CN104083548A - 一种治疗卵巢囊肿的中药组合物及其制备方法 - Google Patents
一种治疗卵巢囊肿的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明属于中药领域,涉及一种中药组合物及其制备方法,特别涉及一种治疗卵巢囊肿的中药组合物及其制备方法。针对目前卵巢囊肿缺少全面有效的治疗,而同时治疗后易复发,疗效不能持续的现有技术缺陷,本发明的提供一种治疗卵巢囊肿的中药组合物,其包括如下组分:巴戟天10-20份、半枝莲12-18份,蒲黄6-10份,徐长卿10-15份、川芎10-20份,野菊花12-16份,丹参6-9份,三七20-30份,黄芪20-30份、柴胡10-16份、茯苓12-18份,黄芩15-25份,延胡索10-20份、白芍6-12份、白术15-20份,甘草10-15份。该中药组合物在治疗卵巢囊肿方面的患者具有很好的治疗效果,具有显著的临床推广价值。
Description
技术领域
本发明属于医药领域,具体涉及一种治疗卵巢囊肿的中药组合物及其制备方法。
背景技术
卵巢囊肿可以是良性的、良恶性交界及恶性的肿瘤,其病理形态多种多样。卵巢囊肿是指卵巢的良性肿瘤,是最常见的妇科疾病。可发生于任何女性年龄,以生育期为多见。患者通常无明显症状,多在查体时偶然发现。临床上病情发展较缓慢,随囊肿的缓慢增大,常有月经紊乱、腹胀腹痛等表现。有时性交会发生疼痛。当囊肿影响到激素分泌时,可能出现阴道不规则出血或体毛增多等症状。如果卵巢囊肿发生蒂扭转,则有严重腹痛腹胀、呼吸困难、食欲降低、恶心及发热等。囊肿逐渐增大后,可于下腹部扪及肿块。囊壁较薄的囊肿在外力作用下会自发破裂,引起急性疼痛、破裂口出血等急性情况,甚至可危及生命。较大的囊肿会对膀胱、直肠、输尿管等附近脏器造成压迫,引起尿频、排尿排便困难,严重者可出现肠梗阻,尿潴留、肾盂积水,继而引起肾脏更严重的病变。当这些症状比较严重时,女性患卵巢囊肿的可能性更高,而且病变恶性罹患卵巢癌的机率及危害就更大。
卵巢囊肿一般采用手术治疗,根据患者年龄、生育要求及对侧卵巢情况进行手术方式的选择。年轻、单侧的卵巢良性肿瘤患者应行患者卵巢囊肿剥除术或卵巢切除术,尽可能保留正常卵巢组织及对侧正常卵巢。即使为双侧卵巢囊肿也应该争取行双侧卵巢囊肿剔除术,保留正常卵巢组织。围绝经期患者可行单侧附件切除术或子宫及双附件切除术。手术中剖视肿瘤肉眼观察区分良恶性,必要时冰冻病理切片组织学检查明确性质,确定手术范围。大的肿瘤尤其高度怀疑恶性肿瘤者,尽可能完整取出,防止肿瘤破裂囊内液流出及肿瘤细胞播散种植。
手术治疗必然破坏人体组织器官,应当是各种治疗方法均无效时的最后选择,如果有不用手术的药物,我们应当首先采用药物治疗。中医药治疗卵巢囊肿的历史源远流长,而且作为现代免疫疾病综合治疗的一个重要方面,近年来越来越受到关注。人们从传统中草药中寻求单药有效成分或复方来治疗癌症具挑战性。纵观世界新药的研究方向,80年代以前主要是研究开发单一的化学药物及其制剂,80年代以后开始发展生物技术和天然植物药物,药物研究方向趋于多样性。结合现代中医药发展理论,从提高药物疗效、降低副作用的角度出发,经过对中药成分进行筛选提取和/或配伍制得的制剂,其副作用小,安全性高,具有化学合成药不能比拟的优势。
发明内容
