CN103858920A - Spinetoram-containing insecticidal composition - Google Patents
Spinetoram-containing insecticidal composition Download PDFInfo
- Publication number
- CN103858920A CN103858920A CN201210524372.5A CN201210524372A CN103858920A CN 103858920 A CN103858920 A CN 103858920A CN 201210524372 A CN201210524372 A CN 201210524372A CN 103858920 A CN103858920 A CN 103858920A
- Authority
- CN
- China
- Prior art keywords
- ethyl pleocidin
- pesticidal combination
- mti
- combination according
- insecticidal composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a pesticide insecticidal composition, its effective component is A) spinetoram and B) nicotine pesticides. The mass percentage of A and B is 1-80: 80-1, and the A and B content in sterilization composition is 1-80% The complex formulation bactericide employs the widely-known method to prepare the dosage forms such as missible oil, a suspending agent, wettable powder, water dispersion granule, emulsion and micron emulsion. The nicotine pesticide is one selected from thiacloprid, Dinotefuran and Clothianidin. The insecticidal composition is suitable for preventing and treating various insects such as Lepidoptera, thysanoptera, coleopteran, diamondback moth, beet armyworm, thrips, plant hopper, whitefly, aphid and Cydia pomonella.
Description
Technical field
The present invention relates to a kind of composition pesticide with synergistic effect, active ingredient for (A) ethyl pleocidin with (B) be selected from one or more in nicotinic insecticide.
Background technology
Ethyl pleocidin, be from actinomycetes thorns saccharopolyspora strain (
saccharopolyspora spinosa) fermentation generation pleocidin (
apinasad) regeneration product.Its former the effective elements of the medicine is ethyl pleocidin-J and ethyl pleocidin-I compound (ratio is 3:1), and their biologically active is without significant difference.
Its mechanism of action is to act on nAChR and r-aminobutyric acid acceptor in insect nerve, causes polypide insensitive to the signal transfer reaction of excitability or inhibition, affects normal nervous activity, until dead.Ethyl pleocidin has tags and stomach poison function, is mainly used in preventing and treating pests with chewing mouthparts and sucking pest.
Nicotinic insecticide is a class efficient pesticides, and its mechanism of action is for acting on acetylcholinergic receptor, interference insect nervous system normal conduction, thus cause insect paralysis dead.Common anabasine active matter has: Imidacloprid, Acetamiprid, Nitenpyram, Diacloden, clothianidin, thiacloprid, MTI-446, the pyridine of piperazine worm, Diacloden etc.Anabasine active matter is low, environmentally safe to mammalian toxicity, insecticidal activity is high.But anabasine insecticide has the shortcoming that insecticidal spectrum is not wide, resistance Upside Risk is large.
Summary of the invention
The object of the present invention is to provide a kind of Synergistic insecticidal compositions, this Pesticidal combination is characterized in that carrying out mixture taking the one (B) of ethyl pleocidin (A) and nicotinic insecticide as active ingredient, prevents and treats the various pests of crops.
Technical scheme of the present invention is: a kind of Pesticidal combination, its active ingredient is that the mass ratio of ethyl pleocidin (A) nicotinic insecticide (B) effective constituents A and B is 1~80: 80~1.
Described nicotinic insecticide can be the one in thiacloprid, clothianidin, MTI-446.
Pesticidal combination of the present invention is characterized in that, tests through toxicity test, and the mass ratio of effective constituents A and B is preferably 1~20: 20~1.
The formulation that described Pesticidal combination of the present invention can be prepared according to the known method of those skilled in the art of the present technique is the formulations such as missible oil, aqueous emulsion, suspending agent, wetting powder, water dispersible granules, microemulsion.
Described effective constituents A and the B gross mass content in preparation is 1 ~ 80%, preferably 1% ~ 30%.All the other compositions are in agricultural chemicals, to allow to use and acceptable auxiliary element.
