CN114432423A - 用于治疗疾病和病症的NFkB活性的抑制剂 - Google Patents

用于治疗疾病和病症的NFkB活性的抑制剂 Download PDF

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Publication number
CN114432423A
CN114432423A CN202111512016.7A CN202111512016A CN114432423A CN 114432423 A CN114432423 A CN 114432423A CN 202111512016 A CN202111512016 A CN 202111512016A CN 114432423 A CN114432423 A CN 114432423A
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拉金德拉·萨哈伊·巴特纳格尔
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202111512016.7A 2014-09-26 2015-09-25 用于治疗疾病和病症的NFkB活性的抑制剂 Pending CN114432423A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462055982P 2014-09-26 2014-09-26
US62/055,982 2014-09-26
CN201580064157.3A CN106999535B (zh) 2014-09-26 2015-09-25 用于治疗疾病和病症的NFκB活性的抑制剂
PCT/US2015/052467 WO2016049580A2 (en) 2014-09-26 2015-09-25 Inhibitors of nf kappa-b activity for treatment of diseases and disorders

Related Parent Applications (1)

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CN201580064157.3A Division CN106999535B (zh) 2014-09-26 2015-09-25 用于治疗疾病和病症的NFκB活性的抑制剂

Publications (1)

Publication Number Publication Date
CN114432423A true CN114432423A (zh) 2022-05-06

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CN202111512016.7A Pending CN114432423A (zh) 2014-09-26 2015-09-25 用于治疗疾病和病症的NFkB活性的抑制剂
CN201580064157.3A Active CN106999535B (zh) 2014-09-26 2015-09-25 用于治疗疾病和病症的NFκB活性的抑制剂

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Country Status (7)

Country Link
US (5) US10030048B2 (https=)
EP (1) EP3197474B1 (https=)
JP (3) JP6851965B2 (https=)
CN (2) CN114432423A (https=)
AU (2) AU2015320341B2 (https=)
CA (1) CA2999711A1 (https=)
WO (1) WO2016049580A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114432423A (zh) 2014-09-26 2022-05-06 拉金德拉·萨哈伊·巴特纳格尔 用于治疗疾病和病症的NFkB活性的抑制剂
US9943566B2 (en) 2016-03-16 2018-04-17 Geoffrey Brooks Consultants, Llc NF-κB inhibitor composition for skin health
CA3191058A1 (en) * 2020-08-28 2022-03-03 Rajendra Sahai Bhatnagar Peptide inhibitors of nf kappa b and use thereof in treatment of covid-19 and inflammatory diseases

Citations (5)

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US5661127A (en) * 1995-05-01 1997-08-26 The Regents Of The University Of California Peptide compositions with growth factor-like activity
CN1233171A (zh) * 1996-09-05 1999-10-27 研究发展基金会 用咖啡酸苯乙酯(CAPE)、CAPE的衍生物、辣椒素(8－甲基－N－香兰基－6－壬烯酰胺)和树脂毒素来抑制核转录因子NF－κB
WO2002026935A2 (en) * 2000-09-29 2002-04-04 The Regents Of The University Of California TGF-β INHIBITORS AND METHODS
US20060293228A1 (en) * 2005-06-24 2006-12-28 Bhatnagar Rajendra S Therapeutic compositions and methods using transforming growth factor-beta mimics
US20120064099A1 (en) * 2008-10-30 2012-03-15 The Trustees Of Columbia University In The City Of New York Compounds that inhibit nfkb and bace1 activity

