CN114306181A - New seven-white composition with whitening, moisturizing and antioxidant effects and preparation method thereof - Google Patents
New seven-white composition with whitening, moisturizing and antioxidant effects and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a novel seven-white composition with whitening, moisturizing and antioxidant effects and a preparation method thereof, wherein a modern scientific technology is combined to innovate and improve a traditional ancient prescription seven-white ointment, dittany bark, white peony root and white sesame are used for carrying out gall-gall replacement on the components including dahurian angelica root, asarum and rhizoma typhonii, a special enzymolysis technology is used for extracting active ingredients of the seven-white composition to prepare the novel seven-white composition, and a series of verifications are carried out on the effects of the seven-white composition, so that the seven-white composition aims to popularize the traditional ancient direction of China all over the world and benefit people who love beauty.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to a novel seven-white composition with whitening, moisturizing and antioxidant effects and a preparation method thereof.
Background
Qibai ointment is prepared from Yuyao Fang: dahurian angelica root, ampelopsis root, white atractylodes rhizome each 10 parts, bletilla tuber 5 parts, asarum herb, giant typhonium rhizome and poria cocos wolf each 3 parts. Grinding the above materials into fine powder, concocting with ovum gallus Domesticus album to give pellet with marble size, and drying in shade. The product is dissolved in warm water before sleeping every night to make face painting. Before the face is coated, the face is washed clean by warm water, the medicines are crushed into powder and directly coated, the skin is difficult to absorb, and the use experience is very poor. And the angelica dahurica, rhizoma typhonii and asarum in the seven-white ointment have certain toxicity.
In the formula, the bighead atractylodes rhizome is the essential medicine for whitening the ancient formula, and is used for tonifying spleen and stomach, nourishing the acquired blood, activating qi and blood and treating gloomy or dark and dark complexion caused by spleen-stomach qi weakness and skin malnutrition. The white poria helps the bighead atractylodes rhizome to invigorate the spleen and replenish qi, and is a minister. Bletilla striata, rhizoma Bletillae, with the effects of tonifying lung, benefiting skin and hair, and Ampelopsis japonica, with the effects of astringing wound and promoting granulation, can be used for preventing and treating skin diseases such as pyocutaneous disease. In addition, rhizoma Seu herba Bergeniae, and radix Paeoniae alba. The four drugs assist the monarch and minister drugs and are adjuvant drugs together. Licorice root, radix Glycyrrhizae coordinates the effects of the other drugs in the recipe, and is used as a guiding drug.
Although the formula is a Chinese classic beauty treatment Chinese formula, modern medicine finds that the dahurian angelica root has certain phototoxicity and can cause dermatitis and the like in the sun after being smeared. Asarum herb is in Aristolochiaceae and has certain toxicity. Rhizoma typhonii also has certain toxicity. The three herbs are not listed in the name of usable cosmetics in China due to their toxicity. Therefore, the market urgently needs to improve and innovate the seven-white ointment so as to adapt to the demand of people on beauty in modern society. Aiming at the defects of seven-white paste, the invention replaces the components by using the modern scientific technology to prepare the novel seven-white composition with the whitening, moisturizing and antioxidant effects. The composition uses the dittany bark instead of the dahurian angelica root, the white paeony root instead of the manchurian wildginger and the white sesame seed instead of the giant typhonium rhizome.
The cortex Dictamni Radicis is a perennial herb of Dictamnus of Rutaceae. Cortex dictamni contains alkaloids, such as dictamnine, which is a characteristic component; in addition, limonin, coumarin, flavonoid, and polysaccharide. The cortex Dictamni Radicis extract has effect in inhibiting melanocyte activity, and can be used for whitening skin products, and also can be used as antiinflammatory agent, antibacterial agent, antioxidant and allergy inhibitor.
The radix Paeoniae is flower plant of Paeonia of Ranunculaceae. The cosmetic mainly adopts extract of dried rhizome and flower thereof. Radix Paeoniae alba contains terpenoid, and paeoniflorin has the highest content and is the main component; the rest is benzoic acid, gallic acid, etc. The radix Paeoniae alba extract has strong antibacterial property, has effects of activating skin and resisting aging, and can be used in anti-aging cosmetic; the extract can be used as moisturizer, antiallergic agent and antiinflammatory agent.
