CN112870101A - Coated sunscreen composition and sunscreen cream composed of same - Google Patents
Coated sunscreen composition and sunscreen cream composed of same Download PDFInfo
- Publication number
- CN112870101A CN112870101A CN202110115783.8A CN202110115783A CN112870101A CN 112870101 A CN112870101 A CN 112870101A CN 202110115783 A CN202110115783 A CN 202110115783A CN 112870101 A CN112870101 A CN 112870101A
- Authority
- CN
- China
- Prior art keywords
- parts
- sunscreen
- coated
- sunscreen composition
- ethylhexyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000516 sunscreening agent Substances 0.000 title claims abstract description 72
- 230000000475 sunscreen effect Effects 0.000 title claims abstract description 59
- 239000000203 mixture Substances 0.000 title claims abstract description 33
- 239000006071 cream Substances 0.000 title claims abstract description 20
- -1 diethyl aminooxybenzoyl hexyl Chemical group 0.000 claims abstract description 18
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims abstract description 13
- 229960001679 octinoxate Drugs 0.000 claims abstract description 13
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 claims abstract description 12
- FDATWRLUYRHCJE-UHFFFAOYSA-N diethylamino hydroxybenzoyl hexyl benzoate Chemical compound CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(N(CC)CC)C=C1O FDATWRLUYRHCJE-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229960001630 diethylamino hydroxybenzoyl hexyl benzoate Drugs 0.000 claims abstract description 7
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 5
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 5
- 239000003974 emollient agent Substances 0.000 claims abstract description 5
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 5
- 239000003906 humectant Substances 0.000 claims abstract description 5
- 239000003755 preservative agent Substances 0.000 claims abstract description 5
- 230000002335 preservative effect Effects 0.000 claims abstract description 5
- 239000002562 thickening agent Substances 0.000 claims abstract description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 13
- 235000011187 glycerol Nutrition 0.000 claims description 11
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 10
- 229960005323 phenoxyethanol Drugs 0.000 claims description 10
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 9
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 9
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 9
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 9
- 229960003415 propylparaben Drugs 0.000 claims description 8
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 7
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 7
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 6
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 6
- OEWBEINAQKIQLZ-CMRBMDBWSA-N [(2s)-2-[(2r)-3,4-bis(2-hexyldecanoyloxy)-5-oxo-2h-furan-2-yl]-2-(2-hexyldecanoyloxy)ethyl] 2-hexyldecanoate Chemical compound CCCCCCCCC(CCCCCC)C(=O)OC[C@H](OC(=O)C(CCCCCC)CCCCCCCC)[C@H]1OC(=O)C(OC(=O)C(CCCCCC)CCCCCCCC)=C1OC(=O)C(CCCCCC)CCCCCCCC OEWBEINAQKIQLZ-CMRBMDBWSA-N 0.000 claims description 6
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 6
- 239000004359 castor oil Substances 0.000 claims description 6
- 235000019438 castor oil Nutrition 0.000 claims description 6
- 229960005150 glycerol Drugs 0.000 claims description 6
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 239000000377 silicon dioxide Substances 0.000 claims description 5
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 4
- ILCOCZBHMDEIAI-UHFFFAOYSA-N 2-(2-octadecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCO ILCOCZBHMDEIAI-UHFFFAOYSA-N 0.000 claims description 4
- ICIDSZQHPUZUHC-UHFFFAOYSA-N 2-octadecoxyethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCO ICIDSZQHPUZUHC-UHFFFAOYSA-N 0.000 claims description 4
- 108020004414 DNA Proteins 0.000 claims description 4
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 235000006708 antioxidants Nutrition 0.000 claims description 4
- 239000000787 lecithin Substances 0.000 claims description 4
- 235000010445 lecithin Nutrition 0.000 claims description 4
- 229940067606 lecithin Drugs 0.000 claims description 4
- 229940098760 steareth-2 Drugs 0.000 claims description 4
- 229940100458 steareth-21 Drugs 0.000 claims description 4
- 229940042585 tocopherol acetate Drugs 0.000 claims description 4
- WTVHAMTYZJGJLJ-UHFFFAOYSA-N (+)-(4S,8R)-8-epi-beta-bisabolol Natural products CC(C)=CCCC(C)C1(O)CCC(C)=CC1 WTVHAMTYZJGJLJ-UHFFFAOYSA-N 0.000 claims description 3
- RGZSQWQPBWRIAQ-CABCVRRESA-N (-)-alpha-Bisabolol Chemical compound CC(C)=CCC[C@](C)(O)[C@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-CABCVRRESA-N 0.000 claims description 3
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 3
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 claims description 3
- IUMSDRXLFWAGNT-UHFFFAOYSA-N Dodecamethylcyclohexasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 IUMSDRXLFWAGNT-UHFFFAOYSA-N 0.000 claims description 3
- RGZSQWQPBWRIAQ-LSDHHAIUSA-N alpha-Bisabolol Natural products CC(C)=CCC[C@@](C)(O)[C@@H]1CCC(C)=CC1 RGZSQWQPBWRIAQ-LSDHHAIUSA-N 0.000 claims description 3
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 3
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 3
- 229940036350 bisabolol Drugs 0.000 claims description 3
