CN117224448B - Anti-wrinkle and soothing composition as well as preparation method and application thereof - Google Patents
Anti-wrinkle and soothing composition as well as preparation method and application thereof Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 9
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- WQXNXVUDBPYKBA-YFKPBYRVSA-N ectoine Chemical compound CC1=[NH+][C@H](C([O-])=O)CCN1 WQXNXVUDBPYKBA-YFKPBYRVSA-N 0.000 claims abstract description 16
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- WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 claims description 2
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- Cosmetics (AREA)
Abstract
The invention provides an anti-wrinkle and soothing composition, a preparation method and application thereof, wherein the anti-wrinkle and soothing composition comprises the following components in parts by weight, 10-50 parts by weight of vitronectin, 0.1-1 part by weight of ergothioneine, 10-30 parts by weight of elctrodeoxycin, 2-5 parts by weight of citrus fruit extract, 1-4 parts by weight of flos mori extract and a solvent. The anti-wrinkle and soothing composition disclosed by the invention can further improve the anti-wrinkle effect and the moisturizing effect of the composition after being matched with the vitronectin, the ergothioneine, the ectoine, the citrus fruit extract and the wang spring flower extract. The anti-wrinkle and skin-care nanoemulsion disclosed by the invention is matched with polyoxyethylene castor oil, isopropyl myristate, glycerol, triethanolamine and triethanolamine oleate to be used as an oil phase, and a microemulsion system formed by the nanoemulsion is matched with water, so that the particle size is more uniform, the absorption of effective components such as vitrine by skin is more facilitated, and the anti-wrinkle and moisturizing effects are improved.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to an anti-wrinkle and soothing composition, and a preparation method and application thereof.
Background
Skin is the largest organ of the human body, and facial wrinkles often affect the mental state and apparent age of the whole person. Anti-wrinkle cosmetics and raw material components in the market are also increasing. Hydroxypropyl tetrahydropyran triol (vitriol) can stimulate the production of aminodextran and prevent water loss in skin. The skin can promote the generation of extracellular matrix protein polysaccharide, and the molecules can make the cell matrix gel after absorbing water, so that the tightness of cells can be increased, and the effect of tightening and resisting aging can be achieved. Thus, the vitreous stain is also widely used in anti-wrinkle cosmetics. However, the effect of the vitriol is single and needs to be enhanced. And the glass color factor is added into the cosmetics, and the dispersion performance of the glass color factor in the cosmetics influences the exertion of the effect of the glass color factor.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide an anti-wrinkle relieving composition, a preparation method and application thereof.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: an anti-wrinkle relieving composition comprises, by weight, 10-50 parts of vitronectin, 0.1-1 part of ergothioneine, 10-30 parts of ectoin, 2-5 parts of citrus (CITRUS RETICULATA) fruit extract, 1-4 parts of flos mori (Magnolia biondii) flower extract and a solvent.
The hydroxypropyl tetrahydropyran triol (vitriol) can stimulate the generation of aminodextran, prevent water loss in skin and has good anti-wrinkle effect, but the vitriol has single effect, and the inventor finds that after the vitriol, the ergothioneine, the ectoine, the citrus fruit extract and the flos verruceae extract are matched, the anti-wrinkle effect and the moisturizing effect of the composition can be further improved.
Preferably, the anti-wrinkle relieving composition comprises 20-40 parts by weight of vitronectin, 0.1-1 part by weight of ergothioneine, 15-25 parts by weight of ectoine, 2-5 parts by weight of citrus fruit extract, 1-4 parts by weight of flos mori extract and a solvent.
Preferably, the anti-wrinkle relieving composition comprises, by weight, 30-35 parts of vitronectin, 0.1-1 part of ergothioneine, 15-20 parts of ectoine, 2-5 parts of citrus fruit extract, 1-4 parts of flos Hemerocallis extract and a solvent.
It has been found that the above anti-wrinkle soothing composition has better properties when the components are in the above weight proportions.
Preferably, the solvent is at least one of water and glycerin.