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US5354736A (en) 1989-08-14 1994-10-11 Regents Of The University Of California Synthetic compounds and compositions with enhanced cell binding
US5674848A (en) 1989-08-14 1997-10-07 The Regents Of The University Of California Bioreactor compositions with enhanced cell binding
US5635482A (en) 1989-08-14 1997-06-03 The Regents Of The University Of California Synthetic compounds and compositions with enhanced cell binding
WO1991002537A1 (en) 1989-08-14 1991-03-07 The Regents Of The University Of California Synthetic peptides that enhance cell binding
AU1404395A (en) * 1993-12-13 1995-07-03 Biogen, Inc. Anti-mullerian hormone receptor polypeptides and antibodies thereto
US6638912B2 (en) 1995-05-01 2003-10-28 The Regents Of The University Of California Peptide compositions mimicking TGF-β activity
US5780436A (en) 1995-05-01 1998-07-14 The Regents Of The University Of California Peptide compositions with growth factor-like activity
US6197586B1 (en) 1997-12-12 2001-03-06 The Regents Of The University Of California Chondrocyte-like cells useful for tissue engineering and methods
US6864355B1 (en) 2000-05-02 2005-03-08 Yale University Inhibition of NF-κB activation by blockade of IKKβ-NEMO interactions at the NEMO binding domain
DE19951360A1 (de) * 1999-10-26 2001-05-03 Aventis Pharma Gmbh Substituierte Indole
WO2001082773A2 (en) 2000-04-28 2001-11-08 The Regents Of The University Of California Structures useful for bone engineering and methods
AUPR279101A0 (en) * 2001-01-30 2001-02-22 Cytopia Pty Ltd Protein kinase signalling
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CN114432423A (zh) 2014-09-26 2022-05-06 拉金德拉·萨哈伊·巴特纳格尔 用于治疗疾病和病症的NFkB活性的抑制剂
US9943566B2 (en) 2016-03-16 2018-04-17 Geoffrey Brooks Consultants, Llc NF-κB inhibitor composition for skin health
DE202018003082U1 (de) 2018-07-03 2019-10-07 Ergon International Gmbh Fahrradsattel
CA3191058A1 (en) 2020-08-28 2022-03-03 Rajendra Sahai Bhatnagar Peptide inhibitors of nf kappa b and use thereof in treatment of covid-19 and inflammatory diseases

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* Cited by examiner, † Cited by third party
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US5661127A (en) * 1995-05-01 1997-08-26 The Regents Of The University Of California Peptide compositions with growth factor-like activity
CN1233171A (zh) * 1996-09-05 1999-10-27 研究发展基金会 用咖啡酸苯乙酯(CAPE)、CAPE的衍生物、辣椒素(8－甲基－N－香兰基－6－壬烯酰胺)和树脂毒素来抑制核转录因子NF－κB
WO2002026935A2 (en) * 2000-09-29 2002-04-04 The Regents Of The University Of California TGF-β INHIBITORS AND METHODS
US20030083265A1 (en) * 2000-09-29 2003-05-01 Bhatnagar Rajendra S. TGF-beta inhibitors and methods
US20060293228A1 (en) * 2005-06-24 2006-12-28 Bhatnagar Rajendra S Therapeutic compositions and methods using transforming growth factor-beta mimics
US20120064099A1 (en) * 2008-10-30 2012-03-15 The Trustees Of Columbia University In The City Of New York Compounds that inhibit nfkb and bace1 activity

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Publication number Publication date
US20170051012A1 (en) 2017-02-23
CN106999535B (zh) 2021-12-21
US10030048B2 (en) 2018-07-24
JP2018500274A (ja) 2018-01-11
JP2023010979A (ja) 2023-01-20
JP6851965B2 (ja) 2021-03-31
JP2021091728A (ja) 2021-06-17
AU2021221579B2 (en) 2025-01-23
US20240083941A1 (en) 2024-03-14
EP3197474A4 (en) 2018-08-22
WO2016049580A3 (en) 2016-05-19
CN106999535A (zh) 2017-08-01
US20260015386A1 (en) 2026-01-15
AU2021221579A1 (en) 2021-09-16
EP3197474C0 (en) 2023-06-07
EP3197474A2 (en) 2017-08-02
US12325760B2 (en) 2025-06-10
US11773135B2 (en) 2023-10-03
US11174286B2 (en) 2021-11-16
JP7184946B2 (ja) 2022-12-06
US20220106359A1 (en) 2022-04-07
WO2016049580A2 (en) 2016-03-31
CA2999711A1 (en) 2016-03-31
US20180298055A1 (en) 2018-10-18
AU2015320341A1 (en) 2017-05-04
EP3197474B1 (en) 2023-06-07
AU2015320341B2 (en) 2021-05-27

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