- HHGZABIIYIWLGA-UHFFFAOYSA-N bisabolol Natural products CC1CCC(C(C)(O)CCC=C(C)C)CC1 HHGZABIIYIWLGA-UHFFFAOYSA-N 0.000 claims description 3
- 229940099417 ceramide 2 Drugs 0.000 claims description 3
- 229920006037 cross link polymer Polymers 0.000 claims description 3
- 229910003472 fullerene Inorganic materials 0.000 claims description 3
- 229940075529 glyceryl stearate Drugs 0.000 claims description 3
- 239000006166 lysate Substances 0.000 claims description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 3
- 229960002216 methylparaben Drugs 0.000 claims description 3
- 229940049964 oleate Drugs 0.000 claims description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 3
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 3
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229940068968 polysorbate 80 Drugs 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 239000004408 titanium dioxide Substances 0.000 claims description 3
- 229930003799 tocopherol Natural products 0.000 claims description 3
- 235000010384 tocopherol Nutrition 0.000 claims description 3
- 229960001295 tocopherol Drugs 0.000 claims description 3
- 239000011732 tocopherol Substances 0.000 claims description 3
- 239000011787 zinc oxide Substances 0.000 claims description 3
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 3
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 claims description 2
- 108010087806 Carnosine Proteins 0.000 claims description 2
- 102000053602 DNA Human genes 0.000 claims description 2
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 2
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 claims description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 claims description 2
- 229940044199 carnosine Drugs 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 230000003750 conditioning effect Effects 0.000 claims description 2
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 2
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Chemical group OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 claims description 2
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 2
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 2
- 229940102552 disteardimonium hectorite Drugs 0.000 claims description 2
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 229940108325 retinyl palmitate Drugs 0.000 claims description 2
- 235000019172 retinyl palmitate Nutrition 0.000 claims description 2
- 239000011769 retinyl palmitate Substances 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 9
- 238000013329 compounding Methods 0.000 abstract description 7
- UUGLJVMIFJNVFH-UHFFFAOYSA-N Benzoesaeure-n-hexylester Natural products CCCCCCOC(=O)C1=CC=CC=C1 UUGLJVMIFJNVFH-UHFFFAOYSA-N 0.000 abstract description 4
- 239000000126 substance Substances 0.000 description 9
- 238000003756 stirring Methods 0.000 description 8
- 239000002994 raw material Substances 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- AFDXODALSZRGIH-UHFFFAOYSA-N 4-methoxycinnamic acid Chemical class COC1=CC=C(C=CC(O)=O)C=C1 AFDXODALSZRGIH-UHFFFAOYSA-N 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000004945 emulsification Methods 0.000 description 3
- 239000002047 solid lipid nanoparticle Substances 0.000 description 3
- 235000021355 Stearic acid Nutrition 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000011265 semifinished product Substances 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 229960004274 stearic acid Drugs 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 1
- 241000235346 Schizosaccharomyces Species 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960001777 castor oil Drugs 0.000 description 1
- 239000011246 composite particle Substances 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- MSRJTTSHWYDFIU-UHFFFAOYSA-N octyltriethoxysilane Chemical compound CCCCCCCC[Si](OCC)(OCC)OCC MSRJTTSHWYDFIU-UHFFFAOYSA-N 0.000 description 1
- 229960003493 octyltriethoxysilane Drugs 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- QQQSFSZALRVCSZ-UHFFFAOYSA-N triethoxysilane Chemical compound CCO[SiH](OCC)OCC QQQSFSZALRVCSZ-UHFFFAOYSA-N 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4966—Triazines or their condensed derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/411—Aromatic amines, i.e. where the amino group is directly linked to the aromatic nucleus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a coated sunscreen composition which is characterized by comprising the following components in parts by weight: 26-30 parts of ethylhexyl methoxycinnamate; 6-10 parts of diethyl amino hydroxybenzoyl hexyl benzoate; 3-5 parts of ethylhexyl triazone. According to the invention, the coated sunscreen composition is prepared by compounding ethylhexyl methoxycinnamate, diethyl aminooxybenzoyl hexyl benzoate and ethylhexyl triazone according to specific weight parts, so that the photostability and the ultraviolet absorption capability are obviously improved, the coated sunscreen composition is added into a sunscreen cream formula and is compounded with a certain content of an emollient containing DNA, an emulsifier, a thickener, a common sunscreen agent, a skin conditioner, a humectant, a preservative and an antioxidant, and the SPF value and PA value of the prepared sunscreen cream are obviously improved, and the sunscreen cream has a biological sunscreen effect.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a coated sunscreen composition and sunscreen cream composed of the same.