The auxiliary agent (auxiliary element) using in Pesticidal combination of the present invention comprises solvent, wetting agent, dispersant, antifreezing agent, thickener, defoamer, disintegrant, filler etc., and other are of value to active ingredient stable known substance of bringing into play with drug effect (being composition conventional in agricultural chemicals or that permission is used) in preparation, concrete composition and consumption, according to formula requirement, determine by normal experiment.
Described emulsifier is selected from any one or more mixtures with arbitrary proportion composition in calcium dodecyl benzene sulfonate and aliphatic acid polyethenoxy ether, alkylphenol polyoxyethylene sulfosuccinate, styrylphenol polyoxyethylene ether, polyoxyethylene nonylphenol ether, castor oil polyoxyethylene ether, aliphatic acid polyethenoxy base ester, polyoxyethylene aliphatic alcohol ether.
Described solvent is any one or more mixed solvents with arbitrary proportion composition in dimethylbenzene or biodiesel, toluene, diesel oil, methyl alcohol, ethanol, n-butanol, isopropyl alcohol, turpentine oil, solvent naphtha, dimethyl formamide, dimethyl sulfoxide (DMSO), water equal solvent.
Described dispersant is selected from one or more in polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, fatty acid glyceride APEO.
Described wetting agent is selected from: lauryl sodium sulfate, calcium dodecyl benzene sulfonate, Nekal BX., one or more in wetting and penetrating agent F, alkylnaphthalene sulfonate, polyoxyethylene triphenylethylene phosphenylic acid salt, spaonin powder, silkworm excrement, soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, sodium bicarbonate.
Described thickener is selected from: one or more in xanthans, CMC, hydroxyethylcellulose, methylcellulose, Magnesiumaluminumsilicate, polyvinyl alcohol.
Described stabilizing agent is selected from: the one in sodium citrate, resorcinol.
Described antifreezing agent is selected from: one or more in ethylene glycol, propane diols, glycerine.
Described defoamer is selected from: silicone oil, silicone compound, C
10-20saturated fat acid compounds, C
8-10one or more in aliphatic alcohols compound.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate.
Pesticidal combination of the present invention has very significantly synergistic effect, can reduce effective ingredient consumption, delays the generation of pest resistance to insecticide, and can be used for the improvement of resistant insect.Be suitable for preventing and treating each Lepidopterous, thrips and coleopteran pest, as diamond-back moth, beet armyworm, thrips, plant hopper, aleyrodid, aphid, the stupid moth of apple etc.Pesticidal combination of the present invention compared with prior art produces following beneficial effect:
be conducive to delay the generation of insect pair and anabasine insecticide resistance, extend medicament service life;
after mixture, there is synergistic effect for homoptera pest;
reduce dosage, for Environmental security.
Embodiment
Ethyl pleocidin proportioning co-toxicities different from MTI-446
1.1 reagent agent
The former medicine of 81% ethyl pleocidin, the former medicine of 95% MTI-446, above-mentioned former medicine provides by research and development centre of Qingdao Hailir Pesticides and Chemical Co., Ltd..
1.2 for examination worm source
Indoor potted apple seedling is raised the apple aphid adult in three ages in 10 generations, temperature (25 ± 2) continuously
oc, relative moisture 50% ± 4%, periodicity of illumination 14/10h (L/D).
1.3 single dose assay methods
Adopt dip method that two former medicines are all used to a small amount of acetone solution, then be diluted to into 5 dense solution of equal difference with 0.1% Tween solution, be diluted in beaker with for subsequent use, and with clear water in contrast.By of the same size three age apple aphid adult in the liquid that soaks worm cage, flood 5S, be placed in the culture dish that diameter is 9 c m after sucking unnecessary liquid, in ware, be placed with fresh apple blade and add a cover.Every concentration is processed 10, repeats 4 times.If blank.In (27 ± 1) DEG C illumination box, keep checking lethality after 24 h, it is dead touching polypide nonresponder by pulling needle.Lethality Abbott formula correction, then according to concentration logarithm---lethality probit value is analyzed (Bliss) method, obtains virulence regression equation and puts dead middle amount LC
50value.
