CN114306145A - Anti-hair loss shampoo and preparation method thereof - Google Patents
Anti-hair loss shampoo and preparation method thereof Download PDFInfo
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- CN114306145A CN114306145A CN202111679274.4A CN202111679274A CN114306145A CN 114306145 A CN114306145 A CN 114306145A CN 202111679274 A CN202111679274 A CN 202111679274A CN 114306145 A CN114306145 A CN 114306145A
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- 239000002453 shampoo Substances 0.000 title claims abstract description 50
- 230000003656 anti-hair-loss Effects 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title abstract description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 65
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 54
- 239000000284 extract Substances 0.000 claims abstract description 36
- 239000000341 volatile oil Substances 0.000 claims abstract description 36
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 claims abstract description 28
- 241000195649 Chlorella <Chlorellales> Species 0.000 claims abstract description 25
- 235000011187 glycerol Nutrition 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 19
- FBNAWLJSQORPAX-UHFFFAOYSA-N 4-methyl-3-propan-2-ylphenol Chemical compound CC(C)C1=CC(O)=CC=C1C FBNAWLJSQORPAX-UHFFFAOYSA-N 0.000 claims abstract description 19
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 19
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 19
- 239000004359 castor oil Substances 0.000 claims abstract description 14
- 235000019438 castor oil Nutrition 0.000 claims abstract description 14
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 14
- 229940044591 methyl glucose dioleate Drugs 0.000 claims abstract description 14
- 239000004094 surface-active agent Substances 0.000 claims abstract description 12
- 229940081510 piroctone olamine Drugs 0.000 claims abstract description 10
- 239000000419 plant extract Substances 0.000 claims abstract description 10
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims abstract description 8
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims abstract description 8
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229940100524 ethylhexylglycerin Drugs 0.000 claims abstract description 6
- 150000003863 ammonium salts Chemical group 0.000 claims abstract description 3
- OVBJJZOQPCKUOR-UHFFFAOYSA-L EDTA disodium salt dihydrate Chemical compound O.O.[Na+].[Na+].[O-]C(=O)C[NH+](CC([O-])=O)CC[NH+](CC([O-])=O)CC([O-])=O OVBJJZOQPCKUOR-UHFFFAOYSA-L 0.000 claims abstract 3
- JFQWHJPQSSMFMH-UHFFFAOYSA-N methyl 4,5,6-trimethylpyrimidine-2-carboxylate Chemical compound COC(=O)C1=NC(=C(C(=N1)C)C)C JFQWHJPQSSMFMH-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000000463 material Substances 0.000 claims description 42
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- SCVVSSZVLZQUDZ-UHFFFAOYSA-N 3-methyl-2,6-dihydro-1H-pyrimidine-2-carboxylic acid Chemical compound CN1C(NCC=C1)C(=O)O SCVVSSZVLZQUDZ-UHFFFAOYSA-N 0.000 claims description 22
- 241000196324 Embryophyta Species 0.000 claims description 18
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 13
- 239000008367 deionised water Substances 0.000 claims description 9
- 229910021641 deionized water Inorganic materials 0.000 claims description 9
- 229940107131 ginseng root Drugs 0.000 claims description 9
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 9
- 239000001243 zingiber officinale rosc. root absolute Substances 0.000 claims description 9
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 8
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 8
- 230000003658 preventing hair loss Effects 0.000 claims description 8
- 229920000289 Polyquaternium Polymers 0.000 claims description 7
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 claims description 7
- 229940048848 lauryl glucoside Drugs 0.000 claims description 7
- 229940083957 1,2-butanediol Drugs 0.000 claims description 6
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 claims description 6
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 claims description 6
- 229960005233 cineole Drugs 0.000 claims description 6
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 5
- 241000544656 Cedrus atlantica Species 0.000 claims description 5
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- 239000001180 angelica archangelica l. root extract Substances 0.000 claims description 3
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- 210000003780 hair follicle Anatomy 0.000 description 7
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- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 6
- 230000003405 preventing effect Effects 0.000 description 6
