CN114231512B - 半胱氨酸蛋白酶 - Google Patents

半胱氨酸蛋白酶 Download PDF

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Publication number
CN114231512B
CN114231512B CN202111557859.9A CN202111557859A CN114231512B CN 114231512 B CN114231512 B CN 114231512B CN 202111557859 A CN202111557859 A CN 202111557859A CN 114231512 B CN114231512 B CN 114231512B
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CN114231512A (zh
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克里斯蒂安·谢尔曼
索菲亚·耶尔努姆
艾玛·努达尔
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Lufthansa Biopharmaceutical Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
CN202111557859.9A 2015-02-12 2016-02-12 半胱氨酸蛋白酶 Active CN114231512B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB1502306.2 2015-02-12
GB201502306A GB201502306D0 (en) 2015-02-12 2015-02-12 Protein
CN201680021601.8A CN107532156A (zh) 2015-02-12 2016-02-12 半胱氨酸蛋白酶
PCT/EP2016/053052 WO2016128558A1 (en) 2015-02-12 2016-02-12 Cysteine protease

Related Parent Applications (1)

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CN201680021601.8A Division CN107532156A (zh) 2015-02-12 2016-02-12 半胱氨酸蛋白酶

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CN114231512A CN114231512A (zh) 2022-03-25
CN114231512B true CN114231512B (zh) 2025-02-14

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CN202111557859.9A Active CN114231512B (zh) 2015-02-12 2016-02-12 半胱氨酸蛋白酶
CN201680021601.8A Pending CN107532156A (zh) 2015-02-12 2016-02-12 半胱氨酸蛋白酶

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US (5) US10696959B2 (https=)
EP (2) EP3256580B1 (https=)
JP (1) JP6961486B2 (https=)
KR (1) KR102524613B1 (https=)
CN (2) CN114231512B (https=)
AU (2) AU2016217800B2 (https=)
BR (1) BR112017017284A2 (https=)
CA (1) CA2976003A1 (https=)
CL (1) CL2017002065A1 (https=)
CO (1) CO2017009061A2 (https=)
DK (1) DK3256580T3 (https=)
EA (1) EA035130B1 (https=)
ES (1) ES2927234T3 (https=)
GB (1) GB201502306D0 (https=)
IL (1) IL253938B (https=)
LT (1) LT3256580T (https=)
MX (1) MX390806B (https=)
MY (1) MY188696A (https=)
PL (1) PL3256580T3 (https=)
PT (1) PT3256580T (https=)
SG (1) SG11201706346QA (https=)
WO (1) WO2016128558A1 (https=)
ZA (1) ZA201705113B (https=)

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IL253938A0 (en) 2017-10-31
CN107532156A (zh) 2018-01-02
US20220170004A1 (en) 2022-06-02
IL253938B (en) 2020-01-30
EP3256580A1 (en) 2017-12-20
MX2017010390A (es) 2017-12-07
US12359183B2 (en) 2025-07-15
US20200283749A1 (en) 2020-09-10
EA035130B1 (ru) 2020-04-30
US11214784B2 (en) 2022-01-04
US20250304937A1 (en) 2025-10-02
WO2016128558A1 (en) 2016-08-18
PT3256580T (pt) 2022-10-03
KR20170116137A (ko) 2017-10-18
CA2976003A1 (en) 2016-08-18
AU2016217800A1 (en) 2017-08-10
GB201502306D0 (en) 2015-04-01
EP4108768A1 (en) 2022-12-28
CO2017009061A2 (es) 2018-01-16
NZ733959A (en) 2024-07-26
PL3256580T3 (pl) 2022-11-28
KR102524613B1 (ko) 2023-04-21
EP3256580B1 (en) 2022-07-06
US20180023070A1 (en) 2018-01-25
EA201791773A1 (ru) 2018-02-28
ZA201705113B (en) 2024-01-31
JP6961486B2 (ja) 2021-11-05
SG11201706346QA (en) 2017-09-28
CN114231512A (zh) 2022-03-25
AU2021266293A1 (en) 2021-12-09
AU2016217800B2 (en) 2021-08-12
US10696959B2 (en) 2020-06-30
BR112017017284A2 (pt) 2018-04-17
LT3256580T (lt) 2022-10-10
CL2017002065A1 (es) 2018-04-02
US11667905B2 (en) 2023-06-06
ES2927234T3 (es) 2022-11-03
MY188696A (en) 2021-12-23
AU2021266293B2 (en) 2024-10-03
MX390806B (es) 2025-03-21
JP2018506286A (ja) 2018-03-08
DK3256580T3 (en) 2022-10-03
US20230357741A1 (en) 2023-11-09

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