CN1145624C - 合成奥美拉唑的新方法 - Google Patents

合成奥美拉唑的新方法 Download PDF

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Publication number
CN1145624C
CN1145624C CNB988017970A CN98801797A CN1145624C CN 1145624 C CN1145624 C CN 1145624C CN B988017970 A CNB988017970 A CN B988017970A CN 98801797 A CN98801797 A CN 98801797A CN 1145624 C CN1145624 C CN 1145624C
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CN
China
Prior art keywords
omeprazole
titanium
methoxy
titanium complex
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB988017970A
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English (en)
Chinese (zh)
Other versions
CN1243512A (zh
Inventor
H���ƶ�����
H·科顿
M·拉松
A·马特松
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
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AstraZeneca AB
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Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1243512A publication Critical patent/CN1243512A/zh
Application granted granted Critical
Publication of CN1145624C publication Critical patent/CN1145624C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CNB988017970A 1997-11-14 1998-11-03 合成奥美拉唑的新方法 Expired - Fee Related CN1145624C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE97041834 1997-11-14
SE9704183A SE9704183D0 (sv) 1997-11-14 1997-11-14 New process

Publications (2)

Publication Number Publication Date
CN1243512A CN1243512A (zh) 2000-02-02
CN1145624C true CN1145624C (zh) 2004-04-14

Family

ID=20408989

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB988017970A Expired - Fee Related CN1145624C (zh) 1997-11-14 1998-11-03 合成奥美拉唑的新方法

Country Status (35)

Country Link
US (1) US6303788B1 (enExample)
EP (1) EP0964859A1 (enExample)
JP (1) JP2001508466A (enExample)
KR (1) KR20000070069A (enExample)
CN (1) CN1145624C (enExample)
AR (1) AR013740A1 (enExample)
AU (1) AU750743B2 (enExample)
BR (1) BR9806871A (enExample)
CA (1) CA2276753A1 (enExample)
DE (1) DE964859T1 (enExample)
DZ (1) DZ2641A1 (enExample)
EE (1) EE04154B1 (enExample)
ES (1) ES2138950T1 (enExample)
GR (1) GR990300046T1 (enExample)
HR (1) HRP990218A2 (enExample)
HU (1) HUP0003737A3 (enExample)
ID (1) ID21999A (enExample)
IL (1) IL130647A0 (enExample)
IN (1) IN190801B (enExample)
IS (1) IS5106A (enExample)
MA (1) MA26564A1 (enExample)
MY (1) MY118199A (enExample)
NO (1) NO318197B1 (enExample)
NZ (1) NZ336447A (enExample)
PL (1) PL334701A1 (enExample)
RU (1) RU2211218C2 (enExample)
SE (1) SE9704183D0 (enExample)
SK (1) SK87299A3 (enExample)
TN (1) TNSN98202A1 (enExample)
TR (1) TR199901643T1 (enExample)
TW (1) TW588046B (enExample)
UA (1) UA68342C2 (enExample)
WO (1) WO1999025711A1 (enExample)
YU (1) YU31199A (enExample)
ZA (1) ZA989999B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
UA72748C2 (en) 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole
IL142703A (en) 1998-11-10 2006-04-10 Astrazeneca Ab Crystalline form of omeprazole
CN100347167C (zh) 2001-02-02 2007-11-07 特瓦制药工业有限公司 取代的2－(2－吡啶基甲基)亚磺酰基－1h－苯并咪唑化合物的生产方法
SE0203092D0 (en) * 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP1802584B1 (en) 2004-10-11 2009-09-16 Ranbaxy Laboratories Limited Processes for the preparation of substituted sulfoxides
EP1801110A1 (en) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Esomeprazole arginine salt
CN1810803B (zh) * 2006-02-17 2010-11-17 中国科学院上海有机化学研究所 高对映体选择性制备(s)-奥美拉唑的方法
CN101538264A (zh) * 2008-03-19 2009-09-23 中国科学院成都有机化学有限公司 手性亚砜类化合物的制备新方法
CN102603621B (zh) * 2012-02-07 2013-09-04 成都苑东药业有限公司 一种新型手性亚砜化合物和以该化合物制备埃索美拉唑钠的方法
CN106083819A (zh) * 2016-06-08 2016-11-09 扬子江药业集团有限公司 一种奥美拉唑的制备方法
ES2948511A1 (es) * 2021-09-08 2023-09-13 Fundacion Para La Investigacion Biomedica Del Hospital Univ De La Princesa Derivados de n-sulfonilureas y su uso terapeutico

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
SE9002043D0 (sv) 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
NZ244301A (en) 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
SE504459C2 (sv) * 1994-07-15 1997-02-17 Astra Ab Förfarande för framställning av substituerade sulfoxider

Also Published As

Publication number Publication date
EE9900391A (et) 2000-04-17
BR9806871A (pt) 2000-04-18
UA68342C2 (en) 2004-08-16
AR013740A1 (es) 2001-01-10
HUP0003737A2 (hu) 2001-10-28
NZ336447A (en) 2001-02-23
TNSN98202A1 (fr) 2005-03-15
KR20000070069A (ko) 2000-11-25
TW588046B (en) 2004-05-21
IN190801B (enExample) 2003-08-23
CA2276753A1 (en) 1999-05-27
ID21999A (id) 1999-08-19
ZA989999B (en) 1999-06-17
IL130647A0 (en) 2000-06-01
EE04154B1 (et) 2003-10-15
YU31199A (sh) 2002-06-19
IS5106A (is) 1999-07-02
CN1243512A (zh) 2000-02-02
JP2001508466A (ja) 2001-06-26
SK87299A3 (en) 2000-02-14
DZ2641A1 (fr) 2003-03-15
NO993298D0 (no) 1999-07-02
MA26564A1 (fr) 2004-12-20
MY118199A (en) 2004-09-30
SE9704183D0 (sv) 1997-11-14
HUP0003737A3 (en) 2002-01-28
PL334701A1 (en) 2000-03-13
ES2138950T1 (es) 2000-02-01
NO993298L (no) 1999-07-02
DE964859T1 (de) 2000-05-04
EP0964859A1 (en) 1999-12-22
GR990300046T1 (en) 2000-07-31
RU2211218C2 (ru) 2003-08-27
NO318197B1 (no) 2005-02-14
HRP990218A2 (en) 2000-08-31
WO1999025711A1 (en) 1999-05-27
AU1058299A (en) 1999-06-07
AU750743B2 (en) 2002-07-25
US6303788B1 (en) 2001-10-16
TR199901643T1 (xx) 2000-01-21

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GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee