CN114533695A - 一种治疗强直性脊柱炎的口服补肾除痹中药组合物及其制备方法 - Google Patents
一种治疗强直性脊柱炎的口服补肾除痹中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗强直性脊柱炎的口服补肾除痹中药组合物及其制备方法,属于中药技术领域。本发明的中药组合物,包括以下重量份数的原料:雷公藤12~16份、淫羊藿20~40份、橘皮8~10份、决明子10~12份、茯苓8~10份、荷叶6~8份、裕民贝母提取物1~3份、金线莲提取物2~4份、圆齿野鸭椿提取物2~4份、蒲公英2~4份、车前子2~5份、红参1~2份、黄岑2~4份、白术2~4份、石膏4~6份、甘草1~3份、无花果根2~3份、天仙藤1~3份、乳蓟1~2份、山楂2~4份、藿香2~4份、砂仁1~2份、葛根3~4份、藏红花1~2份。本发明的中药组合物可以有效的治疗强直性脊柱炎。
Description
技术领域
本发明涉及中药技术领域,特别是涉及一种治疗强直性脊柱炎的口服补肾除痹中药组合物及其制备方法。
背景技术
强直性脊柱炎(AS)是以骶髂关节和脊柱附着点炎症为主要症状的疾病,与HLA-B27呈强关联,某些微生物(如克雷白杆菌)与易感者自身组织具有共同抗原,可引发异常免疫应答,是四肢大关节,以及椎间盘纤维环及其附近结缔组织纤维化和骨化,以及关节强直为病变特点的慢性炎性疾病。强直性脊柱炎属风湿病范畴,病因尚不明确,是以脊柱为主要病变部位的慢性病,引起脊柱强直和纤维化,造成不同程度眼、肺、肌肉、骨骼病变,是自身免疫性疾病。并且该病因病理不清,属于顽固性疾病,较难治疗。
现代医学治疗应用非甾体类抗炎药及免疫制剂甚至激素,虽可缓解症状,但长期服用易造成胃黏膜损害、肝肾损害、骨髓抑制等副作用,患者往往难以耐受,停药后易反复或症状较前加重。相对于西药的对标治疗,中医在对本治疗方面积累了丰富的经验。传统中药在这方面的研究也具有一定优势。从疾病整体出发,辨证论治,对于强直性脊柱炎的治疗还是有方法的。中药中常用毒性药物如雷公藤等,具有优良的消炎止痛作用,服用方便,但肝毒性显著,并且还会造成一定的胃肠反应、白细胞减少等问题。而如何制备得到一种治疗作用显著,且不会引发不良反应的中药组合物,成为本领域技术人员亟待解决的技术难题。
发明内容
本发明的目的是提供一种治疗强直性脊柱炎的口服补肾除痹中药组合物及其制备方法,以解决上述现有技术存在的问题。
为实现上述目的,本发明提供了如下方案:
本发明的技术方案之一:一种治疗强直性脊柱炎的口服补肾除痹中药组合物,包括以下重量份数的原料:雷公藤12~16份、淫羊藿20~40份、橘皮8~10份、决明子10~12份、茯苓8~10份、荷叶6~8份、裕民贝母提取物1~3份、金线莲提取物2~4份、圆齿野鸭椿提取物2~4份、蒲公英2~4份、车前子2~5份、红参1~2份、黄岑2~4份、白术2~4份、石膏4~6份、甘草1~3份、无花果根2~3份、天仙藤1~3份、乳蓟1~2份、山楂2~4份、藿香2~4份、砂仁1~2份、葛根3~4份、藏红花1~2份。
进一步地,所述中药组合物,包括以下重量份数的原料:雷公藤15份、淫羊藿30份、橘皮8份、决明子10份、茯苓8份、荷叶6份、裕民贝母提取物2份、金线莲提取物3份、圆齿野鸭椿提取物4份、蒲公英4份、车前子3份、红参1份、黄岑2份、白术3份、石膏5份、甘草2份、无花果根2份、天仙藤1份、乳蓟2份、山楂3份、藿香2份、砂仁2份、葛根3份、藏红花1份。
雷公藤:具有祛风除湿,活血通络,消肿止痛,杀虫解毒之功效。常用于类风湿性关节炎,风湿性关节炎,肾小球肾炎,肾病综合征,红斑狼疮,口眼干燥综合征,白塞病,湿疹,银屑病,麻风病,疥疮,顽癣。
淫羊藿:味辛甘性温,走肝肾二经。为补命门、益精气、强筋骨、补肾壮阳之要药,具有增加心脑血管血流量,促进造血功能、免疫功能及骨代谢,具有抗衰老、抗肿瘤等功效。
橘皮:健脾开胃、理气消食、燥湿化痰。
决明子:味苦、甘、咸,性微寒,入肝、肾、大肠经;决明子润肠通便,降脂明目,治疗便秘及高血脂,高血压;清肝明目,利水通便,有缓泻作用,降血压降血脂。
茯苓:利水渗湿、健脾止泻、宁心安神、防癌抗癌。
荷叶:清暑化湿、升发清阳、凉血止血。
蒲公英:清热解毒、消肿散结、利尿通淋。
车前子:清热利尿、渗湿止泻、化痰止咳。
红参:大补元气,固脱生津,安神。治劳伤虚损,食少,倦怠,反胃吐食,大便滑泄,虚咳喘促,自汗暴脱,惊悸,健忘,眩晕头痛,阳痿,尿频,消渴,妇女崩漏,小儿慢惊,及久虚不复,一切气血津液不足之证。
黄岑:苦寒,归肺经、胆经、脾经、大肠经和小肠经,有清热燥湿、泻火解毒、凉血、止血、安胎的作用。
白术:利尿消肿、固表止汗、燥湿健脾。
石膏:清热泻火、解渴生津、凝血止血。
甘草:补脾和胃、益气复脉、镇咳平喘、镇痛。
无花果根:具有清热解毒,消肿止痛,祛风除湿,消炎杀菌的功效。
天仙藤:行气化湿、活血止痛。
乳蓟:强化及保护肝脏,阻挡毒性物质;促进肝细胞之再生及重建受损的肝细胞,防止肝硬化;保护肝脏细胞免遭自由基的破坏。
山楂:消食健胃、活血化淤、收敛止痢。
藿香:芳香化浊、和中止呕、发表解暑。
砂仁:温脾开胃、止呕止泻、理气安胎、化湿行气。
葛根:性凉,味甘、辛,入脾、胃经,具清热、降火、排毒诸功效。葛根含有丰富的葛根素、葛根素本糖苷、大豆异黄酮、大豆苷元、氨基酸、微量元素、三萜类物质碱等对人体有益的重要生物活性物质。可提高肝细胞的再生能力,恢复正常肝脏机能,促进胆汁分泌,防止脂肪在肝脏堆积。促进新陈代谢,加强肝脏解毒功能,防止酒精对肝脏的损伤。强化肝胆细胞自身免疫功能,抵抗病毒入侵。
藏红花:藏红花酸能降低胆固醇和增加脂肪代谢,可配合山楂、草决明、泽泻等传统中药,用于脂肪肝的治疗。
进一步地,所述裕民贝母提取物的制备具体包括:将裕民贝母粉碎后加入乙醇溶液回流提取,提取液除去乙醇后,浓缩至膏状得到裕民贝母提取物。
裕民贝母提取物中含有裕贝甲素、裕贝碱苷、西贝素、托贝辛等成分,可以有效的改善肝损伤。
进一步地,所述金线莲提取物的制备具体包括:将金线莲粉碎后,加水一次煎煮后,得到一次滤液和滤渣;在滤渣中加水二次煎煮,得到二次滤液;将一次滤液和二次滤液混合后,浓缩至膏状得到金线莲提取物。
金线莲提取物中含有多糖、牛磺酸、氨基酸、微量元素等成分;多糖有助于增加人体免疫力,分子中的多糖链具有免疫活性;牛磺酸在循环系统中可抑制血小板凝集,降低血脂,保持人体正常血压和防止动脉硬化,对心肌细胞有保护作用,可抗心律失常,对降低血液中胆固醇含量有特殊疗效,可治疗心力衰竭。
进一步地,所述圆齿野鸭椿提取物的制备具体包括:将圆齿野鸭椿粉碎后,加入乙醇,回流提取得到提取液,提取液浓缩除去乙醇得到圆齿野鸭椿提取物。
圆齿野鸭椿提取物中含有鞣质、黄酮类、酚类、酯类等成分,具有抗炎、镇痛、抗肝损伤等作用。
通过裕民贝母提取物、金线莲提取物、圆齿野鸭椿提取物中的活性成分与雷公藤的合理配比,可以有效的降低肝损伤,同时结合组合物中的葛根和藏红花的促进肝脏毒素的代谢作用,可以有效的解决因服用雷公藤造成的肝毒性显著的问题。
本发明的技术方案之二:一种上述的治疗强直性脊柱炎的口服补肾除痹中药组合物的制备方法,包括以下步骤:
(1)按以上重量份数称取原料;