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- DDGPBVIAYDDWDH-UHFFFAOYSA-N 3-[dodecyl(dimethyl)azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC(O)CS([O-])(=O)=O DDGPBVIAYDDWDH-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- 206010001766 Alopecia totalis Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 240000006497 Dianthus caryophyllus Species 0.000 description 1
- 235000009355 Dianthus caryophyllus Nutrition 0.000 description 1
- 241001289529 Fallopia multiflora Species 0.000 description 1
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- 229940079988 potassium cocoyl glycinate Drugs 0.000 description 1
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- 239000010668 rosemary oil Substances 0.000 description 1
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- 229940048109 sodium methyl cocoyl taurate Drugs 0.000 description 1
- GOJYXPWOUJYXJC-UHFFFAOYSA-M sodium;2-[1-(2-hydroxyethyl)-2-undecyl-4,5-dihydroimidazol-1-ium-1-yl]acetate;hydroxide Chemical compound [OH-].[Na+].CCCCCCCCCCCC1=NCC[N+]1(CCO)CC([O-])=O GOJYXPWOUJYXJC-UHFFFAOYSA-M 0.000 description 1
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- Cosmetics (AREA)
Abstract
The invention discloses an anti-hair loss shampoo and a preparation method thereof, belongs to the technical field of hair care products, and comprises the following components in percentage by weight: 28-60% of a surfactant, 0.001-0.1% of a plant extract, 0.6-3% of a plant essential oil, 0.1-0.8% of piroctone olamine, 0.04-0.10% of o-cymene-5-ol, 0.04-0.15% of ethylhexylglycerin, 0.5-2% of 1, 2-hexanediol, 1-3% of butanediol, 1-3% of glycerin, 0.5-1.5% of a chlorella extract, 0.1-0.6% of tetramethylpyrimidinecarboxylic acid, 0.05-0.15% of disodium EDTA, 100.2-0.3% of polyquaternary ammonium salt, 0.15-0.25% of citric acid, 0.6-0.8% of methyl glucose dioleate, 3-5% of PEG-40 hydrogenated castor oil, and the balance of water. The anti-hair loss shampoo disclosed by the invention can effectively clean pores, reduce the oil production of scalp, resist damage and repair scalp through the compounding and proportioning of the components, thereby achieving the anti-hair loss effect.
Description
Technical Field
The invention belongs to the technical field of hair care products, and particularly relates to anti-hair loss shampoo and a preparation method thereof.
Background
With the accelerated pace of life, the pressure of life of people is high, people often work overtime, stay up all night, and the life is irregular, so that health problems are caused, the hair quality is influenced, and the problems of poor hair quality, dryness, easy shedding and the like are often caused. The normal hair loss is the hair in the catagen and telogen phases, and the normal amount of hair can be maintained because the hair entering the catagen phase and the hair newly entering the anagen phase are constantly in dynamic balance. Pathological alopecia refers to abnormal or excessive hair loss, and has many causes, and pathological alopecia is a common skin disease and can cause alopecia symptoms such as seborrheic alopecia, premature alopecia, baldness, alopecia areata, alopecia totalis and the like. Alopecia has a great influence on the overall appearance of people, psychological and physiological problems can be derived, and the normal life of the people suffering from alopecia can be seriously influenced.
The root causes of alopecia are unhealthy scalp, pore blockage, atrophy and degeneration of hair follicles, and cells in the hair follicles shrink and even die due to excessive secretion of grease, hair pore blockage and the like, so that the hair follicles can not absorb nutrients of surrounding hair, and the hair can not grow. Under normal conditions, the hair papilla in the hair follicle has abundant capillary vessels, and can absorb nutrients necessary for hair growth from blood to ensure the normal growth of the hair. The hair can be about 50-100 hairs lost per day due to metabolism, but the whole quantity of the hairs is not affected. However, due to the excessive secretion of sebaceous glands, the blockage of pores, etc., the environment for normal hair growth is damaged, so that the hair cannot grow normally, and phenomena such as alopecia, hair breakage, etc. occur.
At present, the medicines for treating alopecia and growing hair on the market are more and more, and because the research on the reasons of alopecia is not thorough, the existing alopecia-stopping and growing medicines cannot treat both symptoms and root causes, not only has high price, but also has the problems of easy relapse and non-ideal effect after stopping the medicines.
