CN114344188A - Hair loss prevention and hair growth promoting composition and preparation method thereof - Google Patents
Hair loss prevention and hair growth promoting composition and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an anti-hair loss and hair-nourishing composition and a preparation method thereof, wherein the anti-hair loss and hair-nourishing composition comprises freeze-dried powder and solvent liquid: the freeze-dried powder comprises water, a freeze-drying protective agent, composite polypeptide and proteins; the solvent liquid comprises water, a solubilizer, a hair growth promoter, a preservative and a pH regulator; the composite polypeptide comprises acetyl tetrapeptide-3, octapeptide-2, oligopeptide-1, oligopeptide-3, oligopeptide-5, myristoyl pentapeptide-17 and copper peptide; the protein is collagen and/or placenta extract; the hair growth promoter comprises pyrrolidinyl diaminopyrimidine oxide, adenosine and panthenol. The anti-hair loss and hair-nourishing composition can effectively supplement scalp nutrients, regulate scalp cell activity, promote the activation of hair follicle stem cells, promote the absorption of hair papilla to the nutrients, stimulate the hair follicles in a dormant state for a long time to revive and grow, and further play roles in nourishing and strengthening hair and promoting hair growth.
Description
Technical Field
The invention belongs to the technical field of daily chemicals, and particularly relates to an anti-hair loss and hair-growing composition and a preparation method thereof.
Background
Alopecia is caused by many reasons, such as seborrheic alopecia (high androgen), and folliculitis. Besides, the possibility that the alopecia person is caused by overstrain or over-anxiety is not excluded. The alopecia is serious, the number of hairs is reduced, some alopecia can be caused, the personal image can be influenced, and for seborrheic alopecia, the alopecia can be serious mainly due to inherent hereditary factors, and the treatment difficulty is high. Alopecia is caused by folliculitis diseases, mainly because the hair follicles are partially blocked due to insufficient scalp cleaning, and normal circulation and growth of the scalp are affected, thereby causing the problem of alopecia. The problem of hair loss is also exacerbated for people who are more stressed or often in an anxious environment.
Currently, in the cosmetic category, anti-alopecia hair-growing products generally fall into two categories: one is a traditional Chinese medicine formula, common components comprise ginger, tuber fleeceflower root, cacumen biotae, lightyellow sophora root and the like, and the products are used on the market for many years and have common effects; in addition, a novel raw material formula is adopted, such as compounds with definite effects, such as pyrrolidinyl diaminopyrimidine oxide and the like, the methods have certain pertinence, fluff can grow when the method is used, and the fluff can fall off quickly after the method is not used.
In the medical field, there are hair transplantation methods, which are most effective. The method is also an effective mode by orally taking finasteride and applying minoxidil, has certain effect when being used, and begins to fall off without using.
The leading research is now the tissue fusion of hair follicle cells with other cells, which makes it possible to regenerate hair follicles, or to generate new hair follicles. And induces hair generation upon subcutaneous transplantation in nude mice. But these have been in practical use for a longer time.
Disclosure of Invention
The invention aims to provide an anti-hair loss and hair growth promoting composition which can effectively nourish and repair hair follicles, has a long-lasting anti-hair loss effect and hair growth promoting effect and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a hair loss preventing and hair nourishing composition, which comprises freeze-dried powder and solvent liquid: the freeze-dried powder comprises the following raw material components: water, freeze-drying protective agent, composite polypeptide and protein; the solvent liquid comprises the following raw material components: water, solubilizer, hair growth promoter, preservative and pH regulator;
the compound polypeptide comprises acetyl tetrapeptide-3, octapeptide-2, oligopeptide-1, oligopeptide-3, oligopeptide-5, myristoyl pentapeptide-17 and copper peptide, preferably also comprises decapeptide-18 and oligopeptide-54; the protein is collagen and/or placenta extract; the hair growth promoter comprises pyrrolidinyl diaminopyrimidine oxide, adenosine and panthenol, and preferably further comprises acetyl tyrosine, azelaic acid and vanillyl butyl ether.
