CN114246811A - Skin moisturizer with moisturizing effect and preparation method thereof - Google Patents
Skin moisturizer with moisturizing effect and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a skin lotion with a moisturizing effect, and belongs to the field of skin care products. Based on the total weight of the skin lotion, the skin lotion comprises the following components in parts by weight: phase A: the balance of water and 0.05 to 0.3 weight percent of thickening agent; phase B: 0.0 to 10.0 weight percent of polyol, 0.5 to 5 weight percent of compound humectant and 0.03 to 0.2 weight percent of chelating agent; and C phase: 0.01-0.5wt% of pH regulator. The B-phase composite humectant (the total weight is 100%) comprises the following components in percentage by weight: 0.01 to 5.0wt percent of sodium hyaluronate, 0.01 to 5.0wt percent of carrageen crispus, 0.01 to 5.0wt percent of sodium polyglutamate, 0.001 to 40.0wt percent of glycerol, 0.01 to 2.0wt percent of L-serine, 0.0 to 2.0wt percent of L-proline, 0.0 to 0.3wt percent of L-glutamic acid, 0.001 to 15.0wt percent of betaine, 0.0 to 20.0wt percent of urea, 0.001 to 15.0wt percent of sodium pyrrolidone carboxylate, 0.0 to 10.0wt percent of trehalose, 0.0 to 1.0wt percent of preservative, 0.001 to 0.5wt percent of allantoin and 0.001 to 5.0wt percent of pH regulator. Experiments prove that the skin moisturizer has good skin feel, high efficiency and lasting moisturizing effect and wide application prospect.
Description
Technical Field
The invention relates to a skin moisturizer with a long-acting moisturizing effect and a preparation method thereof, and belongs to the field of skin care products.
Background
Moisturizing skin lotions are an important part of the daily skin care products of people. Moisturizing lotion can be used for directly supplementing skin moisture, increasing or maintaining the water content of stratum corneum and promoting the repair of skin barrier function to achieve the moisturizing effect. Whether the moisturizing water can realize long-acting moisturizing effect is always a key concern of people.
The moisturizing effect of moisturizing water on the market at present mainly passes through the following three ways: 1. directly supplying water to skin, and applying or spraying natural spring water or mineral water on skin; the water content of the skin is increased to a certain extent, so that the skin can be moisturized in a short time; 2. the humectant in the product has water absorption and retention properties, and achieves the moisture retention effect through water absorption and retention, and the components mainly comprise glycerol, urea, trehalose and the like; 3. the skin conditioner such as plant extract is added to improve physiological function of skin cells, thereby increasing moisture content of skin. In addition, in order to improve the moisturizing performance of the product, one or two macromolecules such as sodium hyaluronate are added as film forming components. However, these products are not ideal for film forming and long-lasting moisturizing. The reason is that the small molecular moisturizers such as trehalose and sodium pyrrolidone carboxylate can rapidly permeate the horny layer to be absorbed by the skin, the moisturizing effect of the small molecular moisturizers cannot be exerted on the horny layer for a long time, the follow-up skin cannot be continuously supplemented with the small molecular moisturizers, and even if more moisturizing ingredients are added, the long-acting moisturizing effect of the product cannot be achieved.
How to achieve lasting and efficient moisturizing effect of moisturizing skin care water is a technical problem to be urgently solved by technical personnel in the field.
Disclosure of Invention
Aiming at the problems in the prior art, the invention aims to provide the moisturizing lotion which can achieve a lasting and efficient moisturizing effect, improve the skin feeling of a thin skin lotion and provide a moist and tender skin feeling of a product.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the invention provides a skin lotion, which comprises the following components in the following amount:
according to the invention, the components and the dosage of the B-phase compound humectant are as follows:
according to some preferred embodiments of the present invention, the phase B compound moisturizer comprises the following components by weight:
according to some embodiments of the present invention, the preparation process of the B-phase composite humectant comprises the following steps:
(1) adding sodium polyglutamate, Chondrus crispus and sodium hyaluronate into glycerol, stirring and dispersing uniformly, adding into water, stirring, and heating to 70-90 deg.C to dissolve to obtain a first solution;
(2) adding L-serine, L-proline and L-glutamic acid into the first solution obtained in the step (1) to dissolve, adding a pH regulator to regulate the pH to 4.5-5.5, and stirring to obtain a second solution;
(3) stirring and dissolving betaine, sodium pyrrolidone carboxylate, trehalose and allantoin, and adding into the second solution;
(4) cooling to below 40 deg.C, adding urea and antiseptic, stirring, filtering, and discharging.
According to the invention, the long-acting compound humectant which is compounded by three macromolecules of sodium polyglutamate, carrageen crispa and sodium hyaluronate and micromolecules of trehalose and the like is added into the skin care water, and the humectant has the carrier performance and can play a slow release effect, and interacts with other micromolecule moisturizing components to slowly release the micromolecule moisturizing components, thereby playing a long-acting moisturizing effect.
The Chondrus crispus is a linear hydrophilic high polymer, has a repeated alpha- (1 → 4) -D-galactopyranose-beta- (1 → 3) -D-galactopyranose (or 3, 6-diether-D-galactopyranose) disaccharide unit skeleton structure, has a half-ester sulfate group on a galactose residue, has strong anionic activity, and is a typical anionic polysaccharide. Due to its strong anionic properties, it was screened as the main component of the carrier structure. The polyglutamic acid sodium is formed by condensing a D-type glutamic acid monomer and an L-type glutamic acid monomer, is a linear molecule, has strong water absorption because the structure contains a large amount of free carboxyl, and also has certain anionic property because of the action of the carboxyl. The two structures are carried with sodium hyaluronate to form a space net structure, and a large amount of loose porous structures are contained in the space net structure. The amino acid has amino group and carboxyl group, is amphoteric electrolyte, and can react with different ionic substances to regulate pH value of the system to lower the isoelectric point of the amino acid, so that the amino group on the amino acid has positive charge and can react with the half-ester sulfate group on the carrageen crispus and the carboxyl group on the polyglutamic acid to adsorb the amino acid on the macromolecular structure to form a stable carrier structure, and the amino acid and other moisture-keeping components can be slowly released in the aqueous solution to achieve the long-acting slow-release moisture-keeping effect.
The inventor finds out through experiments that the heating temperature in the preparation method of the compound humectant directly influences the form and the moisturizing effect of the compound humectant. When the heating temperature is lower than 60 ℃, the stability, uniformity and the like of the obtained composite humectant are poor, and when the heating temperature is higher than 70 ℃, the stability and the product state are good, and the stability, uniformity, fluidity, moldability and other properties of the humectant have great influence on the performance of the carrier, and the heating temperature in the step (1) of the preparation process of the humectant is preferably higher than 70 ℃. In addition, although the solution is soluble at 95 ℃, on the one hand, the solution is prone to yellowing when heated at high temperatures for a long time, and on the other hand, the high temperatures cause energy waste for industrial production. Therefore, the preparation temperature of the compound humectant is preferably controlled to be 70-90 ℃.