Chinese patent CN111714429A discloses an anti-hair loss shampoo, which comprises the following substances in parts by weight: 30-42 parts of water, 4-12 parts of sodium lauroamphoacetate, 3-12 parts of lauryl hydroxy sulfobetaine, 4-11 parts of sodium methyl cocoyl taurate, 2-12 parts of potassium cocoyl glycinate, 1-8 parts of sodium lauroyl sarcosinate, 0.1-1 part of butanediol, 0.1-2 parts of a ginger root extract, 0.3-2.5 parts of a ginseng root extract, 0.3-1.5 parts of a rhizoma anemarrhenae root extract, 0.1-1 part of 1, 2-hexanediol, 0.5-1 part of a angelica root extract, 0.3-1.8 parts of a polygonum multiflorum root extract and the like. The invention can improve scalp blood circulation, inhibit hair from being damaged by external environment, and prevent alopecia. However, the shampoo does not have the effects of cleaning pores and reducing oil on the scalp, and cannot solve the problem of hair loss caused by pore blockage.
Therefore, the anti-hair loss shampoo has the effects of cleaning pores, reducing scalp oil, resisting damage, repairing scalp and the like, and has important significance in solving the problems in the prior art.
Disclosure of Invention
In view of the defects of the prior art, one of the purposes of the invention is to provide the anti-hair loss shampoo, which can effectively clean pores, reduce oil on the scalp, resist damage and repair the scalp, thereby achieving the anti-hair loss effect.
In order to achieve the purpose, the specific technical scheme of the invention is as follows:
the anti-hair loss shampoo comprises the following components in percentage by weight:
28-60% of surfactant, 0.001-0.1% of plant extract, 0.6-3% of plant essential oil, 0.1-0.8% of piroctone olamine salt, 0.04-0.10% of o-cymene-5-alcohol, 0.04-0.15% of ethylhexyl glycerol, 0.5-2% of 1, 2-hexanediol, 1-3% of butanediol, 1-3% of glycerol, 0.5-1.5% of chlorella extract, 0.1-0.6% of tetrahydro-methyl pyrimidine carboxylic acid, 0.05-0.15% of disodium EDTA (ethylene diamine tetraacetic acid), 100.2-0.3% of polyquaternary ammonium salt, 0.15-0.25% of citric acid, 0.6-0.8% of methyl glucose dioleate, 3-5% of PEG-40 hydrogenated castor oil and the balance of water.
Most shampoo contains a surfactant, and the surfactant easily stimulates scalp to cause skin deterioration; according to the application, the combination of the tetrahydro-methyl pyrimidine carboxylic acid, the chlorella extract and the glycerol is adopted, so that the tetrahydro-methyl pyrimidine carboxylic acid and the chlorella extract are fully dissolved in the glycerol, and on one hand, the damage of dermal collagen can be avoided, the synthesis of collagen fibers is stimulated, the reconstruction of a skin structure is facilitated, and the skin elasticity is recovered; on the other hand, scalp cells can be protected, the barrier function of skin is enhanced, and the cells are prevented from being adversely affected by the surfactant in the shampoo, so that the scalp and the hair using the shampoo have stronger capability of resisting external pollution (such as ultraviolet injury, dust and bacterial invasion). The tetrahydro-methyl pyrimidine carboxylic acid, the chlorella extract and the glycerol have a synergistic effect, and a scalp protective layer is formed under the combined action, so that the damaged skin is reconstructed, the regeneration of collagen is promoted, the health condition of the scalp is improved, and the effects of resisting damage and repairing the scalp are achieved, so that the alopecia preventing effect is achieved.
Preferably, the weight ratio of the piroctone olamine salt to the o-cymene-5-ol to the ethylhexyl glycerin to the 1, 2-hexanediol to the butanediol is 0.2:0.05:0.05:0.9: 2.
In the formula of the anti-hair loss shampoo, o-cymene-5-alcohol with the chemical name of 3-methyl-4-isopropyl phenol is used as a bactericide, piroctone olamine is used as an antidandruff agent, and the piroctone olamine, o-cymene-5-alcohol and ethylhexyl glycerin are compounded and dissolved in 1, 2-hexanediol and butanediol, so that the antidandruff and antibacterial effects of the piroctone olamine and the o-cymene-5-alcohol can be promoted, pores can be cleaned deeply, and the effect of reducing scalp oil production is achieved.
Preferably, the weight ratio of the glycerol to the chlorella extract to the tetrahydro-methyl pyrimidine carboxylic acid is 6:3: 1.