Sesame is an annual herb of the genus sesamum of the family of the lipid-sesame family, and the cosmetic mainly adopts an extract of the seed thereof. Sesame seeds contain proteins, fats, and lignan compounds. The rest is sterol, lecithin, etc. The sesame extract has anti-inflammatory effect, and can be used as skin-activating and anti-aging agent and skin whitening agent.
CN101849899B discloses a traditional Chinese medicine compound extract and cosmetics containing the active ingredients, wherein the traditional Chinese medicine extract composition comprises the following raw materials: the white gourd seed, the tribulus terrestris, the white mulberry root-bark, the sandalwood, the white chrysanthemum, the ginkgo, the white paeony root, the bletilla, the white poria, the bighead atractylodes rhizome and the raw liquorice are relatively more in used raw material variety, and the active ingredients are influenced by adopting high-temperature heating inactivation.
Disclosure of Invention
The invention aims to solve the technical problem of providing the novel seven-white composition which is convenient to use, improves the absorption effect, reduces the material consumption, avoids the influence of high temperature on active ingredients and has the whitening, moisturizing and antioxidant effects.
In order to solve the problems, the invention discloses a novel seven-white composition with whitening, moisturizing and antioxidant effects and a preparation method thereof.
The technical scheme of the invention is that a new seven-white composition with whitening, moisturizing and antioxidant effects comprises the following components in percentage by weight:
1-5% of cortex dictamni extract;
10-20% of white poria extract;
5-10% of bletilla striata extract;
1-5% of a bighead atractylodes rhizome extract;
5-10% of white sesame seed extract;
5-10% of white peony root extract;
1-5% of radix ampelopsis extract;
30% of butanediol;
the balance is added to 100% with deionized water.
The preparation method of the extracts comprises the following steps:
firstly, 60-80g of dittany bark is added with 0.1-0.3% of cellulase, 0.05-0.1% of pectinase and 500-1000g of water, and then heated in a water bath at 30-40 ℃ for 1-2 hours, then 500-1000g of 95% of ethanol is added and heated in a water bath at 60-70 ℃ for 1-2 hours, and then filtered with the diameter of 3 μm. Adding 1-2% active carbon for decolorization, and filtering. Concentrating at 60-70 deg.C to remove ethanol, adding butanediol to 40-50% to obtain cortex Dictamni Radicis extractive solution;
secondly, adding 50-100g of white poria cocos, 0.1-0.3% of cellulase, 0.05-0.1% of pectinase and 500-1000g of water, heating in water bath at 30-40 ℃ for 1 hour, then heating in water bath at 60-70 ℃ for 1-3 hours, filtering with the diameter of 3 mu m, adding butanediol to 20-30% to obtain a white poria cocos extracting solution;
thirdly, adding 500-1000g of water into 50-100g of bletilla striata, heating for 3-5 hours in a water bath at 70-100 ℃, standing overnight, filtering for 3 microns, adding 200-500g of water into filter residues, performing water bath at 70-100 ℃ for 1-3 hours, combining the filtrates, adding butanediol to 20-30% to obtain the bletilla striata extracting solution;
fourthly, 50 to 100g of largehead atractylodes rhizome is added with 0.1 to 0.3 percent of cellulase, 0.05 to 0.1 percent of pectinase and 500 to 1000g of water, the mixture is heated for 0.5 to 1 hour in a water bath at the temperature of between 30 and 40 ℃, then heated for 3 to 5 hours in a water bath at the temperature of between 60 and 70 ℃, filtered by 3 mu m, and added with butanediol to 20 to 30 percent to obtain largehead atractylodes rhizome extracting solution;
fifthly, 50 to 100g of white sesame seeds are processed into powder, 0.1 to 0.3 percent of cellulase, 0.05 to 0.1 percent of pectinase and 1000g of 500-cake water are added, the mixture is heated for 0.5 to 1 hour in a water bath at the temperature of between 30 and 40 ℃, then heated for 3 to 5 hours in a water bath at the temperature of between 60 and 70 ℃, the mixture is kept overnight at normal temperature, filtered by 3 mu m, and added with butanediol to 20 to 30 percent to obtain a white sesame seed extracting solution;
