CN104522013B - A kind of Pesticidal combination containing diafenthiuron and Ivermectin HCL - Google Patents
A kind of Pesticidal combination containing diafenthiuron and Ivermectin HCL Download PDFInfo
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- CN104522013B CN104522013B CN201410823041.0A CN201410823041A CN104522013B CN 104522013 B CN104522013 B CN 104522013B CN 201410823041 A CN201410823041 A CN 201410823041A CN 104522013 B CN104522013 B CN 104522013B
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- diafenthiuron
- ivermectin hcl
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Abstract
The invention discloses a kind of Pesticidal combination containing diafenthiuron and Ivermectin HCL, and comprising diafenthiuron and Ivermectin HCL and insecticides adjuvant, the weight ratio of diafenthiuron and Ivermectin HCL is 100：1~1：100, percentage by weight is 2%~95% in the composition for diafenthiuron and Ivermectin HCL weight summation；According to practical application needs, Pesticidal combination of the present invention can be prepared as middle one kind of suspending agent, water dispersible granules, aqueous emulsion, microemulsion, wettable powder；Pesticidal combination of the present invention has outstanding prevention effect to brassicaceous vegetable diamondback moth, not only with obvious synergistic function, also reduces Pesticide use amount, slow down the generation of pest resistance to insecticide.
Description
Technical field
The present invention relates to agricultural insecticide composition and its application field, specifically using diafenthiuron and Ivermectin HCL to have
The binary complex of composition compounding is imitated, applied to preventing and treating brassicaceous vegetable diamondback moth.
Background technology
Diafenthiuron, english common name：Diafenthiuron, it is a kind of new sulfur ureas efficient pesticides, has and touch
Kill, stomach toxicity, interior suction and fumigation action, and there is certain ovicidal effect, the mainly energy by disturbing insect nervous system
Metabolism, the basic function of nervous system is destroyed, suppress chitin synthesis, insect is not casted off a skin and dead, to lepidoptera pest such as
Diamondback moth is efficient.
Ivermectin HCL, english common name：Ivermectin, the mechanism of action of Ivermectin HCL mainly with without spinal animals
Nerve cell and muscle cell Glutamic Acid combine for the high-affinity of the chloride channel of valve, so as to cause cell membrane to chlorine
The increase of ion permeability, cause nerve cell or muscle cell hyperpolarization, make insect paralysis or dead, agriculturally can be used for
Prevent and treat the agricultural pests such as the snout moth's larva of rice, vegetables diamondback moth, fruit tree mites.
Diamondback moth is a kind of common insect, agriculturally main harm brassicaceous vegetable such as Chinese cabbage, wild cabbage, cabbage mustard etc.,
Destructive disaster is often caused to crop.The alternation of generations occurs for insect, and fertility is strong, under suitable temperature and humidity conditions, evil
Borer population amount exponentially increases rapidly in the short period of time, thus easily insecticide is developed immunity to drugs, while is caused sternly to crop
Endanger again.
Different pesticide species compositions are compounded, and are the common methods for preventing and treating agriculture resistant insect insect.The present inventor exists
On the basis of substantial amounts of indoor virulence and field medicine effect test, depth has been carried out to the screening of the compounded formula of diafenthiuron and Ivermectin HCL
Enter research, it is found that diafenthiuron and Ivermectin HCL are compounded, there is obvious synergistic function in certain proportion,
And there is outstanding prevention effect to diamondback moth, after further study, complete the present invention.
Technical scheme
Present invention solves the technical problem that being to provide a kind of efficient, low toxicity and lasting period length, agricultural pests can be effectively prevented and treated
A kind of Pesticidal combination containing diafenthiuron and Ivermectin HCL.
It is another object of the present invention to the Pesticidal combination is applied into preventing and treating agricultural pests, especially brassicaceous vegetable
Diamondback moth.
To solve the above problems, the technical solution adopted in the present invention is：A kind of killing containing diafenthiuron and Ivermectin HCL
Worm composition, active ingredient are diafenthiuron and Ivermectin HCL, and the weight ratio of diafenthiuron and Ivermectin HCL is 100：1~1：100, fourth
Percentage by weight is 2%~95% in the composition for ether urea and Ivermectin HCL weight summation, and remaining is agriculturally acceptable
Auxiliary agent.
Pesticidal combination method known to of the present invention is prepared into any one formulation for being adapted to agriculturally use, and compares
Good formulation has suspending agent, water dispersible granules, aqueous emulsion, microemulsion, wettable powder, and the processing technology of various preparations is existing
There is technology, can be varied from according to different situations.