Preferably, the anti-hair loss shampoo comprises the following components in percentage by weight: 45% of surfactant, 0.05% of plant extract, 1.1% of plant essential oil, 0.2% of piroctone olamine salt, 0.05% of o-cymene-5-ol, 0.05% of ethylhexyl glycerol, 0.9% of 1, 2-hexanediol, 2% of butanediol, 2% of glycerol, 1% of chlorella extract, 0.33% of tetrahydro-methyl pyrimidine carboxylic acid, 0.1% of disodium EDTA, 100.26% of polyquaternium, 0.19% of citric acid, 0.7% of methyl glucose dioleate, 3.6% of PEG-40 hydrogenated castor oil and the balance of water.
Preferably, the surfactant comprises 12% of sodium lauroyl sarcosinate, 25% of cocamidopropyl betaine and 8% of lauryl glucoside.
Preferably, the plant extract comprises one or more of ginseng root extract, ginger root extract or angelica root extract. The plant extract can nourish hair follicle and strengthen hair root.
Preferably, the plant essential oil comprises sweet orange essential oil, eucalyptol rosemary essential oil and Atlantic cedar essential oil, and the sweet orange essential oil, the eucalyptol rosemary essential oil and the Atlantic cedar essential oil are mixed according to the mass ratio of 9:0.5: 0.5.
The invention also provides a preparation method of the anti-hair loss shampoo, which comprises the following steps:
s1, mixing a proper amount of deionized water with the EDTA disodium and the polyquaternium-10, heating to 50 ℃, keeping the temperature, and stirring at the rotating speed of 360rpm for 30 min; then, adding the surfactant for mixing, and stirring at the rotating speed of 360rpm for 10min to obtain a material A;
s2, mixing the plant essential oil with PEG-40 hydrogenated castor oil, and stirring at the rotating speed of 220rpm for 10min to obtain a material B;
s3, stirring the plant extract, the glycerol, the chlorella extract and the tetrahydro-methyl pyrimidine carboxylic acid at the rotating speed of 220rpm, and fully mixing to obtain a material C;
s4, adding the material B and the material C into the material A, and stirring at a rotating speed of 220rpm for 10min to obtain a material D;
s5, fully mixing the citric acid with a proper amount of deionized water, adding the mixture into the material D for a few times, stirring at a rotating speed of 220rpm, adjusting the pH value to 6.0, stopping adding the citric acid, and continuing stirring at the rotating speed of 220rpm for 2min to obtain a material E;
s6, mixing the piroctone olamine salt, o-cymene-5-alcohol, ethylhexyl glycerol, 1, 2-hexanediol and butanediol, stirring at the rotating speed of 220rpm, and fully mixing to obtain a material F;
s7, mixing the material E and the material F, and stirring for 10min at a rotating speed of 220rpm to obtain a material G;
s8, adding the methyl glucose dioleate into deionized water at 80 ℃ for dissolving, adding the material G for mixing, stirring at a rotating speed of 220rpm for 20min, and adjusting the pH value to 6.0 to prepare the anti-hair loss shampoo.
Compared with the prior art, the invention has the advantages that:
(1) the anti-hair loss shampoo disclosed by the invention adopts the combination of the tetrahydro-methyl pyrimidine carboxylic acid, the chlorella extract and the glycerol, so that on one hand, a scalp protective layer can be formed, the barrier function of scalp skin is enhanced, the capability of the scalp for resisting external pollution is enhanced, and the anti-damage effect is achieved; on the other hand, the damage of dermal collagen can be avoided, the synthesis of collagen fibers is stimulated, the reconstruction of a skin structure is facilitated, and the effect of repairing the scalp is achieved. The two aspects act together, thereby achieving the effect of preventing alopecia; particularly, the effect is best when the weight ratio of the glycerol to the chlorella extract to the tetrahydro-methyl pyrimidine carboxylic acid is 6:3:1, the average daily alopecia amount is reduced from 154 to 53 after the composition is used for a period of time, and the alopecia prevention effect is obvious.
(2) The anti-hair loss shampoo adopts the combination of piroctone olamine salt, o-cymene-5-alcohol, ethylhexyl glycerol, 1, 2-hexanediol and butanediol, wherein the ethylhexyl glycerol can promote the anti-dandruff and antibacterial effects of the piroctone olamine salt and the o-cymene-5-alcohol, and deeply cleans pores; the shampoo provided by the invention has a good grease removing effect.