(2)将雷公藤、淫羊藿、橘皮、决明子、茯苓、荷叶、蒲公英、车前子、红参、黄岑、白术、石膏、甘草、无花果根、天仙藤、乳蓟、山楂、藿香、砂仁、葛根、藏红花混合均匀后,加水一次煎煮,得到一次滤液和滤渣;滤渣中加水二次煎煮,得到二次滤液;
(3)将一次滤液、二次滤液、裕民贝母提取物、金线莲提取物和圆齿野鸭椿提取物混合均匀,煮沸后转文火煎煮得到混合提取液;
(4)将混合提取液浓缩成相对密度为1.35~1.40的稠膏,干燥,粉碎成细粉;
(5)将步骤(4)制备得到的细粉装入胶囊,得到所述口服补肾除痹中药组合物。
进一步地,步骤(2)中,所述一次煎煮的加水量为1000~1500重量份,煎煮时间为2~3h;所述二次煎煮的加水量为800~1000重量份,煎煮时间为1~2h。
进一步地,步骤(3)中,所述文火煎煮的时间为20~30min。
进一步地,步骤(4)中,所述细粉的粒径为100~120目。
进一步地,步骤(5)中,所述胶囊中细粉的重量为0.5g。
本发明公开了以下技术效果:
(1)本发明的中药组合物以雷公藤和淫羊藿为君药,祛风除湿,活血通络,消肿止痛,补命门、益精气、强筋骨、补肾壮阳;以橘皮、决明子茯苓、荷叶为臣药,健脾开胃、利水通便、祛湿消炎;以裕民贝母提取物、金线莲提取物、圆齿野鸭椿提取物、蒲公英、车前子、红参、黄岑为佐药,在保护肝脏的同时,促进肝脏内有毒物质的代谢;以白术、石膏、甘草、无花果根、天仙藤、乳蓟、山楂、藿香、砂仁、葛根、藏红花为使药,养胃、补肾。多种药物相互作用配比,发挥了治疗强直性脊柱炎的作用。
(2)本发明的中药组合物,解决了传统配方中采用雷公藤治疗强直性脊柱炎时,造成肝脏毒性的问题,降低了不良反应的发生,有效地利用了治疗作用显著的雷公藤,为采用中药有效治疗强直性脊柱炎提供了一定的研究基础。
具体实施方式
现详细说明本发明的多种示例性实施方式,该详细说明不应认为是对本发明的限制,而应理解为是对本发明的某些方面、特性和实施方案的更详细的描述。
应理解本发明中所述的术语仅仅是为描述特别的实施方式,并非用于限制本发明。另外,对于本发明中的数值范围,应理解为还具体公开了该范围的上限和下限之间的每个中间值。在任何陈述值或陈述范围内的中间值以及任何其他陈述值或在所述范围内的中间值之间的每个较小的范围也包括在本发明内。这些较小范围的上限和下限可独立地包括或排除在范围内。
除非另有说明,否则本文使用的所有技术和科学术语具有本发明所述领域的常规技术人员通常理解的相同含义。虽然本发明仅描述了优选的方法和材料,但是在本发明的实施或测试中也可以使用与本文所述相似或等同的任何方法和材料。本说明书中提到的所有文献通过引用并入,用以公开和描述与所述文献相关的方法和/或材料。在与任何并入的文献冲突时,以本说明书的内容为准。
在不背离本发明的范围或精神的情况下,可对本发明说明书的具体实施方式做多种改进和变化,这对本领域技术人员而言是显而易见的。由本发明的说明书得到的其他实施方式对技术人员而言是显而易见的。本申请说明书和实施例仅是示例性的。
关于本文中所使用的“包含”、“包括”、“具有”、“含有”等等,均为开放性的用语,即意指包含但不限于。
实施例1
一种治疗强直性脊柱炎的口服补肾除痹中药组合物:
由以下重量份数的原料组成:雷公藤15份、淫羊藿30份、橘皮8份、决明子10份、茯苓8份、荷叶6份、裕民贝母提取物2份、金线莲提取物3份、圆齿野鸭椿提取物4份、蒲公英4份、车前子3份、红参1份、黄岑2份、白术3份、石膏5份、甘草2份、无花果根2份、天仙藤1份、乳蓟2份、山楂3份、藿香2份、砂仁2份、葛根3份、藏红花1份。
一种治疗强直性脊柱炎的口服补肾除痹中药组合物的制备方法:
(1)按以上重量份数称取原料;
