CN114209055A - Composition helpful for blocking oil absorption, preparation method and preparation - Google Patents
Composition helpful for blocking oil absorption, preparation method and preparation Download PDFInfo
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- CN114209055A CN114209055A CN202111565936.5A CN202111565936A CN114209055A CN 114209055 A CN114209055 A CN 114209055A CN 202111565936 A CN202111565936 A CN 202111565936A CN 114209055 A CN114209055 A CN 114209055A
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- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 claims abstract description 14
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a composition helpful for blocking oil absorption, a preparation method and a preparation, and relates to the technical field of biological fat reduction. The invention provides a composition helpful for blocking grease absorption, which comprises the following raw materials in parts by weight: 3-8 parts of needle mushroom, 5-10 parts of agaricus bisporus, 3-5 parts of wild cherry, 1-3 parts of immature bitter orange, 0.5-2 parts of cassia seed, 2-5 parts of radix polygonati officinalis, 2-5 parts of citrus reticulata powder and 8-15 parts of fructo-oligosaccharide. The composition helpful for blocking oil absorption provided by the invention can healthily and reasonably reduce the weight, reduce the oil absorption of the body, reduce the percentage of fat in the weight, has no side effect, and can improve the immunity and the resistance.
Description
Technical Field
The invention relates to the technical field of biological fat reduction, and particularly relates to a composition helpful for blocking fat absorption, a preparation method and a preparation.
Background
The definition of overweight and obesity by the world health organization WHO is: abnormal or excessive fat accumulation that can impair health. The data show that the Chinese obese population in 2019 has the size of more than 2.5 hundred million people, and with the development of the size of the obese population, the health problems caused by obesity gradually become the focus of social attention. The seven-element visited network citizens consider that body management and control are related to health, and the citizens have strong awareness on the health of personal weight.
The world health organization predicts that by 2030, the world overweight population will break through 21.6 billion and the obese population will reach 11.2 billion. A large number of researches prove that the obesity is closely related to metabolic diseases such as diabetes, polycystic ovary syndrome and the like, is also an independent risk factor for causing metabolic diseases such as hypertension, hyperlipidemia, atherosclerosis and the like, and causes great harm to health. Obesity has become the first killer threatening human health and life safety in the 21 st century.
At present, the clinical treatment method for obesity mainly changes life style (diet and exercise therapy), western medicine treatment, operation treatment and the like. The medicine intervention is not easy to be accepted by the obesity patients due to the problems of effectiveness and safety. The gastrointestinal surgery treatment cost is high, the postoperative complication risk is high, and strict operation indexes are provided. Many patients often cannot adhere to methods such as diet control, diet structure adjustment, exercise amount increase and the like, and finally cannot achieve the effect of losing weight.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a composition, a preparation method and a preparation for blocking oil absorption, wherein the provided composition can healthily and reasonably reduce the weight, reduce the oil absorption of the body, reduce the percentage of fat in the body, has no side effect, and can improve the immunity and the resistance.
In order to achieve the purpose, the invention provides a composition for blocking grease absorption, which comprises the following raw materials in parts by weight: 3-8 parts of needle mushroom, 5-10 parts of agaricus bisporus, 3-5 parts of wild cherry, 1-3 parts of immature bitter orange, 0.5-2 parts of cassia seed, 2-5 parts of radix polygonati officinalis, 2-5 parts of citrus reticulata powder and 8-15 parts of fructo-oligosaccharide.
By adopting the scheme, the plant chitosan, beta-glucan and complex sugar contained in the needle mushroom can promote decomposition of fat accumulated in a human body and inhibit absorption of fat by intestinal tracts; the agaricus bisporus contains more plant polysaccharide, can adsorb oil, and is beneficial to reducing weight and blood fat; the wild cherry berries contain abundant vitamins, minerals, antioxidant substances and polyphenol substances, can enhance the cell activity and improve the immunity, and vitamin C and trace elements contained in the wild cherry berries are absorbed and utilized by the human body, so that the cholesterol metabolism in the body can be promoted, and the absorption of the body on oil can be blocked;
fructus Aurantii Immaturus has effects of relieving flatulence, eliminating phlegm and resolving food stagnation; semen Cassiae has effects of improving endogenous heat and intestine dryness, loosening bowel to relieve constipation, lowering blood pressure and blood lipid, removing liver fire and improving eyesight; the flavonoid glycoside contained in rhizoma Polygonati Odorati can reduce blood lipid, and rhizoma Polygonati Odorati can stimulate spleen lymphocyte proliferation and enhance cell immunity; the orange powder is rich in trace elements such as potassium, phosphorus, calcium, magnesium and the like, and can reduce cholesterol, balance beneficial bacteria in intestinal tracts, prevent arteriosclerosis, prevent fatty liver and improve body immunity and resistance; the fructo-oligosaccharide is a water-soluble dietary fiber, can improve the lipid metabolism level of serum cholesterol and the like, is beneficial to discharging toxic metabolites out of the body of a body and reducing the liver burden, has a synergistic effect on all raw materials, does not generate toxicity, can healthily and reasonably reduce the weight, has no side effect, and can improve the immunity and the resistance.
Preferably, the feed also comprises the following raw materials in parts by weight: 3-6 parts of radix puerariae.
