CN114287525A - Ruminant feed additive for improving gastrointestinal tract health and application thereof - Google Patents
Ruminant feed additive for improving gastrointestinal tract health and application thereof Download PDFInfo
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Abstract
The invention relates to a ruminant feed additive for improving gastrointestinal tract health and application thereof. The feed additive provided by the invention can effectively improve the rumen health of ruminants, enhance the rumen function, improve the health environment of the intestinal tract after the ruminants, enhance the stress resistance of organisms and other problems, and the additive comprises the following components in parts by weight per kilogram: saccharomyces boulardii 1-2X 1012cfu, 1-2X 10 of Saccharomyces cerevisiae ruminants12cfu, 50-150g of selenium yeast, 10-100g of polyphenol and the balance of carrier, and the preparation method is prepared by uniformly mixing. The feed additive provided by the invention has the advantages of reasonable compatibility of components, good effect and high safety after being verified for many times, can effectively improve the rumen health of adult ruminants, improves the utilization of fiber feed, and can improve the rumen health of adult ruminantsThe gastrointestinal flora environment improves the immunity of the organism, enhances the anti-stress capability of the organism, can obviously improve the production performance of the ruminant, is a great innovation on the functional additive of the ruminant and assists the healthy development of the ruminant breeding industry.
Description
Technical Field
The invention relates to the technical field of feed additives, in particular to a ruminant feed additive for improving gastrointestinal tract health and application thereof.
Background
Ruminants with high production performance, such as dairy cows, often have great nutrition metabolism pressure, so that the oxidation and oxidation resistance balance of the dairy cows is broken, the ruminants face an oxidative stress state for a long time, the utilization of nutrient substances is seriously influenced, the risk of the dairy cows suffering from diseases is increased, and the production performance is reduced.
Rumen health of dairy cows is the core of pasture management, as the quality of rumen function can affect all other functions of dairy cows. However, rumen environment is affected by factors such as inconsistent feed raw material quality, poor feeding management, environmental differences and the like, so that the proliferation of cellulolytic bacteria is inhibited, the pH is reduced, harmful bacteria and bacterial endotoxin are increased, and the health of rumen is damaged.
The intestinal tract is the largest immune organ of the body and the most important place for absorbing nutrient substances, and for ruminants, the health of the intestinal tract is necessarily affected by the damage of the rumen health because: bacterial endotoxin and harmful bacteria passing through the rumen further harm the intestinal health, often cause the damage of intestinal barrier, cause diarrhea diseases and inflammation increase of the intestinal tract of the ruminant and increase the body diseases.
More and more ruminant feed additives are put into cultivation production, but most products are single, rumen health is too much concerned, and after-intestinal health and organism anti-stress level are ignored, so that application effect is unstable. Therefore, how to effectively improve the body health of the ruminant and improve the production performance should be considered from the perspective of the whole intestinal health, and the food safety of the product needs to be considered at the same time when the healthy growth of the animal is ensured, which is a technical problem to be solved urgently.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide the mixed feed additive for improving the gastrointestinal tract health and stress resistance of the ruminant and the application thereof, which can effectively improve the rumen health of the ruminant, enhance the rumen function, improve the health environment of the rear intestinal tract and enhance the stress resistance level of the organism. The technical scheme provided by the invention is as follows.
In a first aspect, the present invention provides a feed additive comprising: saccharomyces boulardii, Saccharomyces cerevisiae ruminants, selenium yeast and polyphenol.
The saccharomyces boulardii is the only approved fungus probiotics in the feeding yeast, the identification of the strain is accurate, the strain number is CNCM I-1079, the safety and functionality evaluation is carried out, and a large number of clinical tests are carried out. The biological activity of the saccharomyces boulardii is 50 times that of the liver cells, the optimal growth temperature is close to the rumen temperature of 39 ℃, the activity of 65 percent is still achieved in the environment of 52 ℃, the activity of 75 percent is still achieved in the environment with low pH value of 2.0, and the saccharomyces boulardii is incomparable with other saccharomyces cerevisiae. And other saccharomyces cerevisiae on the market hardly has stable effect in the using process, and the effect is gradually reduced after long-term use, and the main reasons are as follows: 1) the optimal growth temperature of the yeast is about 30 ℃, and the rumen temperature acts at 39 ℃, so that the yeast cannot effectively proliferate in the rumen; 2) the acid resistance of the yeast is poor, the survival rate is only 30 percent under the action of the pH2.0 of the abomasum of the ruminant, and the survival rate is low; 3) budding is prone to variant formation, leading to reduced function and development of drug resistance.
