CN114469806B - Composition for relieving skin after sun drying and application thereof - Google Patents
Composition for relieving skin after sun drying and application thereof Download PDFInfo
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- CN114469806B CN114469806B CN202210098138.4A CN202210098138A CN114469806B CN 114469806 B CN114469806 B CN 114469806B CN 202210098138 A CN202210098138 A CN 202210098138A CN 114469806 B CN114469806 B CN 114469806B
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- ceramide
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- 239000000203 mixture Substances 0.000 title claims abstract description 38
- 238000001035 drying Methods 0.000 title claims abstract description 10
- 239000000516 sunscreening agent Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims abstract description 14
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims abstract description 14
- 229940106189 ceramide Drugs 0.000 claims abstract description 14
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims abstract description 14
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000000370 Passiflora edulis Nutrition 0.000 claims abstract description 6
- 244000288157 Passiflora edulis Species 0.000 claims abstract description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 18
- NKEQOUMMGPBKMM-UHFFFAOYSA-N 2-hydroxy-2-[2-(2-hydroxy-3-octadecanoyloxypropoxy)-2-oxoethyl]butanedioic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CC(O)(C(O)=O)CC(O)=O NKEQOUMMGPBKMM-UHFFFAOYSA-N 0.000 claims description 12
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 12
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 12
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 12
- 229940113124 polysorbate 60 Drugs 0.000 claims description 12
- 229940080352 sodium stearoyl lactylate Drugs 0.000 claims description 11
- -1 hexyl diethylhydroxybenzoate Chemical compound 0.000 claims description 9
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 8
- 229960005323 phenoxyethanol Drugs 0.000 claims description 8
- ODFAPIRLUPAQCQ-UHFFFAOYSA-M sodium stearoyl lactylate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O ODFAPIRLUPAQCQ-UHFFFAOYSA-M 0.000 claims description 8
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 7
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 7
- PFHLGILELJGQSJ-UHFFFAOYSA-N 4-(2h-benzotriazol-4-ylmethyl)-2h-benzotriazole;2-butyl-3,4,5,6-tetramethylphenol Chemical compound CCCCC1=C(C)C(C)=C(C)C(C)=C1O.C=1C=CC=2NN=NC=2C=1CC1=CC=CC2=C1N=NN2 PFHLGILELJGQSJ-UHFFFAOYSA-N 0.000 claims description 6
- XTJFFFGAUHQWII-UHFFFAOYSA-N Dibutyl adipate Chemical compound CCCCOC(=O)CCCCC(=O)OCCCC XTJFFFGAUHQWII-UHFFFAOYSA-N 0.000 claims description 6
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims description 6
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 6
- 229920001577 copolymer Polymers 0.000 claims description 6
- 229940100539 dibutyl adipate Drugs 0.000 claims description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 6
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 6
- 229960001679 octinoxate Drugs 0.000 claims description 6
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 6
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 6
- 239000004408 titanium dioxide Substances 0.000 claims description 6
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 6
- 239000000230 xanthan gum Substances 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- 229940082509 xanthan gum Drugs 0.000 claims description 6
- 235000010493 xanthan gum Nutrition 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- VTQVLCXOOIFPBB-UHFFFAOYSA-N 4-ethyl-5-hexyl-1H-triazin-6-one Chemical compound C(C)C1=C(C(NN=N1)=O)CCCCCC VTQVLCXOOIFPBB-UHFFFAOYSA-N 0.000 claims description 4
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 2
- 238000012216 screening Methods 0.000 abstract description 12
- 239000006071 cream Substances 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 7
- 230000036561 sun exposure Effects 0.000 abstract description 5
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 34
- 238000003756 stirring Methods 0.000 description 9
- 230000000475 sunscreen effect Effects 0.000 description 8
- 230000001804 emulsifying effect Effects 0.000 description 7
- 210000001821 langerhans cell Anatomy 0.000 description 6
- 230000037072 sun protection Effects 0.000 description 5
- BQMNFPBUAQPINY-UHFFFAOYSA-N azane;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonic acid Chemical compound [NH4+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C BQMNFPBUAQPINY-UHFFFAOYSA-N 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 229940068196 placebo Drugs 0.000 description 3