针对目前卵巢囊肿治疗药物费用昂贵、副作用高的现有治疗的不足,本发明的第一个目的在于提供一种卵巢囊肿的中药组合物,该中药组合物在治疗卵巢囊肿方面具有疗效确切、副作用低的技术优势,且价格低廉,适合临床使用。本发明所述的中药组合物,按照重量组分计,包括如下组分:巴戟天10-20份、半枝莲12-18份,蒲黄6-10份,徐长卿10-15份、川芎10-20份,野菊花12-16份,丹参6-9份,三七20-30份,黄芪20-30份、柴胡10-16份、茯苓12-18份,黄芩15-25份,延胡索10-20份、白芍6-12份、白术15-20份,甘草10-15份。
巴戟天为中草药双子叶植物茜草科巴戟天的干燥根。主治阳痿遗精、宫冷不孕、月经不调、少腹冷痛、风湿痹痛、筋骨痿软。巴戟天与淫羊霍二者性味相近,均可补肾阳、强筋骨,祛风除湿。然淫羊霍辛、温之性较强,其辛散壮阳之力较峻,且温中寓燥,二药有一缓,一峻,一润、一燥之不同。盐巴戟天擅入肾经,补肾功强,用于肾亏阳蒌、早泄不孕,制巴戟天性缓毒去,使功更专,用治风冷腹痛,关节酸痛,小便失禁等证。
半枝莲为唇形科植物半枝莲的全草。有清热解毒;散瘀止血;利尿消肿的功效。主治热毒痈肿;咽喉疼痛;肺痈;肠痈;瘰疬;毒蛇咬伤;跌打损伤;吐血;衄血;血淋;水肿;腹水及癌症。半枝莲原用于毒蛇咬伤及疮痈肿毒等症;近年来在临床上用于肝炎、肝肿大、肝硬化腹水、癌肿及吐血损伤出血等症。用于肺癌,常与蜀羊泉、寻骨风、鱼腥草等配合应用;用于胃肠道癌症,常与白花蛇舌草、石见穿、八月礼、半边莲等同用。
蒲黄为香蒲科植物狭叶香蒲、宽叶香蒲、东方香蒲和长苞香的花粉,蒲黄别名蒲厘花粉、蒲花、蒲棒花粉、蒲草黄、蒲黄炭、炒蒲黄、酒蒲黄、醋蒲黄,蒲黄的功效是止血、祛瘀、利尿,蒲黄的作用是治吐血、外伤出血、经闭腹痛、产后瘀痛、阴下湿痒,蒲黄用药禁忌是孕妇慎服蒲黄,蒲黄不可多食,令人自利,不益极虚人;一切劳伤发热,阴虚内热,无瘀血者禁用蒲黄。徐长卿,主治:镇痛,止咳,利水消肿,活血解毒。治胃痛,牙痛,风湿疼痛,经期腹痛,慢性气管炎,腹水,水肿,痢疾,肠炎,跌打损伤,湿疹,荨麻疹,毒蛇咬伤。1、用于风湿痹痛、腰痛、跌打损伤疼痛、脘腹痛、牙痛等各种痛症。徐长卿有较好的祛风止痛作用,广泛地用于风湿、寒凝、气滞、血瘀所致的各种痛症。近年来也用于手术后疼痛及癌肿疼痛,有一定的止痛作用。可单味应用,或随证配伍有关的药物。2、用湿疹、风疹块、顽癣等皮肤病。本品有祛风止痒作用。可单用内服或煎汤外洗,亦可配伍苦参、地肤子、白鲜皮等清利湿热的药物。此外,本品还能解蛇毒,治毒蛇咬伤。可与半边莲同用内服或外用。
川芎辛温香燥,走而不守,既能行散,上行可达巅顶;又入血分,下行可达血海。活血祛瘀作用广泛,适宜瘀血阻滞各种病症;祛风止痛,效用甚佳,可治头风头痛、风湿痹痛等症。野菊花为菊科多年生草本植物野菊的头状花序,外形与菊花相似,野生于山坡草地、田边路旁。以色黄无梗、完整、气香、花未全开者为佳。野菊花含可广泛用于治疗疔疮痈肿、咽喉肿痛、风火赤眼、头痛眩晕等病证。同时又有很好的降压作用,可用于高血压病的辅助治疗。中医认为,野菊花性凉,有疏风清热、解毒消肿、健脑明目等功效,可治疗治疗冠心病、高血压、风热感冒、肺炎、鼻炎、支气管炎、咽喉肿痛、目赤模糊、淋巴腺炎、痈疖疔毒、湿疹、皮肤瘙痒、口疮、丹毒等症。
丹参又名赤参,紫丹参,红根等。为双子叶植物唇形科,干燥根及根茎。具有活血调经,祛瘀止痛,凉血消痈,清心除烦,养血安神的功效。现代药理学研究中丹参用于抗肝纤维化治疗研究较多。其机制可能为:①改善肝内微循环、保护肝细胞、减轻肝细胞变性坏死;②增强网状内皮细胞的吞噬作用;③增强调理素活性,提高纤维蛋白连接水平,减轻肝细胞损伤;④抑制脂质过氧化物,减少氧自由基对肝细胞损害。以上机制可保护肝细胞,减少肝细胞损伤、坏死等对星状细胞的刺激,抑制肝纤维化的启动和发展;肝内胶原蛋白含量明显降低,尿HPP排出量升高,提示该药可促进已形成的胶原降解,增生的胶原重新被水解吸收。
