CN114522196A - Compound traditional Chinese medicine for preventing and treating osteoporosis and preparation method thereof - Google Patents

Compound traditional Chinese medicine for preventing and treating osteoporosis and preparation method thereof Download PDF

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CN114522196A
CN114522196A CN202210071537.1A CN202210071537A CN114522196A CN 114522196 A CN114522196 A CN 114522196A CN 202210071537 A CN202210071537 A CN 202210071537A CN 114522196 A CN114522196 A CN 114522196A
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邵敏
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Third Affiliated Hospital Of Guangzhou University Of Traditional Chinese Medicine Third Clinical Medical College Of Guangzhou University Of Traditional Chinese Medicine Affiliated Orthopedic Hospital Of Guangzhou University Of Traditional Chinese Medicine And Guangdong Institute Of Traditional Chine
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Third Affiliated Hospital Of Guangzhou University Of Traditional Chinese Medicine Third Clinical Medical College Of Guangzhou University Of Traditional Chinese Medicine Affiliated Orthopedic Hospital Of Guangzhou University Of Traditional Chinese Medicine And Guangdong Institute Of Traditional Chine
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Abstract

The invention discloses a compound traditional Chinese medicine for preventing and treating osteoporosis and a preparation method thereof, wherein the formula comprises the following raw materials in parts by weight: 4 to 10 parts of drynaria rhizome, 3 to 6 parts of human placenta, 0.06 to 0.12 part of earthworm, 2 to 5.5 parts of bitter rose, 1.3 to 3.8 parts of calcined oyster shell, 2.5 to 6.5 parts of pomegranate bark, 2.5 to 6.5 parts of radix pseudostellariae, 4 to 12 parts of angelica, 1.2 to 3.6 parts of phellodendron, 0.2 to 0.55 part of amethyst, 0.4 to 1.2 parts of kudzu root, 0.3 to 1.5 parts of red paeony root, 4 to 8.5 parts of epimedium herb and 2 to 6.5 parts of dandelion root. The compound traditional Chinese medicine for preventing and treating osteoporosis takes the measures of tonifying kidney yang, strengthening bones and muscles and conditioning estrogen, and can play a role in treating and preventing osteoporosis symptoms, particularly osteoporosis symptoms caused by female amenorrhea, by adjusting the mutual matching of the traditional Chinese medicine raw materials, and the effect is most obvious.

Description

Compound traditional Chinese medicine for preventing and treating osteoporosis and preparation method thereof
Technical Field
The invention relates to the technical field of food preparation, in particular to a compound traditional Chinese medicine for preventing and treating osteoporosis and a preparation method thereof.
Background
Osteoporosis can result from a decrease in bone density and quality, destruction of bone microarchitecture, etc., due to a variety of causes. Osteoporosis includes both primary and secondary categories, with postmenopausal osteoporosis (PMO) being the most common form of primary osteoporosis. Postmenopausal osteoporosis (PMO) is a common disease related to aging, mainly occurs in postmenopausal women, due to the fact that estrogen deficiency causes reduction of bone mass and structural change of bone tissues, bone fragility is increased, fracture is easy, pain, bone deformation, complications and the like caused by fracture seriously affect the health and life quality of old people, and even shorten life.
Postmenopausal osteoporosis (PMO) is mainly caused by estrogen deficiency, occurs in female patients, and is involved in multiple factors such as heredity, life style and nutrition. Family history of osteoporosis, women with special genes affecting bone mass, insufficient calcium intake, lack of physical activity, massive smoking and drinking, early menopause and the like are all high-risk factors. Therefore, for the treatment of this type of diseases, in particular prevention, is of particular importance.
Chinese patent CN104161936A discloses a traditional Chinese medicine composition for preventing and/or treating postmenopausal osteoporosis, which is prepared from the following medicinal materials in parts by weight: 28-31 parts of fructus psoraleae, 27-32 parts of semen cuscutae, 26-32 parts of rhizoma drynariae, 24-26 parts of fructus lycii, 21-25 parts of donkey-hide gelatin, 22-25 parts of raspberry, 22-26 parts of rhizoma cyperi, 23-25 parts of salvia miltiorrhiza and 22-24 parts of radix achyranthis bidentatae. However, the traditional Chinese medicine composition for preventing and/or treating postmenopausal osteoporosis prepared by the patent has poor health-care and prevention effects.
Disclosure of Invention
In view of the above, the present invention provides a compound traditional Chinese medicine for preventing and treating osteoporosis and a preparation method thereof, so as to solve the above technical problems.
The invention provides the following technical scheme: the formula of the compound traditional Chinese medicine for preventing and treating the osteoporosis comprises the following raw materials in parts by weight: 4 to 10 parts of drynaria rhizome, 3 to 6 parts of human placenta, 0.06 to 0.12 part of earthworm, 2 to 5.5 parts of bitter rose, 1.3 to 3.8 parts of calcined oyster shell, 2.5 to 6.5 parts of pomegranate bark, 2.5 to 6.5 parts of radix pseudostellariae, 4 to 12 parts of angelica, 1.2 to 3.6 parts of phellodendron, 0.2 to 0.55 part of amethyst, 0.4 to 1.2 parts of kudzu root, 0.3 to 1.5 parts of red paeony root, 4 to 8.5 parts of epimedium herb and 2 to 6.5 parts of dandelion root.
Further, the formula of the compound traditional Chinese medicine for preventing and treating osteoporosis comprises the following raw materials in parts by weight: 5 to 8 parts of drynaria rhizome, 4.5 to 5.5 parts of human placenta, 0.08 to 0.10 part of earthworm, 3 to 4.5 parts of bitter rose, 2.0 to 3.0 parts of calcined oyster, 3.5 to 5.5 parts of pomegranate peel, 3.5 to 5.5 parts of rhizoma gastrodiae, 6 to 10 parts of angelica, 1.8 to 3.0 parts of phellodendron, 0.35 to 0.45 part of amethyst, 0.6 to 1.0 part of kudzu root, 0.5 to 1.2 parts of red paeony root, 5.5 to 7.0 parts of epimedium herb and 3.5 to 5.0 parts of dandelion root.
Further, the formula of the compound traditional Chinese medicine for preventing and treating osteoporosis comprises the following raw materials in parts by weight: 7 parts of drynaria rhizome, 4.5 parts of human placenta, 0.09 part of earthworm, 3.5 parts of bitter rose, 2.5 parts of calcined oyster shell, 4.5 parts of pomegranate rind, 4.5 parts of radix pseudostellariae, 8 parts of angelica, 2.4 parts of phellodendron, 0.35 part of amethyst, 0.8 part of kudzu root, 0.9 part of red peony root, 6.0 parts of epimedium herb and 4.2 parts of dandelion root.
In the traditional Chinese medicine, the 'kidney generates bone marrow', the marrow is biochemically active when the kidney essence is sufficient, and the bone is nourished and strong, so that the prescription for preventing and treating osteoporosis not only has the effect of directly strengthening the bone, but also simultaneously performs the function of tonifying the kidney, and for the postmenopausal osteoporosis of women, the secretion and improvement of female hormone are considered. The rhizoma drynariae in the raw materials has the effects of tonifying kidney, strengthening bone, healing wound and relieving pain, and has good relieving effects on preventing and treating symptoms of the osteoporosis and symptoms of tinnitus, deafness, kidney deficiency, lumbago and the like caused by the osteoporosis; the placenta hominis has the effects of benefiting qi, nourishing blood and replenishing vital essence, and can also be used for generating estrogen and progestogen for several times to relieve or delay osteoporosis symptoms caused by hormone level; lumbricus has effects of dredging meridian passage, promoting blood circulation, and removing blood stasis, and can be used with radix Angelicae sinensis for treating qi deficiency and blood stagnation; the rose has the effects of promoting qi circulation, relieving depression, regulating blood circulation and relieving pain, can regulate the female hormone level, damage blood stasis and other symptoms, is particularly suitable for regulating women before and after menopause, soothing the liver, regulating qi and relieving mood fluctuation; the oyster is mainly calcium carbonate and calcium phosphate, and the calcined oyster has the effects of astringing, arresting discharge and removing acidity, can also relieve symptoms such as uneasiness, insomnia, liver-yang hyperactivity and the like, and can be used together with the pseudostellaria heterophylla to strengthen the effects of arresting sweating, consolidating exterior, strengthening spleen and replenishing qi; the pericarpium Granati has effects of relieving diarrhea with astringents, and expelling parasite; radix Angelicae sinensis has effects of replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, and loosening bowel to relieve constipation, and can be used for treating rheumatalgia and traumatic injury; cortex Phellodendri is mainly used for treating damp-heat dysentery, leukorrhagia pruritus vulvae, hectic fever due to yin-deficiency, night sweat, etc., and radix Angelicae sinensis and cortex Phellodendri can be used together for replenishing blood, promoting blood circulation, and reducing night sweat symptoms; the amethyst has the effects of relieving palpitation, tranquilizing, lowering adverse qi, warming uterus, nourishing blood, eliminating dampness, treating asthenia, palpitation, and kidney-yang deficiency, and can promote ovary secretion and regulate hormone level; radix Puerariae has effects of expelling pathogenic factors from muscles, relieving fever, promoting fluid production to quench thirst, invigorating yang, and relieving diarrhea; radix Paeoniae Rubra has effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis, and can be used for treating amenorrhea due to blood stagnation when combined with radix Angelicae sinensis; the epimedium has the functions of tonifying kidney yang, strengthening muscles and bones and dispelling wind-damp, can tonify kidney yang, relieve osteoporosis caused by amenorrhea, relieve rheumatic osteoarthropathy symptoms and reduce body discomfort caused by osteoporosis; the herba Taraxaci has effects of clearing heat and detoxicating, promoting diuresis and resolving hard mass, nourishing yin and cooling blood, relaxing muscles and tendons and strengthening teeth.
Furthermore, the bitter rose is dried bitter rose with water content of 4-10 wt% in Yongdeng county in Gansu province. The picnic rose from Yongdeng county in Gansu province is a rare plateau selenium-rich rose variety in the world, and has high selenium content and strong antioxidant function.
Further, the preparation method of the calcined oyster comprises the following steps: cleaning 100 parts of raw oyster shells, soaking in 80-120 parts of rice vinegar at 25-40 ℃ for 10-20 hours, boiling to remove the rice vinegar, drying in an oven at 320-400 ℃ for 50-70 minutes, and crushing to obtain calcined oysters.
Further, the rice vinegar is selected from brown rice vinegar, glutinous rice vinegar, fruit vinegar, and white rice vinegar.
Furthermore, the particle size of the calcined oyster obtained by the grinding is less than or equal to 1500 meshes.
The invention also aims to provide a preparation method of the compound traditional Chinese medicine for preventing and treating osteoporosis, which comprises the following steps:
(1) crushing the drynaria rhizome, the earthworm, the rosa amara, the pomegranate rind, the adenophora tetraphylla, the angelica, the phellodendron, the amethyst, the radix puerariae, the red paeony root, the epimedium herb and the dandelion root in parts by weight, and sieving the crushed materials by a 40-mesh sieve to obtain raw material particles with the particle size of less than 40 meshes;
(2) putting the raw material particles obtained in the step (1) into water of which the weight is 3-7 times that of the raw material particles, soaking for 1 hour, decocting for 1.5-3 hours to obtain primary filtrate and filter residue, adding water of which the weight is 2-4 times that of the filter residue, soaking for 1-2 hours to obtain secondary filtrate, combining the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain an extract with the relative density of 1.15-1.3;
(3) crushing the calcined oyster and the human placenta in parts by weight, sieving the crushed oyster and the human placenta with a 100-mesh sieve, sterilizing, adding the crushed oyster and the human placenta into the extract obtained in the step (2), and uniformly stirring and mixing to obtain a mixed paste;
(4) and (4) adding auxiliary dextrin and cane sugar into the mixed paste obtained in the step (3), uniformly stirring, granulating, and drying to obtain the compound traditional Chinese medicine for preventing and treating osteoporosis.
Further, in the step (4), the adding weight ratio of the mixed paste, the auxiliary dextrin and the sucrose is 10: 2-3.5: 1.0-2.
According to the technical scheme, the invention has the beneficial effects that:
(1) the compound traditional Chinese medicine for preventing and treating osteoporosis takes the measures of tonifying kidney yang, strengthening bones and muscles and conditioning estrogen, and regulates the medicine property and effect among the medicines by adjusting the mutual matching among the traditional Chinese medicine raw materials, so that the compound traditional Chinese medicine can treat and prevent osteoporosis symptoms, particularly osteoporosis symptoms caused by female amenorrhea, and has the most obvious effect.