The anti-hair loss shampoo disclosed by the invention can effectively clean pores, reduce the oil production of scalp, resist damage and repair scalp through the compounding and proportioning of the components, thereby achieving the anti-hair loss effect.
Detailed Description
The technical solutions of the present invention will be described clearly and completely below, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the following examples and comparative examples, as a preferred embodiment, the plant essential oils are composed of sweet orange essential oil, eucalyptol rosemary essential oil and Atlantic cedar essential oil in a mass ratio of 9:0.5: 0.5. Eucalyptol rosemary oil is a commercially available product under the brand name AMARANDAGARDENS/carnation garden, and other components in the following examples and comparative examples are also commercially available.
Example 1
The anti-hair loss shampoo comprises the following components in percentage by weight: 12% of sodium lauroyl sarcosinate, 25% of cocamidopropyl betaine, 8% of lauryl glucoside, 0.02% of ginseng root extract, 0.03% of ginger root extract, 1.1% of plant essential oil, 0.2% of piroctone olamine salt, 0.05% of o-cymene-5-ol, 0.05% of ethylhexyl glycerol, 0.9% of 1, 2-hexanediol, 2% of butanediol, 2% of glycerol, 1% of chlorella extract, 0.33% of tetrahydro-methyl pyrimidine carboxylic acid, 0.1% of EDTA disodium, 100.26% of polyquaternium, 0.19% of citric acid, 0.7% of methyl glucose dioleate, 3.6% of PEG-40 hydrogenated castor oil and the balance of water.
The preparation method of the anti-hair loss shampoo comprises the following steps:
s1, mixing a proper amount of deionized water with EDTA disodium and polyquaternium-10, heating to 50 ℃, keeping the temperature, and stirring at the rotating speed of 360rpm for 30 min; then, adding sodium lauroyl sarcosinate and cocamidopropyl betaine, mixing, and stirring at the rotating speed of 360rpm for 10min to obtain a material A;
s2, mixing the plant essential oil with PEG-40 hydrogenated castor oil, and stirring at the rotating speed of 220rpm for 10min to obtain a material B;
s3, stirring the ginseng root extract and the ginger root extract with glycerol, the chlorella extract and the tetrahydro-methyl pyrimidine carboxylic acid at the rotating speed of 220rpm, and fully mixing to obtain a material C;
s4, adding the material B and the material C into the material A, and stirring at the rotating speed of 220rpm for 10min to obtain a material D;
s5, fully mixing citric acid and a proper amount of deionized water to obtain a citric acid solution with the mass percentage of 19%, adding a small amount of citric acid solution into the material D for multiple times, stirring at the rotating speed of 220rpm, regulating the pH value to 6.0, stopping adding the citric acid, and continuing stirring at the rotating speed of 220rpm for 2min to obtain a material E;
s6, mixing piroctone olamine salt, o-cymene-5-alcohol, ethylhexyl glycerol, 1, 2-hexanediol and butanediol, stirring at the rotating speed of 220rpm, and fully mixing to obtain a material F;
s7, mixing the material E and the material F, and stirring for 10min at a rotating speed of 220rpm to obtain a material G;
s8, adding methyl glucose dioleate into deionized water with the same mass as the methyl glucose dioleate at 80 ℃ for dissolving, adding the material G for mixing, stirring at the rotating speed of 220rpm for 20min, and adjusting the pH value to 6.0 to prepare the anti-hair loss shampoo.
Example 2
The difference between the example 2 and the example 1 is that the anti-hair loss shampoo of the embodiment comprises the following components in percentage by weight: 12% of sodium lauroyl sarcosinate, 25% of cocamidopropyl betaine, 8% of lauryl glucoside, 0.02% of ginseng root extract, 0.03% of ginger root extract, 1.1% of plant essential oil, 0.1% of piroctone olamine salt, 0.04% of o-cymene-5-ol, 0.05% of ethylhexyl glycerol, 0.9% of 1, 2-hexanediol, 2% of butanediol, 2% of glycerol, 0.73% of chlorella extract, 0.6% of tetrahydro-methyl pyrimidine carboxylic acid, 0.1% of disodium EDTA, 100.26% of polyquaternium, 0.19% of citric acid, 0.7% of methyl glucose dioleate, 3.6% of PEG-40 hydrogenated castor oil, and the balance of water.