The freeze-drying protective agent is selected from mannitol, glycerol or phosphate; the solubilizer is selected from ethanol and butanediol; the preservative is phenoxyethanol; the pH regulator is sodium hydroxide.
According to the composite polypeptide, the acetyl tetrapeptide-3 can repair hair follicle cells and stimulate natural growth of eyebrows and hairs; octapeptide-2 can stimulate hair growth and strengthen hair quality; decapeptide-18 produces new hair by activating the β -catenin (a key factor in the mechanism of differentiation of hair follicle epithelial stem cells into hair keratinocytes) signal; the oligopeptide-1 has the effects of promoting the growth of stratum basale tissues, promoting the integral metabolic speed of epidermal and dermal cells, accelerating the repair of skin barriers and improving the repair capacity of skin; oligopeptide-3 is combined with skin cell receptors to strengthen growth factor signal transmission, promote the proliferation and differentiation of epidermal cells, and increase the synthesis of keratinocytes, fibroblasts, hyaluronic acid, elastin and the like; oligopeptide-5 can specifically stimulate the metabolism of epithelial cells, repair cuticle, increase the thickness of the cuticle and enhance the activity of collagen and elastin; oligopeptide-54 is a Noggin derived peptide, a powerful BMP blocker, which promotes hair growth and prevents hair whitening. Myristoyl pentapeptide-17 is a potent eyelash growth promoting pentapeptide which directly activates the keratin gene, thereby growing and thickening eyelashes. The copper peptide can increase the growth of blood vessels and the oxidation resistance, and has the functions of cell reactivation and regeneration.
According to the protein, the collagen can supplement nutrition required by subcutaneous tissues and effectively inhibit hair from drying and splitting, and solid soluble collagen with the purity of not less than 95% and the nitrogen content of not less than 17% is preferred; the placenta extract is preferably a composite placenta solution extracted from SPF pig, Mongolian horse placenta and Hokkaido pure horse placenta, contains fibroblast, keratinocyte, somatomedin, amino acids, etc., and has effects in activating epidermal cells/dermal fibroblasts of human body, promoting collagen production, and keeping moisture. Can nourish scalp and hair follicle, promote the repair of damaged hair follicle stem cells, or provide necessary active substances for hair papilla, and promote the growth and development of hair.
According to the hair growth auxiliary agent, the pyrrolidinyl diaminopyrimidine oxide is similar to the minoxidil in molecular structure, and is also an active hair growth active agent; human hair follicle papilla cells and external hair root sheath cells can both express adenosine receptors, and adenosine is combined with the receptors to activate a series of signal transduction pathways, so that hair growth is promoted; the panthenol can penetrate into hair, keep moisture of hair, improve hair luster, reduce hair bifurcation, prevent brittleness and breakage, and repair damaged hair.
Earlier researches show that the components of the compound polypeptide, the proteins and the hair growth promoter have certain anti-hair loss effect when being used independently, but can not achieve the satisfactory hair regeneration effect. The invention takes the compound polypeptide and the protein as main active raw materials, simulates the protein structure of the cell factor which effectively promotes the hair growth in the secretion of the hair follicle stem cells, takes the hair growth auxiliary agent as an auxiliary active raw material, can strengthen the blood circulation of the scalp and activate the hair follicle, and further has obvious effects of preventing hair loss and growing hair. In order to keep the activity of the composite polypeptide and the protein, the freeze-dried powder is prepared into a finished product, and the finished product is dissolved into transparent liquid by solvent liquid before use to ensure the best hair loss prevention and hair growth effect.