(2) The compound traditional Chinese medicine for preventing and treating osteoporosis prepared by the invention can effectively relieve osteoporosis caused by menopause, and symptoms such as waist and back pain, soreness and weakness of feet and knees, frequent nocturia, spontaneous night sweat, dizziness and tinnitus and the like caused by the osteoporosis, the effective rate of treatment can reach more than 90%, the osteoporosis can be effectively prevented and stopped, the preparation method is simple, the preparation process is operated, and the compound traditional Chinese medicine is suitable for large-scale production.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. The exemplary embodiments and descriptions of the present invention are provided to explain the present invention, but not to limit the present invention.
Example 1
Compound traditional Chinese medicine for preventing and treating osteoporosis and preparation method thereof
The formula of the compound traditional Chinese medicine for preventing and treating the osteoporosis comprises the following raw materials in parts by weight: 4 parts of drynaria rhizome, 3 parts of human placenta, 0.06 part of earthworm, 2 parts of bitter rose, 1.3 parts of calcined oyster shell, 2.5 parts of pomegranate rind, 2.5 parts of adenophora tetraphylla, 4 parts of angelica, 1.2 parts of phellodendron, 0.2 part of amethyst, 0.4 part of kudzu root, 0.3 part of red peony root, 4 parts of epimedium and 2 parts of dandelion root; the preparation method of the calcined oyster comprises the following steps: cleaning 100 parts of raw oyster shells, soaking in 80 parts of rice vinegar at 25 ℃ for 10 hours, boiling to remove the rice vinegar, drying in a drying oven at 320 ℃ for 50 minutes, and crushing to obtain calcined oysters with the particle size of less than or equal to 1500 meshes; the rice vinegar is brown rice vinegar.
The preparation method of the compound traditional Chinese medicine for preventing and treating osteoporosis comprises the following steps:
(1) crushing the drynaria rhizome, the earthworm, the rosa amara, the pomegranate rind, the adenophora tetraphylla, the angelica, the phellodendron, the amethyst, the radix puerariae, the red paeony root, the epimedium herb and the dandelion root in parts by weight, and sieving the crushed materials by a 40-mesh sieve to obtain raw material particles with the particle size of less than 40 meshes;
(2) putting the raw material particles obtained in the step (1) into 3 times of water, soaking for 1 hour, then decocting for 1.5 hours to obtain a primary filtrate and filter residue, adding 2 times of water into the filter residue, soaking for 1 hour to obtain a secondary filtrate, combining the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain an extract with the relative density of 1.15;
(3) crushing the calcined oyster and the human placenta in parts by weight, sieving the crushed oyster and the human placenta with a 100-mesh sieve, sterilizing, adding the crushed oyster and the human placenta into the extract obtained in the step (2), and uniformly stirring and mixing to obtain a mixed paste;
(4) adding auxiliary dextrin and sucrose into the mixed paste obtained in the step (3), wherein the adding weight ratio of the mixed paste to the auxiliary dextrin to the sucrose is 10:2:1.0, uniformly stirring, granulating, and drying to obtain the compound traditional Chinese medicine for preventing and treating osteoporosis.
Example 2
Compound traditional Chinese medicine for preventing and treating osteoporosis and preparation method thereof
The formula of the compound traditional Chinese medicine for preventing and treating the osteoporosis comprises the following raw materials in parts by weight: 10 parts of drynaria rhizome, 6 parts of human placenta, 0.12 part of earthworm, 5.5 parts of bitter rose, 3.8 parts of calcined oyster shell, 6.5 parts of pomegranate rind, 6.5 parts of adenophora tetraphylla, 12 parts of angelica, 3.6 parts of phellodendron, 0.55 part of amethyst, 1.2 parts of kudzu root, 1.5 parts of red peony root, 8.5 parts of epimedium and 6.5 parts of dandelion root; the bitter rose is dried bitter rose with water content of 10 wt% in Yongdeng county of Gansu province; the preparation method of the calcined oyster comprises the following steps: cleaning 100 parts of raw oyster shells, soaking in 120 parts of rice vinegar at 40 ℃ for 20 hours, boiling to remove the rice vinegar, drying in a drying oven at 400 ℃ for 70 minutes, and crushing to obtain calcined oysters with the particle size of less than or equal to 1500 meshes; the rice vinegar is selected from glutinous rice vinegar.
