CN114392263B - Liquiritigenin hair-loss preventing and hair-growing composition and preparation method thereof - Google Patents
Liquiritigenin hair-loss preventing and hair-growing composition and preparation method thereof Download PDFInfo
- Publication number
- CN114392263B CN114392263B CN202111567356.XA CN202111567356A CN114392263B CN 114392263 B CN114392263 B CN 114392263B CN 202111567356 A CN202111567356 A CN 202111567356A CN 114392263 B CN114392263 B CN 114392263B
- Authority
- CN
- China
- Prior art keywords
- hair
- liquiritin
- glycyrrhizin
- hair loss
- deionized water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- GSZUGBAEBARHAW-UHFFFAOYSA-N sophoraflavone B Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C=2OC3=CC(O)=CC=C3C(=O)C=2)C=C1 GSZUGBAEBARHAW-UHFFFAOYSA-N 0.000 title claims description 46
- 201000004384 Alopecia Diseases 0.000 title description 23
- FURUXTVZLHCCNA-UHFFFAOYSA-N Liquiritigenin Natural products C1=CC(O)=CC=C1C1OC2=CC(O)=CC=C2C(=O)C1 FURUXTVZLHCCNA-UHFFFAOYSA-N 0.000 title description 12
- JBQATDIMBVLPRB-UHFFFAOYSA-N isoliquiritigenin Natural products OC1=CC(O)=CC=C1C1OC2=CC(O)=CC=C2C(=O)C1 JBQATDIMBVLPRB-UHFFFAOYSA-N 0.000 title description 12
- FURUXTVZLHCCNA-AWEZNQCLSA-N liquiritigenin Chemical compound C1=CC(O)=CC=C1[C@H]1OC2=CC(O)=CC=C2C(=O)C1 FURUXTVZLHCCNA-AWEZNQCLSA-N 0.000 title description 12
- 208000024963 hair loss Diseases 0.000 title description 10
- 230000003676 hair loss Effects 0.000 title description 9
- 230000003656 anti-hair-loss Effects 0.000 claims abstract description 46
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 35
- 239000004378 Glycyrrhizin Substances 0.000 claims abstract description 33
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims abstract description 33
- 229960004949 glycyrrhizic acid Drugs 0.000 claims abstract description 33
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims abstract description 33
- 235000019410 glycyrrhizin Nutrition 0.000 claims abstract description 33
- NEZONWMXZKDMKF-JTQLQIEISA-N Alkannin Chemical compound C1=CC(O)=C2C(=O)C([C@@H](O)CC=C(C)C)=CC(=O)C2=C1O NEZONWMXZKDMKF-JTQLQIEISA-N 0.000 claims abstract description 28
- 241001071917 Lithospermum Species 0.000 claims abstract description 28
- UNNKKUDWEASWDN-UHFFFAOYSA-N alkannin Natural products CC(=CCC(O)c1cc(O)c2C(=O)C=CC(=O)c2c1O)C UNNKKUDWEASWDN-UHFFFAOYSA-N 0.000 claims abstract description 28
- KSDSYIXRWHRPMN-UHFFFAOYSA-N 4'-O-beta-D-Galactopyranoside-6''-p-Coumaroylprunin-4',5,7-Trihydroxyflavanone Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C2OC3=CC(O)=CC(O)=C3C(=O)C2)C=C1 KSDSYIXRWHRPMN-UHFFFAOYSA-N 0.000 claims description 34
- DEMKZLAVQYISIA-ONJCETCRSA-N Liquiritin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)c1ccc([C@@H]2Oc3c(C(=O)C2)ccc(O)c3)cc1 DEMKZLAVQYISIA-ONJCETCRSA-N 0.000 claims description 34
- DEMKZLAVQYISIA-UHFFFAOYSA-N Liquirtin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C2OC3=CC(O)=CC=C3C(=O)C2)C=C1 DEMKZLAVQYISIA-UHFFFAOYSA-N 0.000 claims description 34
- DEMKZLAVQYISIA-ZRWXNEIDSA-N liquiritin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C([C@H]2OC3=CC(O)=CC=C3C(=O)C2)C=C1 DEMKZLAVQYISIA-ZRWXNEIDSA-N 0.000 claims description 34
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 32
- 239000008367 deionised water Substances 0.000 claims description 27
- 229910021641 deionized water Inorganic materials 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- 238000003756 stirring Methods 0.000 claims description 17
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 16
- 239000004359 castor oil Substances 0.000 claims description 16
- 235000019438 castor oil Nutrition 0.000 claims description 16
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 16
- 210000004209 hair Anatomy 0.000 claims description 16
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 15
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 14
- 244000269722 Thea sinensis Species 0.000 claims description 12
- 235000009569 green tea Nutrition 0.000 claims description 12
- 238000001816 cooling Methods 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 239000002537 cosmetic Substances 0.000 claims description 3
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 2
- 238000004090 dissolution Methods 0.000 claims description 2
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 230000001502 supplementing effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 3
- 239000004229 Alkannin Substances 0.000 claims 2
- 235000019232 alkannin Nutrition 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 24
- 210000004761 scalp Anatomy 0.000 abstract description 17
- 210000003780 hair follicle Anatomy 0.000 abstract description 10
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 25
- 230000000052 comparative effect Effects 0.000 description 22
- 231100000360 alopecia Toxicity 0.000 description 11
- 238000013112 stability test Methods 0.000 description 10
- 238000011156 evaluation Methods 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000013589 supplement Substances 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 239000007799 cork Substances 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 230000003779 hair growth Effects 0.000 description 3