Background
Sunscreen has been a topic of concern in the cosmetic field, and the stability, safety and effectiveness of sunscreen agents are issues that must be addressed. The sunscreens commonly used are mainly chemical sunscreens and physical sunscreens by mechanism. The chemical sun-screening agent can absorb ultraviolet rays to convert the ultraviolet rays into energy to release the energy so as to achieve the sun-screening effect; physical sunscreens are those which block ultraviolet light by reflection to achieve a sunscreen effect. The chemical sunscreen agents are further classified into UVA (320-400 nm) and UVB ultraviolet absorbers (290-320 nm) according to the different ultraviolet absorption bands. Most chemical sunscreens are rejected by the public because they are unstable and irritating to the skin. By coating the sun-screening agent with the solid lipid nanoparticles, the stability of the sun-screening agent can be improved, the irritation can be reduced, the sun-screening effect can be enhanced, and the sun-screening time can be prolonged.
The common emulsification method is more studied on the preparation of the solid lipid nanoparticles coated with the sun-screening agent. The common emulsification method is simple to operate, but the prepared sample is not uniformly dispersed, the dispersion coefficient is large, agglomeration is easy to occur in the storage process, and the centrifugal stability is poor.
Currently, many studies on coated solid lipid nanoparticles exist, for example, chinese patent CN102488630A discloses polysiloxane composite particles coated with a chemical sunscreen agent formed from p-methoxycinnamates, in which the chemical sunscreen agent formed from p-methoxycinnamates is coated in polysiloxane particles, thereby avoiding direct contact with skin, greatly reducing irritation of the chemical sunscreen agent formed from p-methoxycinnamates to skin, and embodying a better sunscreen effect. However, the method is only limited to research on chemical sunscreen agents formed by coating single methoxycinnamate, and the photostability and the ultraviolet absorption capacity of the chemical sunscreen agents still cannot achieve the effect of high-efficiency sunscreen.
However, no relevant report has been found on the research on the remarkable improvement of the photostability and the ultraviolet absorption capability of the coated sunscreen composition obtained by compounding ethylhexyl methoxycinnamate, hexyl diethylaminobenzoyl benzoate and ethylhexyl triazone according to the specific compounding weight parts.
Disclosure of Invention
In order to solve the above technical problems, the primary object of the present invention is to provide a coated sunscreen composition having significantly improved photostability and uv absorption.
It is still another object of the present invention to provide a sunscreen cream containing the above-mentioned coated sunscreen composition, which has significantly improved SPF and PA values and biological sunscreen effect.
The invention relates to a coated sunscreen composition which comprises the following components in parts by weight:
26-30 parts of ethylhexyl methoxycinnamate;
6-10 parts of diethyl amino hydroxybenzoyl hexyl benzoate;
3-5 parts of ethylhexyl triazone.
Preferably, the coated sunscreen composition comprises the following components in parts by weight:
28 parts of ethylhexyl methoxycinnamate;
8 parts of diethylamino hydroxybenzoyl hexyl benzoate;
4 parts of ethylhexyl triazone.
The coating sun-screening composition further comprises the following components in parts by weight: 5.5-7.5 parts of glycerol stearate, 214-6 parts of steareth-214, 21-3 parts of steareth-3, 4-6 parts of glycerol, 1-3 parts of hydrogenated castor oil, 0.5-0.7 part of phenoxyethanol, 0.1-0.3 part of methyl hydroxybenzoate, 0.05-0.15 part of propyl hydroxybenzoate and 36-40 parts of water.