The invention also provides application of any of the anti-wrinkle and soothing composition in preparing cosmetics, wherein the cosmetics are skin lotion, skin care nanoemulsion, skin care cream, skin care essence, skin care eye cream or gel mask, and the cosmetics contain 15-20% by weight of any of the anti-wrinkle and soothing composition.
The invention also provides an anti-wrinkle skin-care nanoemulsion which comprises an oil phase component and a water phase component;
the oil phase component comprises 3 to 5 weight parts of polyoxyethylene castor oil, 10 to 15 weight parts of isopropyl myristate, 3 to 5 weight parts of glycerol, 0.3 to 1 weight part of triethanolamine and 1 to 3 weight parts of triethanolamine oleate;
The aqueous phase component comprises, by weight, 5% -25% of vitriol, 0.05% -0.5% of ergothioneine, 5% -15% of ectoine, 1% -2.5% of citrus fruit extract, 0.5% -2% of flos mori extract and the balance of water;
the oil phase component and the water phase component are in a volume ratio of 1: (1.5-3) mixing to form a nanoemulsion system, wherein the particle size of the nanoemulsion is 150-300 nm, and the PDI of the nanoemulsion is 0.10-0.25.
According to the anti-wrinkle and skin-care nanoemulsion, polyoxyethylene castor oil, isopropyl myristate, glycerol, triethanolamine and triethanolamine oleate are matched to serve as an oil phase, and after being mixed with water phase components, the nanoemulsion can form a more stable microemulsion system, and the content of loaded functional components is higher. And the microemulsion system formed by polyoxyethylene castor oil, isopropyl myristate, glycerol, triethanolamine oleate and water has more uniform particle size, is more beneficial to skin to absorb effective components such as vitronectin and the like, and improves the anti-wrinkle and moisturizing effects.
Preferably, the aqueous phase component comprises, by weight, 10% -20% of vitriol, 0.05% -0.5% of ergothioneine, 8% -12% of escin, 1% -2.5% of citrus fruit extract, 0.5% -2% of flos combining extract and the balance of water.
Preferably, in the oil phase component, the weight ratio of the glycerol, the polyoxyethylene castor oil and the isopropyl myristate is glycerol: polyoxyethylated castor oil: isopropyl myristate= (0.8-1.2): 1:3.
Preferably, the oil phase component and the water phase component are in a volume ratio of 1: (1.8-2.2) and mixing.
The inventor researches that the oil phase component and the water phase component are in a volume ratio of 1: (1.8-2.2), the effect of absorbing the functional components of the formed microemulsion system by the skin is better.
The invention also provides a preparation method of the anti-wrinkle, soothing and skin-care nanoemulsion, which comprises the following steps:
(1) Mixing polyoxyethylene castor oil, isopropyl myristate, glycerol, triethanolamine and triethanolamine oleate according to a weight ratio, heating and stirring at 55-65 ℃ for dissolving for 15-30 min to obtain an oil phase;
(2) Mixing the vitronectin, the ergothioneine, the ectoine, the citrus fruit extract, the flos mori extract and water serving as a solvent according to the weight ratio, heating and stirring at 55-65 ℃ for dissolving for 15-30 min to obtain a water phase;
(3) Adding the water phase in the step (2) into the oil phase in the step (1), and carrying out heat preservation and stirring to obtain colostrum;
(4) And (3) carrying out ultrahigh-pressure nanometer homogenization on the colostrum ultrahigh-pressure nanometer emulsion, wherein the homogenization pressure is 900-1200 bar, and standing and cooling to obtain the anti-wrinkle and soothing skin care nanometer emulsion.