The yeast selenium is the only organic selenium source which is certified by the US FDA and European Union, and can overcome the problems of low absorption rate, high toxicity, secondary pollution and the like of inorganic selenium. Selenium is one of the core components of glutathione peroxidase, participates in the action of scavenging oxygen free radicals of cells, and can improve the level of glutathione peroxidase in vivo by supplementing sufficient high-quality selenium, and effectively improve the antioxidation level of organisms. The selenium yeast is a commercially available product and has universal application.
The polyphenol is a general name of plant components which are widely present in plants and have a plurality of hydroxyl groups, is an important secondary metabolite in the plants, and has a polyphenol structure. The main components of the polyphenol comprise catechin, resveratrol, flavonol glycoside, epigallocatechin, procyanidine, proanthocyanidin, quercetin, theaflavin, castanonin and the like, most of polyphenol compounds are water-soluble substances, exist in vacuoles of plant cells, are combined with sugar in a naturally existing form to form glucoside, are absorbed into cells after being ingested by animals, and are used as exogenous oxygen free radical scavengers to participate in oxidative balance metabolism of the cells. The polyphenol used in the invention is a product sold in Italian Shihua company, has different degrees of effects in the aspects of oxidation resistance, aging resistance, cancer resistance, inflammation reduction, health improvement and the like, and a plurality of polyphenols can be combined together to realize the effect of improving the health of animals. Common polyphenol products in the market are single products, the components are single, and the application effect on animals is difficult to reproduce.
Further, the Saccharomyces boulardii is 1-2X 1012cfu/kg, 1-2X 10 Saccharomyces cerevisiae ruminants12cfu/kg, selenium yeast 50-150g/kg, polyphenol 10-100 g/kg.
Further, the polyphenol is commercially available from Shihua Italy company, and comprises one or more of catechin, resveratrol, flavonol glycoside, epigallocatechin, gallic acid, procyanidin, proanthocyanidin, quercetin, theaflavin, castanonin or castanonin;
further, a carrier is also included; the carrier is preferably zeolite powder, and/or rice hull powder.
In a second aspect, the invention provides a feed for ruminants, which contains the feed additive prepared by the above-mentioned idea.
The use of the feed additive described above in the preparation of feed for ruminants is also claimed in the present invention, as will be appreciated by those skilled in the art.
In a third aspect, the present invention provides a method for preparing the feed additive, comprising:
(1) pulverizing Saccharomyces boulardii, Saccharomyces cerevisiae, selenium yeast, and polyphenol to 16 mesh;
(2) uniformly mixing the crushed raw materials in the step (1), adding carrier auxiliary materials in proportion, mixing for 3-5min by adopting a single-paddle bidirectional mixer, and obtaining a feed additive product uniformly mixed, wherein the CV value is 3%;
in a fourth aspect, the invention also claims the use of the feed additive as described above or the feed as described above in any one of:
(1) the invention further provides application of the feed additive or the feed in improving the rumen health of the ruminant, including enhancing the rumen function of the ruminant, reducing the risk of rumen acidosis of the cow and increasing the number of rumen cellulolytic bacteria.
(2) The invention further provides the use of the feed additive or the feed for improving the intestinal health of ruminants, including increasing the number of beneficial bacteria lactic acid bacteria in the intestinal tract, decreasing the number of harmful bacteria, and decreasing bacterial toxins.
(3) The invention further provides the application of the feed additive or the feed in enhancing the stress resistance of the ruminant organism.
As a preferred embodiment, the present invention provides a feed additive comprising per kilogram parts by weight: saccharomyces boulardii 1-2X 1012cfu, 1-2X 10 of Saccharomyces cerevisiae ruminants12cfu, 50-150g of selenium yeast, 10-100g of polyphenol and the balance of carrier; wherein the carrier is zeolite powder and/or rice hull powder.
In the application provided by the invention, the feed additive or the feed is used for raising dairy cows.
In the application provided by the invention, the feeding amount of the feed additive is 10-20g per day, and the feeding period is the early lactation period and/or the perinatal period of the dairy cow.
The invention has the beneficial effects that:
(1) the feed additive provided by the invention can inhibit the growth of rumen harmful bacteria and protect and promote the growth of beneficial bacteria, and particularly, the feed additive can promote the rapid proliferation of rumen cellulolytic bacteria and effectively regulate the flora structure.
