CN114392263B - Liquiritigenin hair-loss preventing and hair-growing composition and preparation method thereof - Google Patents

Liquiritigenin hair-loss preventing and hair-growing composition and preparation method thereof Download PDF

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CN114392263B
CN114392263B CN202111567356.XA CN202111567356A CN114392263B CN 114392263 B CN114392263 B CN 114392263B CN 202111567356 A CN202111567356 A CN 202111567356A CN 114392263 B CN114392263 B CN 114392263B
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hair
liquiritin
glycyrrhizin
hair loss
deionized water
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CN114392263A (en
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陈凯
魏元刚
范兴勇
金显友
杨永安
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Elionnature Biotechnology Co ltd
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    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
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    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia

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Abstract

The application discloses a glycyrrhizin anti-hair loss and hair-growing composition and a preparation method thereof. The prepared glycyrrhizin anti-hair loss composition has good efficacy through the synergistic effect of the glycyrrhizin and the shikonin, has the efficacy of repairing hair follicles and maintaining scalp besides anti-hair loss, and has high product safety and less side effect. The preparation method is simple, does not need complex instruments and equipment, has lower preparation cost and is easy to popularize.

Description

Liquiritigenin hair-loss preventing and hair-growing composition and preparation method thereof
Technical Field
The application relates to the field of hair care preparations, in particular to a novel glycyrrhizin anti-hair loss hair care composition and a preparation method thereof.
Background
Alopecia is a common phenomenon that afflicts modern people. Modern people have fast life rhythm, large working pressure and serious insomnia phenomenon, and alopecia is not a special problem for the old. In addition, pollution of the air environment, residue of daily necessities on the scalp, damage of scalp hair follicles, seborrheic alopecia, and the like are all main causes of the expansion of the population suffering from alopecia except inheritance.
The sallow glycyrrhizin anti-hair loss composition product, namely the fish dragon, is mixed, and a few sprays are only conceptual products and lack actual curative effects. The spray taking minoxidil and other medicines with practical and scientific basis as main efficacy components has single efficacy, can only treat seborrheic alopecia, and has the problems of easy aggravation of alopecia, scalp itching, easy generation of medicine dependence and the like in the early stage of use.
Disclosure of Invention
The application aims to: the application provides a glycyrrhizin anti-hair loss and hair-growing composition and a preparation method thereof, and the prepared glycyrrhizin anti-hair loss and hair-growing composition has good effects, has the effects of repairing hair follicles and maintaining scalp besides anti-hair loss, and is high in product safety and less in side effect.
The technical scheme is as follows: in order to solve the technical problems, the application adopts the following technical scheme: the anti-hair loss and hair-growing composition containing the liquiritin comprises the following preparation raw materials in parts by weight: 0.5 to 3 percent of glycyrrhizin, 0.1 to 0.3 percent of shikonin, 0.5 to 0.8 percent of PEG-60 hydrogenated castor oil, 0.1 to 0.5 percent of 1, 2-hexanediol, 0.1 to 0.5 percent of p-hydroxyacetophenone, 0.05 to 0.2 percent of ethylhexyl glycerol, 0.05 to 0.3 percent of green tea essence and the balance of deionized water.
Further, the weight ratio of the liquiritin is 1%, and the shikonin is 0.1%.
Furthermore, the purity of the liquiritin is more than or equal to 99.9%, and the purity of the shikonin is more than or equal to 95%.
Further, the deionized water has a conductivity of less than 20 μs/cm, a resistivity of greater than 1MΩ & cm, and a hardness (CaCO) 3 Calculated as) is less than 5ppm.
Furthermore, the preparation raw materials are all cosmetic grade or analytical grade.
The application also discloses a preparation method of the glycyrrhizin anti-hair loss and hair-care composition, which comprises the following steps: adding glycyrrhizin, shikonin, PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone, ethylhexyl glycerol and deionized water into a container, dissolving the glycyrrhizin in a certain proportion, heating to 55-60 ℃ under stirring, preserving heat for more than 1h, then closing heating, cooling to 40-45 ℃ under stirring, adding green tea essence, supplementing evaporated deionized water, and stirring for more than 20min to ensure that the system is uniform, thus obtaining the glycyrrhizin anti-hair loss hair-growing composition.
Furthermore, the adding sequence of the liquiritin, the shikonin, the PEG-60 hydrogenated castor oil, the 1, 2-hexanediol, the p-hydroxyacetophenone, the ethylhexyl glycerol and the deionized water is as follows: adding deionized water, PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone and ethylhexyl glycerol, and adding shikonin and liquiritin after the materials are completely dissolved in the deionized water.