According to the anti-hair loss and hair-growing composition, the freeze-dried powder comprises the following raw material components: 862-937 parts of water, 50-80 parts of mannitol, 3-5 parts of glycerol, 1-2 parts of sodium dihydrogen phosphate, 4-6 parts of disodium hydrogen phosphate, 1-10 parts of copper peptide, 30.5-5 parts of acetyl tetrapeptide, 20.5-5 parts of octapeptide, 180.5-5 parts of decapeptide, 540.5-5 parts of oligopeptide, 170.5-5 parts of myristoyl pentapeptide, 10.5-5 parts of oligopeptide, 30.5-5 parts of oligopeptide, 50.5-5 parts of oligopeptide, 0.5-5 parts of collagen and 0.5-5 parts of placenta extract; the solvent liquid comprises the following raw material components: 40-70 parts of water, 20-40 parts of ethanol, 10-20 parts of butanediol, 0.5-5 parts of pyrrolidinyl diaminopyrimidine oxide, 0.5-5 parts of azelaic acid, 0.5-5 parts of adenosine, 0.1-5 parts of panthenol, 0.1-0.2 part of vanillyl butyl ether, 0.1-5 parts of acetyl tyrosine, 0.01-1 part of phenoxyethanol and 0.01-5 parts of sodium hydroxide.
Preferably, the freeze-dried powder comprises the following raw material components: 910.5 parts of water, 50 parts of mannitol, 3 parts of glycerol, 1.2 parts of sodium dihydrogen phosphate, 4.3 parts of disodium hydrogen phosphate, 7 parts of copper peptide, 33 parts of acetyl tetrapeptide, 23 parts of octapeptide, 182 parts of decapeptide, 542 parts of oligopeptide, 172 parts of myristoyl pentapeptide, 12 parts of oligopeptide, 32 parts of oligopeptide, 52 parts of oligopeptide, 3 parts of collagen and 3 parts of placenta extract; the solvent liquid comprises the following raw material components: 51.5 parts of water, 30 parts of ethanol, 10 parts of butanediol, 2 parts of pyrrolidinyl diaminopyrimidine oxide, 2 parts of azelaic acid, 1 part of adenosine, 1 part of panthenol, 0.1 part of vanillyl butyl ether, 1 part of acetyl tyrosine, 0.5 part of phenoxyethanol and 1 part of sodium hydroxide.
The preparation method of the anti-hair loss and hair-growing composition comprises the following steps:
(1) preparing freeze-dried powder: taking raw materials in parts by weight, stirring the raw materials to be completely dissolved, filtering, and putting filtrate into a freeze dryer for vacuum freeze drying to obtain freeze-dried powder;
(2) preparing a solvent solution: taking raw materials in parts by weight, stirring the raw materials to be completely dissolved, and filtering to obtain filtrate, namely the solvent solution;
(3) preparing the hair loss preventing and hair growing composition: and pouring the solvent solution into the freeze-dried powder, and shaking up to dissolve completely to obtain the anti-hair loss and hair-growing polypeptide protein composition.
Preferably, in the step (1), a 0.22 micron nanofiltration membrane is adopted for the filtration; the vacuum freeze-drying is to pre-freeze for 4 hours at-40 ℃ and then vacuumize for 20 hours.
Preferably, in the step (2), a 0.22 micron nanofiltration membrane is adopted for the filtration.
Preferably, in the step (3), the mass ratio of the vehicle solution to the freeze-dried powder is 3-5g:0.12-0.2 g.
The invention has the beneficial effects that:
the anti-hair loss and hair-nourishing composition provided by the invention can effectively supplement scalp nutrients, regulate scalp cell activity, promote activation of hair follicle stem cells, promote absorption of hair follicles on nutrients and stimulate the hair follicles in a dormant state to revive and grow by using the composite polypeptide, protein and hair growth aid which are specially formed as active ingredients in a combined manner. The hair conditioner plays a deep repairing role from the root cause of alopecia, and can achieve the effects of nourishing hair, fixing hair and promoting hair growth for a long time.