三七又名田七、山漆、人参三七、滇三七,三七为五加科植物三七的根,三七的功效是散瘀止血,消肿定痛,三七的作用是治咯血,吐血,外伤出血,胸腹刺痛,跌仆肿痛,三七用药禁忌是孕妇忌服三七,气血亏虚所致的痛经、月经失调不宜用三七。。黄芪有益气固表、敛汗固脱、托疮生肌、利水消肿之功效。用于治疗气虚乏力,中气下陷,久泻脱肛,便血崩漏,表虚自汗,痈疽难溃,久溃不敛,血虚萎黄,内热消渴,慢性肾炎,蛋白尿,糖尿病等。炙黄芪益气补中,生用固表托疮。柴胡性微寒、味苦、辛,归肝经、胆经,具有透表泄热,疏肝解郁,升举阳气的功效。《本草经疏》:"柴胡,为少阳经表药。主心腹肠胃中结气,饮食积聚,寒热邪气,推陈致新,除伤寒心下烦热者,足少阳胆也。胆为清净之府,无出无入,不可汗,不可吐,不可下,其经在半表半里,故法从和解,小柴胡汤之属是也。其性升而散,居阳,故能达表散邪也。邪结则心下烦热,邪散则烦热自解。阳气下陷,则为饮食积聚,阳升则清气上行,脾胃之气行阳道,则饮食积聚自消散矣。诸痰热结实,胸中邪逆,五脏间游气者,少阳实热之邪所生病也。柴胡苦平而微寒,能除热散结而解表,故能愈以上诸病。
茯苓,俗称云苓、松苓、茯灵,为寄生在松树根上的菌类植物,形状像甘薯,外皮黑褐色,里面白色或粉红色。古人称茯苓为“四时神药”,因为它功效非常广泛,不分四季,将它与各种药物配伍,不管寒、温、风、湿诸疾,都能发挥其独特功效。茯苓味甘、淡、性平,入药具有利水渗湿、益脾和胃、宁心安神之功用。现代医学研究:茯苓能增强机体免疫功能,茯苓多糖有明显的抗肿瘤及保肝脏作用。
黄芩别名山茶根、土金茶根,为唇形科植物,以根入药。有清热燥湿,凉血安胎,解毒功效。主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、卵巢囊肿、痈肿疖疮等症。苍术具有燥湿健脾,祛风散寒,明目的功效,用于湿阻脾胃、脘腹胀满,寒湿白带,湿温病以及湿热下注、脚膝肿痛、痿软无力。治湿阻脾胃,而见脘腹胀满、食欲不振、倦怠乏力、舌苔白腻厚浊等症,常与厚朴、陈皮等配伍应用。
延胡索为罂粟科植物延胡索的块茎,延胡索别名延胡、玄胡索、元胡索、元胡,延胡索有活血散瘀、理气止痛的功效,延胡索有治疗心腹腰膝诸痛、月经不调、产后血晕、恶露不尽、跌打损伤的作用,血热气虚及孕妇忌服延胡索;产后血虚或经血枯少不利,气虚作痛者,皆大非所宜。
白芍也称白花芍药,是毛茛科芍药属植物。在中国已有悠久的栽培历史,驰名中外,其根并入药。白芍性凉,味苦酸,微寒,具有补血柔肝、平肝止痛。敛阴收汗等功效,适用于阴虚发热、月经不调、胸腹胁肋疼痛、四肢挛急,泻痢腹痛、自汗盗汗、崩漏、带下等症。芍药甙有抗菌、解热、抗炎、增加冠状动脉流量、改善心肌营养血流、扩张血管、对抗急性心肌缺血、抑制血小板聚集、镇静、镇痛、解痉、抗溃疡、调节血糖的作用。白芍煎剂能抑制痢疾杆菌、肺炎链球菌、大肠杆菌、伤寒杆菌、溶血性链球菌、绿脓杆菌等。
白术是补气中药,别名:山蓟、杨枹蓟、术、山芥、天蓟、山姜、山连、山精、乞力伽、冬白术。有健脾益气;燥湿利水;止汗;安胎的功效。主治脾气虚弱、神疲乏力、食少少腹胀、大便溏薄、水饮内停、小便不利、水肿、痰饮眩晕、温痹酸痛、气虚自汗、胎动不安。脾胃气虚,不思饮食,倦怠无力,慢性腹泻,消化吸收功能低下者宜食;自汗易汗,老小虚汗,以及小儿流涎者宜食。胃胀腹胀,气滞饱闷者忌食。