(2) The feed additive provided by the invention also enhances the cell antioxidant level and the anti-stress capability of the intestinal tract of the ruminant, improves the nutrition metabolism level of the ruminant and improves the utilization rate of the feed of the ruminant.
(3) When the feed additive provided by the invention is used for feeding dairy cows, the milk yield is obviously improved, the risk of rumen acidosis of the dairy cows is reduced, the number of rumen cellulolytic bacteria is increased, the number of intestinal beneficial bacteria lactic acid bacteria is increased, the production performance of the dairy cows is improved, the metritis incidence of the dairy cows is reduced, and the breeding benefit of a pasture is increased.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention. The reagents or drugs used in the present invention are commercially available.
Example 1
This example provides a formulation for a feed additive. Specifically, the feed additive is 2 multiplied by 10 portions of Bradi in parts by weight12cfu, 1 × 10 of Saccharomyces cerevisiae ruminants12cfu, 100g of selenium yeast, 50g of polyphenol and the balance of carrier, wherein the carrier is rice hull powder, and the carrier is prepared by uniformly mixing.
The embodiment also provides a preparation method of the feed additive, which comprises the following steps:
(1) crushing the feed additive raw materials;
(2) uniformly mixing the crushed raw materials in the step (1), adding carrier auxiliary materials in proportion for mixing, adopting a single-paddle bidirectional mixer, mixing for 3-5min to reach a CV value of 3%, and obtaining a uniformly mixed feed additive product.
Test example 1
This test example tests the function of the feed additive obtained in example 1. The method comprises the following specific steps:
a certain dairy farm in Shandong in 12 months in 2020 performs the field test of the feed additive, 240 dairy cattle in the perinatal period are selected for the test, the test period is 20 days before the birth to 100 days after the birth, and 12g of the feed additive prepared in the embodiment 1 is fed to each dairy cattle every day of 120 cattle as a test group; in addition, 120 cattle are not added with feed additives and used as a control group, peak milk yield and disease incidence of test cattle are observed and recorded, and indexes such as total milk yield are calculated and shown in table 1.
TABLE 1 test results for 120 days
| Index (I) | Test set (example 1) | Control group |
| Peak milk yield (kg/head/day) | 46.22 | 44.01 |
| Milk increment (kilogram) of single cow in lactation period | 541.2 | 0.0 |
| Number of cattle head (head) shifted from abomasum | 0 | 1 |
| Fever ox head number (head) | 10 | 12 |
| Cow head with mammitis | 22 | 24 |
| Number of cattle head (head) with metritis | 56 | 72 |
| Number of ox head without placenta | 0 | 2 |
| Total number of sick cattle (head) | 88 | 111 |
According to the experimental results, the feed additive prepared in the embodiment 1 is added into daily ration in the perinatal period under the experimental condition, so that the milk yield of the postpartum lactation peak value is obviously improved, the cumulative increase of the milk yield of 541.2kg of each cow in the experimental period obviously reduces the postpartum metabolic diseases of the cows, and the health degree of the cows and the breeding benefit of a pasture are improved.
Test example 2
This test example tests the function of the feed additive obtained in example 1. The method comprises the following specific steps:
a certain Mongolian dairy farm in 9 months in 2018 is used for the field test of the feed additive, 68 dairy cattle in perinatal period are selected for the field test, the test period is from 3 weeks before delivery to 9 weeks after delivery, wherein each cow of 34 cows is supplemented with 12.5g of the feed additive prepared in the embodiment 1 every day, and in addition, 34 cows are not added, and the indexes of the test cows such as the concentration of IgG in the postnatal colostrum, the weight change, the milk yield, the total feed efficiency and the like are observed and recorded, which is shown in Table 2.
Table 2 test results for 12 weeks
Test example 3
This test example was carried out on the basis of the feed additive provided in example 1:
in the experimental example, compared with other matching researched in the exploration process, the field test of the feed additive is carried out in a certain dairy farm in Shandong in 10 months in 2019, a dairy herd in the early lactation period is selected to carry out the test, 140 cows are selected in total, the dairy herd is matched and grouped according to the factors of milk yield, fetal times and days of lactation, the dairy herd is randomly divided into 7 groups, the test period is 35 days, each cow in the control group is supplemented with 20g of the feed additive prepared in example 1 every day, each test group uses 20g of the feed additive with the following formula every day, and the milk yield of the test cow, the number of cows with rumen pH lower than 5.6, the number of rumen fiber decomposing bacteria in 24 hours, the number of lactic acid bacteria in excrement and the like are observed and recorded.
