CN114080221B - 用于减轻疼痛的布洛芬与曲马多的组合 - Google Patents

用于减轻疼痛的布洛芬与曲马多的组合 Download PDF

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Publication number
CN114080221B
CN114080221B CN202080049962.XA CN202080049962A CN114080221B CN 114080221 B CN114080221 B CN 114080221B CN 202080049962 A CN202080049962 A CN 202080049962A CN 114080221 B CN114080221 B CN 114080221B
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China
Prior art keywords
ibuprofen
tramadol
pain
arginine
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202080049962.XA
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English (en)
Chinese (zh)
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CN114080221A (zh
Inventor
安东尼奥·波托莱斯佩雷斯
路易斯·纳西索·桑特塞尔纳
玛利亚·戴尔·罗萨里奥·萨拉斯布特龙
埃米利奥·巴尔加斯卡斯特里隆
卡洛斯·卡兰德里亚佩雷斯
拉克尔·奥卡哈达科尔多巴
安格尔·何塞·穆尼奥斯鲁伊斯
玛尔塔·比卡里奥德拉托雷
努里亚·桑斯梅嫩德斯
安东尼娅·戈麦斯卡尔沃
何塞·安格尔·桑切斯加西亚
埃斯特尔·杜阿尔特冈萨雷斯
费尔南多·加西亚阿隆索
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Farmalider SA
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Farmalider SA
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Publication of CN114080221A publication Critical patent/CN114080221A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
CN202080049962.XA 2019-07-09 2020-07-08 用于减轻疼痛的布洛芬与曲马多的组合 Active CN114080221B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19382583.3 2019-07-09
EP19382583 2019-07-09
PCT/EP2020/069306 WO2021005129A1 (en) 2019-07-09 2020-07-08 Combination of ibuprofen and tramadol for relieving pain

Publications (2)

Publication Number Publication Date
CN114080221A CN114080221A (zh) 2022-02-22
CN114080221B true CN114080221B (zh) 2023-12-05

Family

ID=67480112

Family Applications (1)

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CN202080049962.XA Active CN114080221B (zh) 2019-07-09 2020-07-08 用于减轻疼痛的布洛芬与曲马多的组合

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Country Link
US (1) US20220249414A1 (enExample)
EP (1) EP3996699B1 (enExample)
JP (1) JP7656339B2 (enExample)
CN (1) CN114080221B (enExample)
AU (1) AU2020309160B2 (enExample)
BR (1) BR112022000242A2 (enExample)
CA (1) CA3145632C (enExample)
DK (1) DK3996699T3 (enExample)
ES (1) ES2952013T3 (enExample)
FI (1) FI3996699T3 (enExample)
HR (1) HRP20230677T1 (enExample)
HU (1) HUE062529T2 (enExample)
MA (1) MA56341B1 (enExample)
MD (1) MD3996699T2 (enExample)
MX (1) MX2022000373A (enExample)
MY (1) MY207573A (enExample)
PL (1) PL3996699T3 (enExample)
PT (1) PT3996699T (enExample)
RS (1) RS64500B1 (enExample)
SI (1) SI3996699T1 (enExample)
WO (1) WO2021005129A1 (enExample)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516803A (en) * 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
WO2011027009A1 (es) * 2009-09-04 2011-03-10 Farmalider, S.A. Composición farmacéutica de ibuprofeno, tramadol y un aminoácido básico, procedimiento para su preparación y utilización de la misma

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971700A (en) 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents
US3652589A (en) 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
GB1497044A (en) 1974-03-07 1978-01-05 Prodotti Antibiotici Spa Salts of phenyl-alkanoic acids
AU661723B2 (en) * 1991-10-30 1995-08-03 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
US20070117826A1 (en) * 2005-11-23 2007-05-24 Forest Laboratories, Inc. Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
EP2149546A1 (en) * 2008-07-31 2010-02-03 Laboratorios Del. Dr. Esteve, S.A. Salts of tramadol and ibuprofen and their crystal form in the treatment of pain
ES2423866B1 (es) 2012-02-22 2014-06-10 Farmalider, S.A. Composición farmaceútica de ibuprofeno y tramadol para inyección
ES2540151B1 (es) * 2013-10-11 2016-02-29 Farmalider S.A. Composición farmacéutica de ibuprofeno y tramadol para uso oftálmico
GB2541571A (en) * 2014-04-10 2017-02-22 Charleston Laboratories Inc Pharmaceutical compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516803A (en) * 1991-10-30 1996-05-14 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
WO2011027009A1 (es) * 2009-09-04 2011-03-10 Farmalider, S.A. Composición farmacéutica de ibuprofeno, tramadol y un aminoácido básico, procedimiento para su preparación y utilización de la misma
EP2474309A1 (en) * 2009-09-04 2012-07-11 Farmalider, S.A. Pharmaceutical composition comprising ibuprofen, tramadol and a basic amino acid, preparation method thereof and use of same

Also Published As

Publication number Publication date
BR112022000242A2 (pt) 2022-05-31
MA56341B1 (fr) 2023-07-31
SI3996699T1 (sl) 2023-10-30
JP7656339B2 (ja) 2025-04-03
ES2952013T3 (es) 2023-10-26
EP3996699A1 (en) 2022-05-18
DK3996699T3 (da) 2023-07-24
MD3996699T2 (ro) 2023-11-30
CA3145632C (en) 2024-03-12
EP3996699B1 (en) 2023-06-28
MY207573A (en) 2025-03-05
PL3996699T3 (pl) 2023-10-30
HUE062529T2 (hu) 2023-11-28
RS64500B1 (sr) 2023-09-29
CA3145632A1 (en) 2021-01-14
PT3996699T (pt) 2023-07-27
JP2022540854A (ja) 2022-09-20
US20220249414A1 (en) 2022-08-11
MX2022000373A (es) 2022-02-10
HRP20230677T1 (hr) 2023-10-13
WO2021005129A1 (en) 2021-01-14
AU2020309160A1 (en) 2022-02-17
CN114080221A (zh) 2022-02-22
AU2020309160B2 (en) 2025-06-26
FI3996699T3 (fi) 2023-08-01

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