Drawings
FIGS. 1 to 5: photographs of five different subjects before use of example 1 of the present invention and after 30 consecutive days of use were compared;
FIGS. 6 to 10: five different subjects in fig. 1-5 were compared in an electron micrograph (200 x magnification on a scalp monitor) before use of example 1 of the present invention and after 30 consecutive days of use.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
Wherein, the collagen is purchased from Jiangsu Jiangshan gathering biotechnology limited company, and the trade name is as follows: recombinant human collagen (SFA), INCI name: soluble collagen, purity: 97.5 percent and the nitrogen content is 18.5 percent; placenta extract was purchased from HORUS co, LTD, trade name: placental fluid VSF (composition: water 92.2%, ethanol 6.0%, placental protein 1.5%, phenoxyethanol 0.3%).
Example 1
A composition for preventing alopecia and promoting hair growth comprises lyophilized powder and solvent solution;
the freeze-dried powder is prepared from the following raw material components: 910.5g of water, 50g of mannitol, 3g of glycerol, 1.2g of sodium dihydrogen phosphate, 4.3g of disodium hydrogen phosphate, 7g of copper peptide, 33 g of acetyl tetrapeptide, 23 g of octapeptide, 182 g of decapeptide, 542 g of oligopeptide, 172 g of myristoyl pentapeptide, 12g of oligopeptide, 32 g of oligopeptide, 52 g of oligopeptide, 3g of collagen and 3g of placenta extract;
the solvent solution is prepared from the following raw materials: 515g of water, 300g of ethanol, 100g of butanediol, 20g of pyrrolidinyl diaminopyrimidine oxide, 20g of azelaic acid, 10g of adenosine, 10g of panthenol, 1g of vanillyl butyl ether, 10g of acetyl tyrosine, 5g of phenoxyethanol and 10g of sodium hydroxide.
The preparation method of the hair loss preventing and hair growing composition comprises the following steps:
(1) preparing freeze-dried powder: adding a magnetic stirrer into a 1000ml beaker, sequentially adding water, mannitol, sodium dihydrogen phosphate, disodium hydrogen phosphate, glycerol, copper peptide, acetyl tetrapeptide-3, octapeptide-2, decapeptide-18, oligopeptide-1, oligopeptide-3, oligopeptide-5, oligopeptide-54, myristoyl pentapeptide-17, collagen and a placenta extract under stirring, stirring for dissolving, filtering by using a 0.22 micron nanofiltration membrane after complete dissolution, canning the filtrate into a 7ml penicillin bottle for 2g, putting the canned penicillin bottle into a freeze dryer, pre-freezing at-40 ℃ for 4 hours, and vacuumizing for 20 hours to obtain freeze-dried powder;
(2) preparing a solvent solution: adding a magnetic stirrer into a 1000ml beaker, and sequentially adding water, ethanol, butanediol, pyrrolidinyl diaminopyrimidine oxide, adenosine, azelaic acid, panthenol, vanillyl butyl ether, acetyl tyrosine, phenoxyethanol and sodium hydroxide under stirring. Stirring to dissolve, filtering with 0.22 micrometer nanofiltration membrane, and bottling the filtrate into 7ml penicillin bottles for 5 g. Pricking a cover to obtain a solution;
(3) preparing the hair loss preventing and hair growing composition: and pouring the solvent liquid into the freeze-dried powder according to the proportion of 5g of the solvent liquid to 0.2g of the freeze-dried powder, and shaking up to completely dissolve the solvent liquid and the freeze-dried powder to obtain the anti-hair loss and hair growth promoting composition.