- 210000002540 macrophage Anatomy 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 238000011076 safety test Methods 0.000 description 3
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 description 2
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 2
- 244000303040 Glycyrrhiza glabra Species 0.000 description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 2
- 102000018745 NF-KappaB Inhibitor alpha Human genes 0.000 description 2
- 108010052419 NF-KappaB Inhibitor alpha Proteins 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940097043 glucuronic acid Drugs 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000011477 liquorice Nutrition 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000003658 preventing hair loss Effects 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000012855 volatile organic compound Substances 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 108010029908 3-oxo-5-alpha-steroid 4-dehydrogenase Proteins 0.000 description 1
- 102000001779 3-oxo-5-alpha-steroid 4-dehydrogenase Human genes 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 102000007665 Extracellular Signal-Regulated MAP Kinases Human genes 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010051788 Sticky skin Diseases 0.000 description 1
- 102000005747 Transcription Factor RelA Human genes 0.000 description 1
- 108010031154 Transcription Factor RelA Proteins 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 206010068168 androgenetic alopecia Diseases 0.000 description 1
- 201000002996 androgenic alopecia Diseases 0.000 description 1
- 229960003473 androstanolone Drugs 0.000 description 1
- 239000000729 antidote Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940021231 clearskin Drugs 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000003752 improving hair Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229960003632 minoxidil Drugs 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000000865 phosphorylative effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000036560 skin regeneration Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 230000034512 ubiquitination Effects 0.000 description 1
- 238000010798 ubiquitination Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The application discloses a glycyrrhizin anti-hair loss and hair-growing composition and a preparation method thereof. The prepared glycyrrhizin anti-hair loss composition has good efficacy through the synergistic effect of the glycyrrhizin and the shikonin, has the efficacy of repairing hair follicles and maintaining scalp besides anti-hair loss, and has high product safety and less side effect. The preparation method is simple, does not need complex instruments and equipment, has lower preparation cost and is easy to popularize.
Description
Technical Field
The application relates to the field of hair care preparations, in particular to a novel glycyrrhizin anti-hair loss hair care composition and a preparation method thereof.
Background
Alopecia is a common phenomenon that afflicts modern people. Modern people have fast life rhythm, large working pressure and serious insomnia phenomenon, and alopecia is not a special problem for the old. In addition, pollution of the air environment, residue of daily necessities on the scalp, damage of scalp hair follicles, seborrheic alopecia, and the like are all main causes of the expansion of the population suffering from alopecia except inheritance.
The sallow glycyrrhizin anti-hair loss composition product, namely the fish dragon, is mixed, and a few sprays are only conceptual products and lack actual curative effects. The spray taking minoxidil and other medicines with practical and scientific basis as main efficacy components has single efficacy, can only treat seborrheic alopecia, and has the problems of easy aggravation of alopecia, scalp itching, easy generation of medicine dependence and the like in the early stage of use.
Disclosure of Invention
The application aims to: the application provides a glycyrrhizin anti-hair loss and hair-growing composition and a preparation method thereof, and the prepared glycyrrhizin anti-hair loss and hair-growing composition has good effects, has the effects of repairing hair follicles and maintaining scalp besides anti-hair loss, and is high in product safety and less in side effect.
The technical scheme is as follows: in order to solve the technical problems, the application adopts the following technical scheme: the anti-hair loss and hair-growing composition containing the liquiritin comprises the following preparation raw materials in parts by weight: 0.5 to 3 percent of glycyrrhizin, 0.1 to 0.3 percent of shikonin, 0.5 to 0.8 percent of PEG-60 hydrogenated castor oil, 0.1 to 0.5 percent of 1, 2-hexanediol, 0.1 to 0.5 percent of p-hydroxyacetophenone, 0.05 to 0.2 percent of ethylhexyl glycerol, 0.05 to 0.3 percent of green tea essence and the balance of deionized water.