sixthly, 20 to 50g of ampelopsis japonica, 0.1 to 0.3 percent of cellulase and 0.05 to 0.1 percent of pectinase are added, 1000g of water is added, the mixture is heated in water bath at the temperature of between 30 and 40 ℃ for 1 to 2 hours, 1000g of 95 percent ethanol is added, the mixture is heated in water bath at the temperature of between 60 and 70 ℃ for 1 to 2 hours, the mixture is kept overnight at the normal temperature, and is filtered by 3 mu m, and butanediol is added to 40 to 50 percent to obtain an ampelopsis japonica extracting solution;
seventhly, adding 50-100g of white paeony root, adding 0.1-0.3 percent of cellulase and 0.05-0.1 percent of pectinase, 500-1000g of water, heating in water bath at 30-40 ℃ for 1-2h, then adding 500-1000g of 95 percent ethanol, heating in water bath at 60-70 ℃ for 1-2h, standing overnight at normal temperature, filtering by 3 mu m, adding 40-50 percent of butanediol to obtain a white paeony root extracting solution;
eighthly, preparing the new seven-white composition by the extracting solution according to the corresponding proportion.
Compared with the prior art, the invention has the following beneficial effects:
1. the angelica dahurica, the rhizoma typhonii and the asarum in the seven-white ointment in the traditional prescription of the department of Imperial medicine have certain toxicity, and the application adopts safe and nontoxic cortex dictamni, white paeony root and white sesame seeds as substitutes; the angelica dahurica and the asarum are warm in nature and pungent in flavor, and can dispel wind, remove dampness, promote blood circulation and relieve itching; the cortex dictamni is cold in nature and bitter in taste, and is used for cooling blood, stopping bleeding, relieving itching and inhibiting bacteria; the white sesame seeds are neutral in nature, sweet in taste and capable of moistening skin and have a certain whitening effect; the white peony root replaces various diseases on the main surface of the giant typhonium rhizome, and the spot, the stain, the dirt and the defect are removed. The traditional seven-white ointment is smashed into powder and directly smeared, the skin is difficult to absorb, the use experience is extremely poor, raw material essence is extracted and enriched, the cosmetic composition is prepared, the absorption effect is improved, the application range is wide, and the use is convenient.
2. The preparation method adopts cortex dictamni extract, chinaroot greenbrier rhizome extract, bletilla striata extract, bighead atractylodes rhizome extract, white sesame extract, white paeony root extract and Japanese ampelopsis extract to reduce the consumption of materials; the extraction method combining enzymatic extraction and heating extraction is adopted, firstly, cellulase, pectinase and active enzyme are used for breaking cell walls of raw materials, the extraction efficiency is improved, and then ethanol is used as a solvent for extracting active ingredients of the raw materials and simultaneously inactivating biological enzyme, so that compared with the traditional high-temperature heating inactivation, the influence of high temperature on the active ingredients is avoided.
Drawings
FIG. 1 is a graph of the results of a DPPH scavenging assay for SNH compositions of the present invention.
FIG. 2 is a graph of the average difference between the changes in skin moisture content at 0.5h per day according to the present invention.
FIG. 3 is a graph of the average difference between 1.0 h/change in skin moisture content according to the present invention.
FIG. 4 is a graph of the average difference between 1.5 h/change in skin moisture content according to the present invention.
FIG. 5 is a graph of the average difference between 2.0 h/change in skin moisture content according to the present invention.
FIG. 6 is a graph of the mean difference of the change in skin moisture content at 4.0h according to the present invention.
FIG. 7 is a graph of the mean difference between the changes in skin moisture content at 6.0h according to the present invention.
Detailed Description
For the purpose of enhancing an understanding of the present invention, the following detailed description of the present invention is provided in conjunction with the accompanying drawings, which are provided for the purpose of illustration only and are not intended to limit the scope of the present invention.
