CN114521563B - Insecticidal composition containing oxazine and abamectin or emamectin benzoate - Google Patents
Insecticidal composition containing oxazine and abamectin or emamectin benzoate Download PDFInfo
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- CN114521563B CN114521563B CN202210166858.XA CN202210166858A CN114521563B CN 114521563 B CN114521563 B CN 114521563B CN 202210166858 A CN202210166858 A CN 202210166858A CN 114521563 B CN114521563 B CN 114521563B
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- Prior art keywords
- oxazine
- emamectin benzoate
- amide
- abamectin
- insecticidal composition
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- CXEGAUYXQAKHKJ-NSBHKLITSA-N emamectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](NC)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 CXEGAUYXQAKHKJ-NSBHKLITSA-N 0.000 title claims abstract description 53
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 230000000749 insecticidal effect Effects 0.000 title claims abstract description 30
- 239000005660 Abamectin Substances 0.000 title abstract description 51
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 title abstract description 32
- 229950008167 abamectin Drugs 0.000 title abstract description 32
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2h-oxazine Chemical compound N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 title description 10
- ADRRIUGXSOGPPW-UHFFFAOYSA-N 2h-oxazine-3-carboxamide Chemical compound NC(=O)C1=CC=CON1 ADRRIUGXSOGPPW-UHFFFAOYSA-N 0.000 claims description 49
- 241000952610 Aphis glycines Species 0.000 claims description 29
- 239000004562 water dispersible granule Substances 0.000 claims description 9
- 239000005995 Aluminium silicate Substances 0.000 claims description 5
- 235000012211 aluminium silicate Nutrition 0.000 claims description 5
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 claims description 5
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 5
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 3
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 3
- 235000011152 sodium sulphate Nutrition 0.000 claims description 3
- JVFFWGJAAQAIBS-UHFFFAOYSA-K trisodium 2,2-dioctyl-3-sulfonatobutanedioate Chemical compound [Na+].C(CCCCCCC)C(C(C(=O)[O-])S(=O)(=O)[O-])(C(=O)[O-])CCCCCCCC.[Na+].[Na+] JVFFWGJAAQAIBS-UHFFFAOYSA-K 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 abstract description 22
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- 206010059866 Drug resistance Diseases 0.000 abstract description 7
- 239000003795 chemical substances by application Substances 0.000 description 21
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 description 17
- 241000238631 Hexapoda Species 0.000 description 15
- 241001124076 Aphididae Species 0.000 description 13
- 238000012360 testing method Methods 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 150000001875 compounds Chemical class 0.000 description 10
- 230000000694 effects Effects 0.000 description 10
- 239000003814 drug Substances 0.000 description 9
- 239000004495 emulsifiable concentrate Substances 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 231100000419 toxicity Toxicity 0.000 description 8
- 230000001988 toxicity Effects 0.000 description 8
- 239000000839 emulsion Substances 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- 239000004563 wettable powder Substances 0.000 description 7
- 241000258937 Hemiptera Species 0.000 description 5
- 231100000111 LD50 Toxicity 0.000 description 5
- 241001414989 Thysanoptera Species 0.000 description 5
- 230000009471 action Effects 0.000 description 5
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- 239000002270 dispersing agent Substances 0.000 description 5
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- 230000009467 reduction Effects 0.000 description 5
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- 239000000080 wetting agent Substances 0.000 description 5
- 241000254173 Coleoptera Species 0.000 description 4
- 241000255925 Diptera Species 0.000 description 4
- 244000046052 Phaseolus vulgaris Species 0.000 description 4
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 4
- 239000003995 emulsifying agent Substances 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 239000002917 insecticide Substances 0.000 description 4
- 230000002147 killing effect Effects 0.000 description 4
- 239000000178 monomer Substances 0.000 description 4
- -1 pyrazole amide compound Chemical class 0.000 description 4
- 238000010008 shearing Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000000375 suspending agent Substances 0.000 description 4
- 230000001018 virulence Effects 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000009885 systemic effect Effects 0.000 description 3
- 241001124134 Chrysomelidae Species 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000256602 Isoptera Species 0.000 description 2
- 241000255777 Lepidoptera Species 0.000 description 2
- FCOHEOSCARXMMS-UHFFFAOYSA-N Oxaziclomefone Chemical compound C1OC(C)=C(C=2C=CC=CC=2)C(=O)N1C(C)(C)C1=CC(Cl)=CC(Cl)=C1 FCOHEOSCARXMMS-UHFFFAOYSA-N 0.000 description 2