Example 2
A composition for preventing alopecia and promoting hair growth comprises lyophilized powder and solvent solution;
the freeze-dried powder is prepared from the following raw material components: 937g of water, 50g of mannitol, 3g of glycerol, 1g of sodium dihydrogen phosphate, 4g of disodium hydrogen phosphate, 1g of copper peptide, 30.5 g of acetyl tetrapeptide, 20.5 g of octapeptide, 180.5 g of decapeptide, 540.5 g of oligopeptide, 170.5 g of myristoyl pentapeptide, 10.5g of oligopeptide, 30.5 g of oligopeptide, 50.5 g of oligopeptide, 0.5g of collagen and 0.5g of placenta extract;
the solvent solution is prepared from the following raw materials: 700g of water, 200g of ethanol, 100g of butanediol, 5g of pyrrolidinyl diaminopyrimidine oxide, 5g of azelaic acid, 5g of adenosine, 1g of panthenol, 1g of vanillyl butyl ether, 1g of acetyl tyrosine, 0.1g of phenoxyethanol and 0.1g of sodium hydroxide.
The preparation method of the hair loss preventing and hair growing composition comprises the following steps:
(1) preparing freeze-dried powder: adding a magnetic stirrer into a 1000ml beaker, sequentially adding water, mannitol, sodium dihydrogen phosphate, disodium hydrogen phosphate, glycerol, copper peptide, acetyl tetrapeptide-3, octapeptide-2, decapeptide-18, oligopeptide-1, oligopeptide-3, oligopeptide-5, oligopeptide-54, myristoyl pentapeptide-17, collagen and a placenta extract under stirring, stirring for dissolving, filtering by using a 0.22 micron nanofiltration membrane after complete dissolution, canning the filtrate into a 3ml penicillin bottle for 1.2g, putting the canned penicillin bottle into a freeze dryer for pre-freezing at-40 ℃ for 4 hours, and vacuumizing for 20 hours to obtain freeze-dried powder;
(2) preparing a solvent solution: adding a magnetic stirrer into a 1000ml beaker, and sequentially adding water, ethanol, butanediol, pyrrolidinyl diaminopyrimidine oxide, adenosine, azelaic acid, panthenol, vanillyl butyl ether, acetyl tyrosine, phenoxyethanol and sodium hydroxide under stirring. Stirring to dissolve, filtering with 0.22 micrometer nanofiltration membrane, and bottling the filtrate into 3ml penicillin bottles and 3 g. Pricking a cover to obtain a solution;
(3) preparing the hair loss preventing and hair growing composition: pouring the solvent liquid into the freeze-dried powder according to the proportion of 3g of the solvent liquid to 0.12g of the freeze-dried powder, and shaking up to completely dissolve the solvent liquid and the freeze-dried powder to obtain the anti-hair loss and hair growth promoting composition.
Example 3
A composition for preventing alopecia and promoting hair growth comprises lyophilized powder and solvent solution;
the freeze-dried powder is prepared from the following raw material components: 862g of water, 80g of mannitol, 5g of glycerol, 2g of sodium dihydrogen phosphate, 6g of disodium hydrogen phosphate, 10g of copper peptide, 35 g of acetyl tetrapeptide, 25 g of octapeptide, 185 g of decapeptide, 545 g of oligopeptide, 175 g of myristoyl pentapeptide, 15g of oligopeptide, 35 g of oligopeptide, 55 g of oligopeptide, 5g of collagen and 5g of placenta extract;
the solvent solution is prepared from the following raw materials: 400g of water, 400g of ethanol, 200g of butanediol, 50g of pyrrolidinyl diaminopyrimidine oxide, 50g of azelaic acid, 50g of adenosine, 50g of panthenol, 2g of vanillyl butyl ether, 50g of acetyl tyrosine, 10g of phenoxyethanol and 50g of sodium hydroxide.