Example 1
A new seven-white composition with whitening, moisturizing and antioxidant effects comprises the following components in percentage by weight:
1% of cortex dictamni extract;
10% of white poria extract;
5% of bletilla striata extracting solution;
1% of bighead atractylodes rhizome extract;
5% of white sesame seed extracting solution;
5% of white peony root extract;
1% of radix ampelopsis extracting solution;
30% of butanediol;
the balance is added to 100% with deionized water.
The preparation method of the extracts comprises the following steps:
60g of dittany bark, 0.1% of cellulase, 0.05% of pectinase and 500g of water are added, the mixture is heated in a water bath at 40 ℃ for 1 hour, then 500g of 95% of ethanol is added, the mixture is heated in a water bath at 60 ℃ for 1 hour, and the mixture is filtered with the diameter of 3 microns. Adding 1% active carbon for decolorization, and filtering. Concentrating at 60 deg.C to remove ethanol, and adding butanediol to 50% to obtain cortex Dictamni Radicis extractive solution;
secondly, adding 50g of white poria cocos, 0.1% of cellulase, 0.05% of pectinase and 500g of water, heating the mixture for 1 hour in a water bath at the temperature of 30 ℃, then heating the mixture for 1 hour in a water bath at the temperature of 60 ℃, filtering the mixture by a particle size of 3 microns, and adding butanediol to 30% to obtain a white poria cocos extracting solution;
adding 500g of water into 50g of bletilla striata, heating the mixture in a water bath at 70 ℃ for 3 hours, standing the mixture overnight, filtering the mixture by a filter with the diameter of 3 microns, adding 200g of water into filter residues, heating the filter residues in a water bath at 70 ℃ for 1 hour, combining the filter residues, and adding butanediol to 20 percent to obtain a bletilla striata extracting solution;
adding 50g of rhizoma Atractylodis Macrocephalae, 0.1% cellulase, 0.05% pectinase and 500g of water, heating in water bath at 40 deg.C for 1 hr, heating in water bath at 60 deg.C for 3 hr, filtering to 3 μm, and adding butanediol to 20% to obtain rhizoma Atractylodis Macrocephalae extractive solution;
fifthly, 50g of white sesame seeds are processed into powder, 0.1 percent of cellulase, 0.05 percent of pectinase and 500g of water are added, the mixture is heated for 0.5 hour in a water bath at the temperature of 30 ℃ and then heated for 3 hours in a water bath at the temperature of 60 ℃, the mixture is kept overnight at normal temperature, filtered by 3 microns, and added with butanediol to 20 percent to obtain white sesame seed extract;
sixthly, 20g of radix ampelopsis, 0.1 percent of cellulase and 0.05 percent of pectinase are added into the radix ampelopsis, 500g of water is heated for 1 hour in a water bath at the temperature of 30 ℃, 500g of 95 percent of ethanol is added into the water heated for 1 hour in a water bath at the temperature of 60 ℃, the mixture is kept overnight at the normal temperature and filtered by 3 mu m, and butanediol is added into the mixture to 40 percent to obtain an radix ampelopsis extracting solution;
seventhly, 50g of white paeony root, 0.1 percent of cellulase and 0.05 percent of pectinase are added, 500g of water is heated in a water bath for 1 hour at 40 ℃, 500g of 95 percent of ethanol is added, the water bath is heated for 1 hour at 60 ℃, the mixture is kept overnight at normal temperature and is filtered by 3 mu m, and butanediol is added to 40 percent to obtain white paeony root extracting solution;
eighthly, mixing the extracting solutions according to corresponding proportions to prepare the new seven-white composition.
Example 2
A new seven-white composition with whitening, moisturizing and antioxidant effects comprises the following components in percentage by weight:
cortex Dictamni Radicis extract 3%;
15% of white poria extract;
7% of bletilla striata extract;
3% of a bighead atractylodes rhizome extracting solution;
7% of white sesame seed extract;
7% of white peony root extract;
3% of radix ampelopsis extracting solution;
30% of butanediol;
the balance is added to 100% with deionized water.