申请人按照上述中药组合物对卵巢囊肿患者的治疗效果,对上述中药组合物中组分进行了进一步优选,申请人发现当所述中药组合物中组分重量份为巴戟天15份、半枝莲15份,蒲黄8份,徐长卿12份、川芎15,野菊花14份,丹参8份,三七25份,黄芪25份、柴胡12份、茯苓14份,黄芩20份,延胡索15份、白芍9份、白术18份,甘草12份,中药组合物的治疗效果最好。
作为本发明所优选的一种实施方式,上述中药组合物中还可以进一步包含防己10份和葛根15份。两种药物与上述中药组合物联用可进一步增强中药组合物对卵巢囊肿的治疗效果,并可以降低药物对机体的药物毒性。防己,本品为防己科植物粉防己或马兜铃科植物广防己的干燥根,具有利水消肿,祛风止痛功效。主治水肿脚气,小便不利,湿疹疮毒,风湿痹痛,高血压症。一般认为,汉防己利水消肿作用较强,木防己祛风止痛作用较好。现代药学研究证实,其含多种生物碱成分,主要为汉防己碱、去甲基汉防己碱。具有有镇痛、解热、消炎、肌肉松弛、利尿、抗过敏性休克及降低血压的作用。葛根具有发表解肌,透发麻疹,解热生津,升阳止泻之功效。用于外感发热头痛、项强、口渴、麻疹不透,泄泻、高血压颈项强痛等症。现代研究葛根含有20多种异黄酮成分、葛根甙类、三萜类、生物碱及其他活性成分,具有多种药理作用。葛根中的总酮能增加脑及冠状动脉的血流量。葛根对动物和人体的脑循环有明显的促进作用。现代医药学研究表明:野葛根含有丰富的葛根素、荀根素本糖甙、大豆异黄酮、大豆甙元、氨斟酸、微量元素、三萜类物质碱等对人体有益的重要生物活性物质。具有滋补营养、养颜护肤、延缓衰老、改善骨质疏松、调节雌激素水平、清除体内垃圾,以及改善循环、降脂减肥、调节血压等多种保健功能。葛根提高肝细胞的再生能力,恢复正常肝脏机能,促进胆汁分泌,防止脂肪在肝脏堆积。并能促进新陈代谢,加强肝脏解毒功能,防止酒精对肝脏的损伤。
制备本发明中药组合物的方法如下:取上述重量组分的各药材,加药材总重量的5-15倍的水,浸泡10-60分钟,煎煮1-4次,每次1-3小时,滤过,合并滤液,滤液减压浓缩至相对密度1.05-1.25的浸膏,该相对密度是在60摄氏度下的检测结果,加入乙醇至含醇量为60-90%(v/v),静置24小时,取上清液,回收乙醇至浓缩,即得。本发明上述中药组合物可以进一步制备成临床上常用的药物制剂,优选为合剂、片剂、胶囊剂。
本发明还公开一种上述中药组合物的医药用途,即上述中药组合物在制备治疗卵巢囊肿药物中的用途。本发明对上述疾病取得了优异的治疗效果,本发明实施例7证实本发明中药组合物对卵巢囊肿的治疗效果显著,可以对卵巢囊肿具有标本兼治的效果,总有效率高达90%,显著高于对照组。
总之,本发明与现有技术相比,具有很好治疗卵巢囊肿的活性,并且可以本发明为纯中药制剂,对人体特别是对肝脏无毒性。本发明作为卵巢囊肿治疗药物使用时,药物作用全面,能够迅速使患者病情好转,并能从根本上缓解疾病的发病原因;并且本发明中药组合物制备简单,基本无毒,原料易得,适于大众化使用,具有很好的应用前景。
具体实施方式
以下通过具体实施方式进一步描述本发明,但本发明不仅仅限于以下实施例。在本发明的范围内或者在不脱离本发明的内容、精神和范围内,对本发明所述的中药组合物进行适当改进、替换功效相同的组分,对于本领域技术人员来说是显而易见的,它们都被视为包括在本发明的范围之内。
实施例1 本发明的中药组合物合剂
处方:巴戟天10份、半枝莲12份,蒲黄6份,徐长卿10份、川芎10份,野菊花12份,丹参6份,三七20份,黄芪20份、柴胡10份、茯苓12份,黄芩15份,延胡索10份、白芍6份、白术15份,甘草10份。