The joint toxicity measuring method of 1.4 different proportionings
According to the toxicity test result of single dose, be 10% quality than ethyl pleocidin by active ingredient: MTI-446 is respectively 1: 9,3: 7,5: 5,7:3,9:1.Adopt above-mentioned 1.3 methods to carry out toxicity test, calculate LC
50, and press the abundant method of Sun Yun and calculate co-toxicity coefficient (CTC).Co-toxicity coefficient CTC, computing formula following (taking ethyl pleocidin as standard medicament, its toxicity index is 100):
The LC of toxicity index (the TI)=ethyl pleocidin of pleocidin
50the LC of/MTI-446
50× 100
The LC of actual toxicity index (ATI)=ethyl pleocidin of M
50the LC of/M
50× 100
TI × P MTI-446 of TI × P ethyl pleocidin+MTI-446 of theoretical toxicity index (TTI)=ethyl pleocidin of M
TTI × 100 of the ATI/M of co-toxicity coefficient (CTC)=M of M
In formula:
M be ethyl pleocidin from MTI-446 by the mixture of different proportionings
P MTI-446 is MTI-446 shared ratio in mixture
P ethyl pleocidin is ethyl pleocidin shared ratio in mixture
2.1 toxicity test results
Table 1 ethyl pleocidin, the indoor measurement result of MTI-446 to apple aphid
As can be seen from the table, in the mixture of different proportion, its co-toxicity coefficient is all greater than 120, shows certain synergistic effect, wherein ethyl pleocidin: the synergistic effect that MTI-446 is 5:5 is the most obvious, and co-toxicity coefficient is 198.84.Result of the test shows, under indoor conditions, ethyl pleocidin, two kinds of medicaments of MTI-446 all have higher activity to apple aphid, the result of the test of different proportion proportioning shows, by active ingredient ethyl pleocidin: MTI-446 is 1: 9,3: 7,5: 5, when 7:3,9:1, all show stronger synergistic effect, wherein taking ethyl pleocidin: MTI-446 is during as 5:5, and synergistic effect is best.
3 field trial control apple aphids
3.1 field experiment control apple aphids
3.1 test method
3.1.1 application method
Test is sprayed medicine 1 time altogether, and the dispenser date is June 16.Apple aphid adult major part is in 2~3 length of times.When spray medicine, weather is cloudy calm.With sharp agriculture board level pressure knapsack hand sprayer, to each processing even spraying, leave dual sides all requires to be sprayed with effect liquid.Every community liquid 2L.
3.1.2 investigation method
Investigate each community and fix 1 strain apple sapling as investigation strain. record the adult quantity on whole blades.Investigation insect population radix before spray medicine, investigates respectively the borer population of living for 3,7 days and 10 days after spray medicine.This test is investigated 4 times altogether.
3.1.3 drug effect computational methods
Borer population alive before insect population decline rate (%)=(borer population of living after the borer population-dispenser of living before dispenser)/dispenser) × l00
Preventive effect (%)=(treatment region insect population decline rate-check plot insect population decline rate)/(100-check plot insect population decline rate) × 100
3.1.4 poisoning investigation method
After dispenser, 10d range estimation medicament does not have poisoning to produce to crop continuously, apple sapling well-grown.
3.2 field control effectiveness test results
Table 2 treatment agent control apple aphid field control effectiveness test result
As can be seen from Table 2, the Mixed Pharmacy of different proportion, carry out field experiment by different consumptions, after medicine, it is all better than contrasting medicament to the control efficiency of apple aphid, 10% (ethyl pleocidin: MTI-446) (5:5) after medicine 10 days, insecticidal effect is respectively 86.69%, 90.20% and 92.94%, and insecticidal effect increases along with the increase of consumption, and each consumption is processed difference between insecticidal effect and reached extremely remarkable.According to field range estimation, within the scope of test dose, plant growth is normal, and the poisoning phenomenon to apple does not all appear in each treatment agent, illustrates that it is safe to apple.Advise that the insecticide different from the mechanism of action mixes use to delay the generation of pest resistance to insecticide.