The preparation method of the extracts comprises the following steps:
firstly, 70g of dittany bark is added with 0.2 percent of cellulase, 0.075 percent of pectinase and 1000g of water, heated for 2 hours in water bath at 40 ℃, then added with 1000g of 95 percent of ethanol, heated for 2 hours in water bath at 70 ℃, and filtered with the diameter of 3 microns. Adding 2% active carbon for decolorization, and filtering. Concentrating at 70 deg.C to remove ethanol, and adding butanediol to 50% to obtain cortex Dictamni Radicis extractive solution;
secondly, 70g of white poria is added with 0.2 percent of cellulase, 0.075 percent of pectinase and 1000g of water, the mixture is heated for 1 hour in water bath at the temperature of 40 ℃, then heated for 3 hours in water bath at the temperature of 70 ℃, filtered by 3 mu m, and added with butanediol to 30 percent to obtain white poria extract;
adding 1000g of water into 70g of bletilla striata, heating the bletilla striata in a water bath at 100 ℃ for 5 hours, standing the mixture overnight, filtering the mixture by 3 microns, adding 500g of water into filter residues, heating the filter residues in a water bath at 100 ℃ for 3 hours, combining the filter residues, and adding butanediol to 30 percent to obtain a bletilla striata extracting solution;
fourthly, adding 0.2 percent of cellulase, 0.075 percent of pectinase and 1000g of water into 70g of white atractylodes rhizome, heating the mixture in a water bath for 1 hour at the temperature of 40 ℃, then heating the mixture in the water bath for 5 hours at the temperature of 70 ℃, filtering the mixture by 3 mu m, and adding butanediol to 30 percent to obtain a white atractylodes rhizome extracting solution;
fifthly, 70g of white sesame seeds are processed into powder, 0.2 percent of cellulase, 0.075 percent of pectinase and 1000g of water are added, the mixture is heated in water bath for 1 hour at the temperature of 40 ℃, then heated in water bath for 5 hours at the temperature of 70 ℃, and is kept overnight at normal temperature, and filtered by 3 microns, and butanediol is added to 30 percent to obtain white sesame seed extracting solution;
sixthly, 40g of ampelopsis japonica, 0.2 percent of cellulase and 0.075 percent of pectinase are added, 1000g of water is heated for 2 hours in a water bath at 40 ℃, 1000g of 95 percent of ethanol is added, the water is heated for 2 hours in a water bath at 70 ℃, the mixture is kept overnight at normal temperature and is filtered by 3 microns, and butanediol is added to 50 percent to obtain an ampelopsis japonica extracting solution;
seventhly, 70g of white paeony root, 0.2 percent of cellulase, 0.075 percent of pectinase and 1000g of water are added, the mixture is heated for 2 hours in a water bath at 40 ℃, 1000g of 95 percent of ethanol is added, the mixture is heated for 2 hours in the water bath at 70 ℃, the mixture is kept overnight at normal temperature and is filtered by 3 microns, and butanediol is added to 50 percent to obtain white paeony root extract;
eighthly, mixing the extracting solutions according to corresponding proportions to prepare the new seven-white composition.
Example 3
A new seven-white composition with whitening, moisturizing and antioxidant effects comprises the following components in percentage by weight:
5% of cortex dictamni extract;
20% of white poria extract;
10% of bletilla striata extract;
5% of a bighead atractylodes rhizome extracting solution;
10% of white sesame seed extract;
10% of white peony root extract;
5% of radix ampelopsis extracting solution;
30% of butanediol;
the balance is added to 100% with deionized water.