- 241001466030 Psylloidea Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 244000061456 Solanum tuberosum Species 0.000 description 2
- 235000002595 Solanum tuberosum Nutrition 0.000 description 2
- 239000002518 antifoaming agent Substances 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 239000006229 carbon black Substances 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
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- 238000000227 grinding Methods 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 239000003120 macrolide antibiotic agent Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- NQPGZXOPMRKAGJ-UHFFFAOYSA-N n-ethyl-5-methyl-1-(3-methylbutan-2-yl)-n-pyridazin-4-ylpyrazole-4-carboxamide Chemical compound C=1C=NN=CC=1N(CC)C(=O)C=1C=NN(C(C)C(C)C)C=1C NQPGZXOPMRKAGJ-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 230000000361 pesticidal effect Effects 0.000 description 2
- 229920005646 polycarboxylate Polymers 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 1
- 244000003416 Asparagus officinalis Species 0.000 description 1
- 235000005340 Asparagus officinalis Nutrition 0.000 description 1
- 241001674044 Blattodea Species 0.000 description 1
- 241000426497 Chilo suppressalis Species 0.000 description 1
- 239000005894 Emamectin Substances 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 241000189565 Frankliniella Species 0.000 description 1
- 241001466042 Fulgoromorpha Species 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 241000257303 Hymenoptera Species 0.000 description 1
- 241000594031 Liriomyza sativae Species 0.000 description 1
- 240000001307 Myosotis scorpioides Species 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 241000500437 Plutella xylostella Species 0.000 description 1
- 241000256251 Spodoptera frugiperda Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
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- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/58—1,2-Diazines; Hydrogenated 1,2-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention belongs to the field of pesticides, and in particular relates to an insecticidal composition containing oxazin-mefenoxam and abamectin or emamectin benzoate and application thereof, wherein an active ingredient consists of oxazin-mefenoxam and an active ingredient B, and the mass ratio of the oxazin-mefenoxam to the active ingredient B is 1-100:0.5-10; the active ingredient B is any one of abamectin or emamectin benzoate; the insecticidal composition is used for controlling crop pests; the insecticidal composition has remarkable synergistic effect, can effectively reduce the dosage of active ingredients, and slows down the generation of drug resistance of pests.
Description
Technical Field
The invention belongs to the field of pesticide, and provides an insecticidal composition containing oxazine amide and abamectin or emamectin benzoate and application thereof.
Background
The oxazine amide is a pyrazole amide compound, and the English common name is as follows: dimropyridaz; trade name: axalon TM The method comprises the steps of carrying out a first treatment on the surface of the IUPAC name: 1- [ (1 RS) -1, 2-dimethylpropyl]-N-ethyl-5-methyl-N-pyridazin-4-yl-1H-pyrazole-4-carboxamide; CAS accession number: 1403615-77-9; the molecular formula: C16H23N5O; the structural formula is as follows:
。
the product of the oxazine amide has excellent performance and better systemic conductivity. The insecticidal composition is mainly used for controlling pests such as lepidoptera (such as chilo suppressalis, asparagus caterpillar, plutella xylostella, spodoptera frugiperda and the like), coleoptera (such as beetles, corn root beetles, potato leaf beetles, yellow leaf beetles and the like), diptera (such as flies, mosquitoes, vegetable leaf miner and the like), hemiptera (such as aphids, plant hoppers, psyllids, whiteflies and the like), thysanoptera (such as thrips, frankliniella, palmi thrips, thrips and the like), isoptera (such as termites and the like), cockroaches, ants and the like, and is particularly effective on sucking mouthparts such as aphids, whiteflies, psyllids and the like.
Avermectin is a macrolide disaccharide compound and is a natural product isolated from soil microorganisms. The action mechanism is to stimulate the release of gamma-aminobutyric acid, inhibit nerve conduction and lead to paralysis and death of pests. Has stomach toxicity and contact killing effects. Has certain plant systemic property and can be conducted through the parenchyma tissue of the plant.
Emamectin benzoate is emamectin benzoate, is a macrolide disaccharide substance, and enables the insect to paralyze and die by blocking the transmission of motor nerve information of the insect. The action mode is mainly stomach toxicity, has the contact killing function, has no systemic property to crops, but can effectively permeate and apply the epidermis tissues of the crops; compared with avermectin, emamectin benzoate has higher biological activity.