4.1 ethyl pleocidins and the test of clothianidin composition field experiment control wild cabbage diamond-back moth
4.1.1 test method
Tested on July 8th, 2010 to July 18 and carry out in wild cabbage plantation, Shouguang City of Shandong Province.Tested on July 8th, 2010 and carry out routine to water spray by each processing design concentration.Spraying equipment is WF-16 type knapsack hand sprayer, and shower nozzle is single fan nozzle, and operating pressure is 0.2-0.4Mpa, and spray amount is 0.36-0.48L/min, carries out routine spraying, makes every effort to evenly thoughtful when spray medicine.When dispenser, field diamond-back moth is 1~2 adult in age peak period.Every 667 m
2be 70kg to the water yield.
Duration of test weather is good, and daily mean temperature is 18.0~26.8 DEG C.Dispenser fine day on the same day.
4.1.2 investigation method
In dispenser Qian Mei community by 5 samplings of diagonal. choose wild cabbage 3~5 strains (depending on insect density) of Eggs of Diamondback Moth and adult at every.Statistics is demarcated a diamond-back moth number in strain. insect population radix before using this as dispenser.After dispenser the 3rd, 7,10d investigates respectively the diamond-back moth borer population of determining residual survival in strain. to proofread and correct insect population decline rate as control efficiency.
4.1.3 drug effect computational methods.
Correction preventive effect (%)=
× 100;
4.1.4 poisoning investigation method
Duration of test is observed each processing community wild cabbage well-grown, all finds no poisoning phenomenon and occurs.
4.2 field control effectiveness test result of the tests
Table 3 treatment agent control wild cabbage diamond-back moth field control effectiveness test result
As can be seen from Table 3, the Mixed Pharmacy of different proportion, carry out field experiment by different consumptions, after medicine, it is all better than contrasting medicament to the control efficiency of diamond-back moth, it is fast that 10% (ethyl pleocidin: MTI-446) (5:5) prevented and treated diamond-back moth quick-acting, efficiency time is long, and control efficiency is good.After medicine, the insecticidal effect of 10 days reaches respectively 84.34%, 88.78%, 90.14%, and insecticidal effect increases progressively along with the increase of consumption.According to experimental observation, each medication is processed wild cabbage all without poisoning.Suggestion dispenser rests in before 3 ages of diamond-back moth adult period, requires even spraying when dispenser, blade face, blade back even medicine, the suggestion medicament different from other mechanisms of action is used alternatingly, to delay the generation of pest resistance to insecticide.
5, ethyl pleocidin and thiacloprid are paid pairing Brown Planthopper Toxicity Determination
(1) test medicine
The former medicine of 81% ethyl pleocidin; The former medicine of 95% thiacloprid
(2) subjects
Brown Planthopper: pick up from field, Guangxi population, 2 generations of indoor rice seedling captive breeding.
(3) test method
Rice fulgorid: test method is with reference to " the agricultural industry criteria NY/T1154.11-2008 of the People's Republic of China (PRC) ", adopt rice stem infusion process: the rice strain that extracts with root healthy and strong tillering stage to the booting initial stage, clean, be cut into the long company's root rice stem of 15cm, 3 one group of strain, In Shade drying in the air to surface without washmarking.Rice stem is soaked 30 seconds respectively in the liquid having diluted, after taking-up is dried, encase root put into cultivation cup with the absorbent cotton soaking, absorption nymph in 3 mid-term in age is put into cultivation glass, 20 every glass.Be blank if soak clear water, each concentration repeats 3 times.It is 27 DEG C that processing is placed on temperature, and periodicity of illumination is 16h:8h(L:D) incubator in cultivate.Within 4 days, all check death toll.
(4) statistical analysis
Carry out statistical analysis with DPS data processing software, calculate the LC of each medicament
50and 95% confidence limit, evaluate the insecticidal activity of reagent agent to examination worm with this.