By adopting the scheme, the purple kudzuvine root has the effects of clearing heat, tonifying deficiency, dissipating blood stasis, dredging collaterals and detoxifying, and is matched with needle mushroom, agaricus bisporus, wild cherry berry, immature bitter orange, cassia seed, fragrant solomonseal rhizome, citrus powder and fructo-oligosaccharide for use, so that metabolites can be discharged out of a body, the absorption of the body on oil is blocked, and the effects of reducing fat and lowering lipid are further improved.
Preferably, the preparation method of the flammulina velutipes or the agaricus bisporus comprises the following steps:
1) enzymolysis: freeze-drying needle mushrooms or agaricus bisporus, crushing to obtain mushroom powder, adding cellulase, protease and water into the mushroom powder to obtain a mixed solution, adjusting the pH of the mixed solution to 4-5, performing enzymolysis at 45-55 ℃ for 3-5 hours to obtain an enzymolysis solution, wherein the addition amount of the cellulase is 0.1-0.3% of the weight of the mushroom powder, the addition amount of the protease is 0.1-0.3% of the weight of the mushroom powder, and the addition amount of the water is 30-100 times of the weight of the mushroom powder;
2) and (3) post-treatment: and (3) decocting the enzymolysis liquid at 100-110 ℃ for 0.5-1 h, cooling, centrifuging the enzymolysis liquid, filtering the obtained supernatant to remove residues, precipitating with ethanol, and freeze-drying to obtain the product, wherein the dosage of the ethanol is 2-5 times of the volume of the supernatant.
Preferably, the preparation method of the aronia melanocarpa comprises the following steps: cleaning the aronia melanocarpa, crushing and pulping, carrying out filter pressing on pulp to obtain filter residue, adding ethanol and hydrochloric acid into the filter residue, leaching for 1-3 h at 50-60 ℃, carrying out ultrasonic-assisted leaching for 10-15 min, wherein the microwave power is 300-400W, filtering, concentrating the filtrate, and drying, wherein the volume percentage of the ethanol is 90-95%, the molar concentration of the hydrochloric acid is 1-2 mol/L, and the dosage of the filter residue, the ethanol and the hydrochloric acid is 1-3 g, 200-300 mL and 30-60 mL.
Preferably, the preparation method of the immature bitter orange comprises the following steps: the method comprises the steps of ultrasonically cleaning immature bitter oranges, fully drying the immature bitter oranges, adding clear water, decocting for 2-4 hours, filtering, taking filtrate, and performing spray drying to obtain the immature bitter oranges, wherein the mass ratio of the immature bitter oranges to the clear water is 1: 6-10.
Preferably, the preparation method of the cassia seed comprises the following steps:
1) pretreatment: crushing cassia seeds, freeze-drying the crushed cassia seeds at the temperature of-5 to-10 ℃, putting the frozen cassia seed powder into a puffing tank, and puffing at variable temperature and pressure difference to obtain a puffed material of the cassia seeds, wherein the pressure in the puffing tank is increased from normal pressure to 0.3 to 0.6MPa, the puffing temperature is increased to 160 to 250 ℃, the pressure in the puffing tank is instantly reduced to vacuum, and the puffing time is 50 to 100 s;
2) extraction: adding cellulase and water into the semen cassiae puffed material, extracting for 3-6 hours at 50-65 ℃, wherein the addition amount of the cellulase is 0.5-1% of the weight of the semen cassiae puffed material, the addition amount of the water is 30-100 times of the weight of the semen cassiae puffed material, extracting by microwave assistance after enzymolysis is finished, the microwave power is 300-400W, the microwave treatment time is 5-15 min, filtering, and drying filtrate to obtain the semen cassiae puffed material.
Preferably, the preparation method of polygonatum odoratum comprises the following steps: sequentially carrying out ultrasonic cleaning, drying and crushing treatment on polygonatum odoratum, soaking for 12-20 h, carrying out reflux extraction by using 60-85% ethanol in percentage by volume to obtain an extraction solution, adsorbing the extraction solution by using macroporous adsorption resin, eluting by using 10% ethanol until an eluent is colorless, and carrying out reduced pressure concentration and drying to obtain the polygonatum odoratum extract.
The invention also provides a preparation method of the composition for helping to block grease absorption, which comprises the steps of crushing and sieving the raw materials respectively, collecting powder of 100-200 meshes, fully mixing the collected raw materials according to corresponding weight parts, adding 80-90% by volume of ethanol, mixing for 10-20 min, drying for 2-4 h at the temperature of 60-80 ℃, and grinding to obtain the composition.
A preparation of a composition for helping to block oil absorption is prepared by matching the composition for helping to block oil absorption with other pharmaceutic adjuvants.
Preferably, the preparation is in the form of one of tablets, pills, powder, granules, oral liquid, suspension and hard capsules.
Compared with the prior art, the invention has the following beneficial effects:
(1) the needle mushroom, the agaricus bisporus, the aronia serrulata, the immature bitter orange, the cassia seed, the polygonatum odoratum, the citrus powder and the fructo-oligosaccharide are used in a matching mode, and the prepared composition can healthily and reasonably reduce the weight, reduce the absorption of a body to oil and fat, reduce the percentage of fat in the weight, has no side effect, and can improve the immunity and the resistance.