The auxiliary agent used in Pesticidal combination provided by the invention includes solvent, emulsifying agent, wetting agent, stabilizer, scattered
Agent, safener, thickener, pH adjusting agent, defoamer, antifreezing agent, deionized water, filler etc., all it is normal in Pesticide formulation
Various auxiliary agents, specific composition and dosage are determined according to recipe requirements by simple experiment.
The production technology of the various application forms of Pesticidal combination provided by the invention belongs to existing known technology, herein no longer
Repeat.
Pesticidal combination provided by the invention, is used using spray method, can also as needed be used and agriculturally be applied
Other use technology.
Pesticidal combination provided by the invention is used to prevent and treat insect agriculturally, especially brassicaceous vegetable diamondback moth.
Pesticidal combination provided by the invention, generally use spray method use, can also be as needed using agriculturally
Other of application use technology.
The method have the advantages that：
1st, Pesticidal combination provided by the invention shows obvious synergistic effect in certain ratio range, composition
Prevention effect is significantly improved than single dose, reduces the dosage of agricultural chemicals, reduces influence of the agricultural chemicals to environment, reduces
Drug cost.
2nd, the active ingredient mechanism of action of Pesticidal combination provided by the invention is different, and the application of composition can delay
Or overcome the generation of pest resistance to insecticide, increase the service life, be advantageous to the comprehensive regulation of insect.
Embodiment
In order that the objects, technical solutions and advantages of the present invention are more concise, present invention specific examples below
Illustrate, but the present invention is only limitted to absolutely not these embodiments.As described below is only the preferable embodiment of the present invention, is used only for
The description present invention, it is impossible to be interpreted as limiting the scope of the present invention.It is it should be pointed out that all in the spirit and principles in the present invention
Within all any modification, equivalent and improvement done etc., should be included in the scope of the protection.Therefore, this hair
The protection domain of bright patent should be determined by the appended claims.
Content described in embodiment is weight percentage.
Preparation method embodiment 1：17% diafenthiuron Ivermectin HCL wettable powder.
It is well mixed entering after above-mentioned material in proportion coarse crushing in blender, then 17% is made after air-flow crushing
Diafenthiuron Ivermectin HCL wettable powder.
Preparation method embodiment 2：22% diafenthiuron ester Ivermectin HCL water dispersible granules.
By above-mentioned formula, dry pulverization process, granulation, drying, screening preparation system produce 22% diafenthiuron Ivermectin HCL in proportion
Water dispersible granules.
Preparation method embodiment 3：25.25% diafenthiuron Ivermectin HCL suspending agent.
Above-mentioned material is crushed in advance in proportion, adds in sand mill and grinds, system is allocated after high shear mixing
Obtain 25.25% diafenthiuron Ivermectin HCL suspending agent.
Preparation method embodiment 4：25.5% diafenthiuron Ivermectin HCL aqueous emulsion.
Mixed after above-mentioned raw materials are crushed in proportion, 20.5% diafenthiuron Ivermectin HCL is made through high speed shearing emulsification
Aqueous emulsion.
Preparation method embodiment 5：26% diafenthiuron Ivermectin HCL microemulsion.
Mixed after above-mentioned raw materials are crushed in proportion, after being sufficiently stirred dissolving, complement to 100% with deionized water, continue
Stir to transparent, i.e., obtained 26% diafenthiuron Ivermectin HCL microemulsion.
Assays Example 1：Diafenthiuron and Ivermectin HCL are to diamondback moth indoor joint toxicity measuring test
Test medicine uses 97% diafenthiuron active compound and 95% Ivermectin HCL active compound.
Test worm is to gather the instar larvae of diamondback moth 3 through the generation of indoor feeding 3 from wild cabbage vegetable garden.
The diamondback moth larvae that field gathers is put into the Chinese cabbage seedling being ready for, after larvae pupation, pupa is collected into pad
In the culture dish for having moisturizing filter paper, spawning cage is put into by its emergence, then the Chinese cabbage seedling of whole disk is put into spawning cage and allows pickles
Moth larvae is laid eggs, and when often disk Chinese cabbage seedling falls ovum amount up to 500 or so, is taken out Chinese cabbage seed plate, is placed on growth cabinet [temperature：24
~26 DEG C；Relative humidity 70%~80%；Illumination：14(L):10 (D)] in allow egg hatching, raise to 3 instar larvaes.