Furthermore, the glycyrrhizin and shikonin are added into deionized water for a plurality of times in a small amount after PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone and ethylhexyl glycerin are completely dissolved in the deionized water.
Furthermore, the heating temperature can be increased only after the dissolution amount of the liquiritin and the shikonin in the system is more than or equal to 80 percent.
Furthermore, the stirring is performed by a magnetic stirrer, and the stirring speed is more than or equal to 1000rpm.
The glycyrrhizin is called as mono glucuronic acid glycyrrhetinic acid, is an extract of liquorice, has strong function of inhibiting testosterone 5-alpha reductase as an active ingredient of new generation liquorice, and can be used for treating seborrheic alopecia. At the same time, it can also act as an antidote and contact external contaminants with the scalp. Besides, the anti-inflammatory repairing function can also improve scalp inflammation and allergic symptoms and help to prevent alopecia.
The glycyrrhizin plays an anti-inflammatory role by inhibiting NF-kappa B p65 and IκBα degradation and phosphorylating IKB and ERK protein expression, repairing scalp skin and hair follicle, strengthening hair root nutrition, and inhibiting hair loss caused by hair follicle atrophy; the glycyrrhizin also has strong 5-alpha reductase inhibition effect, the 5-alpha reductase can convert testosterone in human body into Dihydrotestosterone (DHT), the DHT can shrink hair follicle, hair is thinned, the growth cycle of hair is shortened, and the hair is shed, namely androgenetic alopecia (seborrheic alopecia), so that the glycyrrhizin has the effect of inhibiting seborrheic alopecia; in addition, the glycyrrhizin can be used as a neutralizing agent to convert micromolecular glucuronic acid generated by the conversion to neutralize external pollution components (free radicals, heavy metals and Volatile Organic Compounds (VOCs)) contacted with the hair and the scalp, so that the irritation of the external pollution components to the scalp and scalp hair follicles is relieved, and a healthy growth environment is brought to the hair.
The lithospermum has the effects of activating blood, detoxifying and repairing, and the high-purity shikonin extracted from the lithospermum root has high safety and good repairing effect, and can effectively repair damaged hair follicles and promote hair growth. In addition, shikonin has the characteristics of natural resistance to inflammation and epidermis repair, has a certain antioxidant activity, is safe to use and has a good effect. Has effects of diminishing inflammation, stopping bleeding, promoting skin regeneration, and can rapidly penetrate into skin and promote wound healing. The action mechanism is that shikonin can inhibit macrophage from releasing inflammatory medium TNF-alpha, inhibit macrophage NF-kappa Bp65 from transferring from cytoplasm to nucleus, increase I-kappa B alpha and ubiquitination protein expression quantity in macrophage, besides, shikonin can induce apoptosis cell and necrosis cell death, quicken metabolism. The hair cream is applied to the scalp, has obvious repairing effect on the scalp and scalp hair follicles, relieves the skin of the head, avoids scalp inflammation caused by bacterial and fungal infection and excessive sebum, and has good anti-drop effect.
The two functional components are compounded, so that the mechanism of preventing hair loss and growing hair is diversified, and a better effect of preventing hair loss and growing hair is achieved.
The beneficial effects are that: compared with the prior art, the application has the following advantages:
(1) The prepared glycyrrhizin anti-hair loss hair-growing composition has good effects, can repair hair follicles and care scalp besides anti-hair loss, and is high in product safety and less in side effect.
(2) The shikonin is a less stable substance, by virtue of the preparation method, the stability of the shikonin can be increased, and the glycyrrhizin anti-hair loss hair-growing composition can be preserved for a long time.
Detailed Description
The application is further illustrated by the following examples:
the purity of the glycyrrhizin used in the examples and the comparative examples is more than or equal to 99.9%, and the purity of shikonin is more than or equal to 95%; the conductivity of deionized water is less than 20 mu s/cm, the resistivity is more than 1MΩ & cm, and the hardness (CaCO is used) 3 Calculated as) is less than 5ppm. Other preparation raw materials are cosmetic grade or analytical grade.
Example 1:
the anti-hair loss and hair-growing composition containing the liquiritin comprises the following components in percentage by weight: 0.5% of glycyrrhizin, 0.1% of shikonin, 0.5% of PEG-60 hydrogenated castor oil, 0.1% of 1, 2-hexanediol, 0.1% of p-hydroxyacetophenone, 0.05% of ethylhexyl glycerol, 0.05% of green tea essence and the balance of deionized water.
The preparation method comprises the following steps: PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone, ethylhexyl glycerol and deionized water are added into a beaker and uniformly mixed by a magnetic stirrer at a speed of more than or equal to 1000rpm, so that the mixture is fully dissolved. Adding a small amount of Liquiritigenin into a beaker for dissolving, dissolving more than 80% of Liquiritigenin in the system, heating, stirring, heating to 55deg.C, and maintaining for 1.5 hr. And (3) closing heating, cooling the system to 40 ℃ in a stirring state, adding green tea essence to supplement evaporated deionized water, stirring for 30min to make the system uniform, and discharging.
