CN114072495A - 具有增强的抗肿瘤活性和免疫抑制抗性的经修饰的免疫细胞 - Google Patents

具有增强的抗肿瘤活性和免疫抑制抗性的经修饰的免疫细胞 Download PDF

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CN114072495A
CN114072495A CN202080021571.7A CN202080021571A CN114072495A CN 114072495 A CN114072495 A CN 114072495A CN 202080021571 A CN202080021571 A CN 202080021571A CN 114072495 A CN114072495 A CN 114072495A
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gene sequence
gene
exon
cells
sequence
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J·M·格尔克
A·D·爱德华兹
D·默里
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Bim Medical Co ltd
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CN202080021571.7A 2019-01-16 2020-01-16 具有增强的抗肿瘤活性和免疫抑制抗性的经修饰的免疫细胞 Pending CN114072495A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962793277P 2019-01-16 2019-01-16
US62/793,277 2019-01-16
US201962839870P 2019-04-29 2019-04-29
US62/839,870 2019-04-29
PCT/US2020/013964 WO2020150534A2 (en) 2019-01-16 2020-01-16 Modified immune cells having enhanced anti-neoplasia activity and immunosuppression resistance

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CN114072495A true CN114072495A (zh) 2022-02-18

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CN202080021571.7A Pending CN114072495A (zh) 2019-01-16 2020-01-16 具有增强的抗肿瘤活性和免疫抑制抗性的经修饰的免疫细胞

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US (1) US20220133790A1 (https=)
EP (1) EP3911735A4 (https=)
JP (2) JP2022518463A (https=)
KR (1) KR20210116526A (https=)
CN (1) CN114072495A (https=)
AU (1) AU2020208616A1 (https=)
CA (1) CA3126699A1 (https=)
SG (1) SG11202107555XA (https=)
WO (1) WO2020150534A2 (https=)

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CN113980896A (zh) * 2021-10-27 2022-01-28 中国人民解放军军事科学院军事医学研究院 Irf1在调控间充质干细胞免疫调节作用及产品上的应用
CN114774364A (zh) * 2022-04-26 2022-07-22 深圳市体内生物医药科技有限公司 一种嵌合抗原受体t细胞及其制备方法和应用
CN116590237A (zh) * 2023-05-29 2023-08-15 上海贝斯昂科生物科技有限公司 一种遗传修饰的自然杀伤细胞及其制备和用途
WO2024193562A1 (zh) * 2023-03-21 2024-09-26 苏州沙砾生物科技有限公司 一种修饰的细胞及其用途

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WO2020160517A1 (en) * 2019-01-31 2020-08-06 Beam Therapeutics Inc. Nucleobase editors having reduced off-target deamination and methods of using same to modify a nucleobase target sequence
CN120174005A (zh) 2019-02-13 2025-06-20 比姆医疗股份有限公司 具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
CN114981409A (zh) * 2019-09-03 2022-08-30 美洛德生物医药公司 用于基因组整合的方法和组合物
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WO2022056459A1 (en) * 2020-09-14 2022-03-17 Vor Biopharma, Inc. Compositions and methods for cd5 modification
WO2022061115A1 (en) * 2020-09-18 2022-03-24 Vor Biopharma Inc. Compositions and methods for cd7 modification
CN116322716A (zh) * 2020-09-23 2023-06-23 克里斯珀医疗股份公司 Regnase-1和/或TGFBRII被破坏的基因工程化T细胞具有改善的功能性和持久性
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CN116801890A (zh) * 2020-11-04 2023-09-22 小利兰·斯坦福大学董事会 用于增强治疗性免疫细胞功效的方法和组合物
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IL303506A (en) * 2020-12-11 2023-08-01 Intellia Therapeutics Inc Polynucleotides, compositions, and methods for genome editing involving deamination
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WO2022215978A1 (ko) * 2021-04-05 2022-10-13 주식회사 셀렌진 Pdcd-1 유전자에 상보적인 가이드 rna 및 이의 용도
CN113179160B (zh) * 2021-04-15 2022-03-18 中国电子科技集团公司第三十研究所 一种适用于qkd中私钥放大的最优输入码长处理方法及单元
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JP2024537991A (ja) 2021-10-14 2024-10-18 アーセナル バイオサイエンシズ インコーポレイテッド 共発現されるｓｈＲＮＡと論理ゲートシステムとを有する免疫細胞
JP2024540723A (ja) * 2021-11-03 2024-11-01 インテリア セラピューティクス，インコーポレーテッド 免疫療法のためのｃｄ３８組成物及び方法
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