CN114127109A - 靶向Claudin18.2的抗体或嵌合抗原受体 - Google Patents
靶向Claudin18.2的抗体或嵌合抗原受体 Download PDFInfo
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- CN114127109A CN114127109A CN202080000840.1A CN202080000840A CN114127109A CN 114127109 A CN114127109 A CN 114127109A CN 202080000840 A CN202080000840 A CN 202080000840A CN 114127109 A CN114127109 A CN 114127109A
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Abstract
公开了一种结合Claudin18.2的抗体或其抗原结合片段或嵌合抗原受体,以及其制备方法和用途。所述嵌合抗原受体依次包括本发明的结合Claudin18.2抗原的抗体或其抗原结合片段、胞外铰链区、跨膜区和胞内信号区。本发明所提供的抗体或其抗原结合片段及嵌合抗原受体对分泌Claudin18.2的细胞有更强的亲和力和杀伤能力,以及更好的肿瘤抑制效果。
Description
PCT国内申请,说明书已公开。
Claims (10)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (5)
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CN2019104591291 | 2019-05-30 | ||
CN2019104596223 | 2019-05-30 | ||
CN201910459129 | 2019-05-30 | ||
CN201910459622 | 2019-05-30 | ||
PCT/CN2020/092849 WO2020239005A1 (zh) | 2019-05-30 | 2020-05-28 | 靶向Claudin18.2的抗体或嵌合抗原受体 |
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CN114127109B CN114127109B (zh) | 2022-06-21 |
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US (1) | US20220204609A1 (zh) |
EP (1) | EP3929214A4 (zh) |
JP (1) | JP7266117B2 (zh) |
KR (1) | KR20220006085A (zh) |
CN (1) | CN114127109B (zh) |
AU (1) | AU2020281380B2 (zh) |
BR (1) | BR112021023897A2 (zh) |
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Cited By (1)
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WO2023174405A1 (zh) * | 2022-03-18 | 2023-09-21 | 广东东阳光药业股份有限公司 | Claudin18.2人源化抗体及其应用 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113645996B (zh) | 2019-02-01 | 2024-04-02 | 新石生物制药有限公司 | 抗claudin 18抗体及其使用方法 |
CN116648261A (zh) * | 2020-12-25 | 2023-08-25 | 信达生物制药(苏州)有限公司 | Claudin18.2嵌合抗原受体以及其用途 |
CN113416260B (zh) * | 2021-04-14 | 2022-02-01 | 南京凯地医疗技术有限公司 | 靶向Claudin18.2的特异性嵌合抗原受体细胞及其制备方法和应用 |
WO2024118593A1 (en) * | 2022-11-28 | 2024-06-06 | Allogene Therapeutics Inc. | Claudin 18.2 targeting chimeric antigen receptors and binding agents and uses thereof |
CN117777306A (zh) * | 2023-07-04 | 2024-03-29 | 深圳豪石生物科技有限公司 | 一种靶向cldn18.2的增强型嵌合抗原受体及其用途 |
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- 2020-05-28 KR KR1020217039106A patent/KR20220006085A/ko not_active Application Discontinuation
- 2020-05-28 WO PCT/CN2020/092849 patent/WO2020239005A1/zh unknown
- 2020-05-28 AU AU2020281380A patent/AU2020281380B2/en active Active
- 2020-05-28 US US17/601,765 patent/US20220204609A1/en active Pending
- 2020-05-28 CN CN202080000840.1A patent/CN114127109B/zh active Active
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EP3929214A4 (en) | 2022-06-22 |
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AU2020281380B2 (en) | 2024-04-11 |
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