It is measured using malicious blade method is pressed from both sides：Beaten with diameter 1cm card punch and take leaf butterfly, be put into culture dish, moisturizing.With hair
Tubule dropper is since low concentration, per leaf butterfly drop 1ul decoctions, after the solvent is volatilized with another leaf butterfly for scribbling gelatinized corn starch
The malicious leaf butterfly of folder is made in pairing, and making, which finishes, to be put in the hole of 12 hole tissue culturing plates.4 repetitions are often handled, often repeat to be no less than
12 malicious leaf butterflies of folder, and the processing of the corresponding organic solvent without medicament is set as control.The each hole of tissue culturing plate inscribed 1
Head test worm, is placed in normal condition culture.After meeting 2~4h of worm, after the complete drug containing leaf butterfly of test worm feeding, added in cultivation plate hole clear
Clean feed continues raising to investigating, and eliminates the test worm for not eaten a complete leaf butterfly.Each dosage processing test worm number 80.Processing
72h investigates test worm death condition afterwards, records total borer population and dead borer population.
Statistical analysis is carried out with DPS statistical analysis softwares, by the LC for calculating each medicament50Lived to evaluate the desinsection of each medicament
Property, and according to the co-toxicity coefficient (CTC values) of the abundant method calculating mixtures of Sun Yun.
Survey toxicity index (ATI)=(standard agent LC50/ reagent agent LC50)×100。
A percentage composition+B medicament toxicity index in theoretical toxicity index (TTI)=A medicament toxicity index × mixture × mixed
B percentage composition in agent.
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] × 100.
The criteria for classifying is acted on according to NY/T11547.7-2006 insecticide combinations：Co-toxicity coefficient (CTC) >=120 is shown as
Synergistic effect；Co-toxicity coefficient (CTC)≤80 shows as antagonism；80 ＜ co-toxicity coefficients (CTC) ＜ 120, which show as being added, to be made
With.
As can be seen from Table 1 and Table 2, diafenthiuron and Ivermectin HCL are 100:1~1:It is malicious altogether when being compounded in the range of 100
Coefficient (CTC) is all higher than 130, and unexpected synergistic function is shown to diamondback moth larvae, it is seen that diafenthiuron and Yi Wei
Rhzomorph compounding has reasonability and feasibility.
The indoor joint toxicity measuring result of table 1, diafenthiuron and Ivermectin HCL to diamondback moth larvae
| Medicament title and proportioning (weight ratio) | LC50(mg/L) | ATI | TTI | CTC |
| Diafenthiuron | 28.14 | 100.00 | - | - |
| Ivermectin HCL | 0.19 | 14656.25 | - | - |
| Diafenthiuron：Ivermectin HCL (100:1) | 7.35 | 382.86 | 244.12 | 156.83 |
| Diafenthiuron：Ivermectin HCL (50:1) | 4.88 | 576.64 | 385.42 | 149.61 |
| Diafenthiuron：Ivermectin HCL (25:1) | 3.07 | 916.61 | 659.86 | 138.91 |
| Diafenthiuron：Ivermectin HCL (1:1) | 0.25 | 11256.00 | 7378.13 | 152.56 |
| Diafenthiuron：Ivermectin HCL (1:25) | 0.14 | 20100.00 | 14096.39 | 142.59 |
| Diafenthiuron：Ivermectin HCL (1:50) | 0.11 | 25581.82 | 14370.83 | 178.01 |
| Diafenthiuron：Ivermectin HCL (1:100) | 0.10 | 28140.00 | 14512.13 | 193.91 |
Assays Example 2：Diafenthiuron and Ivermectin HCL compound the field control effectiveness test to wild cabbage diamondback moth
Test site is located at Huizhou Ma An towns wild cabbage vegetable garden, and diamondback moth endangers peak period dispenser, using spraying
Method.5 chemicals treatments are set using 30% diafenthiuron suspension agent, 0.5% Ivermectin HCL missible oil altogether as comparison medicament, experiment, often
3 repetitions of individual processing.The cornerwise five points investigation insect population in area, 10 wild cabbages of every investigation are throughout managed before dispenser.Apply
3 days after medicine, respectively investigate a prevention effect within 7 days, 14 days, record residual borer population, pass through Revision insect recluced rate and calculate prevention effect, experiment
As a result it is as shown in table 2.