The long-term use of single insecticidal chemical components can easily lead to the improvement of the drug resistance of pests, and the dosage of the insecticide is continuously improved; in order to slow down the generation of drug resistance of pests, except for developing new pesticide varieties, the current domestic pesticide companies generally adopt a pesticide compound mode, and no related report of the combined use of the oxazamate and the avermectin or emamectin benzoate exists in the prior art.
Disclosure of Invention
The invention aims to solve the technical problems of slowing down the generation of drug resistance of pests and reducing the dosage of active ingredients, and provides an insecticidal composition with remarkable synergistic effect, which comprises the following specific technical scheme:
the insecticidal composition containing the oxazine amide and the avermectin or emamectin benzoate comprises the following active ingredients of oxazine amide and an active ingredient B, wherein the mass ratio of the oxazine amide to the active ingredient B is 1-100:0.5-10; the active component B is any one of abamectin or emamectin benzoate.
The mass ratio of the preferred oxazine amide to the avermectin is 25-100:1; the mass ratio of the oxazine amide to the emamectin benzoate is 1-100:0.5-1.
The insecticidal composition comprises agricultural auxiliary ingredients; the weight percentage of the active ingredients is 1-75%; the preferred percentage of active ingredient is 5-50%; the pesticide preparation is wettable powder, water dispersible granules, emulsifiable concentrate, aqueous emulsion, microemulsion, suspending agent and granules.
The specific embodiments of the pesticide formulation prepared from the pesticide composition of the invention are as follows:
the insecticidal composition is an emulsifiable concentrate preparation, and comprises the following components in percentage by mass: 1-50% of oxazine amide; 0.1-10% of abamectin or emamectin benzoate; 5-30% of an emulsifying agent; the balance of solvent. The specific production steps of the emulsifiable concentrate preparation are that the effective components of the oxazine and the avermectin or the emamectin benzoate are added into a solvent to be completely dissolved, then the emulsifier is added into the solvent to be uniformly stirred to form uniform and transparent oily liquid, and the oily liquid is filled, so that the emulsifiable concentrate preparation of the composition can be prepared.
The insecticidal composition is a suspending agent, and comprises the following components in percentage by mass: 1-50% of oxazine amide; 0.1-10% of abamectin or emamectin benzoate; 1-10% of dispersing agent; 1-10% of wetting agent; 1-5% of an antifreezing agent; 0.1-2% of thickener; 0.1-0.8% of defoaming agent; 0-10% of penetration enhancer; 0.1-5% of pH regulator; water, balance. The specific production steps of the suspending agent are that other auxiliary agents are firstly mixed, and are evenly mixed by high-speed shearing, the active ingredient oxazin-chlorfenapyr and abamectin or emamectin benzoate are added, and the suspending agent preparation of the composition can be prepared after grinding balls in a ball grinding machine for 2-3 hours, so that the particle diameters are below 5 mm.
The insecticidal composition is wettable powder and comprises the following components in percentage by mass: 1-50% of oxazine amide; 0.1-10% of abamectin or emamectin benzoate; 3-10% of dispersing agent; 1-5% of a wetting agent; and the balance of filler. The specific production steps of the wettable powder are as follows: the composition of the invention can be prepared by mixing the active ingredient oxazine and abamectin or emamectin benzoate, the dispersing agent, the wetting agent and the filler according to the formula, uniformly stirring in a stirring kettle, and uniformly mixing after passing through a jet mill.
The insecticidal composition is water dispersible granules, and comprises the following components in percentage by mass: 1-50% of oxazine amide; 0.1-10% of abamectin or emamectin benzoate; 3-10% of dispersing agent; 1-10% of a wetting agent; 1-5% of disintegrating agent; 1-5% of a binder; and the balance of filler. The specific production steps of the water dispersible granule are as follows: the water dispersible granule of the composition is prepared by uniformly mixing the active ingredient oxazine and abamectin or emamectin benzoate, a dispersing agent, a wetting agent, a disintegrating agent and a filler according to the formula, crushing the mixture by an ultrafine jet mill, kneading the crushed mixture, adding the kneaded mixture into a fluidized bed granulation dryer for granulation, drying and screening, and then sampling and analyzing the mixture.