The invention has the beneficial effects that: the invention provides an anti-wrinkle and soothing composition, and a preparation method and application thereof. The hydroxypropyl tetrahydropyran triol (vitriol) can stimulate the generation of aminodextran, prevent water loss in skin and has good anti-wrinkle effect, but the vitriol has single effect, and the anti-wrinkle and soothing composition can further improve the anti-wrinkle effect and moisturizing effect of the composition after the vitriol, the ergothioneine, the ectoine, the citrus fruit extract and the flos verrucae extract are matched. According to the anti-wrinkle and skin-care nanoemulsion, polyoxyethylene castor oil, isopropyl myristate, glycerol, triethanolamine and triethanolamine oleate are matched to serve as an oil phase, and after being mixed with water phase components, the nanoemulsion can form a more stable microemulsion system, and the content of loaded functional components is higher. And the microemulsion system formed by polyoxyethylene castor oil, isopropyl myristate, glycerol, triethanolamine oleate and water has more uniform particle size, is more beneficial to skin to absorb effective components such as vitronectin and the like, and improves the anti-wrinkle and moisturizing effects.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples.
Example 1
As the anti-wrinkle skin-care nanoemulsion provided by the embodiment of the invention, the anti-wrinkle skin-care nanoemulsion comprises an oil phase component and a water phase component;
the oil phase component comprises 4 parts by weight of polyoxyethylene castor oil, 12 parts by weight of isopropyl myristate, 4 parts by weight of glycerol, 1.5 parts by weight of triethanolamine and 1.5 parts by weight of triethanolamine oleate;
The aqueous phase component comprises the following components, by weight, of the aqueous phase component, 20% of vitronectin, 0.3% of ergothioneine, 8% of ectoin, 1.5% of citrus fruit extract, 1% of flos Hemerocallis extract and 69.2% of water;
the oil phase component and the water phase component are in a volume ratio of 1:2 are mixed into a nanoemulsion system.
The preparation method of the anti-wrinkle skin-care nanoemulsion comprises the following steps:
(1) Mixing polyoxyethylene castor oil, isopropyl myristate, glycerol, triethanolamine and triethanolamine oleate according to weight proportion, heating and stirring at 60 ℃ for dissolving for 20min to obtain an oil phase;
(2) Mixing vitronectin, ergothioneine, escitalopram, citrus fruit extract, flos Hemerocallis extract and water as solvent according to weight ratio, heating at 60deg.C, stirring, and dissolving for 20min to obtain water phase;
(3) Adding the water phase in the step (2) into the oil phase in the step (1), and carrying out heat preservation and stirring to obtain colostrum;
(4) And (3) carrying out ultrahigh-pressure nanometer homogenization on the colostrum ultrahigh-pressure nanometer emulsion, wherein the homogenization pressure is 1000bar, and standing and cooling to obtain the anti-wrinkle and soothing skin care nanometer emulsion.
Example 2
As the anti-wrinkle skin-care nanoemulsion provided by the embodiment of the invention, the anti-wrinkle skin-care nanoemulsion comprises an oil phase component and a water phase component;
the oil phase component comprises 4 parts by weight of polyoxyethylene castor oil, 12 parts by weight of isopropyl myristate, 4 parts by weight of glycerol, 1.5 parts by weight of triethanolamine and 1.5 parts by weight of triethanolamine oleate;
The aqueous phase component comprises the following components, by weight, of the aqueous phase component, 15% of vitronectin, 0.3% of ergothioneine, 10% of ectoin, 1.5% of citrus fruit extract, 1% of flos Hemerocallis extract and 72.2% of water;
the oil phase component and the water phase component are in a volume ratio of 1:2 are mixed into a nanoemulsion system.
Example 3
As the anti-wrinkle skin-care nanoemulsion provided by the embodiment of the invention, the anti-wrinkle skin-care nanoemulsion comprises an oil phase component and a water phase component;
the oil phase component comprises 4 parts by weight of polyoxyethylene castor oil, 12 parts by weight of isopropyl myristate, 4 parts by weight of glycerol, 1.5 parts by weight of triethanolamine and 1.5 parts by weight of triethanolamine oleate;
The aqueous phase component comprises the following components, by weight, of the aqueous phase component, 20% of vitronectin, 0.3% of ergothioneine, 5% of ectoin, 1% of citrus fruit extract, 0.5% of flos Hemerocallis extract and 73.2% of water;
the oil phase component and the water phase component are in a volume ratio of 1:2 are mixed into a nanoemulsion system.
