CN114533595A - Composition with low peroxide value of snake oil and preparation method thereof - Google Patents

Composition with low peroxide value of snake oil and preparation method thereof Download PDF

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Publication number
CN114533595A
CN114533595A CN202011327409.6A CN202011327409A CN114533595A CN 114533595 A CN114533595 A CN 114533595A CN 202011327409 A CN202011327409 A CN 202011327409A CN 114533595 A CN114533595 A CN 114533595A
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Prior art keywords
snake oil
composition
peroxide value
low
antioxidant
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CN202011327409.6A
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Chinese (zh)
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CN114533595B (en
Inventor
常鲤上
周华锋
杜兆阳
周建青
吴姗姗
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Carlyle Cosmetics Co ltd
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Carlyle Cosmetics Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/447Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4986Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)

Abstract

The invention discloses a composition with a low snake oil peroxide value, which comprises a sulfhydryl antioxidant, snake oil and water, wherein the contents of the components are as follows: 80-99 parts of snake oil, 0.1-5 parts of sulfhydryl antioxidant and 1-20 parts of water by weight, and the preparation method comprises the steps of mixing and stirring the sulfhydryl antioxidant, the snake oil and the water, and then centrifuging to obtain the composition with low peroxide value of the snake oil. Through the mode, the snake oil is mixed with the specific sulfhydryl antioxidant, the treatment effect is good, the peroxide value of the snake oil is effectively reduced, the method is simple to operate and low in cost, and the prepared snake oil is good in quality and can be used for developing a cosmetic formula.