The insecticidal composition is an aqueous emulsion and comprises the following components in percentage by mass: 1-50% of oxazine amide; 0.1-10% of abamectin or emamectin benzoate; 3-30% of an emulsifying agent; 5-15% of a solvent; 2-15% of a stabilizer; 1-5% of an antifreezing agent; 0.1-8% of defoaming agent; 0.2-2% of thickener; water, balance. The specific production steps of the aqueous emulsion are as follows: firstly, adding the oxazine amide, abamectin or emamectin benzoate, a solvent, an emulsifier and a cosolvent together to dissolve the oxazine amide into a uniform oil phase; mixing part of water, antifreeze, antimicrobial and other pesticide auxiliary agents together to form a uniform water phase; adding the oil phase into the water phase while stirring at high speed in a reaction kettle, slowly adding water until reaching a phase inversion point, starting a shearing machine to conduct high-speed shearing, adding the rest water, and shearing for about half an hour to form an oil-in-water type aqueous emulsion, thus obtaining the aqueous emulsion of the composition.
Wherein the auxiliary materials are common components in the field of pesticide preparations.
The use of the insecticidal composition for controlling crop pests. The crops comprise fruit trees, vegetables, soybeans, cotton, grains and potatoes. The pests include lepidoptera, coleoptera, diptera, hemiptera, thysanoptera pests. Preferably aphids or whiteflies.
Compared with the prior art, the invention has the beneficial effects that:
the mixture of the oxazine and the avermectin has synergistic effect on soybean aphids when the mass ratio is 100:1-25:1, and has excellent insecticidal effect. The mixture of the oxazine amide and the emamectin benzoate has a synergistic effect on soybean aphids when the mass ratio is 200:1-1:1. Has excellent insecticidal effect, can effectively reduce the dosage of the monomer active ingredients and slow down the generation of drug resistance of soybean aphids.
The insecticidal activity of the insecticide can be improved by mixing the oxazine amide and the abamectin or the emamectin benzoate in a proper proportion, and the influence of the mixing proportion of the oxazine amide compound in the mixture on the insecticidal activity of the mixture is higher than that of the insecticide active ingredient.
The compound preparation of the oxazine amide and the abamectin or emamectin benzoate prepared by the invention has excellent prevention and control effects on soybean aphids; the prevention effect of 7d after the medicine is over 90 percent.
Detailed Description
The following is a detailed description of the present invention by way of examples. In the present invention, the following examples are provided for better illustration of the present invention and are not intended to limit the scope of the present invention. Materials, reagents and the like used in the examples described below are commercially available unless otherwise specified.
EXAMPLE 1 indoor biological assay of Metropolyxazole amide and Avermectin and emamectin benzoate
Test insect source: soybean aphids, the wing-free adult aphids with identical individuals are selected as test insects.
Test agent: oxazine amide; abamectin; emamectin benzoate;
the measuring method comprises the following steps: the virulence effect of the tested insecticide on soybean aphids is determined by adopting an immersion method. Controls were set up with 5 concentrations of each agent, each concentration being repeated 4 times. The winged aphids and the small-leaf aphids on the bean seedlings are removed, only wingless adult aphids and individual large wingless leaf aphids are reserved, then the bean seedlings are immersed in prepared liquid medicines with different concentrations for 10 seconds, after the leaf stalks of the bean seedlings are wrapped by absorbent cotton balls with good water absorption, the number of aphids is recorded, and after treatment, the bean seedlings are placed in an incubator for normal feeding, and after 48 hours, the death rate is checked. When in examination, the writing brush is used for lightly stirring the insect body, and if the insect body falls down and cannot stand up, the insect body is regarded as death. Test conditions: temperature (25±1) °c, relative humidity around 75%, photoperiod L.D =16: 8.
data analysis: virulence regression equations, LC50 values, were calculated using splsl 6.0 biometric software.
Combined action analysis: the sun cloud Pei method is adopted: wherein CTC < 80 is antagonism, CTC 80-120 is addition, CTC 120 < is synergy. The specific calculation method is as follows:
mix observed virulence index (ATI) = (standard dose EC 50/mixed dose EC 50) ×100;
the mixed agent Theoretical Toxicity Index (TTI) =a agent toxicity index×the percentage of the a agent in the mixed agent+b agent toxicity index×the percentage of the B agent in the mixed agent;
co-toxicity coefficient (CTC) = (mix measured toxicity index (ATI)/mix Theoretical Toxicity Index (TTI)) ×100.