Namely, the difference from example 1 is that the weight ratio of glycerin, chlorella extract and tetrahydro-methylpyrimidine carboxylic acid in this example is 6:2.2:1.8, and the amounts of piroctone olamine and o-cymene-5-ol are reduced.
Example 3
The difference between the example 3 and the example 1 is that the anti-hair loss shampoo of the embodiment comprises the following components in percentage by weight: 12% of sodium lauroyl sarcosinate, 25% of cocamidopropyl betaine, 8% of lauryl glucoside, 0.02% of ginseng root extract, 0.03% of ginger root extract, 0.9% of plant essential oil, 0.4% of piroctone olamine salt, 0.1% of o-cymene-5-ol, 0.1% of ethylhexyl glycerol, 1, 2-hexanediol, 3% of butanediol, 1% of glycerol, 0.55% of chlorella extract, 0.25% of tetrahydro-methyl pyrimidinecarboxylic acid, 0.1% of disodium EDTA, 100.26% of polyquaternium, 0.19% of citric acid, 0.7% of methyl glucose dioleate, 3% of PEG-40 hydrogenated castor oil and the balance of water.
Comparative example 1
The anti-hair loss shampoo comprises the following components in percentage by weight: 12% of sodium lauroyl sarcosinate, 25% of cocamidopropyl betaine, 8% of lauryl glucoside, 0.02% of ginseng root extract, 0.03% of ginger root extract, 1.1% of plant essential oil, 0.05% of piroctone olamine salt, 0.02% of o-cymene-5-ol, 0.1% of ethylhexyl glycerol, 1, 2-hexanediol, 3% of butanediol, 2% of glycerol, 1% of chlorella extract, 0.33% of tetrahydro-methyl pyrimidine carboxylic acid, 0.1% of EDTA disodium, 100.26% of polyquaternium, 0.19% of citric acid, 0.7% of methyl glucose dioleate, 3.6% of PEG-40 hydrogenated castor oil and the balance of water.
Comparative example 1 is different from example 1 in that the amounts of piroctone olamine salt and o-cymene-5-ol were reduced and the amounts of ethylhexyl glycerin, 1, 2-hexanediol and butanediol were simultaneously adjusted.
Comparative example 2
The anti-hair loss shampoo comprises the following components in percentage by weight: 12% of sodium lauroyl sarcosinate, 25% of cocamidopropyl betaine, 8% of lauryl glucoside, 0.02% of ginseng root extract, 0.03% of ginger root extract, 1.1% of plant essential oil, 0.99% of piroctone olamine salt, 0.1% of o-cymene-5-ol, 0.05% of ethylhexyl glycerol, 0.9% of 1, 2-hexanediol, 2% of butanediol, 2% of glycerol, 1.7% of chlorella extract, 0.1% of disodium EDTA, 100.26% of polyquaternium, 0.19% of citric acid, 0.7% of methyl glucose dioleate, 3.6% of PEG-40 hydrogenated castor oil and the balance of water.
That is, compared to example 1, the shampoo for preventing hair loss of this comparative example did not contain tetrahydro-methylpyrimidine carboxylic acid while increasing the amounts of piroctone olamine, o-cymene-5-ol and chlorella extract.
Comparative example 3
Comparative example 3 is substantially the same as example 1 except that the weight percentage of the plant essential oil of the anti-hair loss shampoo of the present comparative example is 3.2%, while the weight percentage of the hydrogenated castor oil with added PEG-40 is 9.6%, and the other components and the amounts thereof are not changed.
Test examples
Test one: alopecia preventing effect
The hair loss prevention shampoo prepared in the examples and the comparative examples selects 70 hair loss patients with age of 20-60 years and no other diseases for evaluating the hair washing effect, namely 60 men and 12 women.
The test method comprises the following steps: the anti-hair loss shampoos prepared in examples 1 to 3 and comparative examples 1 to 3 were used to randomly divide 72 hair loss patients into six groups of 12 patients, 10 male patients and 2 female patients. Before trial, the condition of the health condition of the hair is tracked, so that a bald person combs the hair through 10 times by using a provided standard oak comb before washing the hair in each trial, the number of the hair falling in each time is recorded, the tracking is continued for 3 months, and the test result is shown in table 1.
In the product trial process, the testee is required to wash the hair once every two days, the anti-hair loss shampoo is kept on the hair for 3 minutes and is properly massaged, and then the hair is washed clean by water.