制备方法:取上述重量组分的各药材,加药材总重量的5倍的水,浸泡30分钟,煎煮2次,每次2小时,滤过,合并滤液,滤液减压浓缩至相对密度1.1的浸膏,该相对密度是在60摄氏度下的检测结果,加入乙醇至含醇量为75%(v/v),静置24小时,取上清液,回收乙醇浓缩,加水至1000ml,搅匀,分装,流通蒸汽灭菌35min,即得合剂。
实施例2 本发明的中药组合物片剂
处方:巴戟天20份、半枝莲18份,蒲黄10份,徐长卿15份、川芎20份,野菊花16份,丹参9份,三七30份,黄芪30份、柴胡16份、茯苓18份,黄芩25份,延胡索20份、白芍12份、白术20份,甘草15份。
制备方法:取上述重量组分的各药材,加药材总重量的10倍的水,浸泡60分钟,煎煮1次,每次1小时,滤过,合并滤液,滤液减压浓缩至相对密度1.25的浸膏,该相对密度是在60摄氏度下的检测结果,加入乙醇至含醇量为80%(v/v),静置24小时,取上清液,回收乙醇至浓缩,真空干燥、制粒,压片即得。
实施例3 本发明中药组合物胶囊剂
处方:巴戟天15份、半枝莲15份,蒲黄8份,徐长卿12份、川芎15,野菊花14份,丹参8份,三七25份,黄芪25份、柴胡12份、茯苓14份,黄芩20份,延胡索15份、白芍9份、白术18份,甘草12份。
制备方法:取上述重量组分的各药材,加药材总重量的8倍的水,浸泡45分钟,煎煮4次,每次1.5小时,滤过,合并滤液,滤液减压浓缩至相对密度1.2的浸膏,该相对密度是在60摄氏度下的检测结果,加入乙醇至含醇量为90%(v/v),静置24小时,取上清液,回收乙醇至浓缩,真空干燥,制粒,装胶囊即得。
实施例4 本发明的中药组合物合剂
处方:巴戟天10份、半枝莲12份,蒲黄6份,徐长卿10份、川芎10份,野菊花12份,丹参6份,三七20份,黄芪20份、柴胡10份、茯苓12份,黄芩15份,延胡索10份、白芍6份、白术15份,甘草10份,防己10份,葛根15份。
制备方法:取上述重量组分的各药材,加药材总重量的5倍的水,浸泡30分钟,煎煮2次,每次2小时,滤过,合并滤液,滤液减压浓缩至相对密度1.1的浸膏,该相对密度是在60摄氏度下的检测结果,加入乙醇至含醇量为75%(v/v),静置24小时,取上清液,回收乙醇浓缩,加水至1000ml,搅匀,分装,流通蒸汽灭菌35min,即得合剂。
实施例5 本发明的中药组合物片剂
处方:巴戟天20份、半枝莲18份,蒲黄10份,徐长卿15份、川芎20份,野菊花16份,丹参9份,三七30份,黄芪30份、柴胡16份、茯苓18份,黄芩25份,延胡索20份、白芍12份、白术20份,甘草15份,防己10份,葛根15份。
制备方法:取上述重量组分的各药材,加药材总重量的10倍的水,浸泡60分钟,煎煮1次,每次1小时,滤过,合并滤液,滤液减压浓缩至相对密度1.25的浸膏,该相对密度是在60摄氏度下的检测结果,加入乙醇至含醇量为80%(v/v),静置24小时,取上清液,回收乙醇至浓缩,真空干燥、制粒,压片即得。
实施例6 本发明中药组合物胶囊剂
处方:巴戟天15份、半枝莲15份,蒲黄8份,徐长卿12份、川芎15,野菊花14份,丹参8份,三七25份,黄芪25份、柴胡12份、茯苓14份,黄芩20份,延胡索15份、白芍9份、白术18份,甘草12份,防己10份,葛根15份。
制备方法:取上述重量组分的各药材,加药材总重量的8倍的水,浸泡45分钟,煎煮4次,每次1.5小时,滤过,合并滤液,滤液减压浓缩至相对密度1.2的浸膏,该相对密度是在60摄氏度下的检测结果,加入乙醇至含醇量为90%(v/v),静置24小时,取上清液,回收乙醇至浓缩,真空干燥,制粒,装胶囊即得。
实施例7 本发明中药组合物对卵巢囊肿的临床疗效观察
1临床资料