Further, the weight ratio of the liquiritin is 1%, and the shikonin is 0.1%.
Furthermore, the purity of the liquiritin is more than or equal to 99.9%, and the purity of the shikonin is more than or equal to 95%.
Further, the deionized water has a conductivity of less than 20 μs/cm, a resistivity of greater than 1MΩ & cm, and a hardness (CaCO) 3 Calculated as) is less than 5ppm.
Furthermore, the preparation raw materials are all cosmetic grade or analytical grade.
The application also discloses a preparation method of the glycyrrhizin anti-hair loss and hair-care composition, which comprises the following steps: adding glycyrrhizin, shikonin, PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone, ethylhexyl glycerol and deionized water into a container, dissolving the glycyrrhizin in a certain proportion, heating to 55-60 ℃ under stirring, preserving heat for more than 1h, then closing heating, cooling to 40-45 ℃ under stirring, adding green tea essence, supplementing evaporated deionized water, and stirring for more than 20min to ensure that the system is uniform, thus obtaining the glycyrrhizin anti-hair loss hair-growing composition.
Furthermore, the adding sequence of the liquiritin, the shikonin, the PEG-60 hydrogenated castor oil, the 1, 2-hexanediol, the p-hydroxyacetophenone, the ethylhexyl glycerol and the deionized water is as follows: adding deionized water, PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone and ethylhexyl glycerol, and adding shikonin and liquiritin after the materials are completely dissolved in the deionized water.
Furthermore, the glycyrrhizin and shikonin are added into deionized water for a plurality of times in a small amount after PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone and ethylhexyl glycerin are completely dissolved in the deionized water.
Furthermore, the heating temperature can be increased only after the dissolution amount of the liquiritin and the shikonin in the system is more than or equal to 80 percent.
Furthermore, the stirring is performed by a magnetic stirrer, and the stirring speed is more than or equal to 1000rpm.
The glycyrrhizin is called as mono glucuronic acid glycyrrhetinic acid, is an extract of liquorice, has strong function of inhibiting testosterone 5-alpha reductase as an active ingredient of new generation liquorice, and can be used for treating seborrheic alopecia. At the same time, it can also act as an antidote and contact external contaminants with the scalp. Besides, the anti-inflammatory repairing function can also improve scalp inflammation and allergic symptoms and help to prevent alopecia.
The glycyrrhizin plays an anti-inflammatory role by inhibiting NF-kappa B p65 and IκBα degradation and phosphorylating IKB and ERK protein expression, repairing scalp skin and hair follicle, strengthening hair root nutrition, and inhibiting hair loss caused by hair follicle atrophy; the glycyrrhizin also has strong 5-alpha reductase inhibition effect, the 5-alpha reductase can convert testosterone in human body into Dihydrotestosterone (DHT), the DHT can shrink hair follicle, hair is thinned, the growth cycle of hair is shortened, and the hair is shed, namely androgenetic alopecia (seborrheic alopecia), so that the glycyrrhizin has the effect of inhibiting seborrheic alopecia; in addition, the glycyrrhizin can be used as a neutralizing agent to convert micromolecular glucuronic acid generated by the conversion to neutralize external pollution components (free radicals, heavy metals and Volatile Organic Compounds (VOCs)) contacted with the hair and the scalp, so that the irritation of the external pollution components to the scalp and scalp hair follicles is relieved, and a healthy growth environment is brought to the hair.
The lithospermum has the effects of activating blood, detoxifying and repairing, and the high-purity shikonin extracted from the lithospermum root has high safety and good repairing effect, and can effectively repair damaged hair follicles and promote hair growth. In addition, shikonin has the characteristics of natural resistance to inflammation and epidermis repair, has a certain antioxidant activity, is safe to use and has a good effect. Has effects of diminishing inflammation, stopping bleeding, promoting skin regeneration, and can rapidly penetrate into skin and promote wound healing. The action mechanism is that shikonin can inhibit macrophage from releasing inflammatory medium TNF-alpha, inhibit macrophage NF-kappa Bp65 from transferring from cytoplasm to nucleus, increase I-kappa B alpha and ubiquitination protein expression quantity in macrophage, besides, shikonin can induce apoptosis cell and necrosis cell death, quicken metabolism. The hair cream is applied to the scalp, has obvious repairing effect on the scalp and scalp hair follicles, relieves the skin of the head, avoids scalp inflammation caused by bacterial and fungal infection and excessive sebum, and has good anti-drop effect.