According to the invention, the sodium polyglutamate, the carrageen crispus and the sodium hyaluronate are compounded to form a spatial network structure which has a loose porous structure. Amino acid has two groups of amino and carboxyl, is an ampholyte, and can react with different ionic substances due to the special structure of the ampholyte. By adjusting the pH value of the system, the system is lower than the isoelectric point of amino acid, the amino group on the amino acid has positive charge, and can simultaneously react with half ester sulfate group on the Chondrus crispus and carboxyl group on the polyglutamic acid, so that the amino acid is changed from being simply dissociated in a net structure to be tightly connected on a macromolecular structure, and a stable carrier structure is formed. Meanwhile, various small molecular moisturizers added in addition can be loaded on the carrier network structure, can be brought to the skin surface by the macromolecular carrier, and are slowly released, so that the synergistic effect is achieved, and the long-acting moisturizing effect is achieved.
According to some embodiments of the invention the sodium polyglutamate has a molecular weight of > 50 ten thousand Da, for example may be in the range of 50-300 ten thousand Da, such as 50 ten thousand Da, 80 ten thousand Da, 100 ten thousand Da, 150 ten thousand Da, 250 ten thousand Da, etc.
According to some embodiments of the invention the Chondrus crispus has a molecular weight ≧ 80 ten thousand Da, such as in the range of 80-600 ten thousand Da, such as 100 ten thousand Da, 150 ten thousand Da, 200 ten thousand Da, 500 ten thousand Da, etc.
According to some embodiments of the invention, the sodium hyaluronate is of molecular weight ≧ 5 ten thousand Da, for example, may be in the range of 5-250 ten thousand Da, such as 50 ten thousand Da, 100 ten thousand Da, 150 ten thousand Da, 190 ten thousand Da, etc.
According to a more preferred embodiment of the invention, the molecular weight of the sodium polyglutamate is 100-150 kilodaltons.
According to a more preferred embodiment of the present invention, the molecular weight of the Chondrus crispus is 150-250 ten thousand Da.
According to a more preferred embodiment of the invention, the molecular weight of the sodium hyaluronate is 100-150 ten thousand Da.
According to the present invention, the amount of the sodium polyglutamate is 0.01 to 5wt% based on the total weight of the complex moisturizer of the present invention, for example, 0.01%, 0.02%, 0.03%, 0.05%, 0.06%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.5%, 1.6%, 1.8%, 2%, 2.1%, 2.2%, 2.5%, 2.7, 2.9%, 3%, 3.3%, 3.5%, 3.6%, 3.7%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.6%, 4.8%, 5%, and specific points between the above values are not limited to the extent and are not exhaustive, and the range is not limited to the present invention. Preferably, the content of the sodium polyglutamate is 0.01-3wt% based on the total weight of the moisturizing composition.
According to the present invention, the amount of the carrageen crispus is 0.01-5wt% based on the total weight of the composite moisturizer of the present invention, for example, 0.01%, 0.02%, 0.03%, 0.05%, 0.06%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.5%, 1.6%, 1.8%, 2%, 2.1%, 2.2%, 2.5%, 2.7, 2.9%, 3%, 3.3%, 3.5%, 3.6%, 3.7%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.6%, 4.8%, 5%, and specific points between the above values are not limited to the extent and are not exhaustive, and for the sake of brevity, and the range is not to include specific points. Preferably, the content of the carrageen crispus is 0.1-5wt% based on the total weight of the moisturizing composition of the present invention.
According to the present invention, the sodium hyaluronate is 0.01-5wt% based on the total weight of the composite moisturizer of the present invention, for example, 0.01%, 0.02%, 0.03%, 0.05%, 0.06%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.5%, 1.6%, 1.8%, 2%, 2.1%, 2.2%, 2.5%, 2.7, 2.9%, 3%, 3.3%, 3.5%, 3.6%, 3.7%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.6%, 4.8%, 5%, and specific points between the above values are not limited to the text and are not exhaustive, and the present invention includes specific points. Preferably, the content of the sodium hyaluronate is 0.01-3wt% based on the total weight of the moisturizing composition.
According to the present invention, the glycerin may be 0.001 to 40wt% based on the total weight of the composite moisturizer of the present invention, for example, 0.001%, 0.002%, 0.004%, 0.01%, 1%, 2%, 3%, 4%, 5%, 6%, 10%, 12%, 14%, 15%, 16%, 18%, 19%, 20%, 21%, 22%, 24%, 25%, 27%, 28%, 30%, 31%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, and specific points between the above values are limited to space and for the sake of brevity, and the present invention is not exhaustive list of the specific points included in the range. Preferably, the glycerin is contained in an amount of 15 to 35wt% based on the total weight of the moisturizing composition of the present invention.
According to the present invention, the L-serine is 0.01 to 2wt% based on the total weight of the compound moisturizer of the present invention, for example, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, and 2%, and specific points between the above values are not exhaustive and for the sake of brevity, and the present invention does not list the specific points included in the range. Preferably, the L-serine is used in an amount of 0.5 to 1.5wt% based on the total weight of the moisturizing composition of the present invention.
According to the present invention, the sodium pyrrolidone carboxylate is 0.001 to 15wt% based on the total weight of the complex humectant of the present invention, for example, 0.001%, 0.005%, 0.01%, 0.03%, 0.05%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.3%, 1.5%, 1.8%, 1.9%, 2%, 2.5%, 3%, 4%, 4.2%, 4.5%, 4.6%, 4.7%, 5%, 5.5%, 5.8%, 6%, 6.5%, 7%, 7.2%, 7.5%, 7.8%, 8%, 9%, 9.4%, 9.5%, 9.8%, 10%, 11%, 13%, 15%, and specific points between the above-mentioned values are not included in the present invention, and specific points between the above-mentioned points are not included in the present invention for brevity and for the sake of brevity and the present invention is not limited to the recited ranges in the present invention. Preferably, the sodium pyrrolidone carboxylate is 0.5 to 8wt% based on the total weight of the moisturizing composition of the present invention.
According to the present invention, the betaine is 0.001 to 15wt% based on the total weight of the composite moisturizer of the present invention, for example, 0.001%, 0.01%, 0.03%, 0.05%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.2%, 1.3%, 1.5%, 1.8%, 1.9%, 2%, 2.5%, 3%, 4%, 4.2%, 4.5%, 4.6%, 4.7%, 5%, 5.5%, 5.8%, 6%, 6.5%, 7%, 7.2%, 7.5%, 7.8%, 8%, 9%, 9.4%, 9.5%, 9.8%, 10%, 11%, 12%, 13%, 14%, 15%, and specific points between the above-mentioned values are included in the summary and the present invention is not exhaustive and for the sake of brevity and the stated ranges are not intended to include specific points. Preferably, the betaine is present in an amount of 0.5 to 8wt% based on the total weight of the moisturizing composition of the present invention.
According to the present invention, the pH adjusting agent is 0.001 to 5wt% based on the total weight of the complex moisturizer of the present invention, for example, 0.001%, 0.005%, 0.006%, 0.008%, 0.009%, 0.01%, 0.02%, 0.03%, 0.05%, 0.06%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.5%, 1.6%, 1.8%, 2%, 2.1%, 2.2%, 2.5%, 2.7, 2.9%, 3%, 3.3%, 3.5%, 3.6%, 3.7%, 3.9%, 4%, 4.1%, 4.2%, 4.3%, 4.6%, 4.8%, 5%, and specific points between the above-mentioned values, preferably, the pH adjusting agent is 0.1 to 5wt% based on the total weight of the moisturizing composition of the present invention.
According to the invention, the complex humectant further comprises L-proline.
According to some preferred embodiments of the present invention, the L-proline is 0.01 to 2wt% based on the total weight of the complex moisturizer of the present invention, and for example, may be 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, and 2%, and specific values between the above values are not listed, which is not intended to be exhaustive and for the sake of brevity. Further preferably, the L-proline is used in an amount of 0.1 to 1wt% based on the total weight of the moisturizing composition of the present invention.
According to the present invention, the complex humectant further includes L-glutamic acid.
According to some preferred embodiments of the present invention, the L-glutamic acid is 0.001 to 0.3wt% based on the total weight of the composite moisturizer of the present invention, for example, 0.001%, 0.005%, 0.006%, 0.008%, 0.009%, 0.01%, 0.1%, 0.15%, 0.16%, 0.18%, 0.19%, 0.2%, 0.21%, 0.22%, 0.23%, 0.24%, 0.25%, 0.26%, 0.27%, 0.28%, 0.29%, and 0.3%, and specific points between the above-mentioned values are limited to space and for the sake of brevity, and the present invention is not exhaustive and does not list the specific points included in the range. Further preferably, the amount of the L-glutamic acid is 0.01 to 0.2wt% based on the total weight of the moisturizing composition of the present invention.
According to the invention, the compound humectant further comprises urea.
According to some preferred embodiments of the present invention, the urea is 0.001 to 20wt%, for example, 0.001%, 0.003%, 0.01%, 0.03%, 0.05%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.3%, 1.5%, 1.8%, 1.9%, 2%, 2.5%, 3%, 4%, 4.2%, 4.5%, 4.6%, 4.7%, 5%, 5.5%, 5.8%, 6%, 6.5%, 7%, 7.2%, 7.5%, 7.8%, 8%, 8.5%, 8.7%, 8.8%, 9.4%, 9.5%, 9.8%, 10%, 11%, 11.2%, 11.4%, 11.6%, 11.12%, 12.12%, 12.5%, 14.8%, 15.8%, 14.8%, 15.5%, 14.5%, 16%, 16.6%, 14.6%, 14.8%, 14.2%, 14.5%, 14.8%, 14.5%, 16%, 15%, 16%, 15%, 6%, or more, 16.5%, 16.8%, 17%, 17.1%, 17.2%, 17.4%, 17.6%, 17.8%, 18%, 18.2%, 18.3%, 18.6%, 18.8%, 19%, 19.2%, 19.4%, 19.6%, 19.8%, 20%, and specific points between the above values, are not intended to be exhaustive or to limit the invention to the precise points included in the ranges for brevity. Further preferably, the urea is present in an amount of 0.001 to10 wt%, based on the total weight of the moisturizing composition of the present invention.
According to the invention, the compound humectant further comprises trehalose.
According to some preferred embodiments of the present invention, the trehalose is 0.001 to10 wt% based on the total weight of the composite moisturizer of the present invention, for example, 0.001%, 0.005%, 0.01%, 0.03%, 0.05%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.3%, 1.5%, 1.8%, 1.9%, 2%, 2.5%, 3%, 4%, 4.2%, 4.5%, 4.6%, 4.7%, 5%, 5.5%, 5.8%, 6%, 6.5%, 7%, 7.2%, 7.5%, 7.8%, 8%, 8.2%, 8.4%, 8.6%, 8.8%, 9%, 9.4%, 9.5%, 9.8%, 10%, and specific values therebetween are not included for brevity and while specific values therebetween are not included in the present invention. Further preferably, the trehalose is 0.5 to 8wt% based on the total weight of the moisturizing composition of the present invention.
The allantoin is 0.001 to 0.5wt% based on the total weight of the complex moisturizer of the present invention, and may be, for example, 0.001%, 0.005%, 0.006%, 0.008%, 0.009%, 0.1%, 0.15%, 0.16%, 0.18%, 0.19%, 0.2%, 0.21%, 0.22%, 0.25%, 0.28%, 0.29%, 0.3%, 0.35%, 0.38%, 0.4%, 0.45%, and 0.5%, and specific points between the above values, limited to space and for brevity, are not exhaustive and the invention is not intended to include the specific points included in the range. Preferably, the allantoin is 0.05 to 0.3wt% based on the total weight of the moisturizing composition of the present invention.
According to some specific embodiments of the present invention, the skin care water phase a thickener is a cosmetically acceptable thickener. For example, it may be one or more of carbomer, polyacrylate, xanthan gum and cellulose.
According to some embodiments of the invention, the skin lotion phase B polyol is a cosmetically acceptable polyol. For example, one or more of glycerol, butylene glycol, propylene glycol and dipropylene glycol may be used.
According to some embodiments of the invention, the skin moisturizer phase B sequestrant is a cosmetically acceptable class of sequestrants. For example, EDTA-disodium may be mentioned.
According to some embodiments of the present invention, the skin care water phase B may further comprise a plant extract, which is acceptable in the field of skin care products, or a mixture thereof. For example, the plant extract with anti-allergy effect, the plant extract with whitening effect, the plant extract with acne-removing effect, the plant extract with anti-irritation effect and the plant extract with anti-aging effect can be one or more.
According to some embodiments of the present invention, the plant extract is used in an amount of 0-20wt% based on the total weight of the skin lotion.
According to some embodiments of the invention, the skin care water phase C pH adjusting agent is a cosmetically acceptable pH adjusting agent. For example, triethanolamine, arginine, citric acid, sodium hydroxide, etc. may be mentioned.
According to some embodiments of the present invention, the skin lotion may further comprise a D phase, wherein the D phase comprises a proper amount of a preservative, and the preservative is acceptable in the cosmetic field, and may be, for example, phenoxyethanol/ethylhexyl glycerin, MTI, and the like.
According to some embodiments of the present invention, the skin moisturizer phase D can further comprise a proper amount of essence, which is acceptable in the cosmetic field, and is not particularly limited.