(2) The Pueraria lobata Ohwi added into the composition is beneficial to the body to discharge metabolites out of the body, blocks the body from absorbing grease, and further improves the effects of reducing fat and lowering lipid.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
Example 1
A composition for blocking grease absorption comprises the following raw materials in parts by weight: 8 parts of flammulina velutipes, 10 parts of agaricus bisporus, 5 parts of aronia serrulata, 2 parts of immature bitter orange, 0.5 part of cassia seed, 2 parts of polygonatum odoratum, 2 parts of citrus powder and 8 parts of fructo-oligosaccharide.
The preparation method of the flammulina velutipes or the agaricus bisporus comprises the following steps:
1) enzymolysis: freeze-drying needle mushrooms or agaricus bisporus, crushing to obtain mushroom powder, adding cellulase, protease and water into the mushroom powder to obtain a mixed solution, adjusting the pH of the mixed solution to 4, performing enzymolysis at 45 ℃ for 5 hours to obtain an enzymolysis solution, wherein the addition amount of the cellulase is 0.3 percent of the weight of the mushroom powder, the addition amount of the protease is 0.3 percent of the weight of the mushroom powder, and the addition amount of the water is 100 times of the weight of the mushroom powder;
2) and (3) post-treatment: decocting the enzymolysis solution at 100 deg.C for 1 hr, cooling, centrifuging, filtering the obtained supernatant to remove residue, precipitating with ethanol, and lyophilizing to obtain the final product, wherein the ethanol content is 2 times of the supernatant volume.
The preparation method of the wild cherry berries comprises the following steps: cleaning the aronia melanocarpa, crushing and pulping, carrying out pressure filtration on pulp to obtain filter residue, adding ethanol and hydrochloric acid into the filter residue, leaching for 3 hours at 50 ℃, carrying out ultrasonic-assisted leaching for 10 minutes with the microwave power of 350W, filtering, concentrating the filtrate, and drying, wherein the volume percentage of the ethanol is 90%, the molar concentration of the hydrochloric acid is 2mol/L, and the dosage of the filter residue, the ethanol and the hydrochloric acid is 1g, 200mL and 30 mL.
The preparation method of the immature bitter orange comprises the following steps: ultrasonically cleaning immature bitter orange, fully drying, adding clear water, decocting for 4h, filtering, and spray drying to obtain the immature bitter orange, wherein the mass ratio of the immature bitter orange to the clear water is 1: 8.
The preparation method of the cassia seed comprises the following steps:
1) pretreatment: crushing fresh cassia seeds, freezing at-10 ℃, putting the frozen cassia seed powder into a puffing tank, puffing at variable temperature and pressure difference to obtain a puffed cassia seed material, firstly raising the pressure in the puffing tank from normal pressure to 0.4MPa, raising the puffing temperature to 180 ℃, and then instantly reducing the pressure in the puffing tank to vacuum, wherein the puffing time is 65 s;
2) extraction: adding cellulase and water into the semen Cassiae puffed material, extracting at 65 deg.C for 6 hr, adding cellulase 1 wt% and water 100 times of semen Cassiae puffed material, extracting with microwave assistance after enzymolysis, wherein the microwave power is 350W, the microwave treatment time is 10min, filtering, and drying the filtrate.
The preparation method of the polygonatum comprises the following steps: sequentially performing ultrasonic cleaning, drying and crushing treatment on polygonatum odoratum, soaking for 16h, performing reflux extraction by using 75% ethanol to obtain an extraction solution, adsorbing the extraction solution by using macroporous adsorption resin, eluting by using 10% ethanol until an eluent is colorless, and performing reduced pressure concentration and drying to obtain the polygonatum odoratum compound preparation.
The preparation method of the orange powder comprises the following steps: and (3) dehydrating, drying and grinding the pulp of the fresh orange powder to obtain the orange powder.
A preparation method of a composition helpful for blocking oil absorption comprises the steps of respectively crushing and sieving raw materials, collecting 100-200-mesh powder, fully mixing the collected raw materials according to the weight part ratio of 8 parts of flammulina velutipes, 10 parts of agaricus bisporus, 5 parts of aronia serrulata, 2 parts of immature bitter orange, 0.5 part of cassia seed, 2 parts of polygonatum odoratum, 2 parts of citrus powder and 8 parts of fructo-oligosaccharide, adding 90% ethanol by volume percentage, mixing for 15min, drying for 3h at 70 ℃, and grinding to obtain the composition.
Adding conventional pharmaceutical excipients, and preparing the composition prepared by the embodiment into powder according to a conventional process.
Example 2
A composition for blocking grease absorption comprises the following raw materials in parts by weight: 3 parts of flammulina velutipes, 5 parts of agaricus bisporus, 3 parts of aronia serra, 1 part of immature bitter orange, 1 part of cassia seed, 3 parts of polygonatum odoratum, 3 parts of citrus powder and 15 parts of fructo-oligosaccharide.
The preparation method of the flammulina velutipes or the agaricus bisporus comprises the following steps:
1) enzymolysis: freeze-drying needle mushrooms or agaricus bisporus, crushing to obtain mushroom powder, adding cellulase, protease and water into the mushroom powder to obtain a mixed solution, adjusting the pH of the mixed solution to 5, performing enzymolysis at 55 ℃ for 4 hours to obtain an enzymolysis solution, wherein the addition amount of the cellulase is 0.2 percent of the weight of the mushroom powder, the addition amount of the protease is 0.2 percent of the weight of the mushroom powder, and the addition amount of the water is 60 times of the weight of the mushroom powder;
2) and (3) post-treatment: decocting the enzymolysis solution at 105 deg.C for 0.5h, cooling, centrifuging, filtering the obtained supernatant to remove residue, precipitating with ethanol, and lyophilizing to obtain the final product, wherein the ethanol content is 5 times of the supernatant volume.
