CN113980918A - 一种南极冰藻MAAs合成酶及其编码基因和应用 - Google Patents
一种南极冰藻MAAs合成酶及其编码基因和应用 Download PDFInfo
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- CN113980918A CN113980918A CN202111207603.5A CN202111207603A CN113980918A CN 113980918 A CN113980918 A CN 113980918A CN 202111207603 A CN202111207603 A CN 202111207603A CN 113980918 A CN113980918 A CN 113980918A
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- maas
- seq
- synthetase
- antarctic ice
- algae
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- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 108010056582 methionylglutamic acid Proteins 0.000 description 1
- 108010005942 methionylglycine Proteins 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 1
- 229960001173 oxybenzone Drugs 0.000 description 1
- 108010051242 phenylalanylserine Proteins 0.000 description 1
- 230000000243 photosynthetic effect Effects 0.000 description 1
- 208000007578 phototoxic dermatitis Diseases 0.000 description 1
- 231100000018 phototoxicity Toxicity 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108700042769 prolyl-leucyl-glycine Proteins 0.000 description 1
- 108010031719 prolyl-serine Proteins 0.000 description 1
- 108010070643 prolylglutamic acid Proteins 0.000 description 1
- 108010029020 prolylglycine Proteins 0.000 description 1
- 108010015796 prolylisoleucine Proteins 0.000 description 1
- 108010053725 prolylvaline Proteins 0.000 description 1
- 229960001371 proparacaine hydrochloride Drugs 0.000 description 1
- 238000002331 protein detection Methods 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000003161 ribonuclease inhibitor Substances 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- JDTUMPKOJBQPKX-GBNDHIKLSA-N sedoheptulose 7-phosphate Chemical compound OCC(=O)[C@@H](O)[C@H](O)[C@H](O)[C@H](O)COP(O)(O)=O JDTUMPKOJBQPKX-GBNDHIKLSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 108010048818 seryl-histidine Proteins 0.000 description 1
- 108010026333 seryl-proline Proteins 0.000 description 1
- 108010071207 serylmethionine Proteins 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Images
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
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Abstract
Description
Formula | △ppm | Molecular Weight(理论值) | Molecular Weight(实际值) | RT[min] | Compound Name | Type | λmax (nm) | MolecularFormula |
C<sub>20 </sub>H<sub>28</sub>O<sub>3</sub> | -2.22 | 316.20384 | 316.20314 | 11.393 | Mycosporine-glycine-alanine | Imino-mycosporine | 333 | C<sub>13</sub>H<sub>20</sub>N<sub>2</sub>O<sub>7</sub> |
C<sub>18</sub>H<sub>32</sub>O<sub>7</sub> | -2.1 | 360.2148 | 360.21405 | 13.934 | Mycosporine-glycine-aspartic acid | Imino-mycosporine | 333 | C<sub>14</sub>H<sub>20</sub>N<sub>2</sub>O<sub>9</sub> |
Claims (10)
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CN114395053A (zh) * | 2022-03-25 | 2022-04-26 | 中国科学院南海海洋研究所 | 一种虫黄藻来源的DHQS-OMT融合基因及其在高效合成MAAs中的应用 |
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CN114395053A (zh) * | 2022-03-25 | 2022-04-26 | 中国科学院南海海洋研究所 | 一种虫黄藻来源的DHQS-OMT融合基因及其在高效合成MAAs中的应用 |
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