CN113925905A

CN113925905A - Traditional Chinese medicine composition and application thereof

Info

Publication number: CN113925905A
Application number: CN202111409797.7A
Authority: CN
Inventors: 张淑文; 齐文杰; 王红; 苗彬; 王超; 白杰; 王宝恩
Original assignee: Beijing Friendship Hospital
Current assignee: Beijing Friendship Hospital
Priority date: 2021-11-25
Filing date: 2021-11-25
Publication date: 2022-01-14

Abstract

The invention relates to a traditional Chinese medicine composition and application thereof, wherein the traditional Chinese medicine composition comprises raw rhubarb, immature bitter orange, magnolia officinalis, mirabilite, borneol and sophora flower honey. The six components in the traditional Chinese medicine composition are matched with each other, and the traditional Chinese medicine composition has a remarkable synergistic effect in the aspect of improving gastrointestinal functions. The traditional Chinese medicine composition has important application value in preparing medicines for preventing and/or treating gastrointestinal diseases. The powder for improving the gastrointestinal function, which is prepared from the traditional Chinese medicine composition, can be applied to the abdomen, so that the constipation and the related symptoms of acute pancreatitis with gastrointestinal dysfunction and the like can be obviously improved, and the treatment effect is obvious.

Description

Traditional Chinese medicine composition and application thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicine, relates to a traditional Chinese medicine composition and application thereof, and particularly relates to a traditional Chinese medicine composition for improving gastrointestinal functions and application thereof.

Background

Acute Pancreatitis (AP) is a chemical inflammation in the pancreas and its surrounding tissues which is itself digested by the pancreatic enzymes secreted by the pancreas, is a common acute abdomen disease in surgery, and is often complicated by multiple system multiple organ insufficiency or failure. Clinically, the acute abdominal pain and the elevation of blood amylase or lipase are characterized, and the symptoms mainly comprise acute abdominal pain, fever, nausea, vomiting and the like. Acute pancreatitis is rapid in onset, rapid in development and change, and very complex in clinical diagnosis and treatment: the traditional Chinese medicine composition is a disease induced by multiple factors and involved in multiple links, can generate systemic inflammatory response syndrome, can cause multiple organ dysfunction syndrome after effective treatment in time, has multiple complications, and still has high death rate at present. Patients with acute pancreatitis are often associated with gastrointestinal dysfunction and study statistics show that: the incidence of acute pancreatitis with gastrointestinal dysfunction was 73.7%, with a 13.1% incidence of gastrointestinal failure.

At present, the gastrointestinal dysfunction caused by acute pancreatitis treated by western medicine mainly comprises the methods of increasing gastrointestinal motility through gastrointestinal motility promoting medicines, regulating intestinal flora through microecological preparations, nourishing and repairing intestinal mucosa in intestines and the like, but the curative effect is not obvious. Therefore, the researchers of traditional Chinese medicine begin to use traditional Chinese medicine to treat the gastrointestinal dysfunction of the acute pancreatitis.

For example, CN103393899A discloses a Chinese medicinal composition for treating acute pancreatitis. Decocting Chinese medicinal materials including radix Impatientis, rhizoma Panacis Japonici, radix et rhizoma Thalictri, radix Notoginseng, radix et rhizoma Rhei, flos Pruni mume, cortex moutan, herba Swertiae Bimaculatae and pericarpium Citri Reticulatae viride to obtain decoction. Clinical tests show that the total effective rate of the traditional Chinese medicine is 90.0%, the traditional Chinese medicine is obviously superior to a control group, and the gastrointestinal decompression time, the abdominal pain relieving time, the blood amylase recovery time and the hospitalization time are shorter than those of the control group.

CN111419996A discloses a medicine for treating early severe acute pancreatitis, which is prepared from the following raw materials in parts by weight: 10-20 parts of rheum officinale, 5-10 parts of scutellaria baicalensis, 10-15 parts of rhizoma acori graminei, 5-10 parts of andrographolide, 10-20 parts of herba hyperici japonici, 5-10 parts of caulis bambusae in taeniam, 10-20 parts of immature bitter orange, 5-10 parts of L-glutamine, 10-20 parts of raw gardenia jasminoides, 5-15 parts of gerbera pilosula, 5-15 parts of valeriana jatamansi jones and 5-15 parts of tasselflower herb. The formula of the invention is safe and reliable, all the components supplement each other, and the invention has the effects of clearing away heat and toxic material, removing blood stasis and relieving pain, clearing hollow viscera and benefiting pancreas, strengthening spleen and protecting liver, protecting gastrointestinal cells and enhancing the defense function of the organism, and can inhibit endotoxin shift and bacterial shift and inhibit inflammation.