The invention provides a preparation method of moisturizing skin care lotion in a second aspect.
The skin lotion can be prepared by the conventional preparation process of the skin lotion in the field.
According to some embodiments of the invention, the moisturizing skin lotion preparation step comprises:
(1) adding the phase A thickener into water, stirring and dissolving;
(2) mixing the phase B and the phase A, and stirring;
(3) adding the mixture obtained in the step (2) into the phase C, adjusting the pH value to 6.5-6.8, and stirring;
(4) filtering and discharging at the temperature below 38 ℃.
According to some embodiments of the present invention, the moisturizing skin lotion comprises:
(1) adding the phase A thickener into water, stirring and dissolving;
(2) mixing the phase B and the phase A, and stirring;
(3) adding the mixture obtained in the step (2) into the phase C, adjusting the pH value to 6.5-6.8, and stirring;
(4) adding a D-phase preservative and essence into the mixture obtained in the step (3), and stirring;
(5) filtering and discharging at the temperature below 38 ℃.
The preservative and the essence are those conventionally used in the art and are not particularly limited.
According to some preferred embodiments of the present invention, the preparation process of the B-phase long-acting compound humectant is prepared by the method of the first aspect of the present invention.
In a third aspect, the invention provides a moisturizing lotion obtained by the preparation method of the second aspect.
Compared with the prior art, the invention has the beneficial effects that at least:
(1) the composite humectant is added into the moisturizing skin care water, and the carrier performance of the humectant enables the micromolecular moisturizing components to be slowly released, so that the moisturizing effect of the humectant is fully exerted, and the obvious and lasting moisturizing effect is achieved;
(2) the moisturizing skin care lotion can play a good moisturizing effect in short-term and long-term moisturizing, has good stability and skin feel, can still generate the moisturizing effect after the product is stopped, and has good application value;
(3) the moisturizing skin care lotion provided by the invention enables moisturizing components to be efficiently utilized, and improves the bioavailability of the moisturizing components.
Drawings
FIG. 1 shows sensory evaluation results of example 16, sensory evaluation results of comparative example 5, and sensory evaluation results of a commercial race;
FIG. 2 shows the mean rate of change results of skin moisture content of subjects using example 16 lotion for 48h relative to the initial value; mean change rate results of 48h moisture content versus initial value for test subjects using the skin lotion of comparative example 5; the average change rate result of the moisture content of the skin care lotion for 48 hours relative to the initial value is used by the subject;
FIG. 3 shows mean change rate results of skin moisture content versus initial value for subjects using example 16 lotion for 21 days and after discontinuation; mean change rate results of skin moisture content relative to initial value after subject uses skin lotion of comparative example 5 for 21 days and stops; the average change rate of skin moisture content after the subject uses the skin moisturizer of the commercial competitive products for 21 days and stops using the skin moisturizer is compared with the initial value.
The specific implementation mode is as follows:
to further illustrate the technical means and effects of the present invention, the present invention is further described with reference to the following examples. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting of the invention. The examples, which are not specifically shown for the specific methods, are all routine in the art or according to the product specifications. The reagents or apparatus used are conventional products commercially available from normal sources, not indicated by the manufacturer.
Table 1 raw materials supplier list
| Serial number | Name of raw materials | INCI name | Suppliers of |
|
| 1 | Water (W) | Water (W) | Yibao (good health) | |
| 2 | Hyaluronic acid sodium salt | Hyaluronic acid sodium | Furuida preparation | |
| 3 | Viscarin PC 209 | Chondrus CRISPUS (Chondrus CRISPUS) | (DuPont) | |
| 4 | Polyglutamic acid | Polyglutamic acid sodium | Furuida preparation | |
| 5 | Glycerol | Glycerol | Baojie medicine | |
| 6 | L-Serine | Serine | Tin-free crystal sea | |
| 7 | L-Proline | Proline | Tin-free crystal sea | |
| 8 | L-Glutamic acid | Glutamic acid | Tin-free crystal sea | |
| 9 | NUTRI BETAINE | Betaine | |
|
| 10 | Urea | Urea | Kangpuhuiwei | |
| 11 | NL-50 Pyrrolidinone Carboxylic acid sodium salt | PCA sodium | Gourmet powder | |
| 12 | Trehalose | Trehalose | Japanese forest source | |
| 13 | Microcare Emollient CLG | Octylene | Tuo Er | |
| 14 | | Allantoin | Yashilan | |
| 15 | MTI | Methylisothiazolinone/iodopropynyl alcohol butyl carbamate | Tuo Er |
TABLE 2 Instrument information List
| Name of instrument | Specification and model | Manufacturer of the product |
| Sadoris electronic balance | BSA2202S-CW | Sadoris sp |
| Mettler electronic balance | ML204/02 | Mettlerlatido |
| Stirrer | IKA continental star | IKA |
| Electric ceramic stove | LC-E109S | Guangdong moral and shun electrical equipment |
Examples 1-15 preparation of composite moisturizer
Example 1:
1) adding 0.3 part by weight of sodium polyglutamate (molecular weight of 100 ten thousand Da), 2 parts by weight of Chondrus crispus (molecular weight of 200 ten thousand Da) and 0.2 part by weight of sodium hyaluronate (molecular weight of 100 ten thousand Da) into 35 parts by weight of glycerin, stirring and dispersing uniformly, adding into water, stirring at the rotating speed of 300r/min by using a stirrer, and simultaneously heating to 80 ℃ until the sodium polyglutamate, the Chondrus crispus and the sodium hyaluronate are completely dissolved;
2) weighing 1.2 parts by weight of L-serine and 0.6 part by weight of L-proline, adding into the solution obtained in the step 1) for dissolving, adding L-glutamic acid to adjust the pH value to 4.5-5.5, and uniformly stirring at the rotating speed of a stirrer of 300 r/min;
3) weighing 4 parts by weight of betaine, 6 parts by weight of sodium pyrrolidone carboxylate, 4 parts by weight of trehalose and 0.2 part by weight of allantoin, stirring and dissolving, and adding the obtained solution in the step 2);
4) cooling to below 40 ℃, adding 8 parts by weight of urea and 0.4 part by weight of preservative octylene glycol, stirring uniformly, filtering and discharging.
Example 2:
1) adding 0.3 part by weight of sodium polyglutamate (molecular weight of 100 ten thousand Da), 2 parts by weight of Chondrus crispus (molecular weight of 200 ten thousand Da) and 0.2 part by weight of sodium hyaluronate (molecular weight of 100 ten thousand Da) into 35 parts by weight of glycerin, stirring and dispersing uniformly, adding into water, stirring at the rotating speed of 300r/min by using a stirrer, and simultaneously heating to 80 ℃ until the sodium polyglutamate, the Chondrus crispus and the sodium hyaluronate are completely dissolved;
2) weighing 1.2 parts by weight of L-serine and 0.6 part by weight of L-proline, adding into the solution obtained in the step 1) for dissolving, adding L-glutamic acid to adjust the pH value to 4.5-5.5, and uniformly stirring at the rotating speed of a stirrer of 300 r/min;
3) weighing 4 parts by weight of betaine, 6 parts by weight of sodium pyrrolidone carboxylate, 4 parts by weight of trehalose and 0.2 part by weight of allantoin, stirring and dissolving, and adding into the solution obtained in the step 2);
4) cooling to below 40 ℃, adding 0.4 weight part of preservative octyl glycol, stirring uniformly, filtering and discharging.