The invention also discloses a preparation method of the coated sunscreen composition, which comprises the following steps:
firstly, ethylhexyl methoxycinnamate, diethylamino hydroxybenzoyl hexyl benzoate, ethylhexyl triazone, glyceryl stearate, steareth-21, steareth-2, glycerol, hydrogenated castor oil, phenoxyethanol, methyl hydroxybenzoate and propyl hydroxybenzoate are stirred and mixed uniformly to obtain a mixture; then, while homogenizing the water, adding the mixture into the water, controlling the homogenizing speed to 2800-.
The invention also discloses a sunscreen cream coated with the sunscreen composition.
The invention discloses a sunscreen cream which comprises the following components in parts by weight:
wherein the emollient is selected from one or more of cyclopentadimethylsiloxane, cyclohexasiloxane, polydimethylsiloxane cross-linked polymer, butanediol, 1, 2-pentanediol, caprylic/capric triglyceride, tocopherol, ascorbyl tetraisopalmitate and deoxyribonucleic acid; the thickening agent is one or more selected from disteardimonium hectorite, sodium chloride, fullerene and polyvinylpyrrolidone.
Wherein the common sun-screening agent is selected from one or more of titanium dioxide, silica, aluminum hydroxide, hydrogenated polydimethylsiloxane, triethoxysilane and zinc oxide.
Wherein the skin conditioning agent is selected from one or more of silica, dipotassium glycyrrhizinate, lecithin, tocopherol acetate, medium alumina retinol, ascorbyl tetraisopalmitate, caprylic/capric triglyceride, phytosterol oleate, octyldodecanol, glycerin, polysorbate-80, ceramide 2, stearic acid, bisabolol, and split yeast ferment lysate.
Wherein, the emulsifier is selected from one or more of PEG-10 polydimethylsiloxane.
Wherein the humectant is selected from one or more of butanediol, glycerol and carnosine.
Wherein the preservative is selected from one or more of methylparaben and phenoxyethanol; the antioxidant is selected from one or more of tocopherol acetate.
Compared with the prior art, the invention has the following beneficial effects:
according to the invention, the coated sunscreen composition is prepared by compounding ethylhexyl methoxycinnamate, diethyl aminooxybenzoyl hexyl benzoate and ethylhexyl triazone according to specific weight parts, so that the photostability and the ultraviolet absorption capability are obviously improved, the coated sunscreen composition is added into a sunscreen cream formula and is compounded with a certain content of an emollient containing DNA, an emulsifier, a thickener, a common sunscreen agent, a skin conditioner, a humectant, a preservative and an antioxidant, the SPF value and the PA value of the prepared sunscreen cream are obviously improved, and the sunscreen cream has a biological sunscreen effect and has triple effects of absorption, reflection and scattering.
Detailed Description
The present invention is further illustrated by the following specific embodiments, but the embodiments of the present invention are not limited by the following examples.
The raw materials used in the examples of the present invention and the comparative examples were commercially available.
Test methods or standards for each property:
the testing method of the light stability comprises the following steps: zetasizer Nano ZS type nanometer particle analyzer, test conditions: 0.1% aqueous solution.
Test method of ultraviolet absorption capacity: the sunscreen cream is diluted by 10 times, and the ultraviolet absorption capacity is tested by a lighting experiment.
Test method of SPF value: UV-2000S and Atlas Instrument testing.
PA value test method: UV-2000S and Atlas Instrument testing.
Evaluation method of biological sunscreen efficacy: MED assay.
Examples A1-A3 and comparative examples B1-B8: preparation of coated sunscreen compositions
According to the mixture ratio shown in the table 1, ethylhexyl methoxycinnamate, diethyl aminooxybenzoyl hexyl benzoate, ethylhexyl triazone, glycerol stearate, steareth-21, steareth-2, glycerol, hydrogenated castor oil, phenoxyethanol, methyl hydroxybenzoate and propyl hydroxybenzoate are stirred and mixed uniformly to obtain a mixture; then, adding the mixture into water while homogenizing the water, continuing homogenizing for 3min at the homogenizing speed of 3000r/min, and then stirring and cooling to room temperature at the stirring speed of 3000r/min to obtain the coated sunscreen composition.