TABLE 1 alopecia before and after use by alopecia patients
As can be seen from table 1, the average daily hair loss amount is significantly reduced after the anti-hair loss shampoos of examples 1 to 3 are used, and the average daily hair loss amount is less than 100 after 28 days of continuous use, which falls within the range of normal hair loss, and thus, the anti-hair loss shampoo of the present invention has an excellent anti-hair loss effect. Wherein the hair loss preventing effect is optimal when the weight ratio of the glycerol to the chlorella extract to the tetrahydro-methyl pyrimidine carboxylic acid is 6:3: 1; example 2 the alopecia preventing effect was slightly reduced due to the adjustment of the weight ratio of glycerin, chlorella extract and tetrahydro-methylpyrimidine carboxylic acid and the reduction of the amounts of piroctone olamine and o-cymene-5-ol. By comparing comparative example 1 and example 1, it can be found that the weight percentages of piroctone olamine salt and o-cymene-5-ol are reduced and the anti-falling effect is remarkably reduced. Comparing comparative example 2 with example 1, it can be found that the addition of the use amounts of piroctone olamine, o-cymene-5-ol and chlorella extract in comparative example 2 is not favorable for the balance of scalp flora due to excessive oil control and sterilization, is not favorable for scalp health after long-term use, and is likely to cause alopecia; meanwhile, the anti-dropping agent does not contain tetrahydro-methyl pyrimidine carboxylic acid, so that the barrier function of the anti-dropping agent is weakened, the anti-damage effect is poor, and the anti-dropping effect is obviously reduced. Generally, the hair loss treatment effect is better when the dosage of the plant essential oil is increased, however, when the dosage of the plant essential oil exceeds a proper content, as in comparative example 3, the dosage of the essential oil is increased, and the solvent is also increased in a proper proportion, so that shampoo is easy to remain, hair follicle blockage is caused, the hair is burdened, and the hair loss is aggravated.
And (2) test II: oil index detection
The hair loss prevention shampoo prepared in the examples and the comparative examples selects 72 hair loss patients with age of 20-60 years and no other diseases for evaluating the hair washing effect, namely 60 men and 12 women.
The test method comprises the following steps: 72 hair loss patients were randomly divided into six groups of 12 persons each, 10 persons for male and 2 persons for female, and the hair loss prevention shampoos prepared in examples 1 to 3 and comparative examples 1 to 3 were used for 1 month, respectively. Corresponding oil index was measured on the top hairline and forehead of 72 hair loss patients by CK skin tester, and the results of the oil index are shown in Table 2.
TABLE 2 fat index before and after use for alopecia patients
As can be seen from table 2, after the anti-hair-loss shampoo of examples 1 to 3 is used, the grease indexes of the forehead and the top hair curl positions are significantly reduced, which indicates that the anti-hair-loss shampoo of the present invention has a good oil control effect. By comparing comparative example 1 with example 1, it was found that the weight percentage of piroctone olamine salt and o-cymene-5-ol was reduced in comparative example 1, the oil control effect was deteriorated, and the grease index was increased. Comparing comparative example 2 with example 1, it can be seen that comparative example 2 increased the amounts of piroctone olamine, o-cymene-5-ol and chlorella vulgaris extract, resulting in excessive oil control and sterilization, and although the oil index was significantly reduced, it was not good for scalp health and easily resulted in alopecia from the data of alopecia preventing effect. By comparing comparative example 3 with example 1, it can be seen that in comparative example 3, the amount of the essential oil is increased, and the solvent is also increased in a proper proportion, so that shampoo is easy to remain, hair follicles are easy to block, and the oil index is obviously increased.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. The anti-hair loss shampoo is characterized by comprising the following components in percentage by weight:
28-60% of a surfactant, 0.001-0.1% of a plant extract, 0.6-3% of a plant essential oil, 0.1-0.8% of piroctone olamine, 0.04-0.10% of o-cymene-5-ol, 0.04-0.15% of ethylhexylglycerin, 0.5-2% of 1, 2-hexanediol, 1-3% of butanediol, 1-3% of glycerin, 0.5-1.5% of a chlorella extract, 0.1-0.6% of tetramethylpyrimidinecarboxylic acid, 0.05-0.15% of disodium EDTA, 100.2-0.3% of polyquaternary ammonium salt, 0.15-0.25% of citric acid, 0.6-0.8% of methyl glucose dioleate, 3-5% of PEG-40 hydrogenated castor oil, and the balance of water.
