CN117063941A - Insecticidal composition containing flupirfenidone and beta-cypermethrin - Google Patents
Insecticidal composition containing flupirfenidone and beta-cypermethrin Download PDFInfo
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- CN117063941A CN117063941A CN202311076001.XA CN202311076001A CN117063941A CN 117063941 A CN117063941 A CN 117063941A CN 202311076001 A CN202311076001 A CN 202311076001A CN 117063941 A CN117063941 A CN 117063941A
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- Prior art keywords
- insecticidal composition
- cypermethrin
- beta
- flupirfenidone
- composition containing
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- 239000000203 mixture Substances 0.000 title claims abstract description 29
- KAATUXNTWXVJKI-NSHGMRRFSA-N (1R)-cis-(alphaS)-cypermethrin Chemical compound CC1(C)[C@@H](C=C(Cl)Cl)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 KAATUXNTWXVJKI-NSHGMRRFSA-N 0.000 title claims abstract description 22
- 230000000749 insecticidal effect Effects 0.000 title claims abstract description 20
- 239000004480 active ingredient Substances 0.000 claims abstract description 3
- 241000254127 Bemisia tabaci Species 0.000 claims description 8
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims description 7
- 241000607479 Yersinia pestis Species 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 3
- 239000004495 emulsifiable concentrate Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000004562 water dispersible granule Substances 0.000 claims description 2
- ZXQYGBMAQZUVMI-RDDWSQKMSA-N (1S)-cis-(alphaR)-cyhalothrin Chemical compound CC1(C)[C@H](\C=C(/Cl)C(F)(F)F)[C@@H]1C(=O)O[C@@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 ZXQYGBMAQZUVMI-RDDWSQKMSA-N 0.000 claims 1
- 240000003768 Solanum lycopersicum Species 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000005910 lambda-Cyhalothrin Substances 0.000 claims 1
- 239000004530 micro-emulsion Substances 0.000 claims 1
- 230000000361 pesticidal effect Effects 0.000 claims 1
- 239000003090 pesticide formulation Substances 0.000 claims 1
- 239000000375 suspending agent Substances 0.000 claims 1
- 239000000575 pesticide Substances 0.000 abstract description 11
- 239000012752 auxiliary agent Substances 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 9
- 241000238631 Hexapoda Species 0.000 description 8
- 231100000419 toxicity Toxicity 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- 241000227653 Lycopersicon Species 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 229920000742 Cotton Polymers 0.000 description 4
- 241000219146 Gossypium Species 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- JUUFBMODXQKSTD-UHFFFAOYSA-N N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester Chemical compound N1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(F)C=C1 JUUFBMODXQKSTD-UHFFFAOYSA-N 0.000 description 2
- 241000935974 Paralichthys dentatus Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229960003667 flupirtine Drugs 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000000611 regression analysis Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- -1 (6-chloro-3-pyridylmethyl) (2, 2-difluoroethyl) amino Chemical group 0.000 description 1
- 229940121683 Acetylcholine receptor antagonist Drugs 0.000 description 1
- 239000005946 Cypermethrin Substances 0.000 description 1
- 239000005783 Fluopyram Substances 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 108010052164 Sodium Channels Proteins 0.000 description 1
- 102000018674 Sodium Channels Human genes 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- VIHAEDVKXSOUAT-UHFFFAOYSA-N but-2-en-4-olide Chemical compound O=C1OCC=C1 VIHAEDVKXSOUAT-UHFFFAOYSA-N 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- KAATUXNTWXVJKI-UHFFFAOYSA-N cypermethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 KAATUXNTWXVJKI-UHFFFAOYSA-N 0.000 description 1
- 229960005424 cypermethrin Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000856 effect on pests Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- KVDJTXBXMWJJEF-UHFFFAOYSA-N fluopyram Chemical compound ClC1=CC(C(F)(F)F)=CN=C1CCNC(=O)C1=CC=CC=C1C(F)(F)F KVDJTXBXMWJJEF-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 239000012053 oil suspension Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 238000004382 potting Methods 0.000 description 1
- 239000002728 pyrethroid Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000004563 wettable powder Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Insects & Arthropods (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses an insecticidal composition containing flurfurone and beta-cypermethrin, which belongs to the technical field of pesticides, and comprises the active ingredients of flurfurone and beta-cypermethrin, wherein the mass ratio of the flurfurone to the beta-cypermethrin is 1:30-30:1.
Description
Technical Field
The invention relates to the technical field of pesticides, in particular to an insecticidal composition containing flupirfenidone and beta-cypermethrin.