However, in the prior art, traditional Chinese medicine treatment strategies for acute pancreatitis with gastrointestinal dysfunction are quite limited, treatment means is mainly in the form of decoction, and the treatment effect for gastrointestinal dysfunction is relatively limited.

Therefore, how to develop a traditional Chinese medicine composition for treating acute pancreatitis with gastrointestinal dysfunction becomes a problem which needs to be solved urgently at present in the field.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide a traditional Chinese medicine composition and application thereof, and particularly provides a traditional Chinese medicine composition for improving gastrointestinal function and application thereof.

In order to achieve the purpose, the invention adopts the following technical scheme:

in a first aspect, the invention provides a traditional Chinese medicine composition, which comprises raw rhubarb, immature bitter orange, magnolia officinalis, mirabilite, borneol and sophora flower honey.

Mirabilite is also called Mirabilite and pelvic Xiao, and its property is bitter, salty and cold, entering stomach, large intestine and triple energizer meridians. The oral administration has the effects of moistening dryness, softening hard masses, purging heat and relaxing bowels: it can clear heat and remove toxicity, break blood and promote blood circulation, dissipate nodulation and resolve swelling for external application. Mirabilite is a purgative with strong purgative action, and is used to promote the function of gastrointestinal tract, so it is suitable for its mechanism.

Rhubarb, named Huangliang and Jiangjun, is bitter and cold in nature and has the effects of purging and eliminating accumulation, clearing heat and draining water, detoxifying, stopping bleeding, activating blood and dissolving stasis, and can purge and wash the accumulated stomach and intestine with purgation. Modern medical research considers that the main effective components of rhubarb acting in purgation are conjugated anthraquinone derivatives and dianthrones, especially sennosides of dianthrone.

Immature bitter orange, bitter in taste, pungent, slightly sour and slightly cold in nature enters heart, liver, spleen and stomach meridians. Has the effects of reducing phlegm and removing mass, breaking qi and removing food retention, and is often applied to treating symptoms such as abdominal pain, constipation, food retention, diarrhea and diarrhea, phlegm obstruction and mass in the chest, chest obstruction and chest stagnation, uterine prolapse, gastroptosis, rectocele, edema and the like. Can regulate gastrointestinal smooth muscle, enhance gastrointestinal peristalsis, promote secretion of digestive juice, and strengthen heart.

Hou Po is bitter in taste, neutral in nature and warm in nature, and is ascribed to the spleen, kidney, lung and large intestine meridians. Has effects of eliminating dampness and phlegm, descending qi and relieving fullness, and can be used for treating constipation, phlegm and fluid retention obstructing lung, and lung qi descending.

Borneol is pungent and bitter in flavor and enters heart, spleen and lung meridians. Has effects in inducing resuscitation, dispelling pathogenic fire, inducing resuscitation, refreshing brain, removing nebula, improving eyesight, and relieving swelling and pain.

The sophora flower honey is cool in nature and has the effects of invigorating stomach, moistening lung for arresting cough, resisting allergy, resisting aging, increasing power and tonifying qi. Can relax blood vessels, improve blood circulation of human body, prevent angiosclerosis, and has blood pressure lowering effect after long-term administration. It also has effects in improving mood, relieving neurasthenia, and improving hypnosis and tranquilizing.

According to the traditional Chinese medicine composition, the raw rhubarb, the immature bitter orange, the magnolia officinalis, the mirabilite, the borneol and the sophora flower honey are creatively combined to form the traditional Chinese medicine composition, six medicinal materials in the traditional Chinese medicine composition are mutually matched, the symptoms such as abnormal defecation, abdominal pain and abdominal distension can be relieved, and the traditional Chinese medicine composition has a remarkable synergistic effect in the aspect of improving the gastrointestinal function.

Preferably, the traditional Chinese medicine composition comprises 7-13 parts of raw rhubarb, 7-13 parts of immature bitter orange, 7-13 parts of magnolia officinalis, 7-13 parts of mirabilite, 3-9 parts of borneol and 15-25 parts of sophora flower honey in parts by weight.