The preparation method of the hair loss preventing and hair growing composition comprises the following steps:
(1) preparing freeze-dried powder: adding a magnetic stirrer into a 1000ml beaker, sequentially adding water, mannitol, sodium dihydrogen phosphate, disodium hydrogen phosphate, glycerol, copper peptide, acetyl tetrapeptide-3, octapeptide-2, decapeptide-18, oligopeptide-1, oligopeptide-3, oligopeptide-5, oligopeptide-54, myristoyl pentapeptide-17, collagen and a placenta extract under stirring, stirring for dissolving, filtering by using a 0.22 micron nanofiltration membrane after complete dissolution, canning the filtrate into a 7ml penicillin bottle for 2g, putting the canned penicillin bottle into a freeze dryer, pre-freezing at-40 ℃ for 4 hours, and vacuumizing for 20 hours to obtain freeze-dried powder;
(2) preparing a solvent solution: adding a magnetic stirrer into a 1000ml beaker, and sequentially adding water, ethanol, butanediol, pyrrolidinyl diaminopyrimidine oxide, adenosine, azelaic acid, panthenol, vanillyl butyl ether, acetyl tyrosine, phenoxyethanol and sodium hydroxide under stirring. Stirring to dissolve, filtering with 0.22 micrometer nanofiltration membrane, and bottling the filtrate into 7ml penicillin bottles for 5 g. Pricking a cover to obtain a solution;
(3) preparing the hair loss preventing and hair growing composition: and pouring the solvent liquid into the freeze-dried powder according to the proportion of 5g of the solvent liquid to 0.2g of the freeze-dried powder, and shaking up to completely dissolve the solvent liquid and the freeze-dried powder to obtain the anti-hair loss and hair growth promoting composition.
Example 4
A composition for preventing alopecia and promoting hair growth comprises lyophilized powder and solvent solution;
the freeze-dried powder is prepared from the following raw material components: 911.5g of water, 50g of mannitol, 3g of glycerol, 1.2g of sodium dihydrogen phosphate, 4.3g of disodium hydrogen phosphate, 8g of copper peptide, 34 g of acetyl tetrapeptide, 24 g of octapeptide, 174 g of myristoyl pentapeptide, 12g of oligopeptide, 32 g of oligopeptide, 52 g of oligopeptide and 4g of placenta extract;
the solvent solution is prepared from the following raw materials: 645g of water, 200g of ethanol, 100g of butanediol, 20g of pyrrolidinyl diaminopyrimidine oxide, 15g of adenosine, 15g of panthenol and 5g of phenoxyethanol.
The preparation method of the hair loss preventing and hair growing composition comprises the following steps:
(1) preparing freeze-dried powder: adding a magnetic stirrer into a 1000ml beaker, sequentially adding water, mannitol, sodium dihydrogen phosphate, disodium hydrogen phosphate, glycerol, copper peptide, acetyl tetrapeptide-3, octapeptide-2, oligopeptide-1, oligopeptide-3, oligopeptide-5, myristoyl pentapeptide-17 and a placenta extract under stirring, stirring for dissolving, filtering with a 0.22 micron nanofiltration membrane after complete dissolution, filling the filtrate into 7ml penicillin bottles for 2g, putting the canned penicillin bottles into a freeze dryer, pre-freezing at-40 ℃ for 4 hours, and vacuumizing for 20 hours to obtain freeze-dried powder;
(2) preparing a solvent solution: adding magnetic stirring bar into 1000ml beaker, adding water, ethanol, butanediol, pyrrolidinyl diaminopyrimidine oxide, adenosine, panthenol, and phenoxyethanol in sequence under stirring. Stirring to dissolve, filtering with 0.22 micrometer nanofiltration membrane, and bottling the filtrate into 7ml penicillin bottles for 5 g. Pricking a cover to obtain a solution;
(3) preparing the hair loss preventing and hair growing composition: and pouring the solvent liquid into the freeze-dried powder according to the proportion of 5g of the solvent liquid to 0.2g of the freeze-dried powder, and shaking up to completely dissolve the solvent liquid and the freeze-dried powder to obtain the anti-hair loss and hair growth promoting composition.
Examples of the experiments
1. A plurality of indexes for inspecting the satisfaction effect of the new hair are drawn up: 1.1 the time for growing new hair; 1.2 number of hairs; 1.3 hair thickness/fineness; 1.4 whether the anti-dropping function exists or not.