Example 4
As the anti-wrinkle skin-care nanoemulsion provided by the embodiment of the invention, the anti-wrinkle skin-care nanoemulsion comprises an oil phase component and a water phase component;
the oil phase component comprises 4 parts by weight of polyoxyethylene castor oil, 12 parts by weight of isopropyl myristate, 4 parts by weight of glycerol, 1.5 parts by weight of triethanolamine and 1.5 parts by weight of triethanolamine oleate;
The aqueous phase component comprises the following components, by weight, of the aqueous phase component, 10% of vitriol, 0.5% of ergothioneine, 8% of ectoine, 2.5% of citrus fruit extract, 2% of flos Hedyotidis Diffusae extract and 77% of water;
the oil phase component and the water phase component are in a volume ratio of 1:2 are mixed into a nanoemulsion system.
Example 5
As the anti-wrinkle skin-care nanoemulsion provided by the embodiment of the invention, the anti-wrinkle skin-care nanoemulsion comprises an oil phase component and a water phase component; the only difference between this embodiment and embodiment 1 is: the oil phase component and the water phase component are in a volume ratio of 1:1.5 mixing to form a nanoemulsion system.
Example 6
As the anti-wrinkle skin-care nanoemulsion provided by the embodiment of the invention, the anti-wrinkle skin-care nanoemulsion comprises an oil phase component and a water phase component; the only difference between this embodiment and embodiment 1 is: the oil phase component and the water phase component are in a volume ratio of 1:3 mixing to obtain the nanoemulsion system.
Comparative example 1
The only difference between the anti-wrinkle relieving skin care nanoemulsion as the comparative example of the invention and the example 1 is that: the water phase component does not contain ergothioneine, and the weight proportion is filled with deionized water.
Comparative example 2
The only difference between the anti-wrinkle relieving skin care nanoemulsion as the comparative example of the invention and the example 1 is that: the aqueous phase component does not contain the ectoin, and the weight proportion is filled with deionized water.
Comparative example 3
The only difference between the anti-wrinkle relieving skin care nanoemulsion as the comparative example of the invention and the example 1 is that: the water phase component does not contain citrus fruit extract, and the weight proportion is filled with deionized water.
Comparative example 4
The only difference between the anti-wrinkle relieving skin care nanoemulsion as the comparative example of the invention and the example 1 is that: the water phase component does not contain the extract of the flos mori, and the weight proportion is filled with deionized water.
Comparative example 5
The only difference between the anti-wrinkle relieving skin care nanoemulsion as the comparative example of the invention and the example 1 is that: the oil phase component does not contain polyoxyethylene castor oil.
Comparative example 6
The only difference between the anti-wrinkle relieving skin care nanoemulsion as the comparative example of the invention and the example 1 is that: the oil phase component does not contain isopropyl myristate.
Comparative example 7
The only difference between the anti-wrinkle relieving skin care nanoemulsion as the comparative example of the invention and the example 1 is that: the oil phase component does not contain triethanolamine oleate.
Experimental example
The anti-wrinkle and skin-care nanoemulsions of examples 1 to 7 and comparative examples 1 to 7 were prepared according to the ratio.
Citrus (CITRUS RETICULATA) fruit extract is purchased from 1-4 weight parts of flos Hemerocallis (Magnolia biondii) flower extract is purchased from
1. Particle size and particle size distribution of anti-wrinkle, soothing and skin care nanoemulsion
The particle diameters and particle diameter distributions of the anti-wrinkle soothing skin care nanoemulsions of examples 1 to 6 and comparative examples 1 to 7 were measured by using a Zetasizer Nano ZS laser particle sizer, 1mL of the anti-wrinkle soothing skin care nanoemulsions of examples 1 to 6 and comparative examples 1 to 7 were diluted to 50mL with ultrapure water, 2mL of the anti-wrinkle soothing skin care nanoemulsion was taken and measured in a sample cell at 25℃by using a laser particle sizer, and the measurement result was a mean value of 3 times of parallel measurement. The experimental results are shown in table 1.