- 239000000902 placebo Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229960005196 titanium dioxide Drugs 0.000 description 2
- KHICUSAUSRBPJT-UHFFFAOYSA-N 2-(2-octadecanoyloxypropanoyloxy)propanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C(O)=O KHICUSAUSRBPJT-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- 101000642333 Homo sapiens Survival of motor neuron-related-splicing factor 30 Proteins 0.000 description 1
- BBAFBDLICMHBNU-MFZOPHKMSA-N N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine Chemical compound CCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC BBAFBDLICMHBNU-MFZOPHKMSA-N 0.000 description 1
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 description 1
- 102100036412 Survival of motor neuron-related-splicing factor 30 Human genes 0.000 description 1
- MIUIRGGKIICMBP-NFOZDHADSA-N [27-oxo-27-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]heptacosyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC MIUIRGGKIICMBP-NFOZDHADSA-N 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940048864 ceramide 1 Drugs 0.000 description 1
- 229940044176 ceramide 3 Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000006355 external stress Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000006058 immune tolerance Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000011814 protection agent Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008491 skin homeostasis Effects 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940071209 stearoyl lactylate Drugs 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a composition for relieving skin after sun drying and application thereof. The composition for soothing the skin after sun exposure comprises the following components in percentage by weight: 2% -3% of passion fruit extract, 3% -9% of ceramide and the balance of water. The composition for relieving the skin after sun-drying has good effect of repairing the damaged skin after sun-drying, and can be used for preparing sun-screening products, so that the SPF value of the sun-screening products can be improved, and sun-screening creams with different SPF values can be obtained. The sun cream of the invention is only added with a small amount of physical sun agent, and the skin does not feel airtight after use.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a composition for relieving skin after sun drying and application thereof.
Background
With the improvement of life quality, people are paying more attention to protection of skin against sun, etc. At present, the types of sun cream on the market are rich, but in order to improve sun protection performance, particularly SPF value, some manufacturers often add excessive physical sun protection agents. Although the addition of physical sunscreens can increase the sun protection index of the product, the use of the product is greasy, the skin is impermeable after application, and it causes clogging of skin pores. In order to achieve the effective sun-screening effect, more stimulating components are generally added into the sun-screening cream to form relatively mild sun-screening cream, the sun-screening index of the sun-screening cream is low, and the lasting sun-screening effect under strong sunlight cannot be met.
Disclosure of Invention
The primary object of the present invention is to overcome the disadvantages and shortcomings of the prior art and to provide a composition for soothing the skin after sun exposure.
It is a further object of the present invention to provide the use of the above composition for soothing skin after sun-drying.
It is a further object of the present invention to provide a sunscreen comprising the above composition for soothing post-sun skin.
The aim of the invention is achieved by the following technical scheme: a composition for soothing post-sun skin comprising the following components in weight percent: 2% -3% of passion fruit extract, 3% -9% of ceramide and the balance of water; preferably, the composition for soothing skin after sun exposure comprises the following components in percentage by weight: 2-3% of passion fruit extract, 1 1-3% of ceramide, 3 1-3% of ceramide, 6 1-3% of ceramide and the balance of water; more preferably, the composition for soothing skin after sun exposure comprises the following components in weight percent: 3% of passion fruit extract, 12% of ceramide, 31% of ceramide, 6 3% of ceramide and the balance of water.
The use of the above composition for soothing the skin after sun protection in the preparation of a sunscreen product or a soothing product after sun protection.
The addition amount of the composition for relieving skin after sun-curing is 0.1-3% by weight of the sun-proof product.