Test results:
LC50 values of the oxazine amide, abamectin and their blends against soybean aphids and their combined virulence analysis are shown in table 1. Among the monomer compounds, the pesticide avermectin has better effect of killing soybean aphids, and the LC50 value of the pesticide avermectin is 4.93 mug/ml. The mixed agent of the oxazine amide and the abamectin with different proportions shows a certain insecticidal activity on soybean aphids; wherein, when the mass ratio of the oxazine amide to the avermectin is 100:1, 50:1 and 25:1, the CTC values of the oxazine amide and the avermectin are 127.5, 134.6 and 126.5 respectively; the synergistic effect is shown; CTC values of other ratios are equal to or more than 80 and equal to or less than 120 and are added; the combination of the oxazine amide and the abamectin has no antagonism to soybean aphids. The mixed agent of the oxazine and the avermectin has synergistic effect on soybean aphids when the mass ratio of the mixed agent is 100:1-25:1, has excellent insecticidal effect, can effectively reduce the dosage of the monomer active ingredients, and slows down the generation of drug resistance of the soybean aphids.
LC50 values of the oxazine amide, emamectin benzoate and mixtures thereof against soybean aphids and their combined toxicity analysis are shown in table 1. Among the monomeric compounds, the pesticide emamectin benzoate has a better effect of killing soybean aphids, and the LC50 value of the pesticide emamectin benzoate is 1.24 mug/ml. The mixed agent of the oxazine amide and the emamectin benzoate in different proportions has certain insecticidal activity on soybean aphids; wherein, when the mass ratio of the oxazine amide to the emamectin benzoate is 200:1, 100:1, 50:1, 25:1 and 1:1, the CTC values of the oxazine amide and the emamectin benzoate are 150.0, 146.9, 126.7, 138.3 and 131.1 respectively; the synergistic effect is shown; CTC values of other ratios are equal to or more than 80 and equal to or less than 120 and are added; the combination of the oxazine amide and the emamectin benzoate has no antagonism on soybean aphids. The mixed agent of the oxazine amide and the emamectin benzoate shows synergistic effect on soybean aphids when the mass ratio of the oxazine amide to the emamectin benzoate is 200:1-1:1, has excellent insecticidal effect, can effectively reduce the dosage of the monomer active ingredients, and slows down the generation of drug resistance of the soybean aphids.
The experimental results show that: the compound of the oxazine amide and the abamectin or the emamectin benzoate shows higher insecticidal activity to soybean aphids and shows a synergistic effect; in the compound of the oxazine amide and the abamectin or the emamectin benzoate, the oxazine amide has additive effect when the mixing proportion is low, and has synergistic effect when the proportion is high. The pesticide composition shows that the mixed proportion of the oxazine amide and the abamectin or the emamectin benzoate can improve the insecticidal activity of the pesticide, and the influence of the mixed proportion of the oxazine amide compound in the mixture on the insecticidal activity of the mixture is higher than that of the pesticide active ingredient.
Table 1: indoor combined action determination of oxazine amide and avermectin on soybean aphids
Table 2: indoor combined action determination of oxazine amide and emamectin benzoate on soybean aphids
Example 2: pesticide effect test of compound of oxazamate and abamectin and emamectin benzoate on soybean aphids in field
Test agent:
medicament 1:10.2% oxazine amide avermectin emulsifiable concentrate: comprises the following components in percentage by weight:
10% of oxazine amide, 0.2% of abamectin, 5% of alkylphenol ethoxylates, 500#3% of agricultural emulsion, 3% of castor oil polyoxyethylene ether and 100% of vegetable oil.
Medicament 2:15.3 Methanopyrazolam emamectin benzoate emulsifiable concentrate: comprises the following components in percentage by weight:
15 percent of oxazine, 0.3 percent of emamectin benzoate, 6 percent of alkylphenol ethoxylate, 500#4 percent of agricultural emulsion, 2 percent of castor oil polyoxyethylene ether and 100 percent of vegetable oil.
Medicament 3:31.2% of oxazine amide abamectin wettable powder: comprises the following components in percentage by weight:
30% of oxazine, 1.2% of abamectin, 5% of sodium lignin sulfonate, 4% of polycarboxylate, 4% of white carbon black and 100% of kaolin.
Agent 4:26% of oxazine amide emamectin benzoate wettable powder: comprises the following components in percentage by weight:
25% of oxazine amide, 1% of emamectin benzoate, 4% of sodium lignin sulfonate, 6% of polycarboxylate, 3% of white carbon black and 100% of kaolin.
Medicament 5:20.2% of oxazine amide and abamectin water dispersible granules: comprises the following components in percentage by weight:
20% of oxazine amide, 0.2% of abamectin, 5% of sodium lignin sulfonate, 2% of dioctyl sulfosuccinic acid sodium salt, 2% of sodium dodecyl sulfate, 2% of sodium sulfate, 3% of carboxymethyl cellulose and 100% of kaolin.