TABLE 1 particle size and particle size distribution of anti-wrinkle soothing skin care nanoemulsion
2. Moisture retention performance test
16 Females are selected as volunteers for field test, the age is 30-35 years, no cosmetics can be smeared on the test area in the morning of the test day, the volunteers use clear water to clean the tested face under the guidance of staff, three experimental areas of 1.5cm x1.5cm are marked on the left cheek and the right cheek respectively, matrix blanks are smeared on the left upper arm of the same volunteer as a control, the right cheek is smeared with the same sample to be tested, examples 1-7, comparative examples 1-7 and comparative products are respectively, the test sample amount of each experimental area is 0.1mL of sample taken by a pipette, glycerin and deionized water with the volume ratio of 1:2 are used as matrix blanks, the comparative products are used for preparing aqueous phase components according to the proportion of the examples, and deionized water with the volume of 1/2 is added into the aqueous phase components for uniform dilution.
Before and after the product is used for 3 hours, comeometer CM is used for testing skin moisture of an experiment area, each experiment area is tested for three times to obtain an average value, the experiment areas of three samples to be tested of the same volunteer are averaged and recorded as T 2, and a matrix blank sample is recorded as T 1; the data of the sample to be tested before use is designated as T 0 and the data of the matrix sample before use is designated as T 0'.
Relative change rate (%) = ((T 2-T0)-(T1-T0'))/T0 ×100%).
3. Anti-wrinkle test
16 Females were selected as volunteers, aged 30-35 years, for trial testing. According to the test method, after a user washes the face in the morning, about 2mL (100% +/-3%) of a sample to be tested is taken and uniformly smeared on the face, the sample is used once in the morning for 2 months, and other skin care products are not used in the test process. The same volunteer used the same samples, examples 1-7, comparative examples 1-7, and comparative examples, respectively, which were prepared as aqueous phase components in the proportions of examples, and then added deionized water in an amount of 1/2 of the volume of the aqueous phase components to be diluted uniformly.
Before use, the skin rapid imaging analysis system Derma TOP adopts a fringe projection measurement technology, and wrinkle parameters are obtained through primary positioning of a head sensor and two ear sensors, secondary positioning of facial laser, image shooting of a camera, three-dimensional skin rapid imaging and computer processing of images. Obtaining wrinkle parameters including number, length, width and depth of wrinkles in the region of canthus (outer canthus) 2cmx2cm and forehead 2cmx2cm of each subject, and obtaining wrinkle volume in the region of 2cmx2cm by integration methodN represents the number of wrinkles, a, b, c represents the length, width and depth of the wrinkles, respectively, the two eyes sum up, the volume of the wrinkles before trial is V 0, the test is V 1 when trial is one month, and the test is V 2 when trial is two months.
Trial one month wrinkle improvement rate= (V 0-V1)/V0 ×100%;
Two month wrinkle improvement rate = (V 0-V2)/V0 x 100% was tried.
The moisturizing and anti-wrinkle effects of the anti-wrinkle soothing skin care nanoemulsion are shown in table 2.
TABLE 2 moisturizing and anti-wrinkle effects of anti-wrinkle soothing skin care nanoemulsion
From Table 2, it is shown that the anti-wrinkle and moisturizing effects of the compositions can be further improved by compounding the vitronectin, ergothioneine, ectoine, citrus fruit extract, and flos Hemerocallis extract in comparative examples 1 to 7 and comparative examples 1 to 4. By comparing examples 1-7 with the comparative product, it can be demonstrated that the nanoemulsion formed by combining the efficacy components of vitronectin, ergothioneine, ectoin, citrus fruit extract, and flos mori extract in the form of nanoemulsion, and by using polyoxyethylene castor oil, isopropyl myristate, glycerol, triethanolamine and triethanolamine oleate as oil phases is more beneficial to absorption and efficacy of the efficacy components. The aqueous phase, namely the efficacy components, of the nanoemulsion formed in the examples 1, 6 and 7 are smaller and more stable, and meanwhile, the moisturizing and anti-wrinkle effects are remarkably improved, so that the microemulsion system formed by polyoxyethylene castor oil, isopropyl myristate, glycerol, triethanolamine oleate and water has more uniform particle size, is more beneficial to skin absorption of effective components such as vitriol and the like, and improves the anti-wrinkle and moisturizing effects.