The two functional components are compounded, so that the mechanism of preventing hair loss and growing hair is diversified, and a better effect of preventing hair loss and growing hair is achieved.
The beneficial effects are that: compared with the prior art, the application has the following advantages:
(1) The prepared glycyrrhizin anti-hair loss hair-growing composition has good effects, can repair hair follicles and care scalp besides anti-hair loss, and is high in product safety and less in side effect.
(2) The shikonin is a less stable substance, by virtue of the preparation method, the stability of the shikonin can be increased, and the glycyrrhizin anti-hair loss hair-growing composition can be preserved for a long time.
Detailed Description
The application is further illustrated by the following examples:
the purity of the glycyrrhizin used in the examples and the comparative examples is more than or equal to 99.9%, and the purity of shikonin is more than or equal to 95%; the conductivity of deionized water is less than 20 mu s/cm, the resistivity is more than 1MΩ & cm, and the hardness (CaCO is used) 3 Calculated as) is less than 5ppm. Other preparation raw materials are cosmetic grade or analytical grade.
Example 1:
the anti-hair loss and hair-growing composition containing the liquiritin comprises the following components in percentage by weight: 0.5% of glycyrrhizin, 0.1% of shikonin, 0.5% of PEG-60 hydrogenated castor oil, 0.1% of 1, 2-hexanediol, 0.1% of p-hydroxyacetophenone, 0.05% of ethylhexyl glycerol, 0.05% of green tea essence and the balance of deionized water.
The preparation method comprises the following steps: PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone, ethylhexyl glycerol and deionized water are added into a beaker and uniformly mixed by a magnetic stirrer at a speed of more than or equal to 1000rpm, so that the mixture is fully dissolved. Adding a small amount of Liquiritigenin into a beaker for dissolving, dissolving more than 80% of Liquiritigenin in the system, heating, stirring, heating to 55deg.C, and maintaining for 1.5 hr. And (3) closing heating, cooling the system to 40 ℃ in a stirring state, adding green tea essence to supplement evaporated deionized water, stirring for 30min to make the system uniform, and discharging.
Example 2:
the anti-hair loss and hair-growing composition containing the liquiritin comprises the following components in percentage by weight: 3% of liquiritin, 0.3% of shikonin, 0.8% of PEG-60 hydrogenated castor oil, 0.5% of 1, 2-hexanediol, 0.5% of p-hydroxyacetophenone, 0.2% of ethylhexyl glycerol, 0.3% of green tea essence and the balance of deionized water.
The preparation method comprises the following steps: PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone, ethylhexyl glycerol and deionized water are added into a beaker and uniformly mixed by a magnetic stirrer at a speed of more than or equal to 1000rpm, so that the mixture is fully dissolved. Adding a small amount of Liquiritigenin into a beaker for dissolving more than 80% of Liquiritigenin, heating after dissolving Liquiritigenin in the system, heating to 60deg.C under stirring, and maintaining for 1.5 hr (please supplement specific time). And (3) turning off heating, cooling the system to 45 ℃ in a stirring state, adding green tea essence to supplement evaporated deionized water, stirring for 30min (please supplement specific time) to make the system uniform, and discharging.
Example 3:
the anti-hair loss and hair-growing composition containing the liquiritin comprises the following components in percentage by weight: 1% of liquiritin, 0.1% of shikonin, 0.6% of PEG-60 hydrogenated castor oil, 0.3% of 1, 2-hexanediol, 0.2% of p-hydroxyacetophenone, 0.1% of ethylhexyl glycerol, 0.05% of green tea essence and the balance of deionized water.
The preparation method comprises the following steps: PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone, ethylhexyl glycerol and deionized water are added into a beaker and uniformly mixed by a magnetic stirrer at a speed of more than or equal to 1000rpm, so that the mixture is fully dissolved. Adding a small amount of Liquiritigenin into a beaker for dissolving, dissolving more than 80% of Liquiritigenin in the system, heating, stirring, heating to 58 deg.C, and maintaining for 1.5 hr. And (3) turning off heating, cooling the system to 43 ℃ under the stirring state, adding green tea essence to supplement evaporated deionized water, stirring for 30min to make the system uniform, and discharging.
Comparative example 1:
the anti-hair loss and hair-growing composition containing the liquiritin comprises the following components in percentage by weight: 0.1% of shikonin, 0.6% of PEG-60 hydrogenated castor oil, 0.3% of 1, 2-hexanediol, 0.2% of p-hydroxyacetophenone, 0.1% of ethylhexyl glycerol, 0.05% of green tea essence and the balance of deionized water.