The preparation method of the wild cherry berries comprises the following steps: cleaning the aronia melanocarpa, crushing and pulping, carrying out pressure filtration on pulp to obtain filter residue, adding ethanol and hydrochloric acid into the filter residue, leaching for 2h at 60 ℃, carrying out ultrasonic-assisted leaching for 12min with the microwave power of 300W, filtering, concentrating the filtrate, and drying, wherein the volume percentage of the ethanol is 95%, the molar concentration of the hydrochloric acid is 1mol/L, and the dosage of the filter residue, the ethanol and the hydrochloric acid is 3g, 250mL and 60 mL.
The preparation method of the immature bitter orange comprises the following steps: ultrasonically cleaning fructus Aurantii Immaturus, sufficiently drying, adding clear water, decocting for 2h, filtering, collecting filtrate, and spray drying to obtain the final product, wherein the mass ratio of fructus Aurantii Immaturus to clear water is 1: 6.
The preparation method of the cassia seed comprises the following steps:
1) pretreatment: crushing fresh cassia seeds, freezing at the temperature of minus 5 ℃, putting the frozen cassia seed powder into a puffing tank, puffing at variable temperature and pressure difference to obtain a puffed cassia seed material, firstly raising the pressure in the puffing tank from normal pressure to 0.3MPa, raising the puffing temperature to 160 ℃, and then instantly reducing the pressure in the puffing tank to vacuum, wherein the puffing time is 50 s;
2) extraction: adding cellulase and water into the semen Cassiae puffed material, extracting at 50 deg.C for 3 hr, adding cellulase 0.5 wt% and water 30 times of semen Cassiae puffed material, extracting with microwave auxiliary after enzymolysis, wherein the microwave power is 300W, the microwave treatment time is 5min, filtering, collecting filtrate, and drying to obtain semen Cassiae.
The preparation method of the polygonatum comprises the following steps: sequentially performing ultrasonic cleaning, drying and crushing treatment on polygonatum odoratum, soaking for 12h, performing reflux extraction by using 60% ethanol to obtain an extraction solution, adsorbing the extraction solution by using macroporous adsorption resin, eluting by using 10% ethanol until an eluent is colorless, and performing reduced pressure concentration and drying to obtain the polygonatum odoratum compound preparation.
The preparation method of the orange powder comprises the following steps: and (3) dehydrating, drying and grinding the pulp of the fresh orange powder to obtain the orange powder.
A preparation method of a composition for blocking oil absorption is characterized by respectively crushing and sieving raw materials, collecting 100-200-mesh powder, fully mixing the collected raw materials according to the weight part ratio of 3 parts of flammulina velutipes, 5 parts of agaricus bisporus, 3 parts of aronia serrulata, 1 part of immature bitter orange, 1 part of cassia seed, 3 parts of polygonatum odoratum, 3 parts of citrus reticulata powder and 15 parts of fructo-oligosaccharide, adding 80% ethanol by volume percentage, mixing for 10min, drying for 2h at 60 ℃, and grinding to obtain the composition.
Adding conventional pharmaceutical excipients, and preparing the composition prepared by the embodiment into powder according to a conventional process.
Example 3
A composition for blocking grease absorption comprises the following raw materials in parts by weight: 5 parts of needle mushroom, 7 parts of agaricus bisporus, 4 parts of wild cherry, 2 parts of immature bitter orange, 2 parts of cassia seed, 4 parts of fragrant solomonseal rhizome, 4 parts of tangerine powder and 12 parts of fructo-oligosaccharide.
The preparation method of the flammulina velutipes or the agaricus bisporus comprises the following steps:
1) enzymolysis: freeze-drying needle mushrooms or agaricus bisporus, crushing to obtain mushroom powder, adding cellulase, protease and water into the mushroom powder to obtain a mixed solution, adjusting the pH of the mixed solution to 4.5, performing enzymolysis at 50 ℃ for 3 hours to obtain an enzymolysis solution, wherein the addition amount of the cellulase is 0.3 percent of the weight of the mushroom powder, the addition amount of the protease is 0.3 percent of the weight of the mushroom powder, and the addition amount of the water is 30 times of the weight of the mushroom powder;
2) and (3) post-treatment: decocting the enzymolysis solution at 110 deg.C for 1 hr, cooling, centrifuging, filtering the obtained supernatant to remove residue, precipitating with ethanol, and lyophilizing to obtain the final product, wherein the ethanol content is 3 times of the supernatant volume.
The preparation method of the wild cherry berries comprises the following steps: cleaning the aronia melanocarpa, crushing and pulping, carrying out pressure filtration on pulp to obtain filter residue, adding ethanol and hydrochloric acid into the filter residue, leaching for 1h at 55 ℃, carrying out ultrasonic-assisted leaching for 15min with the microwave power of 400W, filtering, concentrating the filtrate, and drying, wherein the volume percentage of the ethanol is 92%, the molar concentration of the hydrochloric acid is 2mol/L, and the dosage of the filter residue, the ethanol and the hydrochloric acid is 2g, 300mL and 45 mL.