Example 2:
the anti-hair loss and hair-growing composition containing the liquiritin comprises the following components in percentage by weight: 3% of liquiritin, 0.3% of shikonin, 0.8% of PEG-60 hydrogenated castor oil, 0.5% of 1, 2-hexanediol, 0.5% of p-hydroxyacetophenone, 0.2% of ethylhexyl glycerol, 0.3% of green tea essence and the balance of deionized water.
The preparation method comprises the following steps: PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone, ethylhexyl glycerol and deionized water are added into a beaker and uniformly mixed by a magnetic stirrer at a speed of more than or equal to 1000rpm, so that the mixture is fully dissolved. Adding a small amount of Liquiritigenin into a beaker for dissolving more than 80% of Liquiritigenin, heating after dissolving Liquiritigenin in the system, heating to 60deg.C under stirring, and maintaining for 1.5 hr (please supplement specific time). And (3) turning off heating, cooling the system to 45 ℃ in a stirring state, adding green tea essence to supplement evaporated deionized water, stirring for 30min (please supplement specific time) to make the system uniform, and discharging.
Example 3:
the anti-hair loss and hair-growing composition containing the liquiritin comprises the following components in percentage by weight: 1% of liquiritin, 0.1% of shikonin, 0.6% of PEG-60 hydrogenated castor oil, 0.3% of 1, 2-hexanediol, 0.2% of p-hydroxyacetophenone, 0.1% of ethylhexyl glycerol, 0.05% of green tea essence and the balance of deionized water.
The preparation method comprises the following steps: PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone, ethylhexyl glycerol and deionized water are added into a beaker and uniformly mixed by a magnetic stirrer at a speed of more than or equal to 1000rpm, so that the mixture is fully dissolved. Adding a small amount of Liquiritigenin into a beaker for dissolving, dissolving more than 80% of Liquiritigenin in the system, heating, stirring, heating to 58 deg.C, and maintaining for 1.5 hr. And (3) turning off heating, cooling the system to 43 ℃ under the stirring state, adding green tea essence to supplement evaporated deionized water, stirring for 30min to make the system uniform, and discharging.
Comparative example 1:
the anti-hair loss and hair-growing composition containing the liquiritin comprises the following components in percentage by weight: 0.1% of shikonin, 0.6% of PEG-60 hydrogenated castor oil, 0.3% of 1, 2-hexanediol, 0.2% of p-hydroxyacetophenone, 0.1% of ethylhexyl glycerol, 0.05% of green tea essence and the balance of deionized water.
The preparation method is the same as in example 3.
Comparative example 2:
the anti-hair loss and hair-growing composition containing the liquiritin comprises the following components in percentage by weight: 3% of liquiritin, 0.8% of PEG-60 hydrogenated castor oil, 0.5% of 1, 2-hexanediol, 0.5% of p-hydroxyacetophenone, 0.2% of ethylhexyl glycerol, 0.3% of green tea essence and the balance of deionized water.
The preparation method is the same as in example 3.
Sensory evaluation, stability test, safety test and anti-hair loss effect test were performed on the anti-hair loss composition of glycyrrhizin of examples 1-3 and comparative examples 1-2, and the test procedures and results were as follows:
1) Sensory evaluation
The color appearance and fragrance of the liquiritin anti-hair-loss compositions of examples 1 to 3 and comparative examples 1 to 2 were evaluated, and the results are shown in Table 1:
table 1: examples 1-3 and comparative examples 1-2 sensory evaluation of Liquiritigenin anti-hair loss and Hair-growing compositions
Evaluation of content Example 1 Example 2 Example 3 Comparative example 1 Comparative example 2
Clarity of the product Clear and transparent Clear and transparent Clear and transparent Clear and transparent Clear and transparent
Color of Light red, clear Dark red and dark grey Light red, clear Light red, clear Light red, clear
Skin feel Refreshing and cool Slightly sticky Refreshing and cool Refreshing and cool Refreshing and cool
Smell of Elegant and elegant Sweet and greasy Elegant and elegant Elegant and elegant Elegant and elegant
As can be seen from table 1, the sensory evaluation results showed that: example 1, example 3 and comparative examples 1-2 had better appearance, skin feel and fragrance, the formulation of example 2 had less than optimal color loss, slightly sticky skin feel and too heavy fragrance.
2) Stability test
The stability of the liquiritin anti-hair loss hair-growing compositions of examples 1 to 3 and comparative examples 1 to 2 was tested by the following stability tests, respectively.
2.1 Heat resistance test
Taking the liquiritin anti-hair loss hair-growing compositions of examples 1-3 and comparative examples 1-2, pouring In the test tube, the liquid level is about 80mm, a clean cork is plugged, the test tube is put into a constant temperature incubator with the temperature of 48+/-1 ℃, taken out after 48 hours, and is observed and compared with a sample normally put into the room temperature after the room temperature is restored, and the test tube passes the heat-resistant stability test if no obvious difference exists between the test tube and the sample.
2.2 Cold resistance test
