CN114401724A - 一种降糖药物组合物 - Google Patents
一种降糖药物组合物 Download PDFInfo
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- CN114401724A CN114401724A CN202080066833.1A CN202080066833A CN114401724A CN 114401724 A CN114401724 A CN 114401724A CN 202080066833 A CN202080066833 A CN 202080066833A CN 114401724 A CN114401724 A CN 114401724A
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- pharmaceutically acceptable
- acceptable salt
- compound
- metformin
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- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Abstract
一种化合物A（结构式如下式I）和/或其药学上可接受的盐与二甲双胍和/或其药学上可接受的盐的降糖药物组合物，该药物组合物可以实现降糖协同作用。
Description
PCT国内申请，说明书已公开。
Claims (12)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019109232613 | 2019-09-27 | ||
| CN201910923261 | 2019-09-27 | ||
| PCT/CN2020/116525 WO2021057661A1 (zh) | 2019-09-27 | 2020-09-21 | 一种降糖药物组合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114401724A true CN114401724A (zh) | 2022-04-26 |
Family
ID=75165608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080066833.1A Pending CN114401724A (zh) | 2019-09-27 | 2020-09-21 | 一种降糖药物组合物 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN114401724A (zh) |
| WO (1) | WO2021057661A1 (zh) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101904840A (zh) * | 2009-06-08 | 2010-12-08 | 江苏恒瑞医药股份有限公司 | 治疗哺乳动物包括人2型糖尿病的药物组合物 |
| CN102791701A (zh) * | 2009-12-30 | 2012-11-21 | 上海复尚慧创医药研究有限公司 | 作为二肽基肽酶iv(dpp-iv)抑制剂的3-(3-氨基哌啶-1-基)-5-氧代-1,2,4-三嗪衍生物 |
| US20180116911A1 (en) * | 2016-05-05 | 2018-05-03 | Triastek, Inc. | Controlled release dosage form |
| CN108578419A (zh) * | 2018-07-27 | 2018-09-28 | 深圳市泛谷药业股份有限公司 | 一种人参皂苷Rg1和二甲双胍的降糖药物组合物 |
| CN109692164A (zh) * | 2017-10-20 | 2019-04-30 | 深圳信立泰药业股份有限公司 | 化合物a或其盐的药物组合物及其制备方法 |
| CN113423404A (zh) * | 2019-12-02 | 2021-09-21 | 成都苑东生物制药股份有限公司 | 一种黄嘌呤衍生物药物组合物及其制备方法 |
-
2020
- 2020-09-21 CN CN202080066833.1A patent/CN114401724A/zh active Pending
- 2020-09-21 WO PCT/CN2020/116525 patent/WO2021057661A1/zh active Application Filing
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101904840A (zh) * | 2009-06-08 | 2010-12-08 | 江苏恒瑞医药股份有限公司 | 治疗哺乳动物包括人2型糖尿病的药物组合物 |
| CN102791701A (zh) * | 2009-12-30 | 2012-11-21 | 上海复尚慧创医药研究有限公司 | 作为二肽基肽酶iv(dpp-iv)抑制剂的3-(3-氨基哌啶-1-基)-5-氧代-1,2,4-三嗪衍生物 |
| CN103664873A (zh) * | 2009-12-30 | 2014-03-26 | 深圳信立泰药业股份有限公司 | 作为二肽基肽酶iv(dpp-iv)抑制剂的3-(3-氨基哌啶-1-基)-5-氧代-1,2,4-三嗪衍生物 |
| US20180116911A1 (en) * | 2016-05-05 | 2018-05-03 | Triastek, Inc. | Controlled release dosage form |
| CN109692164A (zh) * | 2017-10-20 | 2019-04-30 | 深圳信立泰药业股份有限公司 | 化合物a或其盐的药物组合物及其制备方法 |
| CN108578419A (zh) * | 2018-07-27 | 2018-09-28 | 深圳市泛谷药业股份有限公司 | 一种人参皂苷Rg1和二甲双胍的降糖药物组合物 |
| CN113423404A (zh) * | 2019-12-02 | 2021-09-21 | 成都苑东生物制药股份有限公司 | 一种黄嘌呤衍生物药物组合物及其制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| YANHUA DING，等: "Safety and pharmacokinetic interaction between fotagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin in healthy subjects", EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, vol. 17, no. 06, pages 725 - 731 * |
| 杨文明: "二肽基肽酶-4（DPP-4）抑制剂沙格列汀联合二甲双胍对T2DM的疗效及其对胰岛β细胞功能的影响", 临床医药文献杂志, vol. 05, no. 101 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021057661A1 (zh) | 2021-04-01 |
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