AU2020208616A1 - Modified immune cells having enhanced anti-neoplasia activity and immunosuppression resistance - Google Patents
Modified immune cells having enhanced anti-neoplasia activity and immunosuppression resistance Download PDFInfo
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- AU2020208616A1 AU2020208616A1 AU2020208616A AU2020208616A AU2020208616A1 AU 2020208616 A1 AU2020208616 A1 AU 2020208616A1 AU 2020208616 A AU2020208616 A AU 2020208616A AU 2020208616 A AU2020208616 A AU 2020208616A AU 2020208616 A1 AU2020208616 A1 AU 2020208616A1
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A61K40/32—T-cell receptors [TCR]
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- A61K40/4201—Neoantigens
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/095—Fusion polypeptide containing a localisation/targetting motif containing a nuclear export signal
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- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2320/00—Applications; Uses
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- C12N2510/00—Genetically modified cells
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- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04004—Adenosine deaminase (3.5.4.4)
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- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04005—Cytidine deaminase (3.5.4.5)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962793277P | 2019-01-16 | 2019-01-16 | |
| US62/793,277 | 2019-01-16 | ||
| US201962839870P | 2019-04-29 | 2019-04-29 | |
| US62/839,870 | 2019-04-29 | ||
| PCT/US2020/013964 WO2020150534A2 (en) | 2019-01-16 | 2020-01-16 | Modified immune cells having enhanced anti-neoplasia activity and immunosuppression resistance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2020208616A1 true AU2020208616A1 (en) | 2021-08-12 |
Family
ID=71613446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2020208616A Pending AU2020208616A1 (en) | 2019-01-16 | 2020-01-16 | Modified immune cells having enhanced anti-neoplasia activity and immunosuppression resistance |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20220133790A1 (https=) |
| EP (1) | EP3911735A4 (https=) |
| JP (2) | JP2022518463A (https=) |
| KR (1) | KR20210116526A (https=) |
| CN (1) | CN114072495A (https=) |
| AU (1) | AU2020208616A1 (https=) |
| CA (1) | CA3126699A1 (https=) |
| SG (1) | SG11202107555XA (https=) |
| WO (1) | WO2020150534A2 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201907870VA (en) | 2017-02-28 | 2019-09-27 | Vor Biopharma Inc | Compositions and methods for inhibition of lineage specific proteins |
| CA3110837A1 (en) | 2018-08-28 | 2020-03-05 | Vor Biopharma Inc. | Genetically engineered hematopoietic stem cells and uses thereof |
| EP3850088A4 (en) | 2018-09-07 | 2023-07-19 | Beam Therapeutics, Inc. | Compositions and methods for improving base editing |
| EP3918077A4 (en) * | 2019-01-31 | 2023-03-29 | Beam Therapeutics, Inc. | NUCLEOBASE EDITORS WITH REDUCED OFF-TARGET DEAMINATION AND METHODS OF USING THEM TO MODIFY A NUCLEOBASE TARGET SEQUENCE |
| WO2020168122A1 (en) | 2019-02-13 | 2020-08-20 | Beam Therapeutics Inc. | Modified immune cells having adenosine deaminase base editors for modifying a nucleobase in a target sequence |
| AU2020232691B2 (en) | 2019-03-05 | 2023-06-29 | Nkarta, Inc. | CD19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| JP7831937B2 (ja) * | 2019-09-03 | 2026-03-17 | クリエイト・メディシンズ,インコーポレーテッド | ゲノム組込みのための方法および組成物 |
| EP4034138A4 (en) | 2019-09-27 | 2024-07-31 | Beam Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS |
| US20240238344A1 (en) * | 2020-08-28 | 2024-07-18 | Vor Biopharma Inc. | Compositions and methods for cd123 modification |
| WO2022056459A1 (en) * | 2020-09-14 | 2022-03-17 | Vor Biopharma, Inc. | Compositions and methods for cd5 modification |
| WO2022061115A1 (en) * | 2020-09-18 | 2022-03-24 | Vor Biopharma Inc. | Compositions and methods for cd7 modification |
| CN116322716A (zh) * | 2020-09-23 | 2023-06-23 | 克里斯珀医疗股份公司 | Regnase-1和/或TGFBRII被破坏的基因工程化T细胞具有改善的功能性和持久性 |
| AU2021347359A1 (en) * | 2020-09-25 | 2023-05-18 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| US20230364146A1 (en) * | 2020-09-30 | 2023-11-16 | Vor Biopharma Inc. | Compositions and methods for cd30 gene modification |
| US20250195650A1 (en) * | 2020-11-04 | 2025-06-19 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for enhancing efficacy of therapeutic immune cells |
| US11591381B2 (en) | 2020-11-30 | 2023-02-28 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| JP2023552998A (ja) * | 2020-12-03 | 2023-12-20 | ンカルタ・インコーポレイテッド | 効力および持続性の増強のために免疫細胞を操作する方法、ならびに免疫療法における操作された細胞の使用 |
| CR20230305A (es) * | 2020-12-11 | 2023-11-10 | Intellia Therapeutics Inc | Polinucleótidos, composiciones y métodos para la edición del genoma que implican desaminación |
| WO2022144632A1 (en) | 2020-12-30 | 2022-07-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
| CA3204417A1 (en) * | 2021-01-29 | 2022-08-04 | Allogene Therapeutics, Inc. | Knockdown or knockout of one or more of tap2, nlrc5, ?2m, trac, rfx5, rfxap and rfxank to mitigate t cell recognition of allogeneic cell products |
| WO2022215978A1 (ko) * | 2021-04-05 | 2022-10-13 | 주식회사 셀렌진 | Pdcd-1 유전자에 상보적인 가이드 rna 및 이의 용도 |
| CN113179160B (zh) * | 2021-04-15 | 2022-03-18 | 中国电子科技集团公司第三十研究所 | 一种适用于qkd中私钥放大的最优输入码长处理方法及单元 |
| CA3217458A1 (en) * | 2021-05-06 | 2022-11-10 | Spyro Mousses | Sirna constructs for inhibiting gene expression in targeted cancer cells |
| AU2022272235A1 (en) * | 2021-05-11 | 2023-12-21 | Create Medicines, Inc. | Methods and compositions for genomic integration |
| CA3228879A1 (en) * | 2021-08-16 | 2023-02-23 | Beam Therapeutics Inc. | Persistent allogeneic modified immune cells and methods of use thereof |
| CA3225082A1 (en) | 2021-08-27 | 2023-03-02 | Brian C. Thomas | Enzymes with ruvc domains |
| WO2023034742A1 (en) * | 2021-08-30 | 2023-03-09 | The Board Of Trustees Of The Leland Stanford Junior University | T cells with cell-surface expression of adenosine deaminase and uses thereof |
| AU2022366987A1 (en) | 2021-10-14 | 2024-05-16 | Arsenal Biosciences, Inc. | Immune cells having co-expressed shrnas and logic gate systems |
| CN113980896B (zh) * | 2021-10-27 | 2023-10-20 | 中国人民解放军军事科学院军事医学研究院 | Irf1在调控间充质干细胞免疫调节作用及产品上的应用 |
| EP4426338A2 (en) * | 2021-11-03 | 2024-09-11 | Intellia Therapeutics, Inc. | Cd38 compositions and methods for immunotherapy |
| WO2023086931A2 (en) * | 2021-11-12 | 2023-05-19 | Georgia Tech Research Corporation | Adenosine deaminase 1 compositions and methods for using same |
| MX2024006257A (es) | 2021-11-24 | 2024-07-29 | Metagenomi Inc | Sistemas de endonucleasas. |
| CA3240846A1 (en) * | 2021-12-14 | 2023-06-22 | The Trustees Of The University Of Pennsylvania | Cd5 modified cells comprising chimeric antigen receptors (cars) for treatment of solid tumors |
| CN114774364B (zh) * | 2022-04-26 | 2024-04-26 | 深圳市体内生物医药科技有限公司 | 一种嵌合抗原受体t细胞及其制备方法和应用 |
| EP4532697A2 (en) * | 2022-06-03 | 2025-04-09 | Beam Therapeutics Inc. | Modified regulatory t cells and methods of using the same |
| IL317811A (en) | 2022-07-25 | 2025-02-01 | Interius Biotherapeutics Inc | Mutated polypeptides, compositions containing them and uses thereof |