2. The using method comprises the following steps: after hair is cleaned and dried, the hair-care cream is applied to a scalp hair sparse area for 1 time every day and is continuously applied for 30 days.
3. The scalp is inspected with a scalp inspector at 200 times magnification.
TABLE 1
Wherein, it is many: more than 200; coarse: compared with the original hair, the thickness is consistent; comprises the following steps: meaning that there is significantly less or no hair loss.
The results show that the samples of the example 1 and the example 4 have better hair growth and hair loss prevention effects, the hair quality is more elastic and the gloss feeling is better, and the sample of the example 1 has the best effect.
In addition, the anti-alopecia hair-growing composition prepared in example 1 of the present invention was tested for the overall effect of anti-alopecia hair-growing, and 200 persons tested were used 1 time per day for a trial period of 60 days, and the results showed that: among 122 testers, the hair regrowth is obvious (the number of the hair regrowth is more than 200), the hair regrowth is black and thick, and the hair loss is obviously reduced after the hair regrowth is used for one week; 49 people have a small amount of new hair (more than 50), and the new hair is small in amount, thin and not thick; little or no new hair growth was observed in 29 people. It was also found that 80% of the testers had a significantly faster growth rate of some new hairs after haircutting than other surrounding hairs.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (10)
1. The anti-hair loss and hair-growing composition is characterized by comprising freeze-dried powder and solvent liquid:
the freeze-dried powder comprises the following raw material components: water, freeze-drying protective agent, composite polypeptide and protein;
the solvent liquid comprises the following raw material components: water, solubilizer, hair growth promoter, preservative and pH regulator;
the composite polypeptide comprises acetyl tetrapeptide-3, octapeptide-2, oligopeptide-1, oligopeptide-3, oligopeptide-5, myristoyl pentapeptide-17 and copper peptide; the protein is collagen and/or placenta extract; the hair growth promoter comprises pyrrolidinyl diaminopyrimidine oxide, adenosine and panthenol.
2. The hair loss prevention and hair growth promotion composition of claim 1 wherein the complex polypeptide further comprises decapeptide-18 and oligopeptide-54.
3. The composition according to claim 1 or 2, wherein the hair growth promoting adjuvant further comprises acetyl tyrosine, azelaic acid, vanillyl butyl ether.
4. The anti-hair loss and hair growth composition according to claim 3, wherein the lyoprotectant is selected from the group consisting of mannitol, glycerol, and phosphate; the solubilizer is selected from ethanol and butanediol; the preservative is phenoxyethanol; the pH regulator is sodium hydroxide.
5. The hair loss prevention and hair growth promotion composition according to claim 4,
the freeze-dried powder comprises the following raw material components: 862-937 parts of water, 50-80 parts of mannitol, 3-5 parts of glycerol, 1-2 parts of sodium dihydrogen phosphate, 4-6 parts of disodium hydrogen phosphate, 1-10 parts of copper peptide, 30.5-5 parts of acetyl tetrapeptide, 20.5-5 parts of octapeptide, 180.5-5 parts of decapeptide, 540.5-5 parts of oligopeptide, 170.5-5 parts of myristoyl pentapeptide, 10.5-5 parts of oligopeptide, 30.5-5 parts of oligopeptide, 50.5-5 parts of oligopeptide, 0.5-5 parts of collagen and 0.5-5 parts of placenta extract;
the solvent liquid comprises the following raw material components: 40-70 parts of water, 20-40 parts of ethanol, 10-20 parts of butanediol, 0.5-5 parts of pyrrolidinyl diaminopyrimidine oxide, 0.5-5 parts of azelaic acid, 0.5-5 parts of adenosine, 0.1-5 parts of panthenol, 0.1-0.2 part of vanillyl butyl ether, 0.1-5 parts of acetyl tyrosine, 0.01-1 part of phenoxyethanol and 0.01-5 parts of sodium hydroxide.
