CN104288596A - 一种治疗强直性脊柱炎的中药组合物 - Google Patents
一种治疗强直性脊柱炎的中药组合物 Download PDFInfo
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Abstract
公开了一种治疗强直性脊柱炎的中药组合物,由苡薏仁、赤芍、继骨藤、元参、沙参、麦冬、牛膝、当归、党参、川芎、白芍、滑石粉、甘草、杜仲、狗脊、车前子、知母、黄柏、鹿衔草、益母草、女贞子、大蜈蚣、白花蛇、龟板、鳖甲、穿山甲、茯苓、过山香组成,该中药组合物具有使用方便、疗效迅速、治愈率高、效果持久的优点。
Description
技术领域
本发明属于中医药领域,涉及一种治疗强直性脊柱炎的中药组合物。
背景技术
强直性脊柱炎(AS)是以骶髂关节和脊柱附着点炎症为主要症状的疾病,是四肢大关节、椎间盘纤维环及其附近结缔组织纤维化和骨化以及关节强直为病变特点的慢性炎性疾病。强直性脊柱炎属风湿病范畴,是血清阴性脊柱关节病的一种。该病病因尚不明确,是以脊柱为主要病变部位的慢性病,累及骶髂关节,引起脊柱强直和纤维化,造成不同程度眼、肺、肌肉、骨骼病变,属自身免疫性疾病。该病因病理不清,属于顽固性疾病,较难治疗。
目前强直性脊柱炎的治疗主要以西医药为主,比如非甾体类抗炎药、柳氮磺胺吡啶类、甲氨蝶呤、肾上腺皮质激素等,西药治疗不彻底,而且副作用较大,具有药物依赖性,严重损害了肝、肾等脏器功能。
相对于西药的对标治疗,中医在对本治疗方面积累了丰富的经验。传统中药在这方面的研究也具有一定优势。从疾病整体出发,辨证论治,对于强直性脊柱炎的治疗还是有方法的。国内最初用雷公藤酊治疗强直性脊柱炎,有消炎止痛作用,服用方便。但副作用有强烈的胃肠反应、白细胞减少、月经紊乱及精子活力降低等。
针对现行临床出现的强直性脊柱炎的治疗困境,本发明提供了一种混合性中药组合物,经多例临床实验证实,能够有效治疗强直性脊柱炎。
技术内容
本发明的目的是提供一种用于强直性脊柱炎治疗的中药组合物,该中药组合物能快速消炎止痛、修骨生肌,达到治疗的目的。
本发明的中药组合物由下述中药成分组成:苡薏仁、赤芍、腰骨藤、元参、沙参、麦冬、牛膝、当归、党参、川芎、白芍、滑石粉、甘草、杜仲、狗脊、车前子、知母、黄柏、鹿衔草、益母草、女贞子、大蜈蚣、白花蛇、龟板、鳖甲、穿山甲、茯苓、过山香。
本发明的组合物所用的中药组分配比为:苡薏仁15份;赤芍、腰骨藤各8份;元参、沙参各12份;麦冬、牛膝、当归各7份;党参3份;川芎、白芍、滑石粉各11份;甘草20份;杜仲、狗脊、车前子各18份;知母、黄柏、鹿衔草、益母草、女贞子各10份;大蜈蚣5份; 白花蛇、龟板、鳖甲各7份;穿山甲3份;茯苓、过山香各12份。
本发明中药组合物所用各中药的药理学基础为:
苡薏仁,性凉,味甘、淡。健脾渗湿,除痹止泻。薏米可用于治疗水肿、湿痹拘挛、脾虚泄泻。
赤芍,行瘀、止痛、凉血、消肿。主治治瘀滞经闭、疝瘕积聚、腹痛、胁痛、衄血、血痢、肠风下血、目赤、痈肿、跌扑损伤。
腰骨藤,味苦,性平。祛风除湿,通络止痛。主风湿痹痛,跌打损伤。
元参,味苦咸。性微寒。无毒。主治温热病热和营血、身热、烦渴、舌绛、发斑、骨蒸劳嗽、虚烦不寤、津伤便秘、目涩昏花、咽喉喉肿痛、瘰疬痰核、痈疽疮毒。
沙参,清热养阴,润肺止咳,主治气管炎,百日咳,肺热咳嗽,咯痰黄稠。
麦冬,味甘、微苦,性微寒。归心、肺、胃经。养阴生津,润肺清心。用于肺燥干咳,阴虚痨嗽,喉痹咽痛,津伤口渴,内热消渴,心烦失眠,肠燥便秘。
牛膝,味苦、酸,性平。祛风药,活血祛瘀药。主要用于腰膝酸痛,下肢痿软,血滞经闭,痛经,产后血瘀腹痛,症瘕,胞衣不下,热淋,血淋,跌打损伤,痈肿恶疮,咽喉肿痛。
当归:具有养血和血、活血止痛、养血调经、润肠通便、降逆止咳、头痛内伤发热功效。用于补益心血、滋补肝血、跌打损伤、淤血、腹痛、风寒湿痹、月经不调、经闭、痛经、血虚发热、淤血发热。