Background
Because the novel pesticide compound is difficult to develop and high in cost, the requirements on cost saving, synergy, high safety and good prevention effect are increasingly increased in the market, meanwhile, the single pesticide is easy to generate resistance, the prevention spectrum is limited, the prevention spectrum can be enlarged by mixing the pesticide, the resistance generation is delayed, the prevention effect is improved, and the like, in view of the current situation, the existing compound is reasonably mixed so as to effectively control pests and promote the agricultural production development.
Fluoropirofuranones, chemical name 4- [ (6-chloro-3-pyridylmethyl) (2, 2-difluoroethyl) amino group]Furan-2 (5H) -one, molecular formula: c (C) 12 H 11 ClF 2 N 2 O 2 The pure product is white to beige solid powder, the vapor pressure is 9.1X10-7 Pa (20 ℃), the specific gravity is 1.43, the melting point is 72-74 ℃, the novel nicotinic insecticide is nonflammable, acts on the central nervous system of insects, belongs to the acetylcholine receptor antagonist,the pest control agent is mainly used for pest control of piercing-sucking mouthparts and is safe for crops.
The high-efficiency cypermethrin is a high-efficiency broad-spectrum pyrethroid insecticide, has stomach toxicity and contact killing effects, damages a nervous system by interacting with a pest sodium channel, has good control effect on pests on various crops such as wheat, cotton, vegetables, fruits, soybeans and the like, has low toxicity, and is safe to people and livestock.
Disclosure of Invention
The invention belongs to the field of pesticides, and discloses an insecticidal composition containing flupirfenidone and beta-cypermethrin, which accords with the application trend of pesticide decrement and synergy, has good insecticidal effect and remarkable mixing and synergy, and has excellent control effect on crop pests such as tomato bemisia tabaci.
Furthermore, the insecticidal composition comprises the active ingredients of the flupirfenidone and the beta-cypermethrin, and the mass ratio of the flupirfenidone to the beta-cypermethrin is 1:30-30:1.
The insecticidal composition containing the flupirfenidone and the beta-cypermethrin can be prepared into a pesticide preparation, and various auxiliary agents and carriers are added into the insecticidal composition according to a conventional method, so that the insecticidal composition can be processed into any one of dosage forms known in the art, such as wettable powder, dispersible oil suspension, emulsifiable concentrate, water dispersible granule, water suspension, effervescent agent, dispersing agent and the like.
The insecticidal composition contains various agriculturally acceptable auxiliary agents required for preparing pesticide preparations, and one or more of solvents, emulsifying agents, wetting agents, stabilizing agents, dispersing agents, penetrating agents, thickening agents, antifoaming agents, antifreezing agents, disintegrating agents, binders, fillers, carriers, media and surfactants are known substances, and can be changed according to different situations, and the insecticidal composition is not particularly limited.
Compared with the prior art, the invention has the following advantages: 1. the insecticidal activity is high, the control effect is obviously higher than that of any single agent, and the synergistic effect is realized when the two agents are mixed; 2. the effective components have different action mechanisms, so that the resistance can be effectively delayed; 3. the insecticidal composition has remarkable synergistic effect, can reduce the dosage, is beneficial to reducing the medication cost and can also reduce the environmental pressure of pesticides.
The production process of various dosage forms of the composition belongs to the prior known technology and is not repeated here.
Detailed Description
The following examples are provided to further illustrate the principles of the present invention and are not to be construed as limiting the invention, but are merely intended to provide illustrations of the invention without departing from the spirit and principles of the invention.
1. Formulation examples.
Example 1: 20 parts of flupirfenidone, 1 part of beta-cypermethrin, other auxiliary agents and the like.
Example 2: 10 parts of flupirfenidone, 1 part of beta-cypermethrin, other auxiliary agents and the like.
Example 3: 3 parts of flupirfenidone, 1 part of beta-cypermethrin, other auxiliary agents and the like.
Example 4: 1 part of flupirfenidone, 1 part of beta-cypermethrin, other auxiliary agents and the like.
Example 5: 1 part of flupirfenidone, 3 parts of beta-cypermethrin, other auxiliary agents and the like.
Example 6: 1 part of flupirfenidone, 10 parts of beta-cypermethrin, other auxiliary agents and the like.
Example 7: 1 part of flupirfenidone, 20 parts of beta-cypermethrin, other auxiliary agents and the like.