The preparation method is the same as in example 3.
Comparative example 2:
the anti-hair loss and hair-growing composition containing the liquiritin comprises the following components in percentage by weight: 3% of liquiritin, 0.8% of PEG-60 hydrogenated castor oil, 0.5% of 1, 2-hexanediol, 0.5% of p-hydroxyacetophenone, 0.2% of ethylhexyl glycerol, 0.3% of green tea essence and the balance of deionized water.
The preparation method is the same as in example 3.
Sensory evaluation, stability test, safety test and anti-hair loss effect test were performed on the anti-hair loss composition of glycyrrhizin of examples 1-3 and comparative examples 1-2, and the test procedures and results were as follows:
1) Sensory evaluation
The color appearance and fragrance of the liquiritin anti-hair-loss compositions of examples 1 to 3 and comparative examples 1 to 2 were evaluated, and the results are shown in Table 1:
table 1: examples 1-3 and comparative examples 1-2 sensory evaluation of Liquiritigenin anti-hair loss and Hair-growing compositions
| Evaluation of content | Example 1 | Example 2 | Example 3 | Comparative example 1 | Comparative example 2 |
| Clarity of the product | Clear and transparent | Clear and transparent | Clear and transparent | Clear and transparent | Clear and transparent |
| Color of | Light red, clear | Dark red and dark grey | Light red, clear | Light red, clear | Light red, clear |
| Skin feel | Refreshing and cool | Slightly sticky | Refreshing and cool | Refreshing and cool | Refreshing and cool |
| Smell of | Elegant and elegant | Sweet and greasy | Elegant and elegant | Elegant and elegant | Elegant and elegant |
As can be seen from table 1, the sensory evaluation results showed that: example 1, example 3 and comparative examples 1-2 had better appearance, skin feel and fragrance, the formulation of example 2 had less than optimal color loss, slightly sticky skin feel and too heavy fragrance.
2) Stability test
The stability of the liquiritin anti-hair loss hair-growing compositions of examples 1 to 3 and comparative examples 1 to 2 was tested by the following stability tests, respectively.
2.1 Heat resistance test
Taking the liquiritin anti-hair loss hair-growing compositions of examples 1-3 and comparative examples 1-2, pouring In the test tube, the liquid level is about 80mm, a clean cork is plugged, the test tube is put into a constant temperature incubator with the temperature of 48+/-1 ℃, taken out after 48 hours, and is observed and compared with a sample normally put into the room temperature after the room temperature is restored, and the test tube passes the heat-resistant stability test if no obvious difference exists between the test tube and the sample.
2.2 Cold resistance test
Taking the liquiritin anti-hair loss hair-growing compositions of examples 1-3 and comparative examples 1-2, pouring In the test tube, the liquid level is about 80mm, a clean cork is plugged, the test tube is put into a refrigerator with the temperature of-18+/-2 ℃ and taken out after 48 hours, and the test tube is observed and compared with a sample normally put into the room temperature after the room temperature is recovered, and the test tube passes the heat and cold resistance qualitative test if no obvious difference exists between the test tube and the test tube.
2.3 centrifugal stability test
Adding a sample to be tested with the height of about two thirds into a centrifuge tube, plugging the sample by a cork, then placing the sample into an electrothermal constant temperature incubator which is pre-adjusted to (38+/-1) DEG C, preserving heat for 1 hour, immediately placing the sample into the centrifuge, centrifuging for 30 minutes at the centrifugation speed of 2000r/min, taking out the sample, and observing the sample, and if no layering phenomenon exists, passing the rational stability test.
The stability test results of the liquiritin anti-hair loss composition of examples 1-3 and comparative examples 1-2 are shown in Table 2:
table 2: results of stability test of Liquiritigenin anti-alopecia hair-growing compositions of examples 1-3 and comparative examples 1-2
| Content of test | Example 1 | Example 2 | Example 3 | Comparative example 1 | Comparative example 2 |
| Heat resistance test | By passing through | By passing through | By passing through | By passing through | By passing through |
| Cold resistance test | By passing through | By passing through | By passing through | By passing through | By passing through |
| Centrifugal stability test | By passing through | By passing through | By passing through | By passing through | By passing through |
As shown in table 2: examples 1-3 and comparative examples 1-2 the liquiritin anti-hair loss and hair growth compositions of all formulations passed all stability tests, and the liquiritin anti-hair loss and hair growth compositions of all formulations were good in stability.