党参,味甘,性平。有补中益气、止渴、健脾益肺,养血生津。
川芎,用于活血行气,祛风止痛,川芎辛温香燥,走而不守,既能行散,上行可达巅顶;又入血分,下行可达血海。活血祛瘀作用广泛,适宜瘀血阻滞各种病症;祛风止痛,效用甚佳,可治头风头痛、风湿痹痛等症。昔人谓川芎为血中之气药,殆言其寓辛散、解郁、通达、止痛等功能。
白芍:味苦、酸,性微寒。归肝、脾经。养血敛阴,柔肝止痛,平肝阳。平肝止痛,养血调经,敛阴止汗。用于头痛眩晕,胁痛,腹痛,四肢挛痛,血虚萎黄,月经不调,自汗,盗汗。
滑石粉,味甘、淡,性寒。归膀胱、肺、胃经。利尿通淋,清热解暑,祛湿敛疮。杜仲:有降血压、利尿、中枢作用。能补益肝肾、安胎止血。主要用于肾虚腰痛、肢体痿弱。
狗脊,味苦,性温。《本草再新》:入心、肝、肾三经。补肝肾,祛风湿,健腰脚,利关节。治腰背酸疼,膝痛脚弱,寒湿周痹,失溺,尿频,遗精,白带。
车前子,味甘,性寒。《雷公炮制药性解》:入肝、膀胱、小肠三经。″利水,清热,明目,祛痰。治小便不通,淋浊,带下,尿血,暑湿泻痢,咳嗽多痰,湿痹,目赤障翳。①《本 经》:主气癃、止痛,利水道小便,除湿痹。②《本草经集注》:主虚劳。
知母,性苦寒,有滋阴降火、润燥滑肠、利大小便之效。属清热下火药,主治:温热病、高热烦渴、咳嗽气喘、燥咳、便秘、骨蒸潮热、虚烦不眠、消渴淋浊。
鹿衔草,祛风湿,强筋骨,止血。用于风湿痹痛,腰膝无力,月经过多,久咳劳嗽。
益母草,活血,祛瘀,调经,消水。治月经不调,胎漏难产,胞衣不下,产后血晕,瘀血腹痛,崩中漏下,尿血,泻血,痈肿疮疡。祛瘀生新,又可用于跌打损伤,还对于女性由湿热盆腔炎症有一定疗效。
女贞子,味甘,苦,性平。归肝、肾经。补益药。补益肝肾,清虚热,强腰膝,明耳目,乌须发。
蜈蚣,息风解痉,用于风症痉痛。
白花蛇,味甘、咸。性平,有毒。祛风,通络,止痉。用于风湿顽痹,麻木拘挛,中风口歪,半身不遂,抽搐痉挛,破伤风,麻风疥癣,瘰疬恶疮。主治中风及肢体麻木不仁、筋脉拘急、口眼歪斜、半身不遂、骨节疼痛、脚软不能长久站立。瘙痒及疥癣。又能治肺风鼻塞、瘾疹、身上自癜风、疠疡斑点,破伤风、小儿风热及急慢惊风抽搐。李时珍说:风善行数变,蛇亦善行数蜕,又食石南藤,所以能透骨搜风,截惊定搐,为风痹惊、瘀癣恶疮之要药。本方对风湿痹痛、或筋脉挛急、肌肉麻痹等症,配伍全蝎、当归、白术等配伍应用,以消其毒性,伸其祛风功效。
龟板,滋阴,潜阳,补肾,健骨。
鳖甲,味咸,性寒。滋肾潜阳,软坚散结。
穿山甲,味咸,性凉。归肝、胃经。活血散结,通经下乳,消痈溃坚。主血瘀经闭,症瘕,风湿痹痛,乳汁不下,痈肿,瘰疬。
茯苓:渗湿利水、健脾和胃、宁心安神、强精益髓。用于小便不利、水肿、消渴、淋浊、食少、便溏、呕吐、痰饮、逆咳眩晕、心悸、失眠、小儿惊痫。
过山香,过山香功能解热、解毒、固肺经,为治风湿、关节炎良药,可去瘴气,治腹痛,也是毒蛇咬伤的蛇药之一。
甘草,味甘,性平。入脾、胃、肺经。补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药。用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。用于心气虚,心悸怔忡,脉结代,以及脾胃气虚,倦怠乏力,气喘咳嗽等。另外,也常用来调和诸药。
甘草有抗炎,抗过敏作用,能保护发炎的咽喉和气管粘膜。甘草浸膏和甘草酸对某些毒物有类似葡萄糖醛酸的解毒作用。甘草是于本方中属于使药引导药物直达病变部位,兼有调 和作用。这么一来,药物不必运行到别的器官,导致其他器官受到药物不必要作用损害,减少副作用。
本发明所用药方并非为各类药材的简单组合,而是在考虑到各类药物的性质、口味、药性、配伍禁忌的基础上筛选出来的,并且按照一定配比组成的处方,各方各司其职,既有机配合,又相互促进。
临床疗效
1.样本信息