The co-toxicity coefficient (CTC value) of mixture calculates by following formula:
ATI=(S/M)×100
In formula:
ATI---mixture actual measurement toxicity index;
S---the LC of standard medicament
50, unit is mg/litre (mg/l);
The LC of M---mixture
50, unit is mg/litre (mg/l).
TTI=TI
A×P
A+TI
B×P
B
In formula:
The theoretical toxicity index of TTI---mixture;
TI
a---A medicament toxicity index;
P
a---the percentage composition of A medicament in mixture, unit is percentage;
TI
b---B medicament toxicity index;
P
b---the percentage composition of B medicament in mixture, unit is percentage.
CTC=(ATI/TTI)×100
In formula:
CTC---co-toxicity coefficient
ATI---mixture actual measurement toxicity index
The theoretical toxicity index of TTI---mixture
The co-toxicity coefficient (CTC) >=120 of complex preparation shows as synergistic effect, and CTC≤80 show as antagonism, and 80 < CTC < 120 show as summation action.
(5) interpretation of result
Ethyl pleocidin and thiacloprid composite to the toxicity test of brown planthopper in table 4.
The composite toxicity test result to brown planthopper of table 4 ethyl pleocidin and thiacloprid
Medicament | LC 50(mg/l) | ATI | TTI | CTC |
Ethyl pleocidin (A) | 2.34 | 100.00 | —— | —— |
Thiacloprid (B) | 11.13 | 21.02 | —— | —— |
A:B=9:1 | 1.67 | 140.12 | 98.45 | 142.32 |
A:B=7:3 | 1.37 | 170.80 | 92.82 | 184.01 |
A:B=5:5 | 1.87 | 125.13 | 60.51 | 206.79 |
A:B=3:7 | 6.23 | 37.56 | 24.79 | 151.54 |
A:B=1:9 | 7.13 | 32.82 | 22.57 | 145.39 |
To sum up described in result of the test, the Pesticidal combination that the present invention contains ethyl pleocidin and nicotinic insecticide, the insects such as apple aphid and wild cabbage diamond-back moth and Brown Planthopper are shown to good control efficiency, to target crop safety, compared with single dose, Pesticidal combination of the present invention has mechanism of action uniqueness, unit administration amount is few, quick-acting is good, the advantage that lasting period is long, so, there is great social effect in research and development of the present invention and popularization, can produce very large economic benefit, promote peasant's increasing both production and income, to agricultural product and Environmental security, there are the potentiality that vigorously promote the use.
Claims (6)
1. a Pesticidal combination that contains ethyl pleocidin and nicotinic insecticide.
2. Pesticidal combination according to claim 1, is characterized in that: nicotinic insecticide is selected from the one in clothianidin, thiacloprid, MTI-446.
3. Pesticidal combination according to claim 1, is characterized in that: the mass ratio of ethyl pleocidin and nicotinic insecticide is 1 ~ 80:80 ~ 1.
4. Pesticidal combination according to claim 1, is characterized in that: ethyl pleocidin is 1 ~ 20:20 ~ 1 with the quality optimization ratio of nicotinic insecticide.
5. Pesticidal combination according to claim 1, is characterized in that: active ingredient ethyl pleocidin and the nicotinic insecticide total mass ratio in composition is 1 ~ 80%, preferably than being 1 ~ 30%.