3) Safety test
0.1mL of the glycyrrhizin anti-hair loss composition of examples 1-3 and comparative examples 1-2 is respectively smeared on the heads of 20 laboratory workers, and after 1 day, test results are collected to observe whether the compositions have uncomfortable phenomena such as allergy and the like. The result was that only 1 person of 20 test workers felt a slight itching on the test specimen of example 2 and recovered to normal within one day. The safety test results show that the glycyrrhizin anti-hair loss composition formulas of the examples 1-3 and the comparative examples 1-2 have better safety.
4) Test of anti-drop effect
The test samples are 100 men and 100 women, the ages are evenly distributed between 18 and 60 years, the liquiritin anti-hair loss composition is sprayed on the scalp in the morning and evening, the dosage of each time is about 5mL, the test sample is used for 12 weeks, and the hair loss amount is collected and averaged in the use period of 0 week, 4 weeks, 8 weeks and 12 weeks respectively. The statistical mode of the number of dropped hair is as follows: the hair is combed from front to back by the gaps between fingers, the fingers are clamped during combing, the reverse operation is performed for 5 times, and the sum of the number of the hair left between the fingers after the 5 times of operation is counted to obtain the hair falling number. Setting R as a parameter for improving alopecia, wherein the calculation formula of R is as follows: r=number of hair loss before use/number of hair loss after use of the liquiritin anti-hair-loss composition, R is significantly greater than 1 indicating that the liquiritin anti-hair-loss composition has an effect of improving hair loss, R is significantly less than 1 indicating that the liquiritin anti-hair-loss composition aggravates hair loss, and R is close to 1 indicating that the liquiritin anti-hair-loss composition has no significant anti-hair-loss effect. The test results are shown in Table 3.
Table 3: results of test of anti-hair loss effects of Liquiritigenin anti-hair-growing compositions of examples 1-3 and comparative examples 1-2
| Results statistics | Example 1 | Example 2 | Example 3 | Comparative example 1 | Comparative example 2 |
| Use of 4 week Male R values | 0.99 | 1.05 | 1.06 | 1.01 | 0.99 |
| R-value for 4 weeks females | 1.03 | 0.98 | 1.10 | 1.00 | 1.01 |
| Use of 8 week Male R values | 1.15 | 1.18 | 1.21 | 1.05 | 1.03 |
| R-value for 8 week women | 1.12 | 1.11 | 1.15 | 1.09 | 1.05 |
| Use of 12 week Male R values | 1.19 | 1.25 | 1.23 | 1.07 | 1.03 |
| R-value for 12 week women | 1.17 | 1.19 | 1.22 | 1.05 | 1.07 |
From table 3, it can be seen that the effect of preventing the hair loss can be achieved by adding the effective component of the glycyrrhizin alone or adding the effective component of shikonin alone in the formula, but the overall effect of preventing the hair loss is not as good as that of the formula prepared by compounding the glycyrrhizin and shikonin; examples 1-3 produced an anti-slip effect on both men and women, but the formulation of example 3 was significantly better than the other formulations.
It should be noted that the above-mentioned embodiments illustrate rather than limit the scope of the application, and that those skilled in the art, after reading this disclosure, will be able to modify the application in various equivalent forms within the scope of the application as defined by the appended claims.
Claims (7)
1. The anti-hair loss and hair-growing composition containing the liquiritin is characterized by comprising the following preparation raw materials in parts by weight: 0.5 to 3 percent of glycyrrhizin, 0.1 to 0.3 percent of shikonin, 0.5 to 0.8 percent of PEG-60 hydrogenated castor oil, 0.1 to 0.5 percent of 1, 2-hexanediol, 0.1 to 0.5 percent of p-hydroxyacetophenone, 0.05 to 0.2 percent of ethylhexyl glycerol, 0.05 to 0.3 percent of green tea essence and the balance of deionized water.
2. The anti-hair loss and hair-growing composition of liquiritin according to claim 1, wherein: the weight ratio of the liquiritin is 1%, and the shikonin is 0.1%.
3. The anti-hair loss and hair-growing composition of liquiritin according to claim 1, wherein: the purity of the liquiritin is more than or equal to 99.9%, and the purity of the shikonin is more than or equal to 95%.
4. The anti-hair loss and hair-growing composition of liquiritin according to claim 1, wherein: the conductivity of the deionized water is less than 20 mu s/cm, the resistivity is more than 1MΩ & cm, caCO is used 3 Hardness is less than 5ppm.
5. The anti-hair loss and hair-growing composition of glycyrrhizin according to claim 1, characterized in that the raw materials for preparation are all cosmetic grade or analytically pure grade.