Specific values in the above 7 to 13 parts may be 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts and the like.

Specific values in the above 3 to 9 parts may be 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts and the like.

Specific numerical values of the above 15 to 25 parts may be 15 parts, 15.5 parts, 16 parts, 16.5 parts, 17 parts, 17.5 parts, 18 parts, 18.5 parts, 19 parts, 19.5 parts, 20 parts, 20.5 parts, 21 parts, 21.5 parts, 22 parts, 22.5 parts, 23 parts, 23.5 parts, 24 parts, 24.5 parts, 25 parts and the like.

Preferably, the traditional Chinese medicine composition comprises, by weight, 9-11 parts of raw rhubarb, 9-11 parts of immature bitter orange, 9-11 parts of magnolia officinalis, 9-11 parts of mirabilite, 5-7 parts of borneol and 19-21 parts of sophora flower honey, and more preferably 10 parts of raw rhubarb, 10 parts of immature bitter orange, 10 parts of magnolia officinalis, 10 parts of mirabilite, 6 parts of borneol and 20 parts of sophora flower honey.

When the traditional Chinese medicine composition is prepared according to the preferable parts by weight, the effect on improving the gastrointestinal function is better, and particularly, the preparation ratio is as follows: the gastrointestinal function improving effect is best when the traditional Chinese medicine composition comprises 10 parts of raw rhubarb, 10 parts of immature bitter orange, 10 parts of officinal magnolia bark, 10 parts of mirabilite, 6 parts of borneol and 20 parts of sophora flower honey.

In a second aspect, the present invention provides the use of the Chinese medicinal composition according to the first aspect in the preparation of a medicament for the prevention and/or treatment of gastrointestinal diseases.

Preferably, the gastrointestinal disease includes any one of constipation, acute gastroenteritis, chronic gastroenteritis, or acute pancreatitis with gastrointestinal dysfunction.

Preferably, the dosage form of the medicine comprises any one of tablets, decoctions, pills, paste, medicinal granules, pastilles, syrups or powders, and preferably powder.

Preferably, the medicament further comprises pharmaceutically acceptable auxiliary materials.

Preferably, the adjuvant comprises any one or a combination of at least two of diluents, flavoring agents, binders, excipients or fillers. The combination of the at least two components, such as the combination of the diluent and the flavoring agent, the combination of the excipient and the filler, the combination of the flavoring agent and the excipient, and the like, can be selected in any combination manner, and thus, the details are not repeated herein.

In a third aspect, the present invention provides a powder for improving gastrointestinal function, which is prepared from the raw materials of the traditional Chinese medicine composition according to the first aspect.

In a fourth aspect, the invention provides a preparation method of the powder for improving gastrointestinal function, which comprises the steps of grinding raw rhubarb, immature bitter orange, magnolia officinalis, mirabilite and borneol into powder, and adding sophora flower honey for mixing.

In a fifth aspect, the present invention provides a method for using the powder for improving gastrointestinal function according to the third aspect, comprising applying the powder for improving gastrointestinal function to the abdomen, covering with gauze, and replacing every 24h for 7 days.

Preferably, the use method of the powder for improving the gastrointestinal function comprises applying the powder for improving the gastrointestinal function to the Tianshu acupoint and/or the Shenque acupoint.

The recitation of numerical ranges herein includes not only the above-recited values, but also any values between any of the above-recited numerical ranges not recited, and for brevity and clarity, is not intended to be exhaustive of the specific values encompassed within the range.

Compared with the prior art, the invention has the following beneficial effects:

the traditional Chinese medicine composition is creatively formed by combining raw rhubarb, immature bitter orange, magnolia officinalis, mirabilite, borneol and sophora flower honey, and six medicinal materials in the traditional Chinese medicine composition are mutually matched, so that the traditional Chinese medicine composition has the curative effects of improving abnormal defecation, recovering bowel sound and the like, and has an obvious synergistic effect on the aspect of improving gastrointestinal functions. The invention takes borneol and sophora flower honey as the leading materials, and greatly improves the efficacy of the traditional Chinese medicine formula in percutaneous insertion. And two points of Tianshu and Shenque are selected for external application, so that the drug effect is greatly improved, and the prepared powder for improving the gastrointestinal function has obvious effects of improving constipation and treating acute pancreatitis with gastrointestinal dysfunction, and has important application value.