The sun cream comprises the following components in percentage by weight: the skin soothing composition comprises, by weight, 0.1-3% of a composition for soothing the sun-dried skin, 1-12% of propylene glycol, 1-5% of caprylic/capric triglyceride, 1-15% of titanium dioxide, 1-15% of ethylhexyl methoxycinnamate, 1-5% of cyclopenta-dimethicone, 1-5% of methylenebis-benzotriazole tetramethylbutylphenol, 0-3% of dibutyl adipate, 1-5% of 1, 2-pentanediol, 0.5-5% of hexyl diethylhydroxybenzoate, 1-5% of a compound of glyceryl stearate citrate/polysorbate-60/stearoyl lactylate sodium lactate, 0.2-3% of an ammonium acryloyldimethyl taurate/VP copolymer, 0.3-5% of ethylhexyl triazinone, 0.3-5% of cetostearyl alcohol, 0.3-1% of phenoxyethanol, 0.2-1% of 1, 0.1-1% of xanthan gum and the balance water.
Preferably, the sun cream comprises the following components in percentage by weight: 1-2% of a composition for soothing skin after sun-drying, 10% of propylene glycol, 5% of caprylic/capric triglyceride, 3-5% of titanium dioxide, 1-5% of ethylhexyl methoxycinnamate, 3-4% of cyclopentadimethicone, 2-4% of methylenebis-benzotriazole tetramethylbutylphenol, 0-3% of dibutyl adipate, 3% of 1, 2-pentanediol, 1-2% of hexyl diethylhydroxybenzoate, 1.5-2.5% of a complex of glyceryl stearate citrate/polysorbate-60/sodium stearoyl lactylate, 0.5-1% of an ammonium acryloyldimethyl taurate/VP copolymer, 0.5-0.8% of ethylhexyl triazinone, 0.5-1.5% of cetostearyl alcohol, 0.5% of phenoxyethanol, 0.5% of 1, 2-hexanediol, 0.2% of xanthan gum and the balance of water.
Preferably, the weight ratio of the glyceryl stearate citrate to the polysorbate-60 to the sodium stearoyl lactylate in the glyceryl stearate citrate/polysorbate-60/sodium stearoyl lactylate compound is 6:3:1.
the preparation method of the sun cream comprises the following steps:
(1) Uniformly dispersing propylene glycol, 1, 2-pentanediol, xanthan gum and water at 80-85 ℃ to obtain a water phase;
(2) Uniformly dispersing caprylic/capric triglyceride, titanium dioxide, ethylhexyl methoxycinnamate, dibutyl adipate, hexyl diethylhydroxybenzoate, a compound of glyceryl stearate citrate/polysorbate-60/sodium stearoyl lactylate, ethylhexyl triazone and cetostearyl alcohol at 80-85 ℃ to obtain an oil phase;
(3) Mixing the water phase in the step (1) and the oil phase in the step (2), uniformly dispersing, adding cyclopenta-dimethyl siloxane and ammonium acryloyldimethyl taurate/VP copolymer, and uniformly dispersing;
(4) Cooling the material obtained in the step (3) to 45-55 ℃, adding methylene bis-benzotriazole tetramethylbutylphenol, and uniformly dispersing;
(5) And (3) cooling the material obtained in the step (4) to 40-50 ℃, adding phenoxyethanol and 1, 2-hexanediol, and uniformly dispersing to obtain the sun cream.
And (3) uniformly dispersing in the steps (1) to (5) by adopting a stirring mode.
And (5) mixing the phenoxyethanol and the 1, 2-hexanediol uniformly in advance.
Compared with the prior art, the invention has the following beneficial effects:
the skin composition for relieving after-sun damage has good effect of repairing after-sun damaged skin, and can be used for preparing sun-proof products, so that the SPF value of the sun-proof products can be improved, and sun-proof products with different SPF values can be obtained. The sunscreen product has no air impermeability feeling after use due to the addition of a small amount of physical sunscreen agent.
Drawings
FIG. 1 is a graph comparing the effect of a composition for soothing post-sun skin to post-sun skin; wherein 1 is a composition which is not smeared on skin after relief and is not irradiated with UV, 2 is a composition which is not smeared on skin after relief and is irradiated with UV, 3 is a placebo and is irradiated with UV, and 4 is a treatment of a composition 8 of skin after relief and is irradiated with UV.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The raw materials used in the following examples and comparative examples are all commercially available.
