CN114080238B - 抑制肌肉生长抑制素基因的mRNA的产生的核酸药物 - Google Patents

抑制肌肉生长抑制素基因的mRNA的产生的核酸药物 Download PDF

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CN114080238B
CN114080238B CN202080045447.4A CN202080045447A CN114080238B CN 114080238 B CN114080238 B CN 114080238B CN 202080045447 A CN202080045447 A CN 202080045447A CN 114080238 B CN114080238 B CN 114080238B
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myostatin
mstn
antisense oligonucleotide
compound
salt
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CN114080238A (zh
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松尾雅文
前田和宏
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Kobe University NUC
KNC Laboratories Co Ltd
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KNC Laboratories Co Ltd
Kobe Gakuin Educational Foundation
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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CN202080045447.4A 2019-06-26 2020-06-18 抑制肌肉生长抑制素基因的mRNA的产生的核酸药物 Active CN114080238B (zh)

Applications Claiming Priority (3)

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JP2019-118446 2019-06-26
JP2019118446 2019-06-26
PCT/JP2020/023917 WO2020262184A1 (ja) 2019-06-26 2020-06-18 ミオスタチン遺伝子のｍＲＮＡの産生を抑制する核酸医薬

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CN114080238B true CN114080238B (zh) 2025-02-07

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US (1) US20220220478A1 (https=)
EP (1) EP3995153A4 (https=)
JP (1) JP7715345B2 (https=)
CN (1) CN114080238B (https=)
CA (1) CA3142918A1 (https=)
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008005019A1 (en) * 2006-07-07 2008-01-10 Dale Roderic M K Compositions and methods for the treatment of muscle wasting
JP2017500373A (ja) * 2013-11-11 2017-01-05 サーナ・セラピューティクス・インコーポレイテッドＳｉｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 親油性部分にコンジュゲートされたミオスタチン低分子干渉核酸（ｓｉＮＡ）の全身性送達

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JPH0787982A (ja) 1993-01-29 1995-04-04 Sankyo Co Ltd 修飾オリゴデオキシリボヌクレオチド
US6096881A (en) 1997-05-30 2000-08-01 Hybridon, Inc. Sulfur transfer reagents for oligonucleotide synthesis
AU9063398A (en) 1997-09-12 1999-04-05 Exiqon A/S Oligonucleotide analogues
AU772694B2 (en) * 1999-01-21 2004-05-06 Metamorphix International, Inc. Growth differentiation factor inhibitors and uses therefor
CZ296576B6 (cs) 1999-02-12 2006-04-12 Sankyo Company Limited Nukleosidový analog a oligonukleotidový analog a farmaceutický prostredek, sonda a primer s jeho obsahem
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
US20050124566A1 (en) * 2001-05-18 2005-06-09 Sirna Therapeutics, Inc. RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA)
CN100393320C (zh) * 2005-06-24 2008-06-11 奥林格斯技术有限公司 治疗肌肉萎缩的寡核苷酸药物
US8097596B2 (en) * 2006-06-30 2012-01-17 Lakewood-Amedex, Inc. Compositions and methods for the treatment of muscle wasting
JP6980218B2 (ja) * 2016-04-01 2021-12-15 国立大学法人徳島大学 Ｃａｓ９タンパク質を哺乳動物の受精卵に導入する方法
CN106086031B (zh) * 2016-06-17 2019-08-06 湖北省农业科学院畜牧兽医研究所 猪肌抑素基因编辑位点及其应用
JP7061306B2 (ja) 2017-12-28 2022-04-28 株式会社高尾 弾球遊技機

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008005019A1 (en) * 2006-07-07 2008-01-10 Dale Roderic M K Compositions and methods for the treatment of muscle wasting
JP2017500373A (ja) * 2013-11-11 2017-01-05 サーナ・セラピューティクス・インコーポレイテッドＳｉｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 親油性部分にコンジュゲートされたミオスタチン低分子干渉核酸（ｓｉＮＡ）の全身性送達

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JP7715345B2 (ja) 2025-07-30
US20220220478A1 (en) 2022-07-14
CN114080238A (zh) 2022-02-22
CA3142918A1 (en) 2020-12-30
EP3995153A1 (en) 2022-05-11
WO2020262184A1 (ja) 2020-12-30
JPWO2020262184A1 (https=) 2020-12-30
EP3995153A4 (en) 2023-11-22

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