6. Pesticidal combination according to claim 1, is characterized in that: adopt the known technical scheme of those skilled in the art can be prepared into the formulations such as missible oil, suspending agent, wetting powder, water dispersible granules, aqueous emulsion, microemulsion.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210524372.5A CN103858920A (en) | 2012-12-10 | 2012-12-10 | Spinetoram-containing insecticidal composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210524372.5A CN103858920A (en) | 2012-12-10 | 2012-12-10 | Spinetoram-containing insecticidal composition |
Publications (1)
Publication Number | Publication Date |
---|---|
CN103858920A true CN103858920A (en) | 2014-06-18 |
Family
ID=50898384
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201210524372.5A Pending CN103858920A (en) | 2012-12-10 | 2012-12-10 | Spinetoram-containing insecticidal composition |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103858920A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104286011A (en) * | 2014-09-29 | 2015-01-21 | 青岛康和食品有限公司 | Efficient insecticide containing efficient cyfluthrin, profenofos, dinotefuran and spinetoram |
CN104322533A (en) * | 2014-09-29 | 2015-02-04 | 青岛康合伟业商贸有限公司 | High-efficient pesticide containing flubendiamide, cycloxaprid and spinetoram |
CN106577732A (en) * | 2016-12-14 | 2017-04-26 | 安徽东健化工科技有限公司 | Efficient herbicide |
CN113367164A (en) * | 2018-03-02 | 2021-09-10 | 中国农业科学院棉花研究所 | Method for extracting castor-oil plant insecticidal active substance and combined application of castor-oil plant insecticidal active substance and microbial source insecticide |
-
2012
- 2012-12-10 CN CN201210524372.5A patent/CN103858920A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104286011A (en) * | 2014-09-29 | 2015-01-21 | 青岛康和食品有限公司 | Efficient insecticide containing efficient cyfluthrin, profenofos, dinotefuran and spinetoram |
CN104322533A (en) * | 2014-09-29 | 2015-02-04 | 青岛康合伟业商贸有限公司 | High-efficient pesticide containing flubendiamide, cycloxaprid and spinetoram |
CN106577732A (en) * | 2016-12-14 | 2017-04-26 | 安徽东健化工科技有限公司 | Efficient herbicide |
CN113367164A (en) * | 2018-03-02 | 2021-09-10 | 中国农业科学院棉花研究所 | Method for extracting castor-oil plant insecticidal active substance and combined application of castor-oil plant insecticidal active substance and microbial source insecticide |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102246799A (en) | Insecticidal composition containing spinetoram | |
CN102217615A (en) | Pesticide composition containing Spirotetramat and amide insecticides | |
CN102986700A (en) | Insecticide composition containing flutenzine and bistrifluron | |
CN103190433A (en) | Pesticide composition with spirotetramat and dinotefuran | |
CN103858920A (en) | Spinetoram-containing insecticidal composition | |
CN102047915B (en) | Insecticidal composition containing thiacloprid amide | |
CN102972430A (en) | Insecticidal composition containing thiamethoxam and acetamiprid | |
CN102224825A (en) | Pesticide composition containing sulfoxaflor and nereistoxin compound | |
CN102232385A (en) | Insecticidal composition containing clothianidin and abamectin | |
CN102484994B (en) | Synergy composition of matrine and chlorantraniliprole | |
CN103168787A (en) | Insecticidal composition containing lufenuron and cyantraniliprole | |
CN102960353A (en) | Insecticidal and acaricidal composition containing metaflumizone and flufenzine | |
CN102204549A (en) | Insecticidal composition containing spirotetramat and fenpyroximate | |
CN102428922A (en) | Diacylhydrazine pesticide compounded pesticidal composition | |
CN102972421B (en) | A kind of Pesticidal combination containing emamectin benzoate and triflumuron | |
CN102027967B (en) | Pesticide composition containing pyriproxyfen and metaflumizone and application thereof | |
CN102217623B (en) | Pesticide composition containing chlorbenzuron and flubendiamide | |
CN102246800A (en) | Insecticidal composition containing indoxacarb and dinotefuran | |
CN102960356A (en) | Parasiticide composite containing bistrifluron and methoxyfenozide | |
CN102246779A (en) | Pesticide composition containing spirotetramat and spinosad | |
CN103004818A (en) | Insecticide composition containing fipronil and spirotetramat | |
CN102246786A (en) | Pesticidal composition containing spirotetramat and metaflumizone | |
CN102440260A (en) | Insecticidal composition comprising sulfoxaflor and cyhalothrin | |
CN102077833A (en) | Pesticide composition | |
CN102318636A (en) | A kind of Synergistic insecticidal compositions |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20140618 |