Example 3:
1) adding 0.3 part by weight of sodium polyglutamate (molecular weight of 100 ten thousand Da), 2 parts by weight of Chondrus crispus (molecular weight of 200 ten thousand Da) and 0.2 part by weight of sodium hyaluronate (molecular weight of 100 ten thousand Da) into 40 parts by weight of glycerin, stirring and dispersing uniformly, adding into water, stirring at the rotating speed of 300r/min by using a stirrer, and simultaneously heating to 80 ℃ until the sodium polyglutamate, the Chondrus crispus and the sodium hyaluronate are completely dissolved;
2) weighing 1.2 parts by weight of L-serine and 0.6 part by weight of L-proline, adding into the solution obtained in the step 1) for dissolving, adding L-glutamic acid to adjust the pH value to 4.5-5.5, and uniformly stirring at the rotating speed of a stirrer of 300 r/min;
3) weighing 4 parts by weight of betaine and 6 parts by weight of sodium pyrrolidone carboxylate, and adding the mixture into the solution obtained in the step 2), stirring and dissolving;
4) cooling to below 40 ℃, adding 0.4 weight part of preservative octyl glycol, stirring uniformly, filtering and discharging.
Example 4:
1) adding 0.3 part by weight of sodium polyglutamate (with a molecular weight of 50 ten thousand Da), 2 parts by weight of Chondrus crispus (with a molecular weight of 80 ten thousand Da) and 0.2 part by weight of sodium hyaluronate (with a molecular weight of 50 ten thousand Da) into 35 parts by weight of glycerin, stirring and dispersing uniformly, adding into water, stirring at a stirrer rotating speed of 300r/min, and simultaneously heating to 85 ℃ until the sodium polyglutamate, the Chondrus crispus and the sodium hyaluronate are completely dissolved;
2) weighing 1.2 parts by weight of L-serine and 0.6 part by weight of L-proline, adding into the solution obtained in the step 1) for dissolving, adding L-glutamic acid to adjust the pH value to 4.5-5.5, and uniformly stirring at the rotating speed of a stirrer of 300 r/min;
3) weighing 4 parts by weight of betaine, 6 parts by weight of sodium pyrrolidone carboxylate, 4 parts by weight of trehalose and 0.2 part by weight of allantoin, stirring and dissolving, and adding the obtained solution in the step 2);
4) cooling to below 40 ℃, adding 8 parts by weight of urea and 0.4 part by weight of preservative octylene glycol, stirring uniformly, filtering and discharging.
Example 5:
1) adding 0.3 part by weight of sodium polyglutamate (molecular weight of 150 ten thousand Da), 2 parts by weight of Chondrus crispus (molecular weight of 150 ten thousand Da) and 0.2 part by weight of sodium hyaluronate (molecular weight of 150 ten thousand Da) into 35 parts by weight of glycerin, stirring and dispersing uniformly, adding into water, stirring at the rotating speed of a stirrer of 300r/min, and simultaneously heating to 75 ℃ until the sodium polyglutamate, the Chondrus crispus and the sodium hyaluronate are completely dissolved;
2) weighing 1.2 parts by weight of L-serine and 0.6 part by weight of L-proline, adding into the solution obtained in the step 1) for dissolving, adding L-glutamic acid to adjust the pH value to 4.5-5.5, and uniformly stirring at the rotating speed of a stirrer of 300 r/min;
3) weighing 4 parts by weight of betaine, 6 parts by weight of sodium pyrrolidone carboxylate, 4 parts by weight of trehalose and 0.2 part by weight of allantoin, stirring and dissolving, and adding the obtained solution in the step 2);
4) cooling to below 40 ℃, adding 8 parts by weight of urea and 0.4 part by weight of preservative octylene glycol, stirring uniformly, filtering and discharging.
Example 6:
1) adding 0.3 part by weight of sodium polyglutamate (molecular weight of 100 ten thousand Da), 2 parts by weight of Chondrus crispus (molecular weight of 150 ten thousand Da) and 0.2 part by weight of sodium hyaluronate (molecular weight of 150 ten thousand Da) into 35 parts by weight of glycerin, stirring and dispersing uniformly, adding into water, stirring at the rotating speed of 300r/min by using a stirrer, and simultaneously heating to 80 ℃ until the sodium polyglutamate, the Chondrus crispus and the sodium hyaluronate are completely dissolved;
2) weighing 1.2 parts by weight of L-serine and 0.6 part by weight of L-proline, adding into the solution obtained in the step 1) for dissolving, adding L-glutamic acid to adjust the pH value to 4.5-5.5, and uniformly stirring at the rotating speed of a stirrer of 300 r/min;
3) weighing 4 parts by weight of betaine, 6 parts by weight of sodium pyrrolidone carboxylate, 4 parts by weight of trehalose and 0.2 part by weight of allantoin, stirring and dissolving, and adding the obtained solution in the step 2);
4) cooling to below 40 ℃, adding 8 parts by weight of urea and 0.4 part by weight of preservative octylene glycol, stirring uniformly, filtering and discharging.
Example 7:
1) adding 0.3 part by weight of sodium polyglutamate (molecular weight of 80 ten thousand Da), 2 parts by weight of Chondrus crispus (molecular weight of 200 ten thousand Da) and 0.2 part by weight of sodium hyaluronate (molecular weight of 100 ten thousand Da) into 35 parts by weight of glycerin, stirring and dispersing uniformly, adding into water, stirring at the rotating speed of 300r/min by using a stirrer, and simultaneously heating to 85 ℃ until the sodium polyglutamate, the Chondrus crispus and the sodium hyaluronate are completely dissolved;
2) weighing 1.2 parts by weight of L-serine and 0.6 part by weight of L-proline, adding into the solution obtained in the step 1) for dissolving, adding L-glutamic acid to adjust the pH value to 4.5-5.5, and uniformly stirring at the rotating speed of a stirrer of 300 r/min;
3) weighing 4 parts by weight of betaine, 6 parts by weight of sodium pyrrolidone carboxylate, 4 parts by weight of trehalose and 0.2 part by weight of allantoin, stirring and dissolving, and adding the obtained solution in the step 2);
4) cooling to below 40 ℃, adding 8 parts by weight of urea and 0.4 part by weight of preservative octylene glycol, stirring uniformly, filtering and discharging.
