CN114080388A - 用于合成2-氨基-5-氯-n,3-二甲基苯甲酰胺的高效新方法 - Google Patents

用于合成2-氨基-5-氯-n,3-二甲基苯甲酰胺的高效新方法 Download PDF

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Publication number
CN114080388A
CN114080388A CN202080048608.5A CN202080048608A CN114080388A CN 114080388 A CN114080388 A CN 114080388A CN 202080048608 A CN202080048608 A CN 202080048608A CN 114080388 A CN114080388 A CN 114080388A
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CN
China
Prior art keywords
mixture
acid
alkyl
halogen
formula
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Pending
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CN202080048608.5A
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English (en)
Chinese (zh)
Inventor
陈良
范叶峰
毛涧桦
许志健
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fumeishi Agriculture Singapore Pte Ltd
FMC Corp
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Fumeishi Agriculture Singapore Pte Ltd
FMC Corp
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Application filed by Fumeishi Agriculture Singapore Pte Ltd, FMC Corp filed Critical Fumeishi Agriculture Singapore Pte Ltd
Priority to CN202211336205.8A priority Critical patent/CN115536540B/zh
Priority to CN202210355074.1A priority patent/CN114621130B/zh
Publication of CN114080388A publication Critical patent/CN114080388A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/12—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reactions not involving the formation of oxyimino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN202080048608.5A 2019-11-01 2020-10-28 用于合成2-氨基-5-氯-n,3-二甲基苯甲酰胺的高效新方法 Pending CN114080388A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202211336205.8A CN115536540B (zh) 2019-11-01 2020-10-28 用于合成2-氨基-5-氯-n,3-二甲基苯甲酰胺的高效新方法
CN202210355074.1A CN114621130B (zh) 2019-11-01 2020-10-28 用于合成2-氨基-5-氯-n,3-二甲基苯甲酰胺的高效新方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962929138P 2019-11-01 2019-11-01
US62/929,138 2019-11-01
PCT/US2020/057726 WO2021086957A1 (en) 2019-11-01 2020-10-28 An efficient new process for synthesis of 2-amino-5-chloro-n-,3-dimethylbenzamide

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CN202210355074.1A Division CN114621130B (zh) 2019-11-01 2020-10-28 用于合成2-氨基-5-氯-n,3-二甲基苯甲酰胺的高效新方法
CN202211336205.8A Division CN115536540B (zh) 2019-11-01 2020-10-28 用于合成2-氨基-5-氯-n,3-二甲基苯甲酰胺的高效新方法

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CN114080388A true CN114080388A (zh) 2022-02-22

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CN202210355074.1A Active CN114621130B (zh) 2019-11-01 2020-10-28 用于合成2-氨基-5-氯-n,3-二甲基苯甲酰胺的高效新方法
CN202211336205.8A Active CN115536540B (zh) 2019-11-01 2020-10-28 用于合成2-氨基-5-氯-n,3-二甲基苯甲酰胺的高效新方法

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CN202211336205.8A Active CN115536540B (zh) 2019-11-01 2020-10-28 用于合成2-氨基-5-氯-n,3-二甲基苯甲酰胺的高效新方法

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US (2) US11542241B2 (https=)
EP (2) EP3976583B1 (https=)
JP (3) JP7730309B2 (https=)
KR (1) KR20220091537A (https=)
CN (3) CN114080388A (https=)
AU (1) AU2020372895A1 (https=)
BR (1) BR112022008061A2 (https=)
HU (1) HUE067805T2 (https=)
IL (3) IL313390A (https=)
MA (1) MA56056A (https=)
MX (2) MX2022005229A (https=)
PL (1) PL3976583T3 (https=)
TW (2) TWI881549B (https=)
WO (1) WO2021086957A1 (https=)
ZA (2) ZA202204803B (https=)

Cited By (1)

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CN116987002A (zh) * 2023-06-20 2023-11-03 湖北可赛化工有限公司 一种2-氨基-5-氯-n,3-二甲基苯甲酰胺的制备方法

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BR112022008061A2 (pt) * 2019-11-01 2022-07-12 Fmc Corp Processo eficaz para síntese de 2-amino-5-cloro-n,3-dimetilbenzamida
WO2023073502A1 (en) * 2021-10-28 2023-05-04 Laurus Labs Limited Methods for preparation of anthranilamide and pyrazole-carboxylate intermediate compounds
TW202421613A (zh) * 2022-10-19 2024-06-01 美商富曼西公司 合成２－胺基－５－氯－ｎ，３－二甲基苯甲醯胺之高效新方法
CN115594608A (zh) * 2022-10-20 2023-01-13 九江善水科技股份有限公司（Cn） 一种氯虫苯甲酰胺中间体的制备方法
CN116730859B (zh) * 2023-06-01 2025-06-13 青岛科技大学 一种2-氨基-5-氯-n,3-二甲基苯甲酰胺的制备方法
TW202542105A (zh) 2023-12-19 2025-11-01 印度商皮埃企業有限公司 經取代的鄰胺基苯甲醯胺化合物、其中間產物及其鹽的合成方法
WO2025134140A1 (en) * 2023-12-19 2025-06-26 Pi Industries Ltd. A method for the synthesis of substituted anthranilic amide compounds, intermediates and salts thereof

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PL3976583T3 (pl) 2024-09-16
IL313390A (en) 2024-08-01
TW202408988A (zh) 2024-03-01
IL294707B2 (en) 2024-12-01
KR20220091537A (ko) 2022-06-30
CN114621130A (zh) 2022-06-14
JP2023501851A (ja) 2023-01-20
MX2026001742A (es) 2026-03-02
IL292210B1 (en) 2023-03-01
CN115536540B (zh) 2025-03-25
BR112022008061A2 (pt) 2022-07-12
EP3976583A1 (en) 2022-04-06
TW202126616A (zh) 2021-07-16
IL294707A (en) 2022-09-01
US20220242837A1 (en) 2022-08-04
ZA202403308B (en) 2025-08-27
IL292210B2 (en) 2023-07-01
HUE067805T2 (hu) 2024-11-28
AU2020372895A1 (en) 2022-05-26
TWI881549B (zh) 2025-04-21
ZA202204803B (en) 2024-08-28
CN114621130B (zh) 2025-02-25
US11542241B2 (en) 2023-01-03
MA56056A (fr) 2022-04-06
JP7730309B2 (ja) 2025-08-27
EP3976583B1 (en) 2024-05-01
WO2021086957A1 (en) 2021-05-06
JP2025061138A (ja) 2025-04-10
JP2023002456A (ja) 2023-01-10
CN115536540A (zh) 2022-12-30
US20230096826A1 (en) 2023-03-30
EP4119542A1 (en) 2023-01-18
US12304893B2 (en) 2025-05-20
MX2022005229A (es) 2022-06-08
IL294707B1 (en) 2024-08-01

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