2. And (5) measuring indoor biological activity.
The test method comprises the following steps: bemisia tabaci is collected from a greenhouse tomato field of a field village of fifty-three houses of a thirty-head community in a new station area of a combined fertilizer city, a fluke device is used for collecting Bemisia tabaci adults, the Bemisia tabaci adults are sent to an indoor insect breeding room, the relative humidity is 60% -70% at about 25 ℃, and the photoperiod is L/D= (16:8) h, and fresh tomato potting generation is used for cultivation. Fresh tomato leaves are picked for later use. Soaking the prepared leaf in a beaker containing the liquid medicine for 20s, taking out, placing the leaf on a culture dish filled with filter paper, and naturally airing in a shade place. After the cotton leaves are dried, the wet cotton leaves are used for moisturizing, and the cotton leaves are transferred to a centrifuge tube for standby. Picking up the indoor cultured adults with regular and consistent growth by using the insect sucking device, and then treating at a low temperature for a short period of time to reduce the action force of the bemisia tabaci and prevent the insects from escaping when receiving the insects. After treatment, the adults in the fluke device are poured into a centrifuge tube. Sealing the centrifugal tube with gauze after the insect connection is completed, placing the centrifugal tube at about 25 ℃ with relative humidity of 60% -70% and feeding and observing under the condition that the photoperiod is L & ltD & = (16:8) h. Each treatment was repeated 4 times for about 40 replicates. And (3) observing test results after 48 hours of test, and respectively recording the total number of insects and the dead number of insects by the light touch of the writing brush, wherein the control death rate is more than 5% and needs to be corrected, and is less than 10% as an effective test.
Regression analysis was performed on the results using DPS7.05 software to obtain virulence equations, LC50, LC90 and their confidence intervals.
Calculating the co-toxicity coefficient (CTC) of the mixture by adopting a co-toxicity coefficient method calculated by grand cloud Peel, and determining the synergy of the mixture
Taking a single agent in the mixture as a standard agent, and calculating:
single dose toxicity index= (LC 50 of standard dose/LC 50 of certain single dose) ×100
Theoretical Toxicity Index (TTI) =toxicity index of a single dose×proportion of a single dose in mixture+toxicity index of B single dose×proportion of B single dose in mixture
Actual virulence index (ATI) = (LC 50 value of standard single dose/LC 50 value of cocktail) ×100
Co-toxicity coefficient= (measured toxicity index/theoretical toxicity index) ×100.
Evaluation criteria: the mixture has synergy when the CTC is more than 120, antagonism when the CTC is less than 80, and additive effect between 80 and 120.
Test results: as can be seen from the measurement results in the table 1 and the table 2, the flupirtine and the beta-cypermethrin are mixed and combined for use, the control effect is good, and the flupirtine and the beta-cypermethrin belong to synergistic effect.
TABLE 1 regression analysis of Furfanone and beta-cypermethrin and their compositions against tomato Bemisia tabaci
。
TABLE 2 cotoxicity coefficient of Fluopyram and beta-cypermethrin compositions for tomato bemisia tabaci control
。
In conclusion, the invention has reasonable components, better control effect than the single dosage of each component, is beneficial to reducing the dosage, has synergistic effect when being mixed with the components, and accords with the application trend of green and efficient pesticides with cost saving, decrement and synergy.
Claims (5)
1. An insecticidal composition, characterized in that the active ingredients comprise flupirfenidone and beta-cypermethrin.
2. The insecticidal composition of claim 1, wherein the mass ratio of flupirfuranone to lambda-cyhalothrin is 1:30-30:1.
3. The insecticidal composition according to claims 1-2, characterized in that the insecticidal composition further comprises auxiliary ingredients conventional in the processing of pesticide formulations.
4. A pesticidal composition according to claims 1-3, which is applied to control crop pests such as tomato bemisia tabaci.
5. The insecticidal composition according to claims 1-4, wherein the insecticidal composition can be formulated into common dosage forms such as emulsifiable concentrates, suspending agents, wettable powders, water dispersible granules, aqueous emulsions, microemulsions and the like.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311076001.XA CN117063941A (en) | 2023-08-25 | 2023-08-25 | Insecticidal composition containing flupirfenidone and beta-cypermethrin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311076001.XA CN117063941A (en) | 2023-08-25 | 2023-08-25 | Insecticidal composition containing flupirfenidone and beta-cypermethrin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117063941A true CN117063941A (en) | 2023-11-17 |
Family
ID=88709432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311076001.XA Pending CN117063941A (en) | 2023-08-25 | 2023-08-25 | Insecticidal composition containing flupirfenidone and beta-cypermethrin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117063941A (en) |
-
2023
- 2023-08-25 CN CN202311076001.XA patent/CN117063941A/en active Pending
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