The preparation method of the extracts comprises the following steps:
80g of dittany bark is added with 0.3 percent of cellulase, 0.1 percent of pectinase and 1000g of water, heated in water bath for 2 hours at 40 ℃, added with 1000g of 95 percent of ethanol, heated in water bath for 2 hours at 70 ℃, and filtered with the diameter of 3 mu m. Adding 2% active carbon for decolorization, and filtering. Concentrating at 70 deg.C to remove ethanol, and adding butanediol to 50% to obtain cortex Dictamni Radicis extractive solution;
secondly, 100g of white poria is added with 0.3 percent of cellulase, 0.1 percent of pectinase and 1000g of water, the mixture is heated for 1 hour in water bath at the temperature of 40 ℃, then heated for 3 hours in water bath at the temperature of 70 ℃, filtered by 3 mu m, and added with butanediol to 30 percent to obtain white poria extract;
adding 1000g of water into 100g of bletilla striata, heating the mixture in a water bath at 100 ℃ for 5 hours, standing the mixture overnight, filtering the mixture by a filter with the diameter of 3 microns, adding 500g of water into filter residues, heating the filter residues in a water bath at 100 ℃ for 3 hours, combining the filter residues, and adding butanediol to 30 percent to obtain a bletilla striata extracting solution;
fourthly, 100g of largehead atractylodes rhizome is added with 0.3 percent of cellulase, 0.1 percent of pectinase and 1000g of water, the mixture is heated for 1 hour in water bath at the temperature of 40 ℃, then heated for 5 hours in water bath at the temperature of 70 ℃, filtered by 3 mu m, added with butanediol to 30 percent to obtain largehead atractylodes rhizome extracting solution;
fifthly, processing 100g of white sesame into powder, adding 0.3 percent of cellulase, 0.1 percent of pectinase and 1000g of water, heating the mixture in water bath for 1 hour at 40 ℃, then heating the mixture in water bath for 5 hours at 70 ℃, standing overnight at normal temperature, filtering the mixture by 3 microns, and adding butanediol to 30 percent to obtain a white sesame extracting solution;
sixthly, 50g of radix ampelopsis, 0.3 percent of cellulase and 0.1 percent of pectinase are added into the radix ampelopsis, 1000g of water is heated for 2 hours in a water bath at 40 ℃, 1000g of 95 percent of ethanol is added into the water heated for 2 hours in a water bath at 70 ℃, the mixture is kept overnight at normal temperature and is filtered by 3 mu m, and butanediol is added into the mixture to 50 percent to obtain an radix ampelopsis extracting solution;
seventhly, 100g of white paeony root, 0.3 percent of cellulase, 0.1 percent of pectinase and 1000g of water are added, the mixture is heated for 2 hours in a water bath at the temperature of 30-40 ℃, 1000g of 95 percent ethanol is added, the mixture is heated for 2 hours in a water bath at the temperature of 70 ℃, the mixture is kept overnight at normal temperature and filtered by 3 microns, and butanediol is added to 50 percent to obtain white paeony root extracting solution;
eighthly, mixing the extracting solutions according to corresponding proportions to prepare the new seven-white composition.
Example 4:
the novel seven white composition scavenges DPPH free radical testing.
First, reagent preparation
(1)3.943mg DPPH was made up to 50mL with 95% ethanol.
(2) About 10mg of Trolox is added with 95% ethanol to be 100 mL.
(3) Example 3 novel seven white composition.
Second, the experimental procedure
(1) UV zero calibration, 95% ethanol as blank.
(2) Preliminary experiments (DPPH concentration selection)
Shaking 500 μ L DPPH +1000 μ L95% ethanol for 10s, standing for 10min, and measuring absorbance (absorbance at 520nm of 0.45-0.55, which can be used as the following experimental DPPH solution).
(3) Determination of Trolox
| Sample | Trolox(μL) | 95% ethanol (μ L) | DPPH(μL) |
| |
100 | 900 | 500 |
| |
100 | 900+500 | 0 |
| |
0 | 100+900 | 500 |
| |
0 | 100+900+500 | 0 |
After adding DPPH or 95% ethanol, shaking for 10s, standing for 10min, and measuring the absorbance value.
(4) Experiment of
Adding DPPH or 95% ethanol, shaking for 10s, and standing for 10 min.
(5) The absorbance at 520nm was measured, tabulated and plotted to obtain the IC50 value.
Calculating the formula: inhibition rate (%) [1- (S-SB)/(C-CB) ]. 100
Three, result in
| Inner(uL) | Con(uL/mL) | DPPH(％) |
| 50 | 33.33 | 30.28 |
| 100 | 66.67 | 36.58 |
| 150 | 100.00 | 53.78 |
The new seven-white composition is shown in figure 1 as the result of the DPPH removal test.