Detailed Description

To further illustrate the technical means and effects of the present invention, the following further describes the technical solution of the present invention with reference to the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

Example 1

The embodiment provides powder for improving gastrointestinal function, which is prepared from the following raw materials, by weight, 10 parts of raw rhubarb, 10 parts of immature bitter orange, 10 parts of magnolia officinalis, 10 parts of mirabilite, 6 parts of borneol and 20 parts of sophora flower honey.

The preparation method comprises the following steps: grinding radix et rhizoma Rhei, fructus Aurantii Immaturus, cortex Magnolia officinalis, Natrii sulfas and Borneolum Syntheticum into powder, adding flos Sophorae Mel, and mixing.

Example 2

The embodiment provides powder for improving gastrointestinal function, which is prepared from 9 parts by weight of raw rhubarb, 11 parts by weight of immature bitter orange, 11 parts by weight of magnolia officinalis, 9 parts by weight of mirabilite, 7 parts by weight of borneol and 19 parts by weight of sophora flower honey.

The preparation process is as in example 1.

Example 3

The embodiment provides powder for improving gastrointestinal function, which is prepared from the following raw materials, by weight, 11 parts of raw rhubarb, 9 parts of immature bitter orange, 9 parts of mangnolia officinalis, 11 parts of mirabilite, 5 parts of borneol and 21 parts of sophora flower honey.

The preparation process is as in example 1.

Example 4

The embodiment provides powder for improving gastrointestinal function, which is prepared from the following raw materials, by weight, 8 parts of raw rhubarb, 12 parts of immature bitter orange, 8 parts of magnolia officinalis, 12 parts of mirabilite, 3 parts of borneol and 23 parts of sophora flower honey.

The preparation process is as in example 1.

Example 5

The embodiment provides powder for improving gastrointestinal function, which is prepared from the following raw materials, by weight, 13 parts of raw rhubarb, 7 parts of immature bitter orange, 12 parts of magnolia officinalis, 8 parts of mirabilite, 8 parts of borneol and 18 parts of sophora flower honey.

The preparation process is as in example 1.

Comparative example 1

This comparative example provides a powder for improving gastrointestinal function, which is different from example 1 only in that the component of raw rhubarb of example 1 is absent, and other components and contents are not changed.

The preparation process is as in example 1.

Comparative example 2

This comparative example provides a powder for improving gastrointestinal function, which is different from example 1 only in that the component of immature bitter orange of example 1 is absent and other components and contents are not changed.

The preparation process is as in example 1.

Comparative example 3

The comparative example provides a powder for improving gastrointestinal function, which is different from example 1 only in that the magnolia bark of example 1 is absent, and other components and contents are unchanged.

The preparation process is as in example 1.

Comparative example 4

This comparative example provides a powder for improving gastrointestinal function, which is different from example 1 only in that the component of mirabilite of example 1 is absent, and other components and contents are not changed.

The preparation process is as in example 1.

Comparative example 5

This comparative example provides a powder for improving gastrointestinal function, which is different from example 1 only in that the component of borneol of example 1 is absent, and other components and contents are not changed.

The preparation process is as in example 1.

Comparative example 6

This comparative example provides a powder for improving gastrointestinal function, which is different from example 1 only in that the component of sophora flower honey of example 1 is absent, and other components and contents are not changed.

The preparation process is as in example 1.

Comparative example 7

This comparative example provides a single raw rhubarb component.

Comparative example 8

This comparative example provides a single immature bitter orange component.

Comparative example 9

This comparative example provides a single magnolia bark component.

Comparative example 10

This comparative example provides a single mirabilite component.

Comparative example 11

This comparative example provides a single borneol component.

Comparative example 12

This comparative example provides a single sophora flower honey component.

Comparative example 13

This comparative example provides a powder for improving gastrointestinal function, which differs from example 1 only in that "sophora flower honey" of example 1 is replaced with an equal amount of "gleditsia sinensis", and the other components and contents are not changed.

The preparation method comprises the following steps: grinding the above materials into powder, and mixing.