Description

Composition with low peroxide value of snake oil and preparation method thereof
Technical Field
The invention relates to the technical field of daily chemicals, in particular to a composition with low peroxide value of snake oil and a preparation method thereof.
Background
The snake oil is a traditional natural skin care product, is used for physiotherapy and scald and conditioning dry, wrinkled and rough skin, has excellent compatibility and complementarity with the physiological growth characteristics of human skin, has good permeation, moistening, antibacterial, anti-inflammatory and repairing effects on the skin, and is very suitable for people to perform physiotherapy and skin care. According to the traditional snake oil preparation method, snake fat is decocted at a high temperature, the prepared snake oil is dark yellow, has very heavy snake smell, has rancidity smell after oxidation, is poor in stability, is easy to oxidize, causes the peculiar snake fat smell, cannot be accepted by consumers, and limits the wide application of the snake oil in skin care.
At present, a great deal of research work is done in China aiming at a method for reducing the peroxide value in grease, wherein a method for reducing the peroxide value in the process of preparing vegetable oil and fish oil, such as the research of poplar, Ningquan and the like, is about to reduce the peroxide value in the grease, and a series of experimental researches show that in a non-anoxybiotic system, SnCl is used for reducing the peroxide value in the grease2The dosage is 1 to 2 percent, the reaction time is 1 hour at normal temperature, the effect of removing the peroxide value is obvious, and the peroxide value is reduced from 50 to 0.1. The method for reducing the peroxide value in the fish oil preparation is researched by people who are aged and eastern red, Panrenman, Liguiling and the like, so that an economical and practical scheme is obtained. The antioxidant performance of the compound natural antioxidant on the artificial meat is analyzed and evaluated by people such as Chi national plum, Chi prescription, Wei Shuxin, Lilai, Lishufeng, Wang Anjian and the like, and the natural antioxidant prepared by the method has the most excellent performance when the addition amount of rosemary extract is 0.4 percent, the addition amount of tea polyphenol is 0.03 percent, the addition amount of vitamin C is 0.02 percent and the addition amount of citric acid is 0.02 percent, and the antioxidant performance of the compound natural antioxidant is slightly better than that of TBHQ. Wherein the primary and secondary factors of various natural antioxidants in the composition are tea polyphenols>Rosemary extract>Vitamin C>And (4) citric acid.
The snake oil has poor stability, is easy to oxidize to cause the peroxide value to be increased, increases the oxidation of the snake oil due to the existence of a large amount of peroxy radicals, can cause the fishy smell of the snake oil, and simultaneously, the peroxy radicals can attack skin cell membranes to cause skin injury, cause skin irritation, accelerate skin aging and seriously influence the wide application of the snake oil in skin care products.
Disclosure of Invention
The invention mainly solves the technical problem of providing a composition with low peroxide value of snake oil and a preparation method thereof, and the composition adopts the action of a sulfhydryl antioxidant and the snake oil with high peroxide value, so that the peroxide value of the snake oil is greatly reduced, and the stability of the snake oil is obviously improved.
In order to solve the technical problems, the invention adopts a technical scheme that: the composition with the low snake oil peroxide value comprises a sulfhydryl antioxidant, snake oil and water, wherein the content of each component in the composition with the low snake oil peroxide value is as follows: 80-99 parts of snake oil, 0.1-5 parts of sulfhydryl antioxidant and 1-20 parts of water.
In a preferred embodiment of the present invention, the thiol antioxidant is one or more of cysteine, acetylcysteine, glutathione, mercaptopropionic acid, or lipoic acid.
In a preferred embodiment of the present invention, the water is deionized water.
A preparation method of a composition with low snake oil peroxide value is provided, which comprises the following steps: mixing sulfhydryl antioxidant, adeps Serpentis and water, stirring, and centrifuging to obtain composition with low peroxide value of adeps Serpentis.
In a preferred embodiment of the present invention, the mixing and stirring are performed at a temperature of 30 to 80 ℃.
In a preferred embodiment of the present invention, the mixing and stirring are performed at 300 to 2000rpm for 10 to 30 min.
In a preferred embodiment of the invention, the centrifugation is carried out in a tube centrifuge.
In a preferred embodiment of the present invention, the centrifugation is performed at 8000rpm to 16000 rpm.
The beneficial effects of the invention are: according to the composition with the low peroxide value of the snake oil and the preparation method thereof, the specific sulfhydryl antioxidant is mixed with the snake oil for treatment, the treatment effect is good, the peroxide value of the snake oil is effectively reduced, the method is simple to operate and low in cost, and the prepared snake oil has good quality and can be used for the development of a cosmetic formula.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows:
the composition with the low snake oil peroxide value comprises a sulfhydryl antioxidant, snake oil and water, wherein the content of each component in the composition with the low snake oil peroxide value is as follows: 98 parts of snake oil, 1 part of sulfhydryl antioxidant and 1 part of deionized water in parts by weight. The sulfhydryl antioxidant is cysteine.
The preparation method of the composition with low snake oil peroxide value comprises the following steps: mixing sulfhydryl antioxidant and water, stirring until no particles exist, adding into prepared liquid snake oil, stirring at 45 deg.C and 1500rpm for 30min, and centrifuging at 10000rpm by tubular centrifuge to obtain snake oil with low oxidation value.
Example two:
the composition with the low snake oil peroxide value comprises a sulfhydryl antioxidant, snake oil and water, wherein the content of each component in the composition with the low snake oil peroxide value is as follows: 80 parts of snake oil, 3 parts of sulfhydryl antioxidant and 17 parts of deionized water in parts by weight. The sulfhydryl antioxidant is glutathione.
The preparation method of the composition with low snake oil peroxide value comprises the following steps: mixing sulfhydryl antioxidant and water, stirring until no particles exist, adding into prepared liquid snake oil, stirring at 30 deg.C and 500rpm for 15min, and centrifuging at 15000rpm by tubular centrifuge to obtain snake oil with low oxidation number.
Example three:
the composition with the low snake oil peroxide value comprises a sulfhydryl antioxidant, snake oil and water, wherein the content of each component in the composition with the low snake oil peroxide value is as follows: the snake oil preservative comprises, by weight, 90 parts of snake oil, 3 parts of a mercapto antioxidant and 17 parts of deionized water. The mercapto antioxidant is mercaptopropionic acid.
The preparation method of the composition with low snake oil peroxide value comprises the following steps: mixing sulfhydryl antioxidant and water, stirring until no particles exist, adding into prepared liquid snake oil, stirring at 75 deg.C and 1000rpm for 10min, and centrifuging at 13000rpm by tubular centrifuge to obtain snake oil with low oxidation number.
Comparative example one:
the composition with the low snake oil peroxide value comprises an oil antioxidant and snake oil, wherein the content of each component in the composition with the low snake oil peroxide value is as follows: 98 parts of snake oil, 1 part of grease antioxidant (BHT) and 1 part of water in parts by weight. The grease antioxidant is Butylated Hydroxytoluene (BHT).
The preparation method of the composition with low snake oil peroxide value comprises the following steps: adding oil antioxidant (BHT) and water into the prepared liquid snake oil, stirring at 1500rpm for 30min at 40 deg.C, and centrifuging at 13000rpm by tubular centrifuge to obtain snake oil.
Test of Experimental data
According to the GB T5538-.
Figure DEST_PATH_IMAGE002
The invention has the beneficial effects that:
the composition with the low peroxide value of the snake oil is treated by mixing a specific sulfhydryl antioxidant with the snake oil, so that the treatment effect is good, and the peroxide value of the snake oil is effectively reduced;
secondly, the preparation method of the composition with low snake oil peroxide value is simple to operate and low in cost, and the prepared snake oil is good in quality and can be used for developing a cosmetic formula.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims (8)