Agent 6:40.4% of oxazin and emamectin benzoate water dispersible granules: comprises the following components in percentage by weight:
40% of oxazine amide, 0.4% of emamectin benzoate, 6% of sodium lignin sulfonate, 4% of dioctyl sulfosuccinic acid sodium salt, 2% of sodium dodecyl sulfate, 3% of sodium sulfate, 3% of carboxymethyl cellulose and 100% of kaolin.
The test method comprises the following steps: reference is made to the pesticide field efficacy test criterion part 27, pesticide control of cruciferous vegetable aphids. 4 cells are arranged in each treatment, 25m < 2 > of each cell is arranged, the cells are randomly distributed, the comparison adopts clear water treatment, and 1.5L of water is sprayed in each cell. 5-point sampling method is used for investigating aphid population, aphid population investigation is carried out before and after application for 1, 3 and 7 days, the number of the aphid population is more than 500 per cell, and the rate of reduction of the insect population and the correction control effect are calculated according to investigation results.
The rate of reduction of insect population = (number of live insects before administration-number of live insects after administration)/number of live insects before administration x 100%;
correction control = (treated rate of reduction of insect population-control rate of reduction of insect population)/(100-control rate of reduction of insect population) ×100%
Test results: the results of the field efficacy test of the compound combination of the oxazamate and the avermectin or the emamectin benzoate on the soybean aphids are shown in table 3. The compound preparation of the oxazine amide and the abamectin or emamectin benzoate prepared by the invention has excellent prevention and control effects on soybean aphids; if the dosage of the active ingredients of the 10.2 percent oxazin-chlorfenapyr-avermectin emulsifiable concentrate and the 15.3 percent oxazin-chlorfenapyr-emamectin emulsifiable concentrate is 8 g/mu; the correction and prevention effects of 7d after the medicine on soybean aphids are respectively 90.8% and 94.4%;31.2% of oxazin-chlorfenapyr-avermectin wettable powder and 26% of oxazin-chlorfenapyr-emamectin benzoate wettable powder, wherein the dosage of the active ingredients is 5 g/mu; the correction and prevention effects of 7d after the medicine on soybean aphids are 89.1 percent and 96.5 percent respectively; when the dosage of the active ingredients of 20.2% of oxaziclomefone and avermectin water dispersible granules and 40.4% of oxaziclomefone and emamectin benzoate water dispersible granules is 15 g/mu; the correction and control effects of 7d after the medicine on soybean aphids are 91.8 percent and 97.5 percent respectively.
Table 3: pesticide effect test of compound of oxazamate and abamectin and emamectin benzoate on soybean aphids in field
Variations and modifications to the above would be obvious to those of ordinary skill in the art to which the invention pertains, based on the foregoing disclosure and teachings. Therefore, the invention is not limited to the specific embodiments disclosed and described above, but some modifications and changes of the invention should be also included in the scope of the claims of the invention. In addition, although specific terms are used in the present specification, these terms are for convenience of description only and do not limit the present invention in any way.
Claims (1)
1. The application of the insecticidal composition containing the oxazine amide in preventing and controlling soybean aphids is characterized in that the insecticidal composition is 40.4% oxazine amide and emamectin benzoate water dispersible granules: comprises the following components in percentage by weight: 40% of oxazine amide, 0.4% of emamectin benzoate, 6% of sodium lignin sulfonate, 4% of dioctyl sulfosuccinic acid sodium salt, 2% of sodium dodecyl sulfate, 3% of sodium sulfate, 3% of carboxymethyl cellulose and 100% of kaolin.
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| CN103269589A (en) * | 2010-12-20 | 2013-08-28 | 巴斯夫欧洲公司 | Pesticidal active mixtures comprising pyrazole compounds |
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| CN112616845A (en) * | 2020-12-21 | 2021-04-09 | 青岛滕润翔检测评价有限公司 | Pesticide composition containing pyrazole formamide insecticide and application thereof |
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| CN103269589A (en) * | 2010-12-20 | 2013-08-28 | 巴斯夫欧洲公司 | Pesticidal active mixtures comprising pyrazole compounds |
| CN103492378A (en) * | 2011-04-21 | 2014-01-01 | 巴斯夫欧洲公司 | Novel pesticidal pyrazole compounds |
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