Comparative example 14

The comparative example provides a powder for improving gastrointestinal function, which is different from example 1 only in that "20 parts of sophora flower honey" in example 1 is replaced by "8 parts of astragalus mongholicus, 8 parts of angelica sinensis and 4 parts of peach kernels", and other components and contents are not changed.

Comparative example 15

This comparative example provides a powder for improving gastrointestinal function, which is different from example 1 only in that the sophora flower honey of example 1 is replaced with equal amount of wrinkled giant hyssop vital essence water (pharmaceutical factory, national standard character Z11020377, manufactured by Beijing Tongrentang scientific and technological development corporation), and other components and contents are not changed.

The preparation process is as in example 1.

Test example 1

Evaluation of effect of improving gastrointestinal function:

200 constipation volunteer patients were selected and randomly divided into 20 groups of 10 persons each, and the powder for improving gastrointestinal function or single medicinal material components of examples 1 to 5 and comparative examples 1 to 15 were used, respectively. The use mode is as follows: applying 1g of powder or single medicinal material for improving gastrointestinal function on abdomen, covering Tianshu acupoint and Shenque acupoint, and covering with gauze, and replacing every 24 hr for 28 days. Wherein the single medicinal materials of comparative examples 7-11 and the powders for improving gastrointestinal function of comparative examples 13-14 are powders, and 1mL of water is added for mixing and then applying the abdomen. No other drug for treating gastrointestinal diseases was used by volunteers in each group during the test period. The treatment effect was scored after 28 days: 6 minutes-the average defecation interval is less than two days, the defecation property is normal, the defecation is smooth, and the treatment effect is obviously improved compared with that before treatment; 4 minutes-the average defecation interval is less than 2-3 days, the stool is dry and then soft, and the defecation is slightly laboursome, but the improvement is better than that before the treatment; 2 min-the average defecation interval is 3-5 days, the excrement is dry, the defecation is more laborious, and the improvement is slightly better than before the treatment; 0 point-no obvious change before treatment, and the constipation symptom is not relieved. The average composition of each component is shown in Table 1.

TABLE 1

The results show that: the powder for improving gastrointestinal function provided in examples 1 to 5 has an obvious curative effect on symptoms such as abnormal stool, difficult defecation and the like of a constipation patient, and shows that the traditional Chinese medicine composition has a good effect of improving gastrointestinal function and can be used for preparing a medicine for treating gastrointestinal diseases. The powder for improving the gastrointestinal function prepared by using the preferable weight ratio of 9-11 parts of raw rhubarb, 9-11 parts of immature bitter orange, 9-11 parts of magnolia officinalis, 9-11 parts of mirabilite, 5-7 parts of borneol and 19-21 parts of sophora flower honey has better curative effect, wherein the effect is optimal when the raw rhubarb, the immature bitter orange 10 parts, the magnolia officinalis 10 parts, the mirabilite 10 parts, the borneol 6 parts and the sophora flower honey 20 parts. The powder for improving gastrointestinal function or the single medicinal material provided in comparative examples 1 to 12 has a poorer curative effect than the powder for improving gastrointestinal function in example 1, which shows that the curative effect of the combination of six medicinal materials is more remarkable than that of any single medicinal material or any five medicinal materials, and the synergistic effect of the six medicinal materials on improving gastrointestinal function is proved. The powder for improving gastrointestinal function provided in comparative examples 13 to 15 has a slightly poorer curative effect than the powder for improving gastrointestinal function provided in example 1, which shows that the traditional Chinese medicine composition provided by the invention has a better curative effect on improving gastrointestinal function and has an important application value compared with other medicinal material combinations used in the prior art.

Test example 2

Evaluation of effect on treatment of acute pancreatitis with gastrointestinal dysfunction:

82 patients with acute pancreatitis (affiliated friendship hospital infection department of capital medical university) were selected, wherein the light 41 cases and the medium 41 cases were randomly and averagely divided into two groups, namely a powder group for improving gastrointestinal function and a mosapride group. Powder group for improving gastrointestinal function: the powder for improving gastrointestinal function of example 1 was applied to Tianshu acupoint and Shenque acupoint, and replaced every 24 h. Mosapride group: mosapride (Sumitomo pharmaceutical Co., Ltd., national drug Standard J20110022) was administered 5mg each time, orally, 3 times daily. The mosapride is a third-generation gastrointestinal motility promoting drug. No other drug for treating gastrointestinal diseases is used for patients in each group during