苏道森生物化学有限公司 | 一种利用离心分子蒸馏技术制备高纯度乳酸的方法 |
CN101607887A (zh) * | 2008-06-16 | 2009-12-23 | 中国科学院过程工程研究所 | 发酵法清洁生产乳酸的方法 |
CN103724183A (zh) * | 2013-12-16 | 2014-04-16 | 河南金丹乳酸科技股份有限公司 | 利用分子蒸馏技术工业化生产乳酸的方法 |
CN104178438A (zh) * | 2014-08-01 | 2014-12-03 | 湖北艾尔生物科技有限公司 | 一株适合于糖蜜发酵生产高纯度l-乳酸的德式乳酸杆菌及发酵方法和应用 |
CN104263765A (zh) * | 2014-09-10 | 2015-01-07 | 湖北艾尔生物科技有限公司 | 一种直接发酵生产l-乳酸钠的方法及发酵培养基配方 |
CN107382713A (zh) * | 2017-08-30 | 2017-11-24 | 沈阳金博地生态环保科技有限公司 | 一种提纯乳酸的工艺 |
CN111269107A (zh) * | 2020-04-09 | 2020-06-12 | 安徽固德生物工程有限公司 | 一种l-乳酸提纯精制方法 |
Non-Patent Citations (2)
Title |
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南京药学院药剂学教研组: "《药剂学》", 31 May 1985, 人民卫生出版社 * |
张嫦等: "《精细化工工艺原理与技术》", 31 October 2005, 四川科学技术出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115322088A (zh) * | 2022-07-18 | 2022-11-11 | 吉峰久业生物科技(天津)有限公司 | L-乳酸成品100%含量的工业大生产提取工艺 |
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Publication number | Publication date |
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CN114276233A (zh) | 2022-04-05 |
CN114605254B (zh) | 2022-08-23 |
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GR01 | Patent grant | ||
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CP03 | Change of name, title or address | ||
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Address after: No. 16 Huike Road, Shuanggang Town, Jinnan District, Tianjin, 300350 Patentee after: Oushangyuan Intelligent Equipment Co.,Ltd. Country or region after: China Address before: 300350 6-3-501, Ligang Park, Shuanggang Town, Jinnan District, Tianjin Patentee before: Aoshangyuan (Tianjin) Co.,Ltd. Country or region before: China |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A refined purification method and purification device for crude L-lactic acid Granted publication date: 20220823 Pledgee: Agricultural Bank of China Limited Tianjin Jinnan Branch Pledgor: Oushangyuan Intelligent Equipment Co.,Ltd. Registration number: Y2024980019976 |