The preparation method of the immature bitter orange comprises the following steps: ultrasonically cleaning fructus Aurantii Immaturus, sufficiently drying, adding clear water, decocting for 3h, filtering, collecting filtrate, and spray drying to obtain the final product, wherein the mass ratio of fructus Aurantii Immaturus to clear water is 1: 10.
The preparation method of the cassia seed comprises the following steps:
1) pretreatment: crushing fresh cassia seeds, freezing the crushed cassia seeds at the temperature of-8 ℃, putting the frozen cassia seed powder into a puffing tank, puffing the frozen cassia seed powder at variable temperature and pressure difference to obtain a puffed material of the cassia seeds, firstly raising the pressure in the puffing tank from normal pressure to 0.6MPa, raising the puffing temperature to 250 ℃, and then instantly reducing the pressure in the puffing tank to vacuum, wherein the puffing time is 100 s;
2) extraction: adding cellulase and water into the semen Cassiae puffed material, extracting at 65 deg.C for 5 hr, adding cellulase 0.8 wt% and water 60 times of semen Cassiae puffed material, extracting with microwave assistance after enzymolysis, wherein the microwave power is 400W, the microwave treatment time is 15min, filtering, and drying the filtrate.
The preparation method of the polygonatum comprises the following steps: sequentially performing ultrasonic cleaning, drying and crushing treatment on polygonatum odoratum, soaking for 20h, performing reflux extraction by using 85% ethanol to obtain an extraction solution, adsorbing the extraction solution by using macroporous adsorption resin, eluting by using 10% ethanol until an eluent is colorless, and performing reduced pressure concentration and drying to obtain the polygonatum odoratum compound preparation.
The preparation method of the orange powder comprises the following steps: and (3) dehydrating, drying and grinding the pulp of the fresh orange powder to obtain the orange powder.
A preparation method of a composition for blocking oil absorption is characterized by respectively crushing and sieving raw materials, collecting 100-200-mesh powder, fully mixing the collected raw materials according to the weight part ratio of 5 parts of flammulina velutipes, 7 parts of agaricus bisporus, 4 parts of aronia serrulata, 2 parts of immature bitter orange, 2 parts of cassia seed, 4 parts of polygonatum odoratum, 4 parts of tangerine powder and 12 parts of fructo-oligosaccharide, adding 85% ethanol by volume percentage, mixing for 20min, drying for 4h at 80 ℃, and grinding to obtain the composition.
Adding conventional pharmaceutical excipients, and preparing the composition prepared by the embodiment into powder according to a conventional process.
Example 4
A composition for blocking grease absorption comprises the following raw materials in parts by weight: 8 parts of flammulina velutipes, 8 parts of agaricus bisporus, 5 parts of aronia serrulata, 3 parts of immature bitter orange, 0.5 part of cassia seed, 5 parts of polygonatum odoratum, 5 parts of citrus reticulata powder and 8 parts of fructo-oligosaccharide.
The invention also comprises 3-6 parts of radix puerariae.
The preparation method of the flammulina velutipes or the agaricus bisporus comprises the following steps:
1) enzymolysis: freeze-drying needle mushrooms or agaricus bisporus, crushing to obtain mushroom powder, adding cellulase, protease and water into the mushroom powder to obtain a mixed solution, adjusting the pH of the mixed solution to 5, and performing enzymolysis at 55 ℃ for 4 hours to obtain an enzymolysis solution, wherein the addition amount of the cellulase is 0.1 percent of the weight of the mushroom powder, the addition amount of the protease is 0.1 percent of the weight of the mushroom powder, and the addition amount of the water is 60 times of the weight of the mushroom powder;
2) and (3) post-treatment: decocting the enzymolysis solution at 110 deg.C for 1 hr, cooling, centrifuging, filtering the obtained supernatant to remove residue, precipitating with ethanol, and lyophilizing to obtain the final product, wherein the ethanol content is 4 times of the supernatant volume.
The preparation method of the wild cherry berries comprises the following steps: cleaning the aronia melanocarpa, crushing and pulping, carrying out pressure filtration on pulp to obtain filter residue, adding ethanol and hydrochloric acid into the filter residue, leaching for 1h at 60 ℃, carrying out ultrasonic-assisted leaching for 15min with the microwave power of 350W, filtering, concentrating the filtrate, and drying, wherein the volume percentage of the ethanol is 90%, the molar concentration of the hydrochloric acid is 1mol/L, and the dosage of the filter residue, the ethanol and the hydrochloric acid is 2g, 200mL and 50 mL.
The preparation method of the immature bitter orange comprises the following steps: ultrasonically cleaning fructus Aurantii Immaturus, sufficiently drying, adding clear water, decocting for 2h, filtering, collecting filtrate, and spray drying to obtain the final product, wherein the mass ratio of fructus Aurantii Immaturus to clear water is 1: 8.