Test group 1:
1.5 x 10 of Bradi12cfu, 1 × 10 of Saccharomyces cerevisiae ruminants12cfu, 100g of selenium yeast, 50g of polyphenol and the balance of carrier; mixing was carried out in the same manner as in example 1.
Test group 2:
2 x 10 of Bradi12cfu, 0.8 x 10 of Saccharomyces cerevisiae ruminants12cfu, 100g of selenium yeast, 50g of polyphenol and the balance of carrier; mixing was carried out in the same manner as in example 1.
Test group 3:
2 x 10 of Bradi12cfu, 1 × 10 of Saccharomyces cerevisiae ruminants12cfu, 80g of selenium yeast, 50g of polyphenol and the balance of carrier; mixing was carried out in the same manner as in example 1.
Test group 4:
2 x 10 of Bradi12cfu, 1 × 10 of Saccharomyces cerevisiae ruminants12cfu, 100g of selenium yeast, 30g of polyphenol and the balance of carrier; mixing was carried out in the same manner as in example 1.
Test group 5:
bradi 3 x 1012cfu, 1 × 10 of Saccharomyces cerevisiae ruminants12cfu, 100g of selenium yeast, 50g of polyphenol and the balance of carrier; mixing was carried out in the same manner as in example 1.
Test group 6:
2 x 10 of Bradi12cfu, 1 × 10 of Saccharomyces cerevisiae ruminants12cfu, 100g of selenium yeast and the balance of carrier; mixing was carried out in the same manner as in example 1.
The results shown in Table 3 were obtained in this test example:
TABLE 3 35d feeding test results
Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (10)
1. A feed additive, comprising: saccharomyces boulardii, Saccharomyces cerevisiae ruminants, selenium yeast and polyphenol.
2. The feed additive of claim 1, wherein the feed additive contains Saccharomyces boulardii 1-2 x 10 per kg of feed additive12cfu, 1-2X 10 of Saccharomyces cerevisiae ruminants12cfu, 50-150g of selenium yeast and 10-100g of polyphenol.
3. The feed additive according to claim 2, wherein 1kg of the feed additive contains 1.5-2 x 10 Saccharomyces boulardii12cfu, 1-1.5X 10 of Saccharomyces cerevisiae for rumination12cfu, selenium yeast 100-150g, polyphenol 50-100 g;
preferably, 1kg of feed additive is 2X 10 Saccharomyces boulardii12cfu, 1 × 10 of Saccharomyces cerevisiae ruminants12cfu, 100g of selenium yeast and 50g of polyphenol.
4. The feed additive according to claim 3, wherein the feed additive further comprises a carrier, and the carrier is zeolite powder or rice hull powder.
5. Use of a feed additive according to any one of claims 1 to 4 in the preparation of a feed for ruminants.
6. A feed for ruminants, comprising the feed additive according to any one of claims 1 to 4.
7. A process for preparing a feed additive according to any one of claims 1 to 4, which comprises:
(1) pulverizing Saccharomyces boulardii, Saccharomyces cerevisiae, selenium yeast, and polyphenol;
(2) and (3) uniformly mixing the crushed raw materials in the step (1), adding a carrier auxiliary material in proportion, and mixing to obtain a uniformly mixed feed additive product.
8. Use of the feed additive of any one of claims 1-4 or the feed of claim 6 in any one of:
(1) improving the rumen health of the ruminant, enhancing the rumen function of the ruminant, reducing the risk of rumen acidosis of the dairy cow and increasing the number of rumen cellulolytic bacteria;
(2) the quantity of beneficial bacteria lactic acid bacteria in the intestinal tract of the dairy cow is increased, the quantity of harmful bacteria is reduced, and bacterial toxins are reduced;
(3) enhancing the anti-stress of ruminant organism, improving milk yield of milk cow, reducing metritis of milk cow or increasing the income of pasture.
9. Use according to claim 8, wherein the feed additive according to any one of claims 1-4 or the feed according to claim 6 is used in dairy cattle breeding.
10. The use according to claim 9, wherein the feed additive is fed in an amount of 10-20g and the feeding period is early lactation and/or perinatal period of the cow.
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