(2)将雷公藤、淫羊藿、橘皮、决明子、茯苓、荷叶、蒲公英、车前子、红参、黄岑、白术、石膏、甘草、无花果根、天仙藤、乳蓟、山楂、藿香、砂仁、葛根、藏红花混合均匀后,加1200重量份水一次煎煮2.5h,过滤,得到一次滤液和滤渣;滤渣中加800重量份水二次煎煮1h,过滤,得到二次滤液;
(3)将一次滤液、二次滤液、裕民贝母提取物、金线莲提取物和圆齿野鸭椿提取物混合均匀,煮沸后转文火煎煮20min,得到混合提取液;
(4)将混合提取液浓缩成相对密度为1.35的稠膏,60℃干燥,粉碎成100目的细粉;
(5)将步骤(4)制备得到的细粉装入胶囊,每个胶囊装入0.50g细粉,得到所述口服补肾除痹中药组合物。
裕民贝母提取物的制备方法为:将裕民贝母粉碎至100目得到裕民贝母粉,然后将裕民贝母粉与体积分数为60%的乙醇水溶液以体积比1:10混合均匀后,加热回流提取2h,提取液除去乙醇后,浓缩至膏状(相对密度为1.30),得到裕民贝母提取物。
金线莲提取物的制备方法为:将10份金线莲粉碎至200目得到金线莲粉,加入100重量份水煎煮1.5h,过滤,得到滤液和滤渣;在滤渣中继续加入80重量份水煎煮40min,过滤,得到滤液;合并两次煎煮得到的滤液,浓缩至膏状(相对密度为1.25),得到金线莲提取物。
圆齿野鸭椿提取物的制备方法为:将10份圆齿野鸭椿粉碎至100目,加入200份体积分数为95%的乙醇,回流提取1.5h,得到提取液,提取液旋转蒸发除去乙醇后,得到圆齿野鸭椿提取物。
实施例2
同实施例1,区别在于,中药组合物由以下重量份数的原料组成:雷公藤16份、淫羊藿20份、橘皮8份、决明子12份、茯苓10份、荷叶6份、裕民贝母提取物3份、金线莲提取物2份、圆齿野鸭椿提取物2份、蒲公英2份、车前子5份、红参1份、黄岑4份、白术2份、石膏4份、甘草1份、无花果根3份、天仙藤2份、乳蓟1份、山楂2份、藿香4份、砂仁1份、葛根4份、藏红花1份。
实施例3
同实施例1,区别在于,中药组合物由以下重量份数的原料组成:雷公藤12份、淫羊藿40份、橘皮10份、决明子12份、茯苓10份、荷叶6份、裕民贝母提取物1份、金线莲提取物4份、圆齿野鸭椿提取物4份、蒲公英2份、车前子2份、红参2份、黄岑2份、白术4份、石膏6份、甘草3份、无花果根2份、天仙藤1份、乳蓟2份、山楂4份、藿香2份、砂仁2份、葛根3份、藏红花2份。
对比例1
中药组合物由以下重量份数的原料组成:雷公藤15份、淫羊藿30份、橘皮8份、决明子10份、茯苓8份、荷叶6份、裕民贝母6份、金线莲8份、圆齿野鸭椿10份、蒲公英4份、车前子3份、红参1份、黄岑2份、白术3份、石膏5份、甘草2份、无花果根2份、天仙藤1份、乳蓟2份、山楂3份、藿香2份、砂仁2份、葛根3份、藏红花1份。
中药组合物制备方法:
(1)按以上重量份数称取原料;
(2)将雷公藤、淫羊藿、橘皮、决明子、茯苓、荷叶、裕民贝母、金线莲、圆齿野鸭椿、蒲公英、车前子、红参、黄岑、白术、石膏、甘草、无花果根、天仙藤、乳蓟、山楂、藿香、砂仁、葛根、藏红花混合均匀后,加1200重量份水一次煎煮2.5h,过滤,得到一次滤液和滤渣;滤渣中加800份重量水二次煎煮1h,过滤,得到二次滤液;
(3)将一次滤液、二次滤液混合均匀,煮沸后转文火煎煮20min,得到混合提取液;
(4)将混合提取液浓缩成相对密度为1.35的稠膏,60℃干燥,粉碎成100目的细粉;
(5)将步骤(4)制备得到的细粉装入胶囊,每个胶囊装入0.50g细粉,得到所述口服补肾除痹中药组合物。
对比例2
同实施例1,区别在于,中药组合物中不含有裕民贝母提取物、金线莲提取物、圆齿野鸭椿提取物。
对比例3
同实施例1,区别在于,中药组合物中不含有橘皮、决明子。
对比例4