The preparation method of the cassia seed comprises the following steps:
1) pretreatment: crushing fresh cassia seeds, freezing at-8 ℃, putting the frozen cassia seed powder into a puffing tank, puffing at variable temperature and pressure difference to obtain a puffed cassia seed material, firstly raising the pressure in the puffing tank from normal pressure to 0.5MPa, raising the puffing temperature to 200 ℃, and then instantly reducing the pressure in the puffing tank to vacuum, wherein the puffing time is 50 s;
2) extraction: adding cellulase and water into the semen Cassiae puffed material, extracting at 50 deg.C for 5 hr, adding cellulase 1 wt% and water 100 times of semen Cassiae puffed material, extracting with microwave assistance with microwave power of 400W for 5min, filtering, and drying the filtrate.
The preparation method of the polygonatum comprises the following steps: sequentially performing ultrasonic cleaning, drying and crushing treatment on polygonatum odoratum, soaking for 20h, performing reflux extraction by using 60% ethanol to obtain an extraction solution, adsorbing the extraction solution by using macroporous adsorption resin, eluting by using 10% ethanol until an eluent is colorless, and performing reduced pressure concentration and drying to obtain the polygonatum odoratum compound preparation.
The preparation method of the orange powder comprises the following steps: and (3) dehydrating, drying and grinding the pulp of the fresh orange powder to obtain the orange powder.
A preparation method of a composition for blocking oil absorption is characterized by respectively crushing and sieving raw materials, collecting 100-200-mesh powder, fully mixing the collected raw materials according to the weight part ratio of 8 parts of flammulina velutipes, 8 parts of agaricus bisporus, 5 parts of aronia melanocarpa, 3 parts of immature bitter orange, 0.5 part of cassia seed, 5 parts of polygonatum odoratum, 5 parts of citrus reticulata powder and 8 parts of fructo-oligosaccharide, adding 85% ethanol by volume percentage, mixing for 20min, drying for 4h at 60 ℃, and grinding to obtain the composition.
Adding conventional pharmaceutical excipients, and preparing the composition prepared by the embodiment into powder according to a conventional process.
Example 5
The procedure is as in example 1, except that:
the composition for blocking grease absorption also comprises the following raw materials in parts by weight: 3 parts of radix puerariae.
Example 6
The procedure is as in example 2, except that:
the composition for blocking grease absorption also comprises the following raw materials in parts by weight: 4 parts of radix puerariae.
Example 7
The procedure is as in example 3, except that:
the composition for blocking grease absorption also comprises the following raw materials in parts by weight: 5 parts of radix puerariae.
Example 8
The procedure is as in example 4, except that:
the composition for blocking grease absorption also comprises the following raw materials in parts by weight: 6 parts of radix puerariae.
Example 9
The procedure is as in example 1, except that:
the semen Cassiae is prepared by sequentially cleaning semen Cassiae, drying, and pulverizing to obtain powder.
Example 10
The procedure is as in example 1, except that:
the preparation method of rhizoma Polygonati Odorati comprises sequentially cleaning rhizoma Polygonati Odorati, drying, and pulverizing to obtain powder.
Comparative example 1
The procedure is as in example 1, except that:
the method comprises the following steps: and (3) agaricus bisporus.
Comparative example 2
The procedure is as in example 1, except that:
the method comprises the following steps: wild cherry berries.
Comparative example 3
The procedure is as in example 1, except that:
the method comprises the following steps: immature bitter orange.
Comparative example 4
The procedure is as in example 1, except that:
the method comprises the following steps: yuzhu.
Test example 1 test of the weight-reducing effect of the composition of the present invention
1. Test materials
The feed is selected from commercial feed, and the high-fat feed comprises 70% of basal feed, 4% of cholesterol, 0.5% of sodium cholate, 18% of lard and 7.5% of egg yolk.
120 SPF SD rats with weight of 150-.
2. Test method
2.1 test grouping
The 10 groups of rats are respectively an experiment 1-8 group, a model group and a blank group, wherein the experiment 1-8 group and the model group are fed with high-fat feed, and the blank group is fed with basic feed.
2.2 methods of administration
Experiments 1-8 groups 200mg/kg of the compositions prepared in example 1, example 5, example 9, example 10, comparative examples 1-4, respectively; and (3) adding 100mL of pure water into each composition, uniformly mixing to prepare a suspension, and performing intragastric administration on the suspension of the animals in each experimental group in an oral mode, wherein the pure water with the same volume is administered to the model group and the blank group once a day for 8 weeks continuously.
3. Test data detection and processing
Body weights were recorded weekly for each group of rats, and the rats were sacrificed at the end of 8 weeks of administration, dissected, isolated for perirenal fat, perigenital fat, and omental fat, and weighed to calculate the lipid/body ratio. Fat/body ratio (perirenal fat weight + perigenital fat weight + omental fat weight)/body weight × 100%.
Statistical processing is carried out on experimental data by using anova, and single-factor anova is carried out by using SPSS 25.0 software.
4. Test results
The results of body weight and lipid/body ratio of each group of rats 6 weeks after administration are shown in table 1.
TABLE 1 weight change and lipid/body ratio of rats in each group before and after the test: (
n＝10)
Note: # P < 0.01 compared to blank; comparison with model groups, P < 0.05 and P < 0.01, respectively, are given below.
As can be seen from Table 1, after 8 weeks of experiments, the body weight and the lipid/body ratio of the rats in the model group are greater than those in the blank group, and have very significant difference (P < 0.01), indicating that the obesity model is established. After 8 weeks of experiments, the body weight and the fat/body ratio of the rats in the experimental group 1-2 are obviously lower than those in the model group, the difference is very significant (P is less than 0.01), and the body weight and the fat/body ratio of the rats in the experimental group 2 are lower than those in the experimental group 1, which shows that the purple kudzuvine root added in the composition can further improve the weight-losing effect, because the purple kudzuvine root added is beneficial to the body to discharge metabolites out of the body.
The body weight and the body fat/body ratio of the rats in the experimental group 3, the experimental group 5, the experimental group 6 and the experimental group 7 are obviously lower than those in the model group, the difference is very significant (P is less than 0.01), and the body weight and the body fat/body ratio of the rats in the experimental group 4 and the experimental group 8 are lower than those in the model group, and the difference is significant (P is less than 0.05).
The weight and the fat/body ratio of the rats in the experimental group 1 are obviously higher than those in the experimental groups 5-8, which shows that the agaricus bisporus, the aronia serrulata, the immature bitter orange and the polygonatum odoratum in the composition have better synergistic effect, and the prepared composition lacks one of the agaricus bisporus, the aronia serrulata, the immature bitter orange and the polygonatum odoratum, so that the optimal effect cannot be exerted when the weight and the fat/body ratio of the rats are reduced.
The body weight and lipid/body ratio of the rats of experimental group 3 were higher than those of experimental group 1, indicating that the cassia seed prepared by the method of example 1 used in the composition has an effect of reducing the body weight and lipid/body ratio of the rats better than that of the preparation method of example 9.
The body weight and lipid/body ratio of the rats of experimental group 4 were high compared to that of experimental group 1, indicating that the effect of polygonatum odoratum prepared by the method of example 1 in reducing the body weight and lipid/body ratio of the rats in the composition is due to the preparation method of example 9.
It was tested that the compositions prepared in examples 2-4 had similar effects to example 1 and that the compositions prepared in examples 6-8 had similar effects to example 4.
Test example 2 acute toxicity test of the composition of the present invention
Test methods reference is made to the paper published by the small eastern Sheeter et al: acute toxicity and subchronic toxicity of Astroside powder, acute toxicity test of Astroside powder on mice, recorded in 48 vol 8, page 3097 and 3108 of veterinary drug of animal husbandry, China 2021.
1. Test grouping
30 healthy Kunming mice, each half of male and female, are randomly divided into 3 groups, each group comprises 10 mice, and each half of male and female is respectively an experimental group 9, an experimental group 10 and a control group.
2. Method of administration
The suspension prepared by administering the composition of example 1 daily in the experimental group 9 was subjected to single gavage at the maximum concentration and the maximum volume, the suspension prepared by administering the composition of example 5 daily in the experimental group 10 was subjected to single gavage at the maximum concentration and the maximum volume, the amount of the composition of example 1 and example 5 administered daily was 10g/kg, and the control group was subjected to single gavage with the same volume of physiological saline. Mice were fasted for 12 hours prior to dosing, followed by 14 consecutive days. The behavior, mental state, respiration, feed intake, water intake and death of the mice were observed and recorded for 14 consecutive days after administration, the body weights of the mice were recorded on 7 th and 14 th days, and the mice were sacrificed and dissected at the end of 14 days after administration to examine whether or not there was abnormality in the organs of the mice.
3. Test results
When observed within 14 days, all the mice fed with the composition have normal physiological activities, no poisoning and death, and no pathological change visible to naked eyes after dissection, which shows that the composition has no acute toxicity to the mice after the mice are gavaged at 10 g/kg.
The body weight data of each group of mice was statistically processed using anova, and one-way anova was performed using SPSS 25.0 software, and the results are shown in table 2.
Table 2 effect of the composition of the invention on mouse body weight: (
n＝10)
| Group number | Body weight (g) before administration | Body weight (g) on day 7 of dosing | Body weight (g) on day 14 of administration |
| Experimental group 9 | 20.5±1.5 | 25.6±1.7 | 34.7±2.3 |
| Experimental group 10 | 20.3±1.6 | 24.8±1.5 | 33.2±2.2 |
| Control group | 20.4±1.4 | 26.1±1.8 | 35.6±2.6 |
As can be seen from table 2, the body weights of the mice of the experimental group 9 and the working group 10 were lower than those of the control group without significant difference, indicating that the compositions prepared in examples 1 and 5 had no toxic effect on the mice and high safety.
Tests show that the compositions prepared in examples 2 to 4 have no toxic or side effects similar to those of example 1, and the compositions prepared in examples 6 to 8 have the effects similar to those of example 4 and have no toxic or side effects.
The composition prepared by the invention can be added with conventional pharmaceutical excipients and can be prepared into tablets, pills, granules, oral liquid, suspension or hard capsules according to the conventional process, and the effect of the composition is the same as that of the prepared powder.
As can be seen from the test examples 1 and 2, the composition prepared by the invention can healthily and reasonably reduce the weight, reduce the absorption of the body to oil and fat, reduce the percentage of the fat in the weight, has no side effect, and is beneficial to improving the immunity and the resistance by adding the aronia melanocarpa, the polygonatum odoratum and the citrus powder.
While there have been shown and described what are at present considered the fundamental principles and essential features of the invention and its advantages, it will be apparent to those skilled in the art that the invention is not limited to the details of the foregoing exemplary embodiments, but is capable of other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (10)
1. The composition for blocking grease absorption is characterized by comprising the following raw materials in parts by weight: 3-8 parts of needle mushroom, 5-10 parts of agaricus bisporus, 3-5 parts of wild cherry, 1-3 parts of immature bitter orange, 0.5-2 parts of cassia seed, 2-5 parts of radix polygonati officinalis, 2-5 parts of citrus reticulata powder and 8-15 parts of fructo-oligosaccharide.
2. The composition for assisting in blocking oil absorption according to claim 1, further comprising the following raw materials in parts by weight: 3-6 parts of radix puerariae.
3. The composition for helping to block oil absorption according to claim 1, wherein the preparation method of the flammulina velutipes or the agaricus bisporus comprises the following steps:
1) enzymolysis: freeze-drying needle mushrooms or agaricus bisporus, crushing to obtain mushroom powder, adding cellulase, protease and water into the mushroom powder to obtain a mixed solution, adjusting the pH of the mixed solution to 4-5, performing enzymolysis at 45-55 ℃ for 3-5 hours to obtain an enzymolysis solution, wherein the addition amount of the cellulase is 0.1-0.3% of the weight of the mushroom powder, the addition amount of the protease is 0.1-0.3% of the weight of the mushroom powder, and the addition amount of the water is 30-100 times of the weight of the mushroom powder;
2) and (3) post-treatment: and (3) decocting the enzymolysis liquid at 100-110 ℃ for 0.5-1 h, cooling, centrifuging the enzymolysis liquid, filtering the obtained supernatant to remove residues, precipitating with ethanol, and freeze-drying to obtain the product, wherein the dosage of the ethanol is 2-5 times of the volume of the supernatant.
4. The composition for helping to block oil absorption according to claim 1, wherein the aronia melanocarpa is prepared by the following method: cleaning the aronia melanocarpa, crushing and pulping, carrying out filter pressing on pulp to obtain filter residue, adding ethanol and hydrochloric acid into the filter residue, leaching for 1-3 h at 50-60 ℃, carrying out ultrasonic-assisted leaching for 10-15 min, wherein the microwave power is 300-400W, filtering, concentrating the filtrate, and drying, wherein the volume percentage of the ethanol is 90-95%, the molar concentration of the hydrochloric acid is 1-2 mol/L, and the dosage of the filter residue, the ethanol and the hydrochloric acid is 1-3 g, 200-300 mL and 30-60 mL.
5. The composition for assisting in blocking oil absorption according to claim 1, wherein the immature bitter orange is prepared by a method comprising the following steps of: the method comprises the steps of ultrasonically cleaning immature bitter oranges, fully drying the immature bitter oranges, adding clear water, decocting for 2-4 hours, filtering, taking filtrate, and performing spray drying to obtain the immature bitter oranges, wherein the mass ratio of the immature bitter oranges to the clear water is 1: 6-10.
6. The composition for helping to block oil absorption according to claim 1, wherein the cassia seed is prepared by the following steps:
1) pretreatment: crushing cassia seeds, freeze-drying the crushed cassia seeds at the temperature of-5 to-10 ℃, putting the frozen cassia seed powder into a puffing tank, and puffing at variable temperature and pressure difference to obtain a puffed material of the cassia seeds, wherein the pressure in the puffing tank is increased from normal pressure to 0.3 to 0.6MPa, the puffing temperature is increased to 160 to 250 ℃, the pressure in the puffing tank is instantly reduced to vacuum, and the puffing time is 50 to 100 s;
2) extraction: adding cellulase and water into the semen cassiae puffed material, extracting for 3-6 hours at 50-65 ℃, wherein the addition amount of the cellulase is 0.5-1% of the weight of the semen cassiae puffed material, the addition amount of the water is 30-100 times of the weight of the semen cassiae puffed material, extracting by microwave assistance after enzymolysis is finished, the microwave power is 300-400W, the microwave treatment time is 5-15 min, filtering, and drying filtrate to obtain the semen cassiae puffed material.
7. The composition for assisting in blocking lipid absorption according to claim 1, wherein the method for preparing Yuzhu comprises: sequentially carrying out ultrasonic cleaning, drying and crushing treatment on polygonatum odoratum, soaking for 12-20 h, carrying out reflux extraction by using 60-85% ethanol in percentage by volume to obtain an extraction solution, adsorbing the extraction solution by using macroporous adsorption resin, eluting by using 10% ethanol until an eluent is colorless, and carrying out reduced pressure concentration and drying to obtain the polygonatum odoratum extract.
8. The preparation method of the composition for blocking oil absorption according to any one of claims 1 to 7, wherein the raw materials are respectively crushed and sieved, 100-200 mesh powder is collected, the collected raw materials are fully mixed according to the corresponding weight part ratio, 80-90% by volume of ethanol is added, the mixture is mixed for 10-20 min, the mixture is dried for 2-4 h at the temperature of 60-80 ℃, and the mixture is ground to obtain the composition.
9. A preparation of a composition for helping to block oil absorption, which is characterized in that the preparation is prepared by matching the composition for helping to block oil absorption in any one of claims 1 to 7 with other pharmaceutic adjuvants.
10. The preparation of the composition for helping to block oil absorption according to claim 9, wherein the preparation is in the form of one of tablets, pills, powder, granules, oral liquid, suspension and hard capsules.
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