Example 1
Mixing herba Plumeriae Acutifoliae extract, ceramide 1, ceramide 3, ceramide 6 and deionized water (rest) according to the amount shown in Table 1, and stirring to obtain skin-soothing composition 1-9.
TABLE 1 compositions 1-9 (wt.%)
Langerhans cell repair assays were performed with compositions 1-9 that soothing the skin after sun exposure. Langerhans cells can both initiate an immune response and induce immune tolerance, playing a different important role in skin homeostasis. Langerhans cells are very sensitive to external stress factors, and their reduced numbers mark damaged skin. The repair test is specifically as follows: selecting 10 subjects, counting Langerhans cell number (two replicates) on left and right forearms by using a full-automatic cell counter, and then irradiating with 380nm Ultraviolet (UV) lamp for 30min each day, and applying composition 1-9 for relieving skin after 14 days, wherein the application amount is 2.0mg/cm 2 2 times/day, and is smeared for 7 days. Setting 3 control groups: UV-irradiation-free + no-spread post-sun-treatment skin composition, UV-irradiation + spread placebo (placebo is sample 1 without post-sun-treatment skin composition 8 in example 2 below). Microscopic observation of Pi Langge hans cells on the left and right forearms of the subject after 7 days of application, statistics of the number of langerhans cells by using a fully automatic cell counter, calculation of cell survival rate, and best repair effect of composition 8 on langerhans cells after skin soothing. The results are shown in Table 2 and FIG. 1.
TABLE 2 cytorepair Effect of compositions 1-9 for soothing post-sun skin
Example 2
Table 3 shows the components and amounts of the sunscreen cream prepared using the soothing skin composition 8 of example 1, and the SPF values measured using the standard of cosmetic health Specification 2007. The weight ratio of the glyceryl stearate citrate to the polysorbate-60 to the sodium stearoyl lactylate in the glyceryl stearate citrate/polysorbate-60/sodium stearoyl lactylate compound is 6:3:1.
table 3 Components and amounts (weight percent) of the sunscreen cream
The preparation method of the above 8 sunscreen cream samples is as follows:
1. propylene glycol, 1, 2-pentanediol, xanthan gum and water are put into an emulsifying pot, heated to 85 ℃, stirred and dispersed uniformly to obtain a water phase;
2. adding caprylic/capric triglyceride, titanium dioxide, ethylhexyl methoxycinnamate, dibutyl adipate, hexyl diethylhydroxybenzoate, a compound of glyceryl stearate citrate, polysorbate-60 and sodium stearoyl lactylate, ethylhexyl triazone and cetostearyl alcohol into an oil phase pot, maintaining the temperature at 83 ℃, and stirring and dispersing uniformly to obtain an oil phase;
3. slowly adding the uniformly dispersed oil phase into the water phase in the emulsifying pot, and stirring and dispersing uniformly;
4. mixing cyclopentadimethicone and ammonium acryloyldimethyl taurate/VP copolymer, putting into an emulsifying pot, stirring and dispersing uniformly;
5. stirring and cooling to 50 ℃ in an emulsifying pot, adding methylene bis-benzotriazole tetramethylbutyl phenol into the emulsifying pot, and stirring and dispersing uniformly;
6. stirring and cooling to 45 ℃ in an emulsifying pot, adding phenoxyethanol and 1, 2-hexanediol into the emulsifying pot after the phenoxyethanol and the 1, 2-hexanediol are completely mixed, and stirring and dispersing uniformly;
7. and discharging after the inspection is qualified.
Comparing the SPF values, it can be seen that the SPF value of the sunscreen cream of skin composition 8 after addition of the soothing sun is significantly improved. Considering the comprehensive cost, the optimal addition proportion of the skin composition after the sun-screening product of SPF30+ is eased is 2%, and a system of samples 1-3 is adopted; the addition proportion of the skin composition after the sun-screening cream sun-screening product of SPF15+ is 1-2%, and the system of samples 4-5 is adopted according to the application scene of the product.