As a result: the novel seven-white composition has the effect of scavenging DPPH free radicals, and the IC50 value is about 92 uL/mL.
And (4) conclusion: the new seven-white composition has the function of eliminating DPPH free radicals and has stronger antioxidant effect.
Example 5:
and (5) testing the moisturizing efficacy of the novel seven-ingredient composition.
1. Experimental Material
The instrument comprises the following steps: corneometer CMB25 (CK, germany).
A sample to be tested: example 3 novel seven white composition.
2. Conditions of the experiment
Indoor environment.
② no strong sunlight or direct light.
③ the ambient temperature is 20 +/-2 ℃ and the ambient humidity is 40-60 percent.
3. Subject Condition
First, subjects 18-60 years old are normal.
② patients without serious systemic diseases, immunodeficiency or autoimmune diseases.
③ those with inactive allergic diseases.
Fourthly, the prior art has no allergic history to skin care cosmetics.
Almost within a month, hormone drugs and immunosuppressants are not used.
Sixthly, the patient does not participate in other clinical experiments.
And seventhly, volunteers are added and can finish the specified contents according to the experimental requirements.
And 5 participants.
4. Working principle of skin moisture content
The moisture content of the skin can be measured by adopting a worldwide accepted Cornemeter-capacitance method, the principle of which is based on that the dielectric constant (< 7) of water (81) and other substances is changed greatly, and a properly-shaped measuring capacitor changes along with the change of the capacitance of the skin according to the difference of water content, and the capacitance of the skin is in a measuring range. The capacitance measuring method is superior to other methods in that the test result is practically not affected by polarization effect and ionic conductivity since the skin to be tested is not in unnatural contact with the test probe and almost no current flows through the skin to be tested. The instrument probe and the water in the skin have no inertia in the process of establishing balance, and can realize quick measurement, thereby eliminating the influence of active skin on the measurement result.
5. Test procedure
Testing an area: medial to the forearm.
Preparing before testing. The whitening effect products (cosmetics, external medicines or internal health products) cannot be used 2-3 days before the tested part, the testee needs to uniformly clean the inner side of the forearm before the test, the forearm is wiped clean by dry facial tissue, the measuring area mark is made on the inner side of the forearm of the testee after the cleaning, the testee needs to sit still for at least 30min in a room meeting the standard before formal test, the forearm is exposed and placed in a testing state to keep relaxed.
③ the inner side of the forearm in the experiment is marked with 2 multiplied by 4cm2 experiment area, the same arm can mark a plurality of areas at the same time, and the areas are spaced by 2 cm. The test products and the blank control are randomly distributed on the forearm, the blank value of 30min after cleaning of each test area is firstly measured, then the test sample is uniformly coated in the experimental area by using a latex finger cot according to the dosage of 2.0 +/-0.1 mg sample/cm 2, and the skin moisture content of the test area and the control area is respectively measured after the test sample and the control area are coated for 0.5h, 1.0h, 1.5h, 2.0h, 4.0h, 6.0 h. The measurements of the same volunteer were performed by the same measurement staff.
6. Measurement index
Skin moisture content determination: the measurement was performed 3 times, and the average value was taken.
7. Control format
Different treatment controls were performed using the same.
8. Statistical method
And performing pairing t test.
9. Results and analysis
The measurement results of the test personnel are shown in FIGS. 2-7.
Analysis of
The skin moisturizing effect of the human body is evaluated after the novel seven-ingredient composition is used for 6 hours, and the volunteers have no adverse reactions such as allergy and the like during the use period.
After trial for 6h, the experimental data was analyzed as follows, two-tailed test, t0.05(4) ═ 2.776.
According to statistical analysis, the seven-white composition has the moisturizing effect after the samples are used for 0.5h, 1.0h, 1.5h, 2.0h, 4.0h and 6.0h, and the moisturizing time is 2.0 h. The difference has statistical significance, which indicates that the seven-white composition has the moisturizing effect, and the moisturizing time is 2.0 h.