Taking the liquiritin anti-hair loss hair-growing compositions of examples 1-3 and comparative examples 1-2, pouring In the test tube, the liquid level is about 80mm, a clean cork is plugged, the test tube is put into a refrigerator with the temperature of-18+/-2 ℃ and taken out after 48 hours, and the test tube is observed and compared with a sample normally put into the room temperature after the room temperature is recovered, and the test tube passes the heat and cold resistance qualitative test if no obvious difference exists between the test tube and the test tube.
2.3 centrifugal stability test
Adding a sample to be tested with the height of about two thirds into a centrifuge tube, plugging the sample by a cork, then placing the sample into an electrothermal constant temperature incubator which is pre-adjusted to (38+/-1) DEG C, preserving heat for 1 hour, immediately placing the sample into the centrifuge, centrifuging for 30 minutes at the centrifugation speed of 2000r/min, taking out the sample, and observing the sample, and if no layering phenomenon exists, passing the rational stability test.
The stability test results of the liquiritin anti-hair loss composition of examples 1-3 and comparative examples 1-2 are shown in Table 2:
table 2: results of stability test of Liquiritigenin anti-alopecia hair-growing compositions of examples 1-3 and comparative examples 1-2
Content of test Example 1 Example 2 Example 3 Comparative example 1 Comparative example 2
Heat resistance test By passing through By passing through By passing through By passing through By passing through
Cold resistance test By passing through By passing through By passing through By passing through By passing through
Centrifugal stability test By passing through By passing through By passing through By passing through By passing through
As shown in table 2: examples 1-3 and comparative examples 1-2 the liquiritin anti-hair loss and hair growth compositions of all formulations passed all stability tests, and the liquiritin anti-hair loss and hair growth compositions of all formulations were good in stability.
3) Safety test
0.1mL of the glycyrrhizin anti-hair loss composition of examples 1-3 and comparative examples 1-2 is respectively smeared on the heads of 20 laboratory workers, and after 1 day, test results are collected to observe whether the compositions have uncomfortable phenomena such as allergy and the like. The result was that only 1 person of 20 test workers felt a slight itching on the test specimen of example 2 and recovered to normal within one day. The safety test results show that the glycyrrhizin anti-hair loss composition formulas of the examples 1-3 and the comparative examples 1-2 have better safety.
4) Test of anti-drop effect
The test samples are 100 men and 100 women, the ages are evenly distributed between 18 and 60 years, the liquiritin anti-hair loss composition is sprayed on the scalp in the morning and evening, the dosage of each time is about 5mL, the test sample is used for 12 weeks, and the hair loss amount is collected and averaged in the use period of 0 week, 4 weeks, 8 weeks and 12 weeks respectively. The statistical mode of the number of dropped hair is as follows: the hair is combed from front to back by the gaps between fingers, the fingers are clamped during combing, the reverse operation is performed for 5 times, and the sum of the number of the hair left between the fingers after the 5 times of operation is counted to obtain the hair falling number. Setting R as a parameter for improving alopecia, wherein the calculation formula of R is as follows: r=number of hair loss before use/number of hair loss after use of the liquiritin anti-hair-loss composition, R is significantly greater than 1 indicating that the liquiritin anti-hair-loss composition has an effect of improving hair loss, R is significantly less than 1 indicating that the liquiritin anti-hair-loss composition aggravates hair loss, and R is close to 1 indicating that the liquiritin anti-hair-loss composition has no significant anti-hair-loss effect. The test results are shown in Table 3.
Table 3: results of test of anti-hair loss effects of Liquiritigenin anti-hair-growing compositions of examples 1-3 and comparative examples 1-2
Results statistics Example 1 Example 2 Example 3 Comparative example 1 Comparative example 2
Use of 4 week Male R values 0.99 1.05 1.06 1.01 0.99
R-value for 4 weeks females 1.03 0.98 1.10 1.00 1.01
Use of 8 week Male R values 1.15 1.18 1.21 1.05 1.03
R-value for 8 week women 1.12 1.11 1.15 1.09 1.05
Use of 12 week Male R values 1.19 1.25 1.23 1.07 1.03
R-value for 12 week women 1.17 1.19 1.22 1.05 1.07
From table 3, it can be seen that the effect of preventing the hair loss can be achieved by adding the effective component of the glycyrrhizin alone or adding the effective component of shikonin alone in the formula, but the overall effect of preventing the hair loss is not as good as that of the formula prepared by compounding the glycyrrhizin and shikonin; examples 1-3 produced an anti-slip effect on both men and women, but the formulation of example 3 was significantly better than the other formulations.
It should be noted that the above-mentioned embodiments illustrate rather than limit the scope of the application, and that those skilled in the art, after reading this disclosure, will be able to modify the application in various equivalent forms within the scope of the application as defined by the appended claims.