The preparation method of the compound traditional Chinese medicine for preventing and treating osteoporosis comprises the following steps:
(1) crushing the drynaria rhizome, the earthworm, the rosa amara, the pomegranate rind, the adenophora tetraphylla, the angelica, the phellodendron, the amethyst, the radix puerariae, the red paeony root, the epimedium herb and the dandelion root in parts by weight, and sieving the crushed materials by a 40-mesh sieve to obtain raw material particles with the particle size of less than 40 meshes;
(2) putting the raw material particles obtained in the step (1) into water of which the weight is 7 times that of the raw material particles, soaking for 1 hour, then decocting for 3 hours to obtain primary filtrate and filter residue, adding water of which the weight is 4 times that of the filter residue, soaking and decocting for 2 hours to obtain secondary filtrate, combining the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain an extract with the relative density of 1.3;
(3) crushing the calcined oyster and the human placenta in parts by weight, sieving the crushed oyster and the human placenta with a 100-mesh sieve, sterilizing, adding the crushed oyster and the human placenta into the extract obtained in the step (2), and uniformly stirring and mixing to obtain a mixed paste;
(4) adding auxiliary dextrin and sucrose into the mixed paste obtained in the step (3), wherein the adding weight ratio of the mixed paste to the auxiliary dextrin to the sucrose is 10:3.5:2, uniformly stirring, granulating, and drying to obtain the compound traditional Chinese medicine for preventing and treating osteoporosis.
Example 3
Compound traditional Chinese medicine for preventing and treating osteoporosis and preparation method thereof
The formula of the compound traditional Chinese medicine for preventing and treating the osteoporosis comprises the following raw materials in parts by weight: 5 parts of drynaria rhizome, 4.5 parts of human placenta, 0.08 part of earthworm, 3 parts of bitter rose, 2.0 parts of calcined oyster shell, 3.5 parts of pomegranate rind, 3.5 parts of adenophora tetraphylla, 6 parts of angelica, 1.8 parts of phellodendron, 0.35 part of amethyst, 0.6 part of kudzu root, 0.5 part of red peony root, 5.5 parts of epimedium and 3.5 parts of dandelion root; the above bitter rose is dried bitter rose with water content of 4 wt% in Yongdeng county of Gansu province; the preparation method of the calcined oyster comprises the following steps: cleaning 100 parts of raw oyster shells, soaking the oyster shells in 90 parts of rice vinegar at 30 ℃ for 12 hours, boiling and steaming the rice vinegar, drying the rice vinegar in an oven at 340 ℃ for 55 minutes, and crushing to obtain calcined oysters with the particle size of less than or equal to 1500 meshes; the rice vinegar is fruit vinegar.
The preparation method of the compound traditional Chinese medicine for preventing and treating osteoporosis comprises the following steps:
(1) crushing the drynaria rhizome, the earthworm, the rosa amara, the pomegranate rind, the adenophora tetraphylla, the angelica, the phellodendron, the amethyst, the radix puerariae, the red paeony root, the epimedium herb and the dandelion root in parts by weight, and sieving the crushed materials by a 40-mesh sieve to obtain raw material particles with the particle size of less than 40 meshes;
(2) putting the raw material particles obtained in the step (1) into 4 times of water, soaking for 1 hour, then decocting for 2 hours to obtain a primary filtrate and filter residue, adding 2.5 times of water into the filter residue, soaking for 1.5 hours to obtain a secondary filtrate, combining the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain an extract with the relative density of 1.2;
(3) crushing the calcined oyster and the human placenta in parts by weight, sieving the crushed oyster and the human placenta with a 100-mesh sieve, sterilizing, adding the crushed oyster and the human placenta into the extract obtained in the step (2), and uniformly stirring and mixing to obtain a mixed paste;
(4) adding auxiliary dextrin and sucrose into the mixed paste obtained in the step (3), wherein the adding weight ratio of the mixed paste to the auxiliary dextrin to the sucrose is 10:2.5: 1.2, uniformly stirring, granulating, and drying to obtain the compound traditional Chinese medicine for preventing and treating osteoporosis.