同实施例1,区别在于,中药组合物中含有雷公藤30份、淫羊藿15份。
效果例1
采用实施例1~3和对比例1~4制备得到的中药组合物治疗小鼠踝关节肿胀。
实验用SD大鼠:体重在150g左右的雄性SD大鼠90只,购自凯学生物科技(上海)有限公司。
(1)将SD大鼠随机分成9组,分组情况如表1所示。
表1
(2)实验用大鼠模型的建立
试验前1d用软尺测量所有大鼠右后肢踝关节周长(cm)作为基础值,并在所有大鼠右后足垫皮内注射Freund’s完全佐剂0.1mL/只致炎。
(3)治疗
(1)模型对照组:灌胃生理盐水,剂量为20mg/kg大鼠,早晚各灌胃一次。
(2)阳性药物对照组:灌胃消炎痛(广东华南药业集团有限公),剂量为1mg/kg大鼠,早晚各灌胃一次。
(3)中药组合物组:7组分别灌胃实施例1~3和对比例1~4制备得到的中药组合物,剂量为20mg/kg大鼠,早晚各灌胃一次。
按以上方法连续给药15d后测量大鼠右后肢踝关节周长(cm),计算踝关节肿胀值,公式如下:
踝关节肿胀值=治疗15d后肢踝关节周长-试验前踝关节周长;结果见表2。
表2
分组 | 给药后踝关节肿胀值(mm) |
第1组 | 0.78 |
第2组 | 0.54 |
第3组 | 0.55 |
第4组 | 0.58 |
第5组 | 0.56 |
第6组 | 0.58 |
第7组 | 0.63 |
第8组 | 0.61 |
第9组 | 0.66 |
从表2中可以看出,本发明的实施例1~3制备得到的中药组合物具有良好的消炎作用,效果与西药消炎痛相当,并且改变本发明的中药组分及用量会影响治疗效果。
效果例2
取效果例1中,模型对照组(第1组)、中药组合物(第3~9组)治疗15d后的大鼠肝脏,采用丙二醛MDA测定试剂盒(南京建成生物工程研究所)测定肝脏中MDA含量,结果见表3。
表3
分组 | MDA含量(mg/g) |
第1组 | 34.28 |
第3组 | 32.18 |
第4组 | 33.24 |
第5组 | 32.57 |
第6组 | 38.75 |
第7组 | 42.51 |
第8组 | 33.15 |
第9组 | 40.28 |
取效果例1中,模型对照组(第1组)、中药组合物(第3~9组)治疗15d后的大鼠肝脏,采用总超氧化物歧化酶T-SOD测定试剂盒(上海酶联生物科技有限公司)测定肝脏中超氧化物歧化酶(T-SOD)的活性,结果见表4。
表4
从表3和表4中可以看出,本发明的中药组合物可以使肝脏中的丙二醛含量维持在正常范围,同时可以避免因服用药物造成的肝脏中超氧化物歧化酶(T-SOD)的活性降低的问题,说明服用本发明制备的中药组合物,不会对肝脏产生明显的不良影响。
效果例3
选取30~50岁的强直性脊柱炎患者60例,随机分为治疗组和对照组两组,其中,治疗组30例,男性23例,女性7例;对照组30例,男性22例,女性8例。
治疗组服用本发明实施例1制备得到的中药组合物,每次服用1g(2粒胶囊),早晚各服用1次,饭后服用。
对照组服用消炎痛(广东华南药业集团有限公),每次服用50mg,早晚各服用1次,饭后服用。
评定标准:
无效:服用药物没有任何有效效果;
轻微抑制症状:轻微缓解疼痛和僵直,可以改善和提高患者生活质量。有效抑制症状:有效缓解疼痛和僵直,有效改善和提高患者生活质量治愈:类风湿因子和X射线检查治疗效果达到完全改变。
治疗结果见表5。
有效率=(有效抑制症状人数+治愈人数)/治疗总人数×100%。
表5
从表5中可以看出,本发明的中药组合物对强直性脊柱炎具有很好的治疗效果。