6. A method for preparing the anti-hair loss and hair-growing composition of liquiritin as claimed in claim 1, which is characterized by comprising the following steps: adding deionized water, PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone and ethylhexyl glycerol, adding alkannin and glycyrrhizin after all the materials are dissolved in the deionized water, starting heating after the dissolution amount of the glycyrrhizin and the alkannin in a system is more than or equal to 80%, heating to 55-60 ℃ under stirring, preserving heat for more than 1h, then closing heating, cooling to 40-45 ℃ under stirring, adding green tea essence, supplementing evaporated deionized water, stirring for more than 20min to ensure that the system is uniform, and obtaining the glycyrrhizin anti-hair-loss hair-growing composition.
7. The method for preparing the liquiritin anti-hair loss and hair care composition according to claim 6, wherein the method comprises the following steps: the glycyrrhizin and shikonin are added into deionized water for a small amount for multiple times after being completely dissolved in PEG-60 hydrogenated castor oil, 1, 2-hexanediol, p-hydroxyacetophenone and ethylhexyl glycerin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111567356.XA CN114392263B (en) | 2021-12-20 | 2021-12-20 | Liquiritigenin hair-loss preventing and hair-growing composition and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111567356.XA CN114392263B (en) | 2021-12-20 | 2021-12-20 | Liquiritigenin hair-loss preventing and hair-growing composition and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114392263A CN114392263A (en) | 2022-04-26 |
| CN114392263B true CN114392263B (en) | 2023-11-14 |
Family
ID=81227243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111567356.XA Active CN114392263B (en) | 2021-12-20 | 2021-12-20 | Liquiritigenin hair-loss preventing and hair-growing composition and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114392263B (en) |
Citations (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10273423A (en) * | 1997-03-27 | 1998-10-13 | Shiseido Co Ltd | Cosmetic for hair |
| CN101415465A (en) * | 2006-03-31 | 2009-04-22 | 万能药生物有限公司 | Novel compositions for hair disorders and process of preparation thereof |
| CN107049993A (en) * | 2016-12-22 | 2017-08-18 | 江苏耐雀生物工程技术有限公司 | A kind of scorching film of the anti-oral ulcer containing alkannin and preparation and application |
| CN107411988A (en) * | 2017-05-24 | 2017-12-01 | 江苏耐雀生物工程技术有限公司 | A kind of toner containing active ingredient of Chinese herbs and its preparation method and application |
| CN108135879A (en) * | 2015-12-02 | 2018-06-08 | 金印株式会社 | Educate generation hair accelerating agent |
| CN109620861A (en) * | 2019-02-21 | 2019-04-16 | 南京紫源康医药科技有限公司 | A kind of itch-stopping bactericidal maintenance liquid and preparation method thereof |
| CN109620859A (en) * | 2019-02-27 | 2019-04-16 | 南京紫源康医药科技有限公司 | A kind of scar repairs ointment and preparation method thereof |
| CN109662945A (en) * | 2017-10-13 | 2019-04-23 | 南京紫源康医药科技有限公司 | A kind of micro emulsion and preparation method thereof containing alkannin |
| CN110693743A (en) * | 2019-10-28 | 2020-01-17 | 上海新高姿化妆品有限公司 | Hair loss preventing and hair nourishing composition, shampoo and preparation method |
| CN112451468A (en) * | 2020-12-17 | 2021-03-09 | 亿利耐雀生物科技有限公司 | Plant extract hair dye powder with anti-allergic function and preparation method thereof |
| CN112553282A (en) * | 2019-09-25 | 2021-03-26 | 天津科技大学 | Method for preparing glycyrrhetinic acid monoglucuronide by enzyme method |
| CN112915041A (en) * | 2021-03-19 | 2021-06-08 | 上海奥利实业有限公司 | Oil-insoluble transparent oil solution of dipotassium glycyrrhizinate and its preparation method and application |
-
2021
- 2021-12-20 CN CN202111567356.XA patent/CN114392263B/en active Active
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10273423A (en) * | 1997-03-27 | 1998-10-13 | Shiseido Co Ltd | Cosmetic for hair |
| CN101415465A (en) * | 2006-03-31 | 2009-04-22 | 万能药生物有限公司 | Novel compositions for hair disorders and process of preparation thereof |
| CN113509478A (en) * | 2015-12-02 | 2021-10-19 | 金印株式会社 | Hair-growing agent |
| CN108135879A (en) * | 2015-12-02 | 2018-06-08 | 金印株式会社 | Educate generation hair accelerating agent |