| WO2024054062A1 (ko) * | 2022-09-08 | 2024-03-14 | 주식회사 에이조스바이오 | 세포 내 형질주입을 위한 신규한 폴리펩타이드 조성물 |
| EP4587570A2 (en) * | 2022-09-16 | 2025-07-23 | Arsenal Biosciences, Inc. | Immune cells with combination gene perturbations |
| CN120239746A (zh) * | 2022-09-19 | 2025-07-01 | 图恩疗法股份有限公司 | 用于调节t细胞功能的组合物、系统和方法 |
| JP2025532979A (ja) * | 2022-09-30 | 2025-10-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 養子t細胞治療薬を増強させるための組成物および方法 |
| KR20250158048A (ko) | 2023-03-03 | 2025-11-05 | 아스널 바이오사이언시스, 인크. | Psma 및 ca9을 표적으로 하는 시스템 |
| WO2024186841A2 (en) * | 2023-03-06 | 2024-09-12 | La Jolla Institute For Immunology | Nfkbid cells and methods for immunotherapy |
| WO2024193562A1 (zh) * | 2023-03-21 | 2024-09-26 | 苏州沙砾生物科技有限公司 | 一种修饰的细胞及其用途 |
| WO2024215414A1 (en) * | 2023-04-12 | 2024-10-17 | Beam Therapeutics Inc. | Modified immune effector cells with improved efficacy |
| EP4455157A1 (en) * | 2023-04-27 | 2024-10-30 | Fundacion Publica Andaluza Progreso Y Salud M.P.- Fps | Polynuceotide for t cell specific transgene expression |
| IL324508A (en) * | 2023-05-16 | 2026-01-01 | Prime Medicine Inc | Genome editing compositions targeting the b2m gene and methods of use |
| CN121195068A (zh) * | 2023-05-26 | 2025-12-23 | 爱迪塔斯医药公司 | 靶向cd70表达的crispr相关方法和组合物 |
| CN116590237B (zh) * | 2023-05-29 | 2023-10-31 | 上海贝斯昂科生物科技有限公司 | 一种遗传修饰的自然杀伤细胞及其制备和用途 |
| WO2025111533A1 (en) * | 2023-11-22 | 2025-05-30 | The General Hospital Corporation | Car-t cells comprising a cdkn1b gene knockout and methods of use thereof |
| WO2025119307A1 (zh) * | 2023-12-06 | 2025-06-12 | 北京齐禾生科生物科技有限公司 | 优化的qbe碱基编辑系统及其应用 |
| WO2025122896A1 (en) * | 2023-12-08 | 2025-06-12 | The Trustees Of The University Of Pennsylvania | Cd5 modified cells comprising heterologous tcrs and methods of using the same |
| WO2025238594A2 (en) * | 2024-05-16 | 2025-11-20 | Fondazione Istituto Italiano Di Tecnologia | DESIGN OF SYNTHETIC miRNAS TO RESTORE THE CORRECT GENE DOSAGE OF GENES ASSOCIATED WITH T LYMPHOCYTE EXHAUSTION |
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| WO2016069282A1 (en) * | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Altering gene expression in modified t cells and uses thereof |
| CA3012607A1 (en) * | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Crispr enzymes and systems |
| EP4043556B1 (en) * | 2015-06-30 | 2024-02-07 | Cellectis | Methods for improving functionality in nk cell by gene inactivation using specific endonuclease |
| US20170020922A1 (en) * | 2015-07-16 | 2017-01-26 | Batu Biologics Inc. | Gene editing for immunological destruction of neoplasia |
| JP7109784B2 (ja) * | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したCas9蛋白質 |
| EA201891338A1 (ru) * | 2015-12-04 | 2018-12-28 | Новартис Аг | Композиции и способы для иммуноонкологии |
| BR112019000057A2 (pt) * | 2016-07-05 | 2019-04-02 | The Johns Hopkins University | composições e métodos com base em crispr/cas9 para o tratamento de degeneração de retina |
| CN108753823B (zh) * | 2018-06-20 | 2022-09-23 | 李广磊 | 利用碱基编辑技术实现基因敲除的方法及其应用 |
| CN108949825A (zh) * | 2018-07-30 | 2018-12-07 | 苏州茂行生物科技有限公司 | 一种靶向her2的car-t细胞的制备方法及应用 |
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| SG11202107555XA (en) | 2021-08-30 |
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| WO2020150534A3 (en) | 2020-10-01 |
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| EP3911735A4 (en) | 2023-07-12 |
| EP3911735A2 (en) | 2021-11-24 |
| WO2020150534A2 (en) | 2020-07-23 |
| JP2022518463A (ja) | 2022-03-15 |
| CA3126699A1 (en) | 2020-07-23 |
| JP2024174899A (ja) | 2024-12-17 |
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