Example 8:
1) adding 1 weight part of sodium polyglutamate (molecular weight is 50 ten thousand Da), 0.01 weight part of Chondrus crispus (molecular weight is 200 ten thousand Da) and 1 weight part of sodium hyaluronate (molecular weight is 100 ten thousand Da) into 15 weight parts of glycerin, stirring and dispersing uniformly, adding into water, stirring at the rotating speed of 300r/min by using a stirrer, and simultaneously heating to 80 ℃ until the sodium polyglutamate, the Chondrus crispus and the sodium hyaluronate are completely dissolved;
2) weighing 2 parts by weight of L-serine and 2 parts by weight of L-proline, adding into the medium obtained in the step 1), dissolving, adding L-glutamic acid, adjusting the pH value to 4.5-5.5, and uniformly stirring at a stirrer rotating speed of 300 r/min;
3) weighing 10 parts by weight of betaine, 10 parts by weight of sodium pyrrolidone carboxylate, 10 parts by weight of trehalose and 0.5 part by weight of allantoin, stirring and dissolving, and adding into the solution obtained in the step 2);
4) cooling to below 40 ℃, adding 20 parts by weight of urea and 0.3 part by weight of preservative octylene glycol, stirring uniformly, filtering and discharging.
Example 9:
1) adding 0.2 part by weight of sodium polyglutamate (with the molecular weight of 250 ten thousand Da), 5 parts by weight of Chondrus crispus (with the molecular weight of 200 ten thousand Da) and 0.2 part by weight of sodium hyaluronate (with the molecular weight of 100 ten thousand Da) into 40 parts by weight of glycerin, stirring and dispersing uniformly, adding into water, stirring at the rotating speed of 300r/min by using a stirrer, and simultaneously heating to 80 ℃ until the sodium polyglutamate, the Chondrus crispus and the sodium hyaluronate are completely dissolved;
2) weighing 1 part by weight of L-serine and 0.5 part by weight of L-proline, adding into the solution obtained in the step 1) for dissolving, adding L-glutamic acid to adjust the pH value to 4.5-5.5, and uniformly stirring at the rotating speed of 300r/min of a stirrer;
3) weighing 5 parts by weight of betaine, 5 parts by weight of sodium pyrrolidone carboxylate, 10 parts by weight of trehalose and 0.1 part by weight of allantoin, stirring and dissolving, and adding into the solution obtained in the step 2);
4) cooling to below 40 ℃, adding 10 parts by weight of urea and 0.3 part by weight of preservative octylene glycol, stirring uniformly, filtering and discharging.
Example 10:
1) adding 0.2 weight part of sodium polyglutamate (molecular weight of 100 ten thousand Da), 1 weight part of Chondrus crispus (molecular weight of 100 ten thousand Da) and 0.1 weight part of sodium hyaluronate (molecular weight of 100 ten thousand Da) into 20 weight parts of glycerin, stirring and dispersing uniformly, adding into water, stirring at the rotating speed of 300r/min by using a stirrer, and simultaneously heating to 75 ℃ until the sodium polyglutamate, the Chondrus crispus and the sodium hyaluronate are completely dissolved;
2) weighing 0.01 part by weight of L-serine and 0.5 part by weight of L-proline, adding into the solution obtained in the step 1), dissolving, adding L-glutamic acid, adjusting the pH value to 4.5-5.5, and uniformly stirring at the rotating speed of 300r/min by using a stirrer;
3) weighing 5 parts by weight of betaine, 5 parts by weight of sodium pyrrolidone carboxylate, 5 parts by weight of trehalose and 0.2 part by weight of allantoin, stirring and dissolving, and adding the mixture into the solution obtained in the step 2);
4) cooling to below 40 ℃, adding 5 parts by weight of urea and 0.5 part by weight of preservative octylene glycol, stirring uniformly, filtering and discharging.
Example 11:
1) adding 2 parts by weight of sodium polyglutamate (molecular weight of 100 ten thousand Da), 2 parts by weight of Chondrus crispus (molecular weight of 500 ten thousand Da) and 2 parts by weight of sodium hyaluronate (molecular weight of 100 ten thousand Da) into 40 parts by weight of glycerin, stirring and dispersing uniformly, adding into water, stirring at the rotating speed of a stirrer of 300r/min, and simultaneously heating to 85 ℃ until the sodium polyglutamate, the Chondrus crispus and the sodium hyaluronate are completely dissolved;
2) weighing 1 part by weight of L-serine, 0.01 part by weight of L-proline and 0.1 part by weight of L-glutamic acid, adding into the solution obtained in the step 1) for dissolving, adding citric acid and sodium hydroxide to adjust the pH value to 4.5-5.5, and uniformly stirring at the rotating speed of a stirrer of 300 r/min;
3) weighing 5 parts by weight of betaine, 3 parts by weight of sodium pyrrolidone carboxylate, 5 parts by weight of trehalose and 0.1 part by weight of allantoin, stirring and dissolving, and adding the mixture into the solution obtained in the step 2);
4) cooling to below 40 deg.C, adding urea 10 weight parts and antiseptic phenoxyethanol/ethylhexyl glycerol 0.8 weight parts, stirring, filtering, and discharging.
Example 12:
1) adding 1 weight part of poly-sodium glutamate (molecular weight 100 ten thousand Da), 1 weight part of Chondrus crispus (molecular weight 80 ten thousand Da) and 1 weight part of sodium hyaluronate (molecular weight 100 ten thousand Da) into 10 weight parts of glycerin, stirring and dispersing uniformly, adding into water, stirring at the rotating speed of a stirrer of 300r/min, and simultaneously heating to 70 ℃ until the solution is completely dissolved;
2) weighing 1.5 parts by weight of L-serine, 1 part by weight of L-proline and 0.1 part by weight of L-glutamic acid, adding into the solution obtained in the step 1) for dissolving, adding citric acid and sodium hydroxide to adjust the pH value to 4.5-5.5, and uniformly stirring at the rotating speed of a stirrer of 300 r/min;
3) weighing 5 parts by weight of betaine, 5 parts by weight of sodium pyrrolidone carboxylate, 0.5 part by weight of trehalose and 0.1 part by weight of allantoin, stirring and dissolving, and adding into the solution obtained in the step 2);
4) cooling to below 40 deg.C, adding 5 weight parts of urea and 0.8 weight part of antiseptic phenoxyethanol/ethylhexyl glycerol, stirring, filtering, and discharging.