| CN107049993A (en) * | 2016-12-22 | 2017-08-18 | 江苏耐雀生物工程技术有限公司 | A kind of scorching film of the anti-oral ulcer containing alkannin and preparation and application |
| CN107411988A (en) * | 2017-05-24 | 2017-12-01 | 江苏耐雀生物工程技术有限公司 | A kind of toner containing active ingredient of Chinese herbs and its preparation method and application |
| CN109662945A (en) * | 2017-10-13 | 2019-04-23 | 南京紫源康医药科技有限公司 | A kind of micro emulsion and preparation method thereof containing alkannin |
| CN109620861A (en) * | 2019-02-21 | 2019-04-16 | 南京紫源康医药科技有限公司 | A kind of itch-stopping bactericidal maintenance liquid and preparation method thereof |
| CN109620859A (en) * | 2019-02-27 | 2019-04-16 | 南京紫源康医药科技有限公司 | A kind of scar repairs ointment and preparation method thereof |
| CN112553282A (en) * | 2019-09-25 | 2021-03-26 | 天津科技大学 | Method for preparing glycyrrhetinic acid monoglucuronide by enzyme method |
| CN110693743A (en) * | 2019-10-28 | 2020-01-17 | 上海新高姿化妆品有限公司 | Hair loss preventing and hair nourishing composition, shampoo and preparation method |
| CN112451468A (en) * | 2020-12-17 | 2021-03-09 | 亿利耐雀生物科技有限公司 | Plant extract hair dye powder with anti-allergic function and preparation method thereof |
| CN112915041A (en) * | 2021-03-19 | 2021-06-08 | 上海奥利实业有限公司 | Oil-insoluble transparent oil solution of dipotassium glycyrrhizinate and its preparation method and application |
Non-Patent Citations (3)
| Title |
|---|
| 18α-单葡萄糖醛酸甘草次酸及其衍生物的合成及生物活性评价;杨永安;中国博士学位论文全文数据库 工程科技Ⅰ辑;第2020卷(第05期);第B016-54页 * |
| 中药色素成分促毛囊生长的机制研究初探;马东雪;中国优秀硕士学位论文全文数据库 医药卫生科技辑;第2020卷(第02期);第E056-1062页 * |
| 紫甘软膏的制备及应用;梅全喜，等;中国医院药学杂志;第1986卷(第11期);第25-27页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114392263A (en) | 2022-04-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108938485B (en) | Hair growth liquid for preventing alopecia and preparation method thereof | |
| CN111631993B (en) | Composition containing sophora flavescens and magnolia officinalis extracts and cosmetic using composition | |
| WO2024045952A1 (en) | Recombinant collagen-containing composition having effects of repairing and soothing, eye cream containing same, preparation method therefor, and use thereof | |
| CN107970128B (en) | Formula and production process of hair growth promoting liquid containing diaminopyrimidine oxide | |
| CN110302121B (en) | Infant hip-protecting cream containing plant essence and preparation method thereof | |
| CN113425661B (en) | Plant composition with cleaning and repairing effects and application thereof | |
| CN116265007A (en) | Anti-drop oil-control and soothing essence and preparation method thereof | |
| CA3061545A1 (en) | Skin care composition | |
| US20040101577A1 (en) | Composition for treating acne vulgaris and fabrication method | |
| JP4598900B2 (en) | Use of ginkgo flavonoid extracts substantially free of terpenes in the oral and dental field and compositions containing such extracts | |
| CN112315883B (en) | Skin care composition for controlling oil and removing acne and preparation and application thereof | |
| JPH07126146A (en) | Sin external preparation | |
| CN114392263B (en) | Liquiritigenin hair-loss preventing and hair-growing composition and preparation method thereof | |
| KR101034405B1 (en) | Antibiotic composition containing herbal medicine extracts | |
| CN110613663A (en) | Skin repairing composition, skin care product and preparation method thereof | |
| CN115770209A (en) | Rod-shaped lithospermum ointment containing three-purple oil and preparation method thereof | |
| CN115670952A (en) | Oil-control anti-acne composition, skin care product and preparation method | |
| CN111388400A (en) | Composition for balancing skin oil secretion and preparation method thereof | |
| JPH03209309A (en) | Alopecia-preventing agent | |
| CN114306188B (en) | Preparation method of whitening and anti-inflammatory mask liquid | |
| CN113499271A (en) | Anti-allergy compound and preparation method and application thereof | |
| CN107714585B (en) | Moisturizing cream containing centella asiatica extract | |
| JP5855949B2 (en) | Keratin production promoter, hair dye and nail polish | |
| CN115554207B (en) | Plant composition and preparation method thereof | |
| CN110478285B (en) | Composition for resisting scalp aging |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |