CN114129478A - Application of cortex cinnamomi japonici extract in shampoo - Google Patents

Abstract

The invention discloses application of a hard-shelled cinnamon extract in shampoo, wherein the hard-shelled cinnamon is extracted to obtain the hard-shelled cinnamon extract, and the hard-shelled cinnamon extract is added into the shampoo. The cortex Cinnamomi extract can inhibit the proliferation of Malassezia and staphylococcus, maintain the scalp oil secretion and scalp metabolism balance, and can not damage scalp cells, thereby improving scalp and hair quality fundamentally. The hard-shelled cinnamon extract has the advantages of simple extraction process, easily-obtained raw materials, low cost, safety, reliability, mild performance, no adverse reaction, good effects of removing dandruff, relieving itching, preventing broken hair and hair loss, growing and blackening hair, no need of complex production equipment, industrial production and contribution to popularization.

Description

Application of cortex cinnamomi japonici extract in shampoo

Technical Field

The invention belongs to the technical field of daily chemical articles, and particularly relates to application of a hard-shelled cinnamon extract in shampoo.

Background

Shampoo has become a necessity of daily life of people, and the types of shampoo on the market are various, but most of the shampoo cannot fundamentally improve the hair quality, and cannot fundamentally remove dandruff, relieve itching and promote hair growth.

The scalp has three major balances to maintain the ecological environment of the scalp: 1. flora: when the malassezia on the scalp is bred in a large quantity, the phenomenon of itching of the head can be caused; 2. grease: the imbalance of the grease secretion of the scalp can cause the scalp to be greasy, and then a large amount of malassezia bacteria are generated; 3. metabolic balance: the cuticle metabolism of scalp can cause cutin to peel off and fall off, thereby generating dandruff and itch.

With the development of economy, the pace of life is accelerated, the pressure is increased greatly, and the immune function of a human body is disordered. In addition, at present, hair follicles of the head are damaged by over-scalding, dyeing, hair-pulling and the like, and phenomena such as alopecia and the like are easy to occur.

The shampoo in the market mainly has the effects of removing dandruff and relieving itching by adding antibacterial agents such as zinc pyrithione, ketoconazole, climbazole, piroctone olamine and the like, but zinc compounds such as zinc pyrithione and the like can kill harmful fungi and normal scalp cells and damage the scalp; ketoconazole has a strong anti-inflammatory effect, but causes diseases such as hyperglycemia, Kouxin syndrome, urine glucose and the like after long-term use; while galangin, piroctone olamine, etc. cause scalp allergy and unbalance scalp lipid secretion.

The cortex Cinnamomi is a plant of genus Osmanthus, family Lauraceae, class dicotyledonae, and is grown in evergreen broad-leaved forest. The cinnamomum japonicum contains a large amount of flavonoid compounds, alpha-pyrone compounds, alkaloid compounds, lignanoid compounds and other compounds, and the compounds show various biological activities.

Disclosure of Invention

In view of the prior art, the invention aims to provide the application of the cinnamomum japonicum thunb extract in shampoo; the cortex cinnamomi japonici extract can inhibit the breeding of a large amount of malassezia and staphylococcus, maintain the lipid secretion of scalp and the metabolic balance of scalp, prevent broken hair, hair loss and hair blackening, avoid the damage to scalp cells, and fundamentally improve the scalp and the hair quality.

Furthermore, the shampoo is mainly used for removing dandruff, relieving itching and promoting hair growth.

The invention also aims to provide shampoo which comprises the cinnamomum japonicum extract.

Further, the weight ratio of the cinnamomum japonicum extract to the shampoo is 0.1-10%.

Further, the extraction process of the hard-shelled cinnamon extract is as follows:

pulverizing trunk, branch and/or root of cortex Cinnamomi, adding solvent, heating to obtain viscous mixture, and filtering to remove residue.

Further, the solvent includes a first solvent and a second solvent.

Further, repeatedly extracting with a first solvent, mixing the extractive solutions, concentrating under reduced pressure, diluting with water, stirring, extracting with a second solvent, mixing the extractive solutions, concentrating under reduced pressure, and heating to obtain a viscous mixture.

The above extraction method can effectively extract more effective active ingredients and obtain effective active substances with high purity by extracting under first solvent and then under second solvent.

Preferably, the first solvent is one or more of water, methanol, ethanol, chloroform and diethyl ether.

Preferably, the second solvent is one or more of water, ethyl acetate, petroleum ether, n-butanol, chloroform, diethyl ether and acetone.

Further, the extraction with the first solvent is repeated for 3 times; the repeated extraction for 3 times aims to extract more effective nutrient substances in the hard-shelled cinnamon.

Further, the extraction with the second solvent is carried out for 5 times; the repeated extraction for 5 times is to improve the purity of the hard-shelled cinnamon extract.

The invention further aims to provide a preparation method of the shampoo, which comprises the following steps:

and mixing the auxiliary raw materials, adding the cinnamomum japonicum extract, uniformly stirring, cooling, and then adjusting the pH value and the viscosity to obtain the shampoo.

Further, the auxiliary raw materials comprise the following components in percentage by weight: 10-15% of surfactant, 0.08-0.12% of preservative, 0.5-2% of viscosity regulator, 1-2.5% of humectant, 0.1-0.5% of pH regulator, 0.2-0.8% of essence and 65-85% of deionized water.

Further, the surfactant is palm kernel oil diethanolamide.

Further, the preservative is cason.

Further, the viscosity regulator is sodium chloride.

Further, the humectant is capric triglyceride.

Further, the pH regulator is citric acid.

Further, the essence is natural essence.

The human scalp is distributed with a plurality of microorganisms, which mainly comprise staphylococcus, propionibacterium and malassezia. Propionibacterium can inhibit dandruff, Staphylococcus can cause dandruff, and Malassezia can cause diseases to scalp. Malassezia serrata belongs to anaerobic fungi with lipase activity, can produce oleic acid and stimulate the release of inflammatory cytokines, destroys the compact structure of stratum corneum cells and intercellular lipid layers of the scalp, obviously thins the thickness of the stratum corneum of the scalp of a person, destroys the barrier function of the scalp, and causes the repeated production of dandruff and the falling of hair. Propionibacterium bacteria can inhibit the proliferation of Staphylococcus by secreting the relevant bacteriocin, while Staphylococcus can inhibit the proliferation of Propionibacterium by metabolizing glycerol, which when the balance between the two is disrupted can lead to the production of dandruff. The malassezia oleifera on the scalp decomposes triglyceride and saturated fatty acid in the sebum into unsaturated fatty acid through secretory lipase, and the unsaturated fatty acid has proinflammatory effect and can permeate into the cuticle of the scalp to cause itching of the scalp on one hand, and on the other hand, calcium ions can flow into scalp cells to further cause hyperkeratosis of the scalp keratinocytes so as to accelerate dandruff generation and alopecia. In addition, the oil on the scalp is easily oxidized by ultraviolet rays to produce lipid peroxides, which further stimulate the scalp to secrete more sebum.

The cortex cinnamomi japonici contains a large amount of flavonoid compounds, alpha-pyrone compounds, alkaloid compounds and lignanoid compounds, and the flavonoid compounds, the alpha-pyrone compounds, the alkaloid compounds and the lignanoid compounds have antibacterial and anti-inflammatory effects. The inventor finds that the extract obtained by extracting the hard cinnamon with the solvent can effectively inhibit the propagation of staphylococcus and malassezia in the research and development process. It may be flavonoid, alpha-pyrone, alkaloid, and lignan compounds acting on the division of Staphylococcus and Malassezia, reducing the generation of unsaturated fatty acids, and protecting the barrier function of scalp. In addition, the cinnamomum japonicum thunb extract is applied to preparing the shampoo, and the prepared shampoo has the effects of removing dandruff, relieving itching, preventing broken hair, hair loss and blackening hair, but does not have the effect on other cinnamomum japonicum plants.

Compared with the prior art, the invention has the following beneficial effects:

(1) according to the invention, the cinnamomum japonicum thunb is extracted to obtain a mucus-like extract which can be directly added into shampoo and is different from the forms of other plant extracts.

(2) The extract of cortex Cinnamomi is in viscous state, and the viscous liquid has effects of moistening scalp and relieving itching; the mucus can wrap the hair to prevent the hair from being broken, thereby preventing hair from falling; the mucus can also adhere to white hair to continuously deliver nutrition, and promote the white hair to turn into black hair.

(3) The hard-shelled cinnamon extract has the advantages of simple extraction process, easily-obtained raw materials, low cost, safety, reliability, mild performance, no adverse reaction, good effects of removing dandruff, relieving itching, preventing broken hair and hair loss, growing and blackening hair, no need of complex production equipment, industrial production and contribution to popularization.

Detailed Description

In order to make those skilled in the art better understand the technical solution of the present invention, the following will clearly and completely describe the technical solution of the present invention with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

The extraction process of the hard-shelled cinnamon extract comprises the following steps: pulverizing dried cortex Cinnamomi (10 kg) trunk and branch, extracting with 95% industrial ethanol and diethyl ether respectively at room temperature for 3 times, soaking for 3 days, mixing extractive solutions, concentrating under reduced pressure to recover ethanol and diethyl ether to obtain crude product, adding appropriate amount of water into the crude product, ultrasonic stirring, extracting with ethyl acetate, petroleum ether, n-butanol, chloroform, diethyl ether and acetone respectively for 5 times, mixing extractive solutions, concentrating under reduced pressure to recover ethyl acetate, petroleum ether, n-butanol, chloroform, diethyl ether and acetone, heating the obtained mixture to viscous liquid, and filtering to remove residue to obtain cortex Cinnamomi extract.

Example 2

The extraction process of the hard-shelled cinnamon extract comprises the following steps: pulverizing dried cortex Cinnamomi (10 kg) trunk and branch, extracting with water at room temperature for 3 times, soaking for 3 days, mixing the extractive solutions, concentrating under reduced pressure, reducing water content, ultrasonic stirring, extracting with ethyl acetate, petroleum ether, n-butanol, chloroform, diethyl ether and acetone for 5 times, mixing the extractive solutions, concentrating under reduced pressure, recovering ethyl acetate, petroleum ether, n-butanol, chloroform, diethyl ether and acetone, heating the obtained mixture to viscous liquid, and filtering to remove residue to obtain cortex Cinnamomi extract.

Example 3

The extraction process of the hard-shelled cinnamon extract comprises the following steps: pulverizing dried cortex Cinnamomi (10 kg) trunk and branch, extracting with water at room temperature for 3 times, soaking for 3 days, mixing the extractive solutions, concentrating under reduced pressure, reducing water content, ultrasonic stirring, extracting with water for 5 times, mixing the extractive solutions, heating the mixture to obtain viscous liquid, and filtering to remove residue to obtain cortex Cinnamomi extract.

This example provides the use of the cinnamomum japonicum extract in shampoo.

Example 4

Fully mixing 12 kg of palm kernel oil diethanolamide, 0.1 kg of cason, 2 kg of capric triglyceride, 0.5 kg of natural essence and 83.4 kg of deionized water, adding 0.1 kg of the hard-shell cinnamon extract prepared in example 1, uniformly stirring, cooling, and adding 1.5 kg of sodium chloride and 0.4 kg of citric acid to obtain the shampoo.

Example 5

Fully mixing 12 kg of palm kernel oil diethanolamide, 0.1 kg of cason, 2 kg of capric triglyceride, 0.5 kg of natural essence and 78 kg of deionized water, adding 5.5 kg of the hard-shelled cinnamon extract prepared in example 1, uniformly stirring, cooling, and adding 1.5 kg of sodium chloride and 0.4 kg of citric acid to obtain the shampoo.

Example 6

Fully mixing 12 kg of palm kernel oil diethanolamide, 0.1 kg of cason, 2 kg of capric triglyceride, 0.5 kg of natural essence and 73.5 kg of deionized water, adding 10 kg of the hard-shell cinnamon extract prepared in example 1, uniformly stirring, cooling, and adding 1.5 kg of sodium chloride and 0.4 kg of citric acid to obtain the shampoo.

Example 7

Fully mixing 12 kg of palm kernel oil diethanolamide, 0.1 kg of cason, 2 kg of capric triglyceride, 0.5 kg of natural essence and 78 kg of deionized water, adding 5.5 kg of the hard-shelled cinnamon extract prepared in the example 2, uniformly stirring, cooling, and adding 1.5 kg of sodium chloride and 0.4 kg of citric acid to obtain the shampoo.

Example 8

Fully mixing 12 kg of palm kernel oil diethanolamide, 0.1 kg of cason, 2 kg of capric triglyceride, 0.5 kg of natural essence and 78 kg of deionized water, adding 5.5 kg of the hard-shelled cinnamon extract prepared in the example 3, uniformly stirring, cooling, and adding 1.5 kg of sodium chloride and 0.4 kg of citric acid to obtain the shampoo.

Comparative example 1

Shampoo sold in market

And (5) testing the performance.

And (3) testing the antibacterial effect:

(1) preparation of a culture medium:

mixing olive oil 10g, glucose 10g, peptone 5g, agar 8.5g, yeast extract 5g, chloramphenicol 0.05g, and distilled water 500mL, boiling for 5 times, sterilizing, and storing at 4 deg.C under sterile condition.

(2) Preparation of the plate:

respectively inoculating a standard malassezia furfur strain and a standard staphylococcus to a culture medium, culturing for 5 days at a constant temperature of 37 ℃, eluting bacterial colonies by using normal saline, respectively preparing bacterial suspensions of 105 cfu/mL-106 cfu/mL, respectively coating 0.5mL of the bacterial suspensions on a 12cm Leeming & Notman culture medium plate, standing for 15min, and air-drying the plate under a sterile condition.

(3) Determination of the bacteriostatic effect:

a qualitative filter paper sheet was punched into a circular filter paper sheet having a diameter of 5mm, sterilized, oven-dried, and a small amount of each of the shampoos prepared in examples 4 to 8 and comparative example 1 was dropped onto the filter paper sheet, and the filter paper sheets each containing the shampoo prepared in examples 4 to 8 and comparative example 1 were attached to a flat plate, incubated at 32 ℃ for 7 days in an incubator, and the diameters of the zones were measured, and the results are shown in Table 1.

Table 1. results of bacteriostatic property test of shampoos prepared in examples 4 to 8 and comparative example 1.

As shown in Table 1, the Pimenta racemosa extract has a good bacteriostatic effect on staphylococcus and malassezia.

Hair regrowth performance test:

the left and right sides of the spine of 70 mice in each male and female half are depilated, and the depilated surface area is 10% of the surface area of the mouse body. Blank control group, examples 4-8 group, comparative example 1 group each group of 10 mice in each male and female half. Blank control group: the right side of each mouse was coated with distilled water, examples 4-8 groups: the right side of each mouse was coated with 0.5g/ml of the shampoo prepared in examples 4 to 8, comparative example 1: the right side of each mouse was externally coated with 0.5g/ml of the shampoo prepared in comparative example 1. The left area of each group was not treated. Mice were sacrificed 10 days after continuous dosing. The skin on the left and right sides of the spinal column of the mouse is respectively stained, the number change of the whole skin layer and the hair follicle of each mouse is observed under a microscope, the average number change of the hair follicle cells of the epidermis and the number change of the layer of the epidermis of each group of mice are recorded, and the skin tissue of which the precursor is 1cm multiplied by 1cm is measured, and the result is shown in table 2.

Table 2. results of hair regrowth test of shampoos prepared in examples 4-8 and comparative example 1.

As shown in Table 2, when the shampoos obtained in examples 4 to 8 were applied to the skin of mice, the average number of hair follicle cells and the number of skin layers were significantly increased, as compared with the blank control group and the comparative example 1, which indicates that the shampoos obtained in examples 4 to 8 have good effects of regulating the nerves and blood circulation of skin hair follicles, and are beneficial to the regeneration of hair.

Testing the anti-dandruff and antipruritic performance:

264 dandruff and scalp itching-prone volunteers of male and female half-and-half ages of 18-65 years old are averagely selected and randomly divided into 6 groups, 44 persons in each group use the prepared shampoos of examples 4-8 and comparative example 1 respectively, the hair is washed once a day, the time duration of each time is the same, after 7 days of continuous use, the using effect of the volunteers is observed and counted, and the result is shown in table 3.

And (4) judging the standard: very effective: the scalp is not itchy any more, and dandruff basically disappears; the method is more effective: scalp itching and dandruff symptoms are reduced; and (4) invalidation: scalp itching and dandruff symptoms were not improved.

Effective rate is (very effective + comparatively effective) number of people/number of test persons × 100%.

TABLE 3 test results of anti-dandruff and antipruritic properties of shampoos prepared in examples 4 to 8 and comparative example 1.

As can be seen from table 3, the shampoos prepared in examples 4 to 8 had good anti-dandruff and anti-itching effects, compared to the commercially available shampoo.

Irritation and allergy test:

the backs of 140 male and female halves of the mice were shaved and washed with distilled water, and the shaving surface area was 10% of the surface area of the bodies of the mice. The blank control group, examples 4-8 groups, comparative example 1 group were 20 mice each male and female. Blank control group: each mouse was coated with distilled water on the back, examples 4-8 groups: the backs of the mice were coated with the shampoos prepared in examples 4 to 8, comparative example 1: the shampoo prepared in comparative example 1 was applied to the back of each mouse. After 1 hour, each mouse is washed by warm water, and the condition that the skin of the mouse has erythema or edema and the like is continuously observed within 24 hours. The results are shown in Table 4.

And (4) judging the standard: severe allergy: severe erythema and edema; mild allergy: mild erythema and edema; no allergy: erythema and edema were not observed.

The non-allergic rate is no allergy/number of test mice × 100%.

Table 4. results of allergy test of shampoos prepared in examples 4-8 and comparative example 1.

As shown in Table 4, the Pimenta racemosa extract was added to the shampoo without causing any allergic reaction.

In conclusion, the hard-shelled cinnamon extract is safe and reliable, mild in performance, free of adverse reaction, good in effects of removing dandruff, relieving itching and growing hair, and capable of being produced industrially.

Finally, it should be noted that the above-mentioned embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the same, and although the present invention is described in detail with reference to the above-mentioned embodiments, it should be understood by those skilled in the art that the modifications and equivalents of the specific embodiments of the present invention can be made by those skilled in the art after reading the present specification, but these modifications and variations do not depart from the scope of the claims of the present application.

Claims (10)

1. Use of cortex Cinnamomi extract in shampoo is provided.

2. The use of the cinnamomum japonicum extract of claim 1 in shampoos, wherein: the shampoo is mainly used for removing dandruff, relieving itching and promoting hair growth.

3. A shampoo is characterized in that: comprises a hardshell cinnamon extract.

4. The shampoo according to claim 3, wherein: the weight ratio of the cortex cinnamomi japonici extract to the shampoo is 0.1-10%.

5. The shampoo according to claim 3, wherein: the extraction process of the cinnamomum japonicum extract is as follows:

pulverizing trunk, branch and/or root of cortex Cinnamomi, adding solvent, heating to obtain viscous mixture, and filtering to remove residue.

6. The shampoo according to claim 5, wherein: the solvent includes a first solvent and a second solvent.

7. The shampoo according to claim 6, wherein: repeatedly extracting with first solvent, mixing extractive solutions, concentrating under reduced pressure, diluting with water, stirring, extracting with second solvent, mixing extractive solutions, concentrating under reduced pressure, and heating to obtain viscous mixture.

8. The shampoo according to claim 6, wherein: the first solvent is one or more of water, methanol, ethanol, chloroform and diethyl ether.

9. The shampoo according to claim 6, wherein: the second solvent is one or more of water, ethyl acetate, petroleum ether, n-butanol, chloroform, diethyl ether and acetone.

10. The shampoo according to claim 3, wherein: the preparation method of the shampoo comprises the following steps:

and mixing the auxiliary raw materials, adding the cinnamomum japonicum extract, uniformly stirring, cooling, and then adjusting the pH value and the viscosity to obtain the shampoo.