选择确诊的卵巢囊肿患者120例临床观察,病人随机分成治疗组和对照组两组,治疗组女性80例,年龄20~50岁,平均年龄35岁,病程1~15年;对照组女性80例,年龄21~49岁,平均年龄35岁,病程1~13年;治疗组和对照组两组病例的病程、症状轻重程度基本一致,无显著差异,具有可比性。
2研究方法
2.1治疗方法
治疗组服用按照本发明实施例6制备得到的中药胶囊剂,其中每粒胶囊中含生药量800mg,用法用量:口服,每日2次,早晚各1次,每次3粒,饭后温开水送服;8天为1个疗程,轻者1个疗程,重者2~4个疗程可痊愈。
对照组服用金鸡颗粒(市售),用开水冲服,一次8克,一日2次。10天为1疗程,必要时可连服2~3个疗程。
2.2疗效标准参照《中药新药临床研究指导原则》拟定。
(1)治愈:临床症状消除,B超检查囊肿消失。
(2)显效:临床症状明显减轻,B超检查囊肿明显缩小。
(3)有效:临床症状有所减轻,B超检查囊肿缩小。
(4)无效:通过治疗后症状无无减轻,B超检查囊肿未见缩小。
3实验结果
表1本发明中药组合物对卵巢囊肿的治疗效果
组别 | 治愈 | 显效 | 有效 | 无效 | 总有效率 |
治疗组 | 35 | 28 | 10 | 7 | 90% |
对照组 | 10 | 15 | 17 | 38 | 52.5% |
由表1可以看出,本发明中药组合物对卵巢囊肿的治疗效果显著,总有效率高达90%,显著高于对照组。
Claims (7)
1.一种治疗卵巢囊肿的中药组合物,其特征在于,其包括如下重量份的组分:巴戟天10-20份、半枝莲12-18份,蒲黄6-10份,徐长卿10-15份、川芎10-20份,野菊花12-16份,丹参6-9份,三七20-30份,黄芪20-30份、柴胡10-16份、茯苓12-18份,黄芩15-25份,延胡索10-20份、白芍6-12份、白术15-20份,甘草10-15份。
2.如权利要求1所述的中药组合物,其特征在于,其还包括防己10份和葛根15份。
3.如权利要求1所述的中药组合物,其特征在于,其包括如下重量份的组分:巴戟天15份、半枝莲15份,蒲黄8份,徐长卿12份、川芎15,野菊花14份,丹参8份,三七25份,黄芪25份、柴胡12份、茯苓14份,黄芩20份,延胡索15份、白芍9份、白术18份,甘草12份。
4.如权利要求3所述的中药组合物,其特征在于,其还包括防己10份和葛根15份。
5.如权利要求1-4所述的中药组合物,其特征在于,所述中药组合物为合剂、片剂、胶囊剂。
6.一种制备权利要求1-4所述中药组合物的方法,其特征在于,其包括如下步骤:取上述重量组分的各药材,加药材总重量的5-15倍的水,浸泡10-60分钟,煎煮1-4次,每次1-3小时,滤过,合并滤液,滤液减压浓缩至相对密度1.05-1.25的浸膏,该相对密度是在60摄氏度下的检测结果,加入乙醇至含醇量为60-90%(v/v),静置24小时,取上清液,回收乙醇至浓缩,即得。
7.权利要求1所述中药组合物在制备治疗卵巢囊肿药物中的用途。
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CN104800799B (zh) * | 2015-04-27 | 2018-04-27 | 陈玉龙 | 一种治疗子宫内膜增厚伴卵巢囊肿的中药剂 |
CN105287952A (zh) * | 2015-10-24 | 2016-02-03 | 四川双鑫生物科技有限公司 | 一种可治疗卵巢囊肿的中药组合物及其制备方法 |
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