Example 4
Compound traditional Chinese medicine for preventing and treating osteoporosis and preparation method thereof
The formula of the compound traditional Chinese medicine for preventing and treating the osteoporosis comprises the following raw materials in parts by weight: 8 parts of drynaria rhizome, 5.5 parts of human placenta, 0.10 part of earthworm, 4.5 parts of bitter rose, 3.0 parts of calcined oyster shell, 5.5 parts of pomegranate rind, 5.5 parts of radix pseudostellariae, 10 parts of angelica, 3.0 parts of phellodendron, 0.45 part of amethyst, 1.0 part of kudzu root, 1.2 parts of red paeony root, 7.0 parts of epimedium herb and 5.0 parts of dandelion root; the bitter rose is dried bitter rose with water content of 8 wt% in Yongdeng county of Gansu province; the preparation method of the calcined oyster comprises the following steps: cleaning 100 parts of raw oyster shells, soaking in 140 parts of rice vinegar at 35 ℃ for 18 hours, boiling to remove the rice vinegar, drying in a 380 ℃ oven for 65 minutes, and crushing to obtain calcined oysters with the particle size of less than or equal to 1500 meshes; the rice vinegar is selected from white rice vinegar.
The preparation method of the compound traditional Chinese medicine for preventing and treating osteoporosis comprises the following steps:
(1) crushing the drynaria rhizome, the earthworm, the rosa amara, the pomegranate rind, the adenophora tetraphylla, the angelica, the phellodendron, the amethyst, the radix puerariae, the red paeony root, the epimedium herb and the dandelion root in parts by weight, and sieving the crushed materials by a 40-mesh sieve to obtain raw material particles with the particle size of less than 40 meshes;
(2) putting the raw material particles obtained in the step (1) into 6 times of water, soaking for 1 hour, then decocting for 2.5 hours to obtain a primary filtrate and filter residue, adding 3.5 times of water into the filter residue, soaking and decocting for 2 hours to obtain a secondary filtrate, combining the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain an extract with the relative density of 1.25;
(3) crushing the calcined oyster and the human placenta in parts by weight, sieving the crushed oyster and the human placenta with a 100-mesh sieve, sterilizing, adding the crushed oyster and the human placenta into the extract obtained in the step (2), and uniformly stirring and mixing to obtain a mixed paste;
(4) adding auxiliary dextrin and sucrose into the mixed paste obtained in the step (3), wherein the adding weight ratio of the mixed paste to the auxiliary dextrin to the sucrose is 10:3.0:1.8, uniformly stirring, granulating, and drying to obtain the compound traditional Chinese medicine for preventing and treating osteoporosis.
Example 5
Compound traditional Chinese medicine for preventing and treating osteoporosis and preparation method thereof
The formula of the compound traditional Chinese medicine for preventing and treating the osteoporosis comprises the following raw materials in parts by weight: 7 parts of drynaria rhizome, 4.5 parts of human placenta, 0.09 part of earthworm, 3.5 parts of bitter rose, 2.5 parts of calcined oyster shell, 4.5 parts of pomegranate rind, 4.5 parts of radix pseudostellariae, 8 parts of angelica, 2.4 parts of phellodendron, 0.35 part of amethyst, 0.8 part of kudzu root, 0.9 part of red peony root, 6.0 parts of epimedium herb and 4.2 parts of dandelion root; the bitter rose is dried bitter rose with water content of 7 wt% in Yongdeng county of Gansu province; the preparation method of the calcined oyster comprises the following steps: cleaning 100 parts of raw oyster shells, soaking the oyster shells in 100 parts of rice vinegar for 15 hours at 30 ℃, boiling and steaming the rice vinegar, drying the oyster shells in a 360 ℃ oven for 60 minutes, and crushing the oyster shells to obtain calcined oysters with the particle size of less than or equal to 1500 meshes; the rice vinegar is brown rice vinegar.