1. The composition with the low snake oil peroxide value is characterized by comprising a sulfhydryl antioxidant, snake oil and water, wherein the composition with the low snake oil peroxide value comprises the following components in percentage by weight: 80-99 parts of snake oil, 0.1-5 parts of sulfhydryl antioxidant and 1-20 parts of water.
2. The composition of claim 1, wherein the thiol antioxidant is one or more of cysteine, acetylcysteine, glutathione, mercaptopropionic acid, or lipoic acid.
3. The composition of claim 1, wherein the water is deionized water.
4. The method for preparing a composition having a low peroxide value of snake oil according to claim 1, comprising the steps of: mixing sulfhydryl antioxidant, adeps Serpentis and water, stirring, and centrifuging to obtain composition with low peroxide value of adeps Serpentis.
5. The method for preparing a composition having a low peroxide value of snake oil according to claim 4, wherein the mixing and stirring are performed at a temperature of 30 to 80 ℃.
6. The method for preparing a composition with low peroxide value of snake oil according to claim 4, wherein the mixing and stirring are performed at 300-2000 rpm for 10-30 min.
7. The method of claim 4, wherein the centrifugation is performed in a tubular centrifuge.
8. The method for preparing a composition with low snake oil peroxide value according to claim 4, wherein the centrifugation is carried out at 8000rpm to 16000 rpm.
CN202011327409.6A 2020-11-24 2020-11-24 Composition with low peroxide value of snake oil and preparation method thereof Active CN114533595B (en)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106729725A (en) * 2017-03-21 2017-05-31 北京百慧生化制药有限责任公司 Application of the lipoic acid as antioxidant in ethyl polyenoate preparation or pupal fat alpha linolenic acid ethyl ester preparation
CN107746747A (en) * 2017-11-08 2018-03-02 厦门汇盛生物有限公司 It is a kind of to reduce pufa oils peroxide value and the method for anisidine value
CN108420793A (en) * 2017-12-26 2018-08-21 厦门本素药业有限公司 A kind of blank mixed micelle and its preparation method and application
CN109700693A (en) * 2018-12-29 2019-05-03 江苏隆力奇生物科技股份有限公司 A kind of snake oil clean skin product and preparation method thereof
CN110897939A (en) * 2019-12-25 2020-03-24 苏州克劳丽化妆品有限公司 Snake oil skin-care micro-condensation bead composition and preparation method thereof
KR20200085047A (en) * 2019-01-04 2020-07-14 전정호 The powder shampoo and the method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106729725A (en) * 2017-03-21 2017-05-31 北京百慧生化制药有限责任公司 Application of the lipoic acid as antioxidant in ethyl polyenoate preparation or pupal fat alpha linolenic acid ethyl ester preparation
CN107746747A (en) * 2017-11-08 2018-03-02 厦门汇盛生物有限公司 It is a kind of to reduce pufa oils peroxide value and the method for anisidine value
CN108420793A (en) * 2017-12-26 2018-08-21 厦门本素药业有限公司 A kind of blank mixed micelle and its preparation method and application
CN109700693A (en) * 2018-12-29 2019-05-03 江苏隆力奇生物科技股份有限公司 A kind of snake oil clean skin product and preparation method thereof
KR20200085047A (en) * 2019-01-04 2020-07-14 전정호 The powder shampoo and the method thereof
CN110897939A (en) * 2019-12-25 2020-03-24 苏州克劳丽化妆品有限公司 Snake oil skin-care micro-condensation bead composition and preparation method thereof

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