Claims (2)
1. A new seven-white composition with whitening, moisturizing and antioxidant effects is characterized by comprising the following components in percentage by weight:
1-5% of cortex dictamni extract;
10-20% of white poria extract;
5-10% of bletilla striata extract;
1-5% of a bighead atractylodes rhizome extract;
5-10% of white sesame seed extract;
5-10% of white peony root extract;
1-5% of radix ampelopsis extract;
30% of butanediol;
the balance is added to 100% with deionized water.
2. The preparation method for preparing the novel seven-white composition with whitening, moisturizing and antioxidant effects as claimed in claim 1 is characterized by comprising the following steps:
firstly, 60-80g of dittany bark is added with 0.1-0.3% of cellulase, 0.05-0.1% of pectinase and 500-1000g of water, heated for 1-2 hours in a water bath at 30-40 ℃, then added with 500-1000g of 95% ethanol and heated for 1-2 hours in a water bath at 60-70 ℃, and filtered with the diameter of 3 mu m; adding 1-2% active carbon for decolorization, and filtering; concentrating at 60-70 deg.C to remove ethanol, adding butanediol to 40-50% to obtain cortex Dictamni Radicis extractive solution;
secondly, adding 50-100g of white poria cocos, 0.1-0.3% of cellulase, 0.05-0.1% of pectinase and 500-1000g of water, heating in water bath at 30-40 ℃ for 1 hour, then heating in water bath at 60-70 ℃ for 1-3 hours, filtering with the diameter of 3 mu m, adding butanediol to 20-30% to obtain a white poria cocos extracting solution;
thirdly, adding 500-1000g of water into 50-100g of bletilla striata, heating for 3-5 hours in a water bath at 70-100 ℃, standing overnight, filtering for 3 microns, adding 200-500g of water into filter residues, performing water bath at 70-100 ℃ for 1-3 hours, combining the filtrates, adding butanediol to 20-30% to obtain the bletilla striata extracting solution;
fourthly, 50 to 100g of largehead atractylodes rhizome is added with 0.1 to 0.3 percent of cellulase, 0.05 to 0.1 percent of pectinase and 500 to 1000g of water, the mixture is heated for 0.5 to 1 hour in a water bath at the temperature of between 30 and 40 ℃, then heated for 3 to 5 hours in a water bath at the temperature of between 60 and 70 ℃, filtered by 3 mu m, and added with butanediol to 20 to 30 percent to obtain largehead atractylodes rhizome extracting solution;
fifthly, 50 to 100g of white sesame seeds are processed into powder, 0.1 to 0.3 percent of cellulase, 0.05 to 0.1 percent of pectinase and 1000g of 500-cake water are added, the mixture is heated for 0.5 to 1 hour in a water bath at the temperature of between 30 and 40 ℃, then heated for 3 to 5 hours in a water bath at the temperature of between 60 and 70 ℃, the mixture is kept overnight at normal temperature, filtered by 3 mu m, and added with butanediol to 20 to 30 percent to obtain a white sesame seed extracting solution;
sixthly, 20 to 50g of ampelopsis japonica, 0.1 to 0.3 percent of cellulase and 0.05 to 0.1 percent of pectinase are added, 1000g of water is added, the mixture is heated in water bath at the temperature of between 30 and 40 ℃ for 1 to 2 hours, 1000g of 95 percent ethanol is added, the mixture is heated in water bath at the temperature of between 60 and 70 ℃ for 1 to 2 hours, the mixture is kept overnight at the normal temperature, and is filtered by 3 mu m, and butanediol is added to 40 to 50 percent to obtain an ampelopsis japonica extracting solution;
seventhly, adding 50-100g of white paeony root, adding 0.1-0.3 percent of cellulase and 0.05-0.1 percent of pectinase, 500-1000g of water, heating in water bath at 30-40 ℃ for 1-2h, then adding 500-1000g of 95 percent ethanol, heating in water bath at 60-70 ℃ for 1-2h, standing overnight at normal temperature, filtering by 3 mu m, adding 40-50 percent of butanediol to obtain a white paeony root extracting solution;
eighthly, preparing the new seven-white composition by the extracting solution according to the corresponding proportion.
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