Claims (7)

1. The anti-hair loss and hair-growing composition containing the liquiritin is characterized by comprising the following preparation raw materials in parts by weight: 0.5 to 3 percent of glycyrrhizin, 0.1 to 0.3 percent of shikonin, 0.5 to 0.8 percent of PEG-60 hydrogenated castor oil, 0.1 to 0.5 percent of 1, 2-hexanediol, 0.1 to 0.5 percent of p-hydroxyacetophenone, 0.05 to 0.2 percent of ethylhexyl glycerol, 0.05 to 0.3 percent of green tea essence and the balance of deionized water.
2. The anti-hair loss and hair-growing composition of liquiritin according to claim 1, wherein: the weight ratio of the liquiritin is 1%, and the shikonin is 0.1%.
3. The anti-hair loss and hair-growing composition of liquiritin according to claim 1, wherein: the purity of the liquiritin is more than or equal to 99.9%, and the purity of the shikonin is more than or equal to 95%.
4. The anti-hair loss and hair-growing composition of liquiritin according to claim 1, wherein: the conductivity of the deionized water is less than 20 mu s/cm, the resistivity is more than 1MΩ & cm, caCO is used 3 Hardness is less than 5ppm.
5. The anti-hair loss and hair-growing composition of glycyrrhizin according to claim 1, characterized in that the raw materials for preparation are all cosmetic grade or analytically pure grade.
6. A method for preparing the anti-hair loss and hair-growing composition of liquiritin as claimed in claim 1, which is characterized by comprising the following steps: adding deionized water, PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone and ethylhexyl glycerol, adding alkannin and glycyrrhizin after all the materials are dissolved in the deionized water, starting heating after the dissolution amount of the glycyrrhizin and the alkannin in a system is more than or equal to 80%, heating to 55-60 ℃ under stirring, preserving heat for more than 1h, then closing heating, cooling to 40-45 ℃ under stirring, adding green tea essence, supplementing evaporated deionized water, stirring for more than 20min to ensure that the system is uniform, and obtaining the glycyrrhizin anti-hair-loss hair-growing composition.
7. The method for preparing the liquiritin anti-hair loss and hair care composition according to claim 6, wherein the method comprises the following steps: the glycyrrhizin and shikonin are added into deionized water for a small amount for multiple times after being completely dissolved in PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone and ethylhexyl glycerin.
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Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10273423A (en) * 1997-03-27 1998-10-13 Shiseido Co Ltd Cosmetic for hair
CN101415465A (en) * 2006-03-31 2009-04-22 万能药生物有限公司 Novel compositions for hair disorders and process of preparation thereof
CN107049993A (en) * 2016-12-22 2017-08-18 江苏耐雀生物工程技术有限公司 A kind of scorching film of the anti-oral ulcer containing alkannin and preparation and application
CN107411988A (en) * 2017-05-24 2017-12-01 江苏耐雀生物工程技术有限公司 A kind of toner containing active ingredient of Chinese herbs and its preparation method and application
CN108135879A (en) * 2015-12-02 2018-06-08 金印株式会社 Educate generation hair accelerating agent
CN109620861A (en) * 2019-02-21 2019-04-16 南京紫源康医药科技有限公司 A kind of itch-stopping bactericidal maintenance liquid and preparation method thereof
CN109620859A (en) * 2019-02-27 2019-04-16 南京紫源康医药科技有限公司 A kind of scar repairs ointment and preparation method thereof
CN109662945A (en) * 2017-10-13 2019-04-23 南京紫源康医药科技有限公司 A kind of micro emulsion and preparation method thereof containing alkannin
CN110693743A (en) * 2019-10-28 2020-01-17 上海新高姿化妆品有限公司 Hair loss preventing and hair nourishing composition, shampoo and preparation method
CN112451468A (en) * 2020-12-17 2021-03-09 亿利耐雀生物科技有限公司 Plant extract hair dye powder with anti-allergic function and preparation method thereof
CN112553282A (en) * 2019-09-25 2021-03-26 天津科技大学 Method for preparing glycyrrhetinic acid monoglucuronide by enzyme method
CN112915041A (en) * 2021-03-19 2021-06-08 上海奥利实业有限公司 Oil-insoluble transparent oil solution of dipotassium glycyrrhizinate and its preparation method and application