Example 13:
1) adding 0.01 weight part of sodium polyglutamate (molecular weight of 100 ten thousand Da), 3 weight parts of Chondrus crispus (molecular weight of 200 ten thousand Da) and 0.01 weight part of sodium hyaluronate (molecular weight of 5 ten thousand Da) into 8 weight parts of glycerin, stirring and dispersing uniformly, adding into water, stirring at the rotating speed of 300r/min by using a stirrer, and simultaneously heating to 90 ℃ until the sodium polyglutamate, the Chondrus crispus and the sodium hyaluronate are completely dissolved;
2) weighing 0.8 part by weight of L-serine, 1.8 parts by weight of L-proline and 0.1 part by weight of L-glutamic acid, adding into the solution obtained in the step 1), dissolving, adding citric acid and sodium hydroxide to adjust the pH value to 4.5-5.5, and uniformly stirring at the rotating speed of a stirrer of 300 r/min;
3) weighing 4 parts by weight of betaine, 0.2 part by weight of sodium pyrrolidone carboxylate, 1 part by weight of trehalose and 0.01 part by weight of allantoin, stirring and dissolving, and adding into the solution obtained in the step 2);
4) cooling to below 40 deg.C, adding 1 weight part of urea and 0.8 weight part of antiseptic phenoxyethanol/ethylhexyl glycerol, stirring, filtering, and discharging.
Example 14:
1) adding 0.01 weight part of sodium polyglutamate (molecular weight is 80 ten thousand Da), 3 weight parts of Chondrus crispus (molecular weight is 80 ten thousand Da) and 0.01 weight part of sodium hyaluronate (molecular weight is 50 ten thousand Da) into 8 weight parts of glycerin, stirring and dispersing uniformly, adding into water, stirring at the rotating speed of 300r/min by using a stirrer, and simultaneously heating to 85 ℃ until the sodium polyglutamate, the Chondrus crispus and the sodium hyaluronate are completely dissolved;
2) weighing 0.8 part by weight of L-serine, 1.8 parts by weight of L-proline and 0.1 part by weight of L-glutamic acid, adding into the solution obtained in the step 1), dissolving, adding citric acid and sodium hydroxide to adjust the pH value to 4.5-5.5, and uniformly stirring at the rotating speed of a stirrer of 300 r/min;
3) weighing 4 parts by weight of betaine, 0.2 part by weight of sodium pyrrolidone carboxylate, 1 part by weight of trehalose and 0.01 part by weight of allantoin, stirring and dissolving, and adding into the solution obtained in the step 2);
4) cooling to below 40 deg.C, adding 1 weight part of urea and 0.8 weight part of antiseptic phenoxyethanol/ethylhexyl glycerol, stirring, filtering, and discharging.
Example 15:
1) adding 0.01 weight part of sodium polyglutamate (molecular weight is 50 ten thousand Da), 3 weight parts of Chondrus crispus (molecular weight is 80 ten thousand Da) and 0.01 weight part of sodium hyaluronate (molecular weight is 190 ten thousand Da) into 8 weight parts of glycerin, stirring and dispersing uniformly, adding into water, stirring at the rotating speed of 300r/min by using a stirrer, and simultaneously heating to 85 ℃ until the sodium polyglutamate, the Chondrus crispus and the sodium hyaluronate are completely dissolved;
2) weighing 0.8 part by weight of L-serine, 1.8 parts by weight of L-proline and 0.1 part by weight of L-glutamic acid, adding into the solution obtained in the step 1), dissolving, adding citric acid and sodium hydroxide to adjust the pH value to 4.5-5.5, and uniformly stirring at the rotating speed of a stirrer of 300 r/min;
3) weighing 4 parts by weight of betaine, 0.2 part by weight of sodium pyrrolidone carboxylate, 1 part by weight of trehalose and 0.01 part by weight of allantoin, stirring and dissolving, and adding into the solution obtained in the step 2);
4) cooling to below 40 deg.C, adding 1 weight part of urea and 0.8 weight part of antiseptic phenoxyethanol/ethylhexyl glycerol, stirring, filtering, and discharging.
Examples 16-25 preparation of moisturizing lotions
Examples 16-25 moisturizing lotions were prepared as follows:
(1) adding the phase A thickener into water, stirring and dissolving;
(2) mixing the phase B and the phase A, and stirring;
(3) adding the mixture obtained in the step (2) into the phase C, adjusting the pH value to 6.5-6.8, and stirring;
(4) adding a D-phase raw material into the mixture obtained in the step (3), and stirring;
(5) filtering and discharging at the temperature below 38 ℃.
The components and the dosage of the moisturizing skin-care lotion in the examples 16 to 25 are respectively as follows:
example 16 moisturizing lotion components and amounts:
example 17 moisturizing lotion components and amounts:
example 18 moisturizing lotion components and amounts:
example 19 moisturizing lotion components and amounts:
example 20 moisturizing lotion components and amounts:
example 21 moisturizing and skin-care lotion components and amounts:
example 22 moisturizing lotion components and amounts:
example 23 moisturizing lotion components and amounts:
example 24 moisturizing lotion components and amounts:
example 25 moisturizing lotion components and amounts:
comparative examples 1 to 5:
comparative examples 1-5 have the following components and amounts:
efficacy evaluation test
First, off-line state observation and skin feel stability test
The skin lotions of example 16 and comparative examples 1-5 were subjected to the offline state and stability observation, and the results are shown in the following table:
as can be seen from the observation results, the skin lotions of comparative examples 1 to 3 were too thin and insufficient in moisturizing degree as moisturizing skin lotions, as compared with example 16; comparative example 4 was thick and sticky to the skin.
Second, sensory evaluation
Sensory evaluation method:
the subject claims: chinese women with healthy skin, 36 people in total, are divided into 3 groups, and the skin care products are stopped 2 days before the test of the testee.
The skin care product sensory evaluation of the testee can be put into the group after being qualified.
And (3) testing a sample:
example 16 skin lotion, comparative example 5 skin lotion, some commercially available spotlighted article (main ingredients: water, dipropylene glycol, diglycerin, glycerin, PEG-60 hydrogenated castor oil, acrylic acid/C10-30 alkanol acrylate crosspolymer, niacinamide, polysorbate-20, potassium hydroxide, butylene glycol, carbomer, etc.).
The test method comprises the following steps:
after the test sample is used by the test subject, the moistening degree, the softness, the filming feeling, the slippery feeling and the moistening degree after absorption of the test product are respectively graded. The evaluation statistics are shown in FIG. 1.
As shown in FIG. 1, the skin lotion of example 16 is excellent in the moisturizing feeling, soft feeling and the like, and the film-forming feeling and the slippery feeling are also better than those of comparative example 5 and the commercially available competitive products.
Short-term and long-term moisturizing effect evaluation
The short-term and long-acting slow-release moisturizing effect of the tested sample is tested through 48-hour moisturizing experiments and 21-day human moisturizing experiments.
(1) Moisturizing experiment for 48h
And (3) testing a sample:
example 16 skin lotion, comparative example 5 skin lotion, some commercially available spotlighted article (main ingredients: water, dipropylene glycol, diglycerin, glycerin, PEG-60 hydrogenated castor oil, acrylic acid/C10-30 alkanol acrylate crosspolymer, niacinamide, polysorbate-20, potassium hydroxide, butylene glycol, carbomer, etc.).