2. The shampoo for preventing hair loss as claimed in claim 1, wherein the weight ratio of the piroctone olamine salt, the o-cymene-5-ol, the ethylhexyl glycerin, the 1, 2-hexanediol and the butanediol is 0.2:0.05:0.05:0.9: 2.
3. the shampoo for preventing hair loss as claimed in claim 1, wherein the weight ratio of the glycerol, the chlorella extract and the tetrahydro-methyl pyrimidine carboxylic acid is 6:3: 1.
4. the anti-hair loss shampoo as claimed in claim 1, which is characterized by comprising the following components in percentage by weight: 45% of surfactant, 0.05% of plant extract, 1.1% of plant essential oil, 0.2% of piroctone olamine salt, 0.05% of o-cymene-5-ol, 0.05% of ethylhexyl glycerol, 0.9% of 1, 2-hexanediol, 2% of butanediol, 2% of glycerol, 1% of chlorella extract, 0.33% of tetrahydro-methyl pyrimidine carboxylic acid, 0.1% of disodium EDTA, 100.26% of polyquaternium, 0.19% of citric acid, 0.7% of methyl glucose dioleate, 3.6% of PEG-40 hydrogenated castor oil and the balance of water.
5. The anti-hair loss shampoo as claimed in claim 1, wherein the surfactant comprises 12% of sodium lauroyl sarcosine, 25% of cocamidopropyl betaine and 8% of lauryl glucoside.
6. The shampoo for preventing hair loss as claimed in claim 1, wherein the plant extract comprises one or more of ginseng root extract, ginger root extract or angelica root extract.
7. The anti-hair loss shampoo as claimed in claim 1, wherein the plant essential oils comprise sweet orange essential oil, eucalyptol rosemary essential oil and Atlantic cedar essential oil, and the sweet orange essential oil, the eucalyptol rosemary essential oil and the Atlantic cedar essential oil are mixed according to a mass ratio of 9:0.5: 0.5.
8. The method for preparing the shampoo for preventing hair loss as claimed in any one of claims 1 to 7, which comprises the following steps:
s1, mixing a proper amount of deionized water with the EDTA disodium and the polyquaternium-10, heating to 50 ℃, keeping the temperature, and stirring at the rotating speed of 360rpm for 30 min; then, adding the surfactant for mixing, and stirring at the rotating speed of 360rpm for 10min to obtain a material A;
s2, mixing the plant essential oil with PEG-40 hydrogenated castor oil, and stirring at the rotating speed of 220rpm for 10min to obtain a material B;
s3, stirring the plant extract, the glycerol, the chlorella extract and the tetrahydro-methyl pyrimidine carboxylic acid at the rotating speed of 220rpm, and fully mixing to obtain a material C;
s4, adding the material B and the material C into the material A, and stirring at a rotating speed of 220rpm for 10min to obtain a material D;
s5, fully mixing the citric acid with a proper amount of deionized water, adding the mixture into the material D for a few times, stirring at a rotating speed of 220rpm, adjusting the pH value to 6.0, stopping adding the citric acid, and continuing stirring at the rotating speed of 220rpm for 2min to obtain a material E;
s6, mixing the piroctone olamine salt, o-cymene-5-alcohol, ethylhexyl glycerol, 1, 2-hexanediol and butanediol, stirring at the rotating speed of 220rpm, and fully mixing to obtain a material F;
s7, mixing the material E and the material F, and stirring for 10min at a rotating speed of 220rpm to obtain a material G;
s8, adding the methyl glucose dioleate into deionized water at 80 ℃ for dissolving, adding the material G for mixing, stirring at a rotating speed of 220rpm for 20min, and adjusting the pH value to 6.0 to prepare the anti-hair loss shampoo.
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| CN107296771A (en) * | 2017-07-31 | 2017-10-27 | 曾万祥 | A kind of desquamation compositions and extra quality multiple-effect are without silicone oil shampoo |
| CN109846773A (en) * | 2018-11-26 | 2019-06-07 | 广州瑞誉化工科技有限公司 | A kind of scalp composition and its preparation method and application can inhibit alopecia seborrheica |
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