CN114555634B - 用于扩增调节性t细胞的白介素-2突变蛋白 - Google Patents

用于扩增调节性t细胞的白介素-2突变蛋白 Download PDF

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CN114555634B
CN114555634B CN202080071358.7A CN202080071358A CN114555634B CN 114555634 B CN114555634 B CN 114555634B CN 202080071358 A CN202080071358 A CN 202080071358A CN 114555634 B CN114555634 B CN 114555634B
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cells
human
mutein
protein
fusion protein
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CN114555634A (zh
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D·L·贝茨
S·J·索恩
H·卡特拉尔
Z·王
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Amgen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61P37/02—Immunomodulators
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

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CN202080071358.7A 2019-08-13 2020-08-13 用于扩增调节性t细胞的白介素-2突变蛋白 Active CN114555634B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962886283P 2019-08-13 2019-08-13
US62/886283 2019-08-13
PCT/US2020/046202 WO2021030602A1 (en) 2019-08-13 2020-08-13 Interleukin-2 muteins for the expansion of t-regulatory cells

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CN114555634A CN114555634A (zh) 2022-05-27
CN114555634B true CN114555634B (zh) 2025-01-10

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US (1) US12600758B2 (https=)
EP (2) EP4385573A3 (https=)
JP (2) JP2022544236A (https=)
KR (1) KR20220044577A (https=)
CN (1) CN114555634B (https=)
AR (1) AR119769A1 (https=)
AU (1) AU2020328038B2 (https=)
BR (1) BR112022002666A2 (https=)
CA (1) CA3150441A1 (https=)
CL (3) CL2022000355A1 (https=)
CO (1) CO2022002818A2 (https=)
CR (1) CR20220111A (https=)
IL (1) IL290433A (https=)
JO (1) JOP20220036A1 (https=)
MX (1) MX2022001866A (https=)
PE (1) PE20220706A1 (https=)
PH (1) PH12022550326A1 (https=)
TW (1) TW202120534A (https=)
UY (1) UY38836A (https=)
WO (1) WO2021030602A1 (https=)

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WO2019028419A1 (en) 2017-08-03 2019-02-07 Synthorx, Inc. CYTOKINE CONJUGATES FOR THE TREATMENT OF PROLIFERATIVE AND INFECTIOUS DISEASES
ES3059360T3 (en) 2018-11-08 2026-03-19 Synthorx Inc Interleukin 10 conjugates and uses thereof
KR20260039812A (ko) 2019-02-06 2026-03-20 신톡스, 인크. Il-2 콘쥬게이트 및 이의 사용 방법
AU2020328038B2 (en) 2019-08-13 2025-10-09 Amgen Inc. Interleukin-2 muteins for the expansion of T-regulatory cells
CN114555632A (zh) 2019-08-23 2022-05-27 新索思股份有限公司 Il-15缀合物及其用途
MX2022002740A (es) 2019-09-10 2022-03-25 Synthorx Inc Conjugados de il-2 y metodos de uso para tratar enfermedades autoinmunes.
IL310292A (en) 2021-07-22 2024-03-01 Univ Dundee Medicinal myotains
CN115487292B (zh) * 2022-09-28 2025-01-21 河北师范大学 一种治疗糖尿病的联合用药物及其应用

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