TABLE 1 proportions (parts by weight) of the components of examples A1-A3 and comparative examples B1-B8
Examples 1 to 3 and comparative examples 1 to 6: preparation of sunscreen cream
1) Adding the raw materials of phase A [ 1,2, 3, 4, 5, 6, 7 and 8 ] into a main pot according to the formula of the table 2, stirring and dispersing uniformly, and homogenizing for 5 min;
2) adding the raw materials of the phase B (9, 10, 11, 12, 13 and 14) into a side pan, stirring and dispersing, heating to 85 ℃, preserving heat for 20-30min, and cooling to below 40 ℃;
3) stirring the phase B [ 9, 10, 11, 12, 13, 14 ], sequentially adding the phase C [ 15, 16, 17, 18, 19, 20 ] raw materials into a side pot, and uniformly stirring and dispersing;
4) slowly adding the raw materials (B + C phase) in the side pan into the main pan, stirring and dispersing uniformly, slowly homogenizing for 3-5min, and keeping the temperature at 25-30 deg.C;
5) adding the raw materials of phase D [ 21, 22, 23 ] into a main pot, and stirring until the system is uniform;
6) self-checking the plate, and discharging after the plate is qualified; storing the semi-finished product and reporting for inspection; and (5) checking the semi-finished product to be qualified, and filling to obtain the sunscreen cream.
Wherein, the component 1 is compounded by cyclopentadidimethyl siloxane and cyclohexasiloxane;
the component 4 is compounded by polydimethylsiloxane and polydimethylsiloxane cross-linked polymer;
the component 6 is compounded by titanium dioxide, silica, aluminum hydroxide and hydrogenated polydimethylsiloxane. The component 7 is compounded by triethoxyoctylsilane and zinc oxide;
the component 15 is prepared by compounding fullerene, polyvinylpyrrolidone, butanediol and water;
the component 17 is prepared by compounding deoxyribonucleic acid DNA, ascorbyl tetraisopalmitate, tocopherol (vitamin E), caprylic/capric triglyceride, 1, 2-pentanediol, butanediol and water;
the component 18 is prepared by compounding propyl hydroxybenzoate, methyl hydroxybenzoate, phenoxyethanol, caprylic/capric triglyceride, ascorbyl tetraisopalmitate, retinol palmitate, tocopherol acetate, lecithin and water;
the component 19 is prepared by EDTA disodium, propyl hydroxybenzoate, methyl hydroxybenzoate, phenoxyethanol, schizosaccharomyces cerevisiae fermentation product lysate, bisabolol, stearic acid, ceramide 2, polysorbate-80, caprylic/capric triglyceride, glycerol, octyldodecanol, tocopheryl acetate, phytosterol oleate, lecithin and water.
TABLE 2 concrete formulation of sunscreen cream
TABLE 3
Wherein, the component 20 in the sunscreen cream formula of the comparative example 6 is a sunscreen agent prepared by normal emulsification, and the specific preparation method comprises the following steps: according to the mixture ratio of table 1, ethylhexyl methoxycinnamate, diethyl aminooxybenzoyl hexyl benzoate, ethylhexyl triazone, glyceryl stearate, steareth-21, steareth-2, glycerol, hydrogenated castor oil, phenoxyethanol, methylparaben, propylparaben and water are normally emulsified to obtain the normally emulsified sunscreen agent.
Claims (10)
1. The coated sunscreen composition is characterized by comprising the following components in parts by weight:
26-30 parts of ethylhexyl methoxycinnamate;
6-10 parts of diethyl amino hydroxybenzoyl hexyl benzoate;
3-5 parts of ethylhexyl triazone.
2. A coated sunscreen composition according to claim 1 comprising, in parts by weight:
28 parts of ethylhexyl methoxycinnamate;
8 parts of diethylamino hydroxybenzoyl hexyl benzoate;
4 parts of ethylhexyl triazone.
3. A coated sunscreen composition according to claim 1 or 2 further comprising the following components in parts by weight: 5.5-7.5 parts of glycerol stearate, 214-6 parts of steareth-214, 21-3 parts of steareth-3, 4-6 parts of glycerol, 1-3 parts of hydrogenated castor oil, 0.5-0.7 part of phenoxyethanol, 0.1-0.3 part of methyl hydroxybenzoate, 0.05-0.15 part of propyl hydroxybenzoate and 36-40 parts of water.