The result of the test of table 2, diafenthiuron and Ivermectin HCL mixture preventing and treating wild cabbage diamondback moth
As can be seen from Table 2 diafenthiuron and Ivermectin HCL compound the preventive effect of wild cabbage diamondback moth is intended to after 3d, 7d, 14d it is bright
It is aobvious to be used higher than the diafenthiuron suspension agent single dose of the same period 30% and 0.5% Ivermectin HCL missible oil single dose uses, illustrate diafenthiuron and according to
Dimension rhzomorph compounding can improve the preventive effect to wild cabbage diamondback moth compared with two kinds of single doses are used alone, while 30d preventive effects are still after medicine
Up to more than 90%, illustrate that there is good lasting effect, do not find that the compound drug produces poisoning to wild cabbage during experiment.
Assays Example 3：Wild cabbage diamondback moth is tested the resistance to the action of a drug indoor measurement of diafenthiuron and Ivermectin HCL.
Diafenthiuron, Ivermectin HCL active compound are configured to test required test medicine.Worm sources are gathered from Huizhou.
Experiment uses dip method, and test worm is impregnated in place by the concentration that test medicine uses for the 50%-90% lethal doses of wild cabbage diamondback moth
Manage in liquid, the test worm of death is rejected after 72 hours, the test worm left continues to raise indoors, so handles 20 generation test worms repeatedly.
If the decoction processing containing only auxiliary agent is blank control.Each medicament is determined to the half of 1st generation, the 5th generation, the 10th generation and the 20th generation test worm
Lethasl concentration LC50, by contrasting LC of each treatment agent to 1st generation, the 5th generation, the 10th generation and the 20th generation test worm50To evaluate examination
Worm changes to the resistance to the action of a drug of reagent agent.
According to table 3 as can be seen that after diafenthiuron and Ivermectin HCL complex preparation 20 generation test worms of processing, test worm population is multiple to this
The resistance to the action of a drug with auxiliary agent handles the resistance to the action of a drug caused by 20 generation test worms significantly lower than diafenthiuron and Ivermectin HCL single dose.This experiment table
Bright, diafenthiuron and Ivermectin HCL compounding effectively can delay wild cabbage diamondback moth to develop immunity to drugs.
Table 3, diafenthiuron and Ivermectin HCL compounding are to the drug-fast determination test result of wild cabbage diamondback moth
Note：Above table medium multiple represents the resistance to the action of a drug of the corresponding algebraically diamondback moth to each medicament.
In summary, the present invention uses two kinds of active components as diafenthiuron and the complex composition of Ivermectin HCL, and existing
Unitary agent compare, not only with obvious synergistic effect, also with good insecticidal effect, lasting period length, to crops
Safety, can slow down the generation of pest resistance to insecticide, be worth the popularization and application in agricultural production.
Claims (3)
- A kind of 1. Pesticidal combination containing diafenthiuron and Ivermectin HCL, it is characterised in that：Active ingredient is diafenthiuron and Yi Wei The weight ratio of rhzomorph, diafenthiuron and Ivermectin HCL is 100：1~1：100, diafenthiuron and Ivermectin HCL weight summation are in composition Middle percentage by weight is 2%~95%.
- A kind of 2. Pesticidal combination containing diafenthiuron and Ivermectin HCL according to claim 1, it is characterised in that：In reality Border can be prepared as one kind of suspending agent, water dispersible granules, aqueous emulsion, microemulsion, wettable powder when applying.
- 3. a kind of Pesticidal combination containing diafenthiuron and Ivermectin HCL described in claim 1 is in preventing and treating agricultural pests cruciate flower Application in section vegetables diamondback moth.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1386419A (en) * | 2001-05-22 | 2002-12-25 | 王玉万 | Composite insecticide containing macrolide insect repellents for sanitary purpose |
| WO2003099012A1 (en) * | 2002-05-23 | 2003-12-04 | Syngenta Limited | Phosphonates and derivatives thereof as enhancers of the activity of insecticides |
| CN1918993A (en) * | 2006-09-19 | 2007-02-28 | 东莞市农业科学研究中心 | Pesticide composition containing avermectin and butyl ether urea and its application |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1386419A (en) * | 2001-05-22 | 2002-12-25 | 王玉万 | Composite insecticide containing macrolide insect repellents for sanitary purpose |
| WO2003099012A1 (en) * | 2002-05-23 | 2003-12-04 | Syngenta Limited | Phosphonates and derivatives thereof as enhancers of the activity of insecticides |
| CN1918993A (en) * | 2006-09-19 | 2007-02-28 | 东莞市农业科学研究中心 | Pesticide composition containing avermectin and butyl ether urea and its application |
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