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10273423A (en) * 1997-03-27 1998-10-13 Shiseido Co Ltd Cosmetic for hair
CN101415465A (en) * 2006-03-31 2009-04-22 万能药生物有限公司 Novel compositions for hair disorders and process of preparation thereof
CN113509478A (en) * 2015-12-02 2021-10-19 金印株式会社 Hair-growing agent
CN108135879A (en) * 2015-12-02 2018-06-08 金印株式会社 Educate generation hair accelerating agent
CN107049993A (en) * 2016-12-22 2017-08-18 江苏耐雀生物工程技术有限公司 A kind of scorching film of the anti-oral ulcer containing alkannin and preparation and application
CN107411988A (en) * 2017-05-24 2017-12-01 江苏耐雀生物工程技术有限公司 A kind of toner containing active ingredient of Chinese herbs and its preparation method and application
CN109662945A (en) * 2017-10-13 2019-04-23 南京紫源康医药科技有限公司 A kind of micro emulsion and preparation method thereof containing alkannin
CN109620861A (en) * 2019-02-21 2019-04-16 南京紫源康医药科技有限公司 A kind of itch-stopping bactericidal maintenance liquid and preparation method thereof
CN109620859A (en) * 2019-02-27 2019-04-16 南京紫源康医药科技有限公司 A kind of scar repairs ointment and preparation method thereof
CN112553282A (en) * 2019-09-25 2021-03-26 天津科技大学 Method for preparing glycyrrhetinic acid monoglucuronide by enzyme method
CN110693743A (en) * 2019-10-28 2020-01-17 上海新高姿化妆品有限公司 Hair loss preventing and hair nourishing composition, shampoo and preparation method
CN112451468A (en) * 2020-12-17 2021-03-09 亿利耐雀生物科技有限公司 Plant extract hair dye powder with anti-allergic function and preparation method thereof
CN112915041A (en) * 2021-03-19 2021-06-08 上海奥利实业有限公司 Oil-insoluble transparent oil solution of dipotassium glycyrrhizinate and its preparation method and application

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
18α-单葡萄糖醛酸甘草次酸及其衍生物的合成及生物活性评价;杨永安;中国博士学位论文全文数据库 工程科技Ⅰ辑;第2020卷(第05期);第B016-54页 *
中药色素成分促毛囊生长的机制研究初探;马东雪;中国优秀硕士学位论文全文数据库 医药卫生科技辑;第2020卷(第02期);第E056-1062页 *
紫甘软膏的制备及应用;梅全喜,等;中国医院药学杂志;第1986卷(第11期);第25-27页 *

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