自2005年6月到2013年9月,本发明中药组合物累计治疗强直性脊椎炎患者46人,患者均系门诊确诊病人,其中男38人,女8人,年龄最大者63岁,最小者18岁。
2.疗效标准
痊愈:临床症状消失,血沉降至正常水平,一年内不复发。
显著:临床症状得到改善,或临床症状消失,但效果持续时间有限,一年内复发。
有效:临床症状大部分改善,疼痛程度明显减轻,疼痛次数减少,疼痛时间减短。
无效:临床症状无任何改变或恶化。
3.治疗方法
采用汤剂给药,每日一次,十日为一个疗程。
4.样本病例
5.典型病例
郑某某:男,31岁,已婚,交警。2011年5月8日来诊,主诉;2007年3月份开始腰部疼痛经多方治疗得以缓解,2008年5月份开始腰部疼痛严重,前往泉州第二医院CT检查诊断为腰椎间盘突出症,经泉州第二医院治疗无效,后来长期理疗推拿等维持,2009年1月 份经人介绍厦门有个医腰椎间盘突出症的名医就前往就医,但去了就好来了又痛这样反复多次后又再次严重起来,颈部至颈椎胸椎腰椎全部僵硬活动受限,左膝部脚大拇趾次趾两踝关节红肿极痛行走等活动受限,到泉州海滨医院诊断为痛风症给予消炎止痛治疗后无效,2010年2月11日前往泉州180医院检查出血沉690多,180医院确诊是强直性脊柱炎给予消炎止痛等抗制措施,后来看到报纸广告陈李济活络止痛丸开始服用感觉效还可以,可是连续服用8个月多时间看来陈李济活络止痛丸不是纯中医制剂,2010年12月份又再次病重经民间中草药及密验方治疗三个月多后原没好转一直低烧不退,再次180医院还是消炎止痛等抗制措施,2011年3月16日前往泉州正骨医院住院中西医结合治疗至4月13日病无起色血沉570出院。2011年5月8日来诊时;颈部至颈椎胸椎腰椎全部僵硬活动受限,右膝部肿、左脚大拇趾次趾两踝关节红肿极痛,低烧体温38C度以下。余给予口头协议如你有耐心配合我能还你一个健康完整的身体,但喝中药的时间最少要一年以上要半年后才有明显的疗效,他已经清楚自己所患的是难治病坚定信心的积极配合治疗。给予;陈建福,祖传76味祛痹还原汤加减治疗1个月后痛减肿退体温恢复正常,陈建福:祖传76味祛痹还原汤加减治疗2个月后到泉州侨乡体检中心检测血沉153,3后个月后再次到泉州侨乡体检中心检测血沉降到57,4个月后又到泉州侨乡体检中心检测血沉16恢复正常。
具体实施例
取炮制后苡薏仁15克;赤芍、腰骨藤各8克;元参、沙参各12克;麦冬、牛膝、当归各7克;党参3克;川芎、白芍、滑石粉各11克;甘草20克;杜仲、狗脊、车前子各18克;知母、黄柏、鹿衔草、益母草、女贞子各10克;大蜈蚣5克;白花蛇、龟板、鳖甲各7克;穿山甲3克;茯苓、过山香各12克,置于瓦罐中,加入1.5公升清水,武火煮开后,改成文火煎煮40分钟,冷却,滤除药渣,药汁分两日饮用。
Claims (2)
1.一种治疗强直性脊柱炎的中药组合物,其特征是由以下中药按照重量份组成:苡薏仁、赤芍、腰骨藤、元参、沙参、麦冬、牛膝、当归、党参、川芎、白芍、滑石粉、甘草、杜仲、狗脊、车前子、知母、黄柏、鹿衔草、益母草、女贞子、大蜈蚣、白花蛇、龟板、鳖甲、穿山甲、茯苓、过山香。
2.如权利要求1所述的治疗强直性脊柱炎的中药组合物,其各组分重量配比为:苡薏仁15份;赤芍、腰骨藤各8份;元参、沙参各12份;麦冬、牛膝、当归各7份;党参3份;川芎、白芍、滑石粉各11份;甘草20份;杜仲、狗脊、车前子各18份;知母、黄柏、鹿衔草、益母草、女贞子各10份;大蜈蚣5份;白花蛇、龟板、鳖甲各7份;穿山甲3份;茯苓、过山香各12份。
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CN114533695A (zh) * | 2022-03-15 | 2022-05-27 | 佛山市第五人民医院(佛山市干部疗养院、佛山市工伤康复中心) | 一种治疗强直性脊柱炎的口服补肾除痹中药组合物及其制备方法 |
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