The test method comprises the following steps:
36 qualified subjects were selected, and 12 subjects were divided into three groups, and comparative example 5, a commercially available competitive product, and skin lotion of example 16 were used.
Volunteers measured the initial skin moisture content of the cheeks after sitting still in a constant humidity and temperature room for 1 h. After applying the test sample to the cheek, the moisture content of the cheek skin was measured at 2, 4, 6, 8, 24, 48 hours after applying the sample.
Testing an instrument:
skin moisture tester (Corneometer CM825, CK, germany).
The test results are shown in fig. 2.
(2) 21d and human body moisturizing experiment after product disuse
The experimental method and the tested sample are the same as the 48-hour moisturizing experiment.
Volunteers measured the initial skin moisture content of the cheeks after sitting still in a constant humidity and temperature room for 1 h. The test samples were smeared on the cheeks twice a day, morning and evening, for the next 21d, and were discontinued after 21 d. Cheek skin hydration was tested using a skin hydration tester at 21d after sample application and at 2d, 5d after sample discontinuation.
As can be seen from fig. 2, within 48 hours after the test sample was applied, the mean rate of change of the moisture content of the cheek skin of the subjects in the group to which the skin lotion of example 16 was applied from the initial value was significantly higher than that of the comparative example 5 and the race set. The moisturizing water has good moisturizing effect within 48 hours.
As can be seen from fig. 3, after 21 days using the test sample, the mean rate of change of the moisture content of the cheek skin of the subjects in the group using the moisturizing water from the initial value was significantly higher than those of the two groups of the application moisturizing water race and the comparative example 5, and within 5 days of the disuse of the sample, the mean rate of change of the moisture content of the cheek skin of the subjects in the group using the moisturizing water from the initial value was also significantly higher than those of the other two groups.
The moisturizing lotion disclosed by the invention has good skin feel, has lasting and efficient moisturizing and moisturizing effects, and can still generate a moisturizing effect on skin after the product is stopped.
Claims (10)
1. The skin moisturizer with moisturizing effect comprises the following raw materials in parts by weight:
addition amount (wt%) of phase-group raw material name
TO 100A Water
0.05-0.30 of thickening agent
Polyol B0.00-10.00
0.50-5.00% of compound humectant
Chelating agent 0.03-0.20
C pH regulator 0.01-0.50,
the compound humectant comprises the following raw materials in parts by weight:
raw material name addition amount (wt%)
Water TO100
0.01-5.00 g of sodium hyaluronate
Chondrus CRISPUS (Chondrus CRISPUS) 0.01-5.00
0.01-5.00% of sodium polyglutamate
Glycerin 0.001-40.00
L-serine 0.01-2.00
L-proline 0.00-2.00
L-glutamic acid 0.00-0.30
Betaine 0.001-15.00
Urea 0.00-20.00
Pyrrolidone carboxylic acid sodium 0.001-15.00
Trehalose 0.00-10.00
0.00-1.00% of preservative
Allantoin 0.001-0.50
pH regulator 0.001-5.00.
2. The skin lotion according to claim 1, wherein the compound moisturizer comprises the following raw materials in parts by weight:
raw material name addition amount (wt%)
Water TO100
0.01-5.00 g of sodium hyaluronate
Chondrus CRISPUS (Chondrus CRISPUS) 0.01-5.00
0.01-5.00% of sodium polyglutamate
Glycerin 0.001-40.00
L-serine 0.01-2.00
L-proline 0.01-2.00
L-glutamic acid 0.001-0.30
Betaine 0.001-15.00
0.001-20.00% of urea
Pyrrolidone carboxylic acid sodium 0.001-15.00
Trehalose 0.001-10.00
0.001-1.00% of preservative
Allantoin 0.001-0.50
pH regulator 0.001-5.00.
3. The skin moisturizer of claim 1 or 2, wherein the compound moisturizer is prepared by a method comprising the following steps:
1) adding sodium polyglutamate, Chondrus crispus and sodium hyaluronate into glycerol, stirring, adding into water, stirring, and heating to 70-90 deg.C for dissolving to obtain a first solution;
2) adding L-serine, L-proline and L-glutamic acid into the first solution obtained in the step 1) for dissolving, adding a pH regulator, regulating the pH to 4.5-5.5, and stirring to obtain a second solution;
3) stirring and dissolving betaine, sodium pyrrolidone carboxylate, trehalose and allantoin, and adding the mixture into the second solution obtained in the step 2);
4) cooling to below 40 deg.C, adding urea and antiseptic, stirring, filtering, and discharging.
4. The lotion according to any one of claims 1 to 3, wherein the molecular weight of the sodium polyglutamate is equal to or greater than 50 ten thousand Da, and/or the molecular weight of the Chondrus crispus is equal to or greater than 80 ten thousand Da, and/or the molecular weight of the sodium hyaluronate is equal to or greater than 5 ten thousand Da; preferably, the molecular weight of the sodium polyglutamate is more than or equal to100 ten thousand Da, and/or the molecular weight of the Chondrus crispus is more than or equal to 200 ten thousand Da, and/or the molecular weight of the sodium hyaluronate is more than or equal to100 ten thousand Da.
5. The skin moisturizer according to any one of claims 1 to 4, wherein the phase A thickener is a cosmetically acceptable thickener, preferably one or more of carbomer, polyacrylates, xanthan gum and cellulose.
6. The skin lotion according to any one of claims 1 to 5, wherein the B-phase polyol is a cosmetically acceptable polyol, preferably one or more of glycerol, butylene glycol, propylene glycol and dipropylene glycol; and/or the phase B chelating agent is a cosmetically acceptable chelating agent, preferably EDTA-disodium.
7. The lotion according to any one of claims 1-6, wherein phase B further comprises a botanical extract acceptable in the field of skin care products, said botanical extract being present in an amount of 0-20 wt%.
8. The lotion according to any one of claims 1 to 7, wherein the phase C pH regulator is a cosmetically acceptable pH regulator, preferably triethanolamine, arginine, sodium hydroxide; and/or the skin lotion also comprises a phase D, a proper amount of preservative and/or essence, wherein the preservative is acceptable in the field of cosmetics, and is preferably phenoxyethanol/ethylhexyl glycerin.
9. A method of preparing a lotion according to any of claims 1 to 8 comprising the steps of:
(1) adding the phase A thickener into water, stirring and dissolving;
(2) mixing the phase B and the phase A, and stirring;
(3) adding the mixture obtained in the step (2) into the phase C, adjusting the pH value to 6.5-6.8, and stirring;
(4) filtering and discharging at the temperature below 38 ℃.
10. A moisturizing skin lotion prepared by the method of claim 9.
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Application publication date: 20220329 |