以上所述的实施例仅是对本发明的优选方式进行描述,并非对本发明的范围进行限定,在不脱离本发明设计精神的前提下,本领域普通技术人员对本发明的技术方案做出的各种变形和改进,均应落入本发明权利要求书确定的保护范围内。
Claims (10)
1.一种治疗强直性脊柱炎的口服补肾除痹中药组合物,其特征在于,包括以下重量份数的原料:雷公藤12~16份、淫羊藿20~40份、橘皮8~10份、决明子10~12份、茯苓8~10份、荷叶6~8份、裕民贝母提取物1~3份、金线莲提取物2~4份、圆齿野鸭椿提取物2~4份、蒲公英2~4份、车前子2~5份、红参1~2份、黄岑2~4份、白术2~4份、石膏4~6份、甘草1~3份、无花果根2~3份、天仙藤1~3份、乳蓟1~2份、山楂2~4份、藿香2~4份、砂仁1~2份、葛根3~4份、藏红花1~2份。
2.根据权利要求1所述的治疗强直性脊柱炎的口服补肾除痹中药组合物,其特征在于,包括以下重量份数的原料:雷公藤15份、淫羊藿30份、橘皮8份、决明子10份、茯苓8份、荷叶6份、裕民贝母提取物2份、金线莲提取物3份、圆齿野鸭椿提取物4份、蒲公英4份、车前子3份、红参1份、黄岑2份、白术3份、石膏5份、甘草2份、无花果根2份、天仙藤1份、乳蓟2份、山楂3份、藿香2份、砂仁2份、葛根3份、藏红花1份。
3.根据权利要求1所述的治疗强直性脊柱炎的口服补肾除痹中药组合物,其特征在于,所述裕民贝母提取物的制备具体包括:将裕民贝母粉碎后加入乙醇溶液回流提取,提取液除去乙醇后,浓缩至膏状得到裕民贝母提取物。
4.根据权利要求1所述的治疗强直性脊柱炎的口服补肾除痹中药组合物,其特征在于,所述金线莲提取物的制备具体包括:将金线莲粉碎后,加水一次煎煮后,得到一次滤液和滤渣;在滤渣中加水二次煎煮,得到二次滤液;将一次滤液和二次滤液混合后,浓缩至膏状得到金线莲提取物。
5.根据权利要求1所述的治疗强直性脊柱炎的口服补肾除痹中药组合物,其特征在于,所述圆齿野鸭椿提取物的制备具体包括:将圆齿野鸭椿粉碎后,加入乙醇,回流提取得到提取液,提取液浓缩除去乙醇得到圆齿野鸭椿提取物。
6.一种根据权利要求1~5任一项所述的治疗强直性脊柱炎的口服补肾除痹中药组合物的制备方法,其特征在于,包括以下步骤:
(1)按以上重量份数称取原料;
(2)将雷公藤、淫羊藿、橘皮、决明子、茯苓、荷叶、蒲公英、车前子、红参、黄岑、白术、石膏、甘草、无花果根、天仙藤、乳蓟、山楂、藿香、砂仁、葛根、藏红花混合均匀后,加水一次煎煮,得到一次滤液和滤渣;滤渣中加水二次煎煮,得到二次滤液;
(3)将一次滤液、二次滤液、裕民贝母提取物、金线莲提取物和圆齿野鸭椿提取物混合均匀,煮沸后转文火煎煮得到混合提取液;
(4)将混合提取液浓缩成相对密度为1.35~1.40的稠膏,干燥,粉碎成细粉;
(5)将步骤(4)制备得到的细粉装入胶囊,得到所述口服补肾除痹中药组合物。
7.根据权利要求6所述的治疗强直性脊柱炎的口服补肾除痹中药组合物的制备方法,其特征在于,步骤(2)中,所述一次煎煮的加水量为1000~1500重量份,煎煮时间为2~3h;所述二次煎煮的加水量为800~1000重量份,煎煮时间为1~2h。
8.根据权利要求6所述的治疗强直性脊柱炎的口服补肾除痹中药组合物的制备方法,其特征在于,步骤(3)中,所述文火煎煮的时间为20~30min。
9.根据权利要求6所述的治疗强直性脊柱炎的口服补肾除痹中药组合物的制备方法,其特征在于,步骤(4)中,所述细粉的粒径为100~120目。
10.根据权利要求6所述的治疗强直性脊柱炎的口服补肾除痹中药组合物的制备方法,其特征在于,步骤(5)中,所述胶囊中细粉的重量为0.5g。
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