6. The hair loss prevention and hair growth promotion composition according to claim 5,
the freeze-dried powder comprises the following raw material components: 910.5 parts of water, 50 parts of mannitol, 3 parts of glycerol, 1.2 parts of sodium dihydrogen phosphate, 4.3 parts of disodium hydrogen phosphate, 7 parts of copper peptide, 33 parts of acetyl tetrapeptide, 23 parts of octapeptide, 182 parts of decapeptide, 542 parts of oligopeptide, 172 parts of myristoyl pentapeptide, 12 parts of oligopeptide, 32 parts of oligopeptide, 52 parts of oligopeptide, 3 parts of collagen and 3 parts of placenta extract;
the solvent liquid comprises the following raw material components: 51.5 parts of water, 30 parts of ethanol, 10 parts of butanediol, 2 parts of pyrrolidinyl diaminopyrimidine oxide, 2 parts of azelaic acid, 1 part of adenosine, 1 part of panthenol, 0.1 part of vanillyl butyl ether, 1 part of acetyl tyrosine, 0.5 part of phenoxyethanol and 1 part of sodium hydroxide.
7. The method for preparing the hair loss prevention and hair growth promotion composition according to any one of claims 1 to 6, comprising the steps of:
(1) preparing freeze-dried powder: taking raw materials in parts by weight, stirring the raw materials to be completely dissolved, filtering, and putting filtrate into a freeze dryer for vacuum freeze drying to obtain freeze-dried powder;
(2) preparing a solvent solution: taking raw materials in parts by weight, stirring the raw materials to be completely dissolved, and filtering to obtain filtrate, namely the solvent solution;
(3) preparing the hair loss preventing and hair growing composition: and pouring the solvent solution into the freeze-dried powder, and shaking up to dissolve completely to obtain the anti-hair loss and hair-growing polypeptide protein composition.
8. The method of claim 7, wherein the filtering is performed with a 0.22 micron nanofiltration membrane.
9. The method for preparing the hair loss prevention and hair growth promotion composition according to claim 7, wherein in the step (1), the vacuum freeze-drying is performed by pre-freezing at-40 ℃ for 4 hours and then vacuumizing for 20 hours.
10. The method for preparing the hair loss prevention and hair growth promotion composition according to claim 7, wherein in the step (3), the mass ratio of the solvent solution to the lyophilized powder is 3-5g:0.12-0.2 g.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115245570A (en) * | 2022-06-16 | 2022-10-28 | 上海松皓生物科技有限公司 | Anti-hair loss and hair-nourishing composition and application thereof |
| CN115337221A (en) * | 2022-08-31 | 2022-11-15 | 陕西中鸿科瑞再生医学研究院有限公司 | Composition beneficial to preventing hair loss and growing hair and preparation method and application thereof |
| CN116421491A (en) * | 2023-05-30 | 2023-07-14 | 广州市名嫡化妆品有限公司 | Adenosine aqueous composition, adenosine solution, and preparation method and application thereof |
| CN116492242A (en) * | 2023-04-20 | 2023-07-28 | 无锡知妍生物科技有限公司 | Alopecia preventing composition, preparation method and application thereof |
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| CN115337221A (en) * | 2022-08-31 | 2022-11-15 | 陕西中鸿科瑞再生医学研究院有限公司 | Composition beneficial to preventing hair loss and growing hair and preparation method and application thereof |
| CN116492242A (en) * | 2023-04-20 | 2023-07-28 | 无锡知妍生物科技有限公司 | Alopecia preventing composition, preparation method and application thereof |
| CN116421491A (en) * | 2023-05-30 | 2023-07-14 | 广州市名嫡化妆品有限公司 | Adenosine aqueous composition, adenosine solution, and preparation method and application thereof |
| CN116421491B (en) * | 2023-05-30 | 2023-11-10 | 广州市名嫡化妆品有限公司 | Adenosine aqueous composition, adenosine solution, and preparation method and application thereof |
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