Finally, it should be noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present invention may be modified or substituted equally without departing from the spirit and scope of the technical solution of the present invention.
Claims (2)
1. The anti-wrinkle skin-care nanoemulsion is characterized by comprising an oil phase component and a water phase component;
the oil phase component comprises 4 parts by weight of polyoxyethylene castor oil, 12 parts by weight of isopropyl myristate, 4 parts by weight of glycerol, 1.5 parts by weight of triethanolamine and 1.5 parts by weight of triethanolamine oleate;
The aqueous phase component comprises, by weight, 10-20% of vitriol, 0.3-0.5% of ergothioneine, 5-10% of ectoine, 1-2.5% of citrus fruit extract, 0.5-2% of flos Hemerocallis extract and the balance of water;
The oil phase component and the water phase component are in a volume ratio of 1: (1.5-3) mixing into a nanoemulsion system, wherein the particle size of the nanoemulsion is 33.5-38.2 nm, and the PDI of the nanoemulsion is 0.201-0.215;
The preparation method of the anti-wrinkle, soothing and skin-care nanoemulsion comprises the following steps of:
(1) Mixing polyoxyethylene castor oil, isopropyl myristate, glycerol, triethanolamine and triethanolamine oleate according to weight proportion, heating and stirring at 60 ℃ for dissolving for 200min to obtain an oil phase;
(2) Mixing vitronectin, ergothioneine, escitalopram, citrus fruit extract, flos Hemerocallis extract and water as solvent according to weight ratio, heating at 60deg.C, stirring, and dissolving for 20min to obtain water phase;
(3) Adding the water phase in the step (2) into the oil phase in the step (1), and carrying out heat preservation and stirring to obtain colostrum;
(4) And (3) carrying out ultrahigh-pressure nanometer homogenization on the colostrum ultrahigh-pressure nanometer emulsion, wherein the homogenization pressure is 1000bar, and standing and cooling to obtain the anti-wrinkle and soothing skin care nanometer emulsion.
2. The anti-wrinkle soothing skin care nanoemulsion according to claim 1, wherein the oil phase component and the water phase component are in a volume ratio of 1: (1.8-2.2) and mixing.
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|---|---|---|---|---|
| CN105748408A (en) * | 2014-12-17 | 2016-07-13 | 北京盈科瑞药物研究院有限公司 | Micro-emulsion and micro-emulsion preparation, and preparation methods thereof |
| CN108186503A (en) * | 2018-03-26 | 2018-06-22 | 广东盛美化妆品有限公司 | A kind of whitening emulsion of the extract containing Magnolia binodii and preparation method thereof |
| CN113679628A (en) * | 2021-09-02 | 2021-11-23 | 广州睿森生物科技有限公司 | Skin care composition for comprehensively improving skin problems and application thereof |
| CN116139057A (en) * | 2022-12-30 | 2023-05-23 | 陕西畅想制药有限公司 | Preparation and application of anti-aging composition and cosmetics |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748408A (en) * | 2014-12-17 | 2016-07-13 | 北京盈科瑞药物研究院有限公司 | Micro-emulsion and micro-emulsion preparation, and preparation methods thereof |
| CN108186503A (en) * | 2018-03-26 | 2018-06-22 | 广东盛美化妆品有限公司 | A kind of whitening emulsion of the extract containing Magnolia binodii and preparation method thereof |
| CN113679628A (en) * | 2021-09-02 | 2021-11-23 | 广州睿森生物科技有限公司 | Skin care composition for comprehensively improving skin problems and application thereof |
| CN116139057A (en) * | 2022-12-30 | 2023-05-23 | 陕西畅想制药有限公司 | Preparation and application of anti-aging composition and cosmetics |
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