While the foregoing is directed to the preferred embodiments of the present invention, it will be appreciated by those skilled in the art that changes and modifications may be made without departing from the principles of the invention, such changes and modifications are also intended to be within the scope of the invention.
Claims (4)
1. The sun cream is characterized by comprising the following components in percentage by weight: 1 to 3 percent of composition for relieving skin after sun-drying, 10 percent of propylene glycol, 5 percent of caprylic/capric triglyceride, 4 to 5 percent of titanium dioxide, 1.2 to 5 percent of ethylhexyl methoxycinnamate, 3 to 4 percent of cyclopentadimethicone, 2 to 4 percent of methylene bis-benzotriazole tetramethylbutyl phenol, 0 to 3 percent of dibutyl adipate, 3 percent of 1, 2-pentanediol, 1 to 2 percent of hexyl diethylhydroxybenzoate, 1.5 to 2.5 percent of compound of glyceryl stearate citrate/polysorbate-60/sodium stearoyl lactylate, 0.5 to 1 percent of acrylamide/VP copolymer, 0.5 to 0.8 percent of ethylhexyl triazinone, 0.5 to 1.5 percent of cetostearyl alcohol, 0.5 percent of phenoxyethanol, 0.5 percent of 1, 2-hexanediol, 0.2 percent of xanthan gum and the balance of water; the composition for soothing the skin comprises the following components in percentage by weight: 2-3% of passion fruit extract, 1 1-3% of ceramide, 31-3% of ceramide, 6 1-3% of ceramide and the balance of water.
2. The sun cream according to claim 1, characterized in that it comprises the following components in weight percent: 1-2% of a composition for soothing skin after sun-drying, 10% of propylene glycol, 5% of caprylic/capric triglyceride, 4-5% of titanium dioxide, 1.2-5% of ethylhexyl methoxycinnamate, 3-4% of cyclopentadimethicone, 2-4% of methylenebis-benzotriazole tetramethylbutylphenol, 0-3% of dibutyl adipate, 3% of 1, 2-pentanediol, 1-2% of hexyl diethylhydroxybenzoate, 1.5-2.5% of a compound of glyceryl stearate citrate/polysorbate-60/sodium stearoyl lactylate, 0.5-1% of an acrylamide/VP copolymer, 0.5-0.8% of ethylhexyl triazinone, 0.5-1.5% of cetostearyl alcohol, 0.5% of phenoxyethanol, 0.5% of 1, 2-hexanediol, 0.2% of xanthan gum and the balance of water.
3. The sun cream according to claim 1, wherein the composition for soothing the skin after sun comprises the following components in weight percent: 3% of passion fruit extract, 12% of ceramide, 31% of ceramide, 6 3% of ceramide and the balance of water.
4. The sun cream according to claim 1, wherein the weight ratio of the glyceryl stearate citrate, the polysorbate-60 and the sodium stearoyl lactylate in the glyceryl stearate citrate/polysorbate-60/sodium stearoyl lactylate compound is 6:3:1.
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| CN202210098138.4A CN114469806B (en) | 2022-01-27 | 2022-01-27 | Composition for relieving skin after sun drying and application thereof |
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| CN202210098138.4A CN114469806B (en) | 2022-01-27 | 2022-01-27 | Composition for relieving skin after sun drying and application thereof |
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| CN114469806B true CN114469806B (en) | 2023-12-19 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20050129776A1 (en) * | 2002-05-03 | 2005-06-16 | Inserm | Microparticles supporting cells and active substances |
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| DE102004014612A1 (en) * | 2004-03-23 | 2005-10-13 | Beiersdorf Ag | Cosmetic or dermatological preparation, useful e.g. for moistening skin, as skin protection cream, cleansing milk and sun protection cream, comprises taurine and polymers e.g. nylon, distarch phosphate, aluminum starch octenyl succinate |
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