4. A process for the preparation of a coated sunscreen composition according to any of claims 1 to 3 comprising the steps of:
firstly, ethylhexyl methoxycinnamate, diethylamino hydroxybenzoyl hexyl benzoate, ethylhexyl triazone, glyceryl stearate, steareth-21, steareth-2, glycerol, hydrogenated castor oil, phenoxyethanol, methyl hydroxybenzoate and propyl hydroxybenzoate are stirred and mixed uniformly to obtain a mixture; then, while homogenizing the water, adding the mixture into the water, controlling the homogenizing speed to 2800-.
5. A sunscreen comprising the encapsulated sunscreen composition of any of claims 1-4.
6. The sunscreen cream according to claim 5, characterized by comprising the following components in parts by weight:
26-34 parts of the coated sunscreen composition of any of the above claims 1-4;
30-35 parts of an emollient;
2-2.5 parts of an emulsifier;
0.2-0.5 part of thickening agent;
6-10 parts of common sun-screening agent;
2-3 parts of a skin conditioner;
2-2.5 parts of a humectant;
0.3-0.7 part of preservative;
0.3-0.7 part of antioxidant;
16-18 parts of water.
7. The sunscreen cream as claimed in claim 6, wherein said emollient is selected from one or more of cyclopentadimethylsiloxane, cyclohexasiloxane, polydimethylsiloxane crosspolymer, butylene glycol, 1,2 pentanediol, caprylic/capric triglyceride, tocopherol, ascorbyl tetraisopalmitate, deoxyribonucleic acid; the thickening agent is one or more selected from disteardimonium hectorite, sodium chloride, fullerene, polyvinylpyrrolidone and butanediol.
8. The sunscreen cream as claimed in claim 6, wherein the common sunscreen agent is one or more selected from titanium dioxide, silica, aluminum hydroxide, hydrogenated polydimethylsiloxane, triethoxy siloxane and zinc oxide.
9. The sunscreen of claim 6 wherein said skin conditioning agent is selected from one or more of silica, dipotassium glycyrrhizinate, lecithin, tocopheryl acetate, retinol palmitate, ascorbyl tetraisopalmitate, caprylic/capric triglyceride, phytosterol oleate, octyldodecanol, glycerin, polysorbate-80, ceramide 2, hardates, cracked yeast diligen lysate, disodium EDTA, bisabolol.
10. Sunscreen according to claim 6, characterized in that said emulsifier is selected from PEG-10 polydimethylsiloxane; the humectant is selected from one or more of butanediol, glycerol and carnosine; the preservative is selected from one or more of methylparaben and phenoxyethanol; the antioxidant is selected from tocopherol acetate.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114469806A (en) * | 2022-01-27 | 2022-05-13 | 露乐健康科技股份有限公司 | Composition for relieving after-sun skin and application thereof |
| CN115670983A (en) * | 2022-11-25 | 2023-02-03 | 广州远想生物科技股份有限公司 | Sunscreen composition, sunscreen cream containing sunscreen composition and preparation method of sunscreen cream |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109010087A (en) * | 2018-09-16 | 2018-12-18 | 韩后化妆品股份有限公司 | A kind of efficient sunscreen composition with cooling effect |
| CN110279605A (en) * | 2019-07-29 | 2019-09-27 | 西安博和医疗科技有限公司 | Sunscreen composition |
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- 2021-01-28 CN CN202110115783.8A patent/CN112870101A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010087A (en) * | 2018-09-16 | 2018-12-18 | 韩后化妆品股份有限公司 | A kind of efficient sunscreen composition with cooling effect |
| CN110279605A (en) * | 2019-07-29 | 2019-09-27 | 西安博和医疗科技有限公司 | Sunscreen composition |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114469806A (en) * | 2022-01-27 | 2022-05-13 | 露乐健康科技股份有限公司 | Composition for relieving after-sun skin and application thereof |
| CN114469806B (en) * | 2022-01-27 | 2023-12-19 | 露乐健康科技股份有限公司 | Composition for relieving skin after sun drying and application thereof |
| CN115670983A (en) * | 2022-11-25 | 2023-02-03 | 广州远想生物科技股份有限公司 | Sunscreen composition, sunscreen cream containing sunscreen composition and preparation method of sunscreen cream |
| CN115670983B (en) * | 2022-11-25 | 2024-03-12 | 广州远想生物科技股份有限公司 | Sun-screening composition, sun-screening cream containing same and preparation method thereof |
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