The preparation method of the compound traditional Chinese medicine for preventing and treating osteoporosis comprises the following steps:
(1) crushing the drynaria rhizome, the earthworm, the rosa amara, the pomegranate rind, the adenophora tetraphylla, the angelica, the phellodendron, the amethyst, the radix puerariae, the red paeony root, the epimedium herb and the dandelion root in parts by weight, and sieving the crushed materials by a 40-mesh sieve to obtain raw material particles with the particle size of less than 40 meshes;
(2) putting the raw material particles obtained in the step (1) into water of which the weight is 5 times that of the raw material particles, soaking for 1 hour, then decocting for 2 hours to obtain primary filtrate and filter residue, adding water of which the weight is 3 times that of the filter residue, soaking and decocting for 1.5 hours to obtain secondary filtrate, combining the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain an extract with the relative density of 1.2;
(3) crushing the calcined oyster and the human placenta in parts by weight, sieving the crushed oyster and the human placenta with a 100-mesh sieve, sterilizing, adding the crushed oyster and the human placenta into the extract obtained in the step (2), and uniformly stirring and mixing to obtain a mixed paste;
(4) and (4) adding auxiliary dextrin and sucrose into the mixed paste obtained in the step (3), wherein the adding weight ratio of the mixed paste to the auxiliary dextrin to the sucrose is 10:2.5:1.5, granulating after uniformly stirring, and drying to obtain the compound traditional Chinese medicine for preventing and treating osteoporosis.
Test examples
1. General data
1) Test group a: 100 patients with age of 45-54 years have obvious osteoporosis clinical symptoms after menopause, and the affected parts comprise cervical vertebra, lumbar vertebra, knee joint and naked joint and are confirmed by clinicians. 100 patients were randomized into trial a1 group 50 and control a2 group 50.
2) Test group b: 50 people are 42-49 years old, have no obvious osteoporosis clinical symptoms after amenorrhea is finished, but have obvious emotion and other body reactions after amenorrhea.
2. Method of administration
The calcium carbonate chewable tablets are taken by the test a1 group and the control a2 group twice a day, 1 tablet each time, and the compound traditional Chinese medicine for preventing and treating osteoporosis, prepared by the embodiment 5, is further taken by the test a1 group of patients twice a day, 2 tablets each time, 30 days as a treatment course, and 2 treatment courses are continuously taken.
Patients in test group b took the compound traditional Chinese medicine for preventing and treating osteoporosis prepared in embodiment 5 of the invention singly twice a day, 2 granules each time, 30 days as a treatment course, and continuously took 2 treatment courses.
3. Criteria for efficacy assessment
1) Diagnostic criteria
Is made according to the flat-top requirement of the clinical research guiding principle of the new traditional Chinese medicine for treating the osteoporosis in the clinical research guiding principle of the new traditional Chinese medicine. The performance includes: soreness and weakness of waist and knees, walking difficulty, dizziness, vertigo, inability to hold the weight, reddish or pale tongue, thin or white tongue coating, deep and thready pulse, and osteoporosis.
2) Flat top standard of therapeutic effect
And (3) curing: clinical symptoms and physical signs disappear, the function returns to normal, and the disease does not relapse for more than one year
The effect is shown: the clinical symptoms and physical signs are obviously relieved, and the function is basically recovered to be normal
The method has the following advantages: partial reduction of clinical symptoms and signs
And (4) invalidation: the treatment is continued for more than one course of treatment, and the symptoms and physical signs are not changed.
4. Therapeutic results
The therapeutic effect of the patients in test group a is shown in table 1.
Group of The number of people cured Number of effective people Number of effective persons Number of invalid persons Total effective rate
Test a1 group 21 persons 13 persons 12 persons 4 persons 92%
Test a2 group 18 persons 10 persons 10 persons 12 persons 76%
In the test group b, no osteoporosis symptom appears in 44 patients and slight osteoporosis symptom appears in 6 patients within 2-5 years after two treatment courses of medicine.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes may be made to the embodiment of the present invention by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (9)

1. The compound traditional Chinese medicine for preventing and treating osteoporosis is characterized in that the formula of the compound traditional Chinese medicine for preventing and treating osteoporosis comprises the following raw materials in parts by weight: 4 to 10 parts of drynaria rhizome, 3 to 6 parts of human placenta, 0.06 to 0.12 part of earthworm, 2 to 5.5 parts of bitter rose, 1.3 to 3.8 parts of calcined oyster shell, 2.5 to 6.5 parts of pomegranate bark, 2.5 to 6.5 parts of radix pseudostellariae, 4 to 12 parts of angelica, 1.2 to 3.6 parts of phellodendron, 0.2 to 0.55 part of amethyst, 0.4 to 1.2 parts of kudzu root, 0.3 to 1.5 parts of red paeony root, 4 to 8.5 parts of epimedium herb and 2 to 6.5 parts of dandelion root.
2. The compound traditional Chinese medicine for preventing and treating osteoporosis of claim 1, wherein the formula of the compound traditional Chinese medicine for preventing and treating osteoporosis comprises the following raw materials in parts by weight: 5 to 8 parts of drynaria rhizome, 4.5 to 5.5 parts of human placenta, 0.08 to 0.10 part of earthworm, 3 to 4.5 parts of bitter rose, 2.0 to 3.0 parts of calcined oyster, 3.5 to 5.5 parts of pomegranate peel, 3.5 to 5.5 parts of rhizoma gastrodiae, 6 to 10 parts of angelica, 1.8 to 3.0 parts of phellodendron, 0.35 to 0.45 part of amethyst, 0.6 to 1.0 part of kudzu root, 0.5 to 1.2 parts of red paeony root, 5.5 to 7.0 parts of epimedium herb and 3.5 to 5.0 parts of dandelion root.
3. The compound traditional Chinese medicine for preventing and treating osteoporosis of claim 1, wherein the formula of the compound traditional Chinese medicine for preventing and treating osteoporosis comprises the following raw materials in parts by weight: 7 parts of drynaria rhizome, 4.5 parts of human placenta, 0.09 part of earthworm, 3.5 parts of bitter rose, 2.5 parts of calcined oyster shell, 4.5 parts of pomegranate rind, 4.5 parts of radix pseudostellariae, 8 parts of angelica, 2.4 parts of phellodendron, 0.35 part of amethyst, 0.8 part of kudzu root, 0.9 part of red peony root, 6.0 parts of epimedium herb and 4.2 parts of dandelion root.
4. The compound traditional Chinese medicine for preventing and treating osteoporosis of claim 1, wherein the rosa laevigata is dried rosa laevigata of Yongdeng county, Gansu province with a water content of 4-10 wt%.
5. The compound traditional Chinese medicine for preventing and treating osteoporosis of claim 1, wherein the preparation method of the calcined oyster comprises the following steps: cleaning 100 parts of raw oyster shells, soaking in 80-120 parts of rice vinegar at 25-40 ℃ for 10-20 hours, boiling to remove the rice vinegar, drying in an oven at 320-400 ℃ for 50-70 minutes, and crushing to obtain calcined oysters.
6. The compound traditional Chinese medicine for preventing and treating osteoporosis as claimed in claim 5, wherein the rice vinegar is selected from any one of brown rice vinegar, glutinous rice vinegar, fruit vinegar and white rice vinegar.
7. The compound traditional Chinese medicine for preventing and treating osteoporosis of claim 5, wherein the particle size of the calcined oyster obtained by crushing is less than or equal to 1500 meshes.
8. The preparation method of the compound traditional Chinese medicine for preventing and treating osteoporosis as claimed in any one of claims 1 to 7, comprising the following steps:
(1) crushing the drynaria rhizome, the earthworm, the rosa amara, the pomegranate rind, the adenophora tetraphylla, the angelica, the phellodendron, the amethyst, the radix puerariae, the red paeony root, the epimedium herb and the dandelion root in parts by weight, and sieving the crushed materials by a 40-mesh sieve to obtain raw material particles with the particle size of less than 40 meshes;
(2) putting the raw material particles obtained in the step (1) into water of which the weight is 3-7 times that of the raw material particles, soaking for 1 hour, decocting for 1.5-3 hours to obtain primary filtrate and filter residue, adding water of which the weight is 2-4 times that of the filter residue, soaking for 1-2 hours to obtain secondary filtrate, combining the primary filtrate and the secondary filtrate, and concentrating under reduced pressure to obtain an extract with the relative density of 1.15-1.3;
(3) crushing the calcined oyster and the human placenta in parts by weight, sieving the crushed oyster and the human placenta with a 100-mesh sieve, sterilizing, adding the crushed oyster and the human placenta into the extract obtained in the step (2), and uniformly stirring and mixing to obtain a mixed paste;
(4) and (4) adding auxiliary dextrin and cane sugar into the mixed paste obtained in the step (3), uniformly stirring, granulating, and drying to obtain the compound traditional Chinese medicine for preventing and treating osteoporosis.
9. The preparation method of the compound traditional Chinese medicine for preventing and treating osteoporosis of claim 8, wherein in the step (4), the weight ratio of the mixed paste to the auxiliary dextrin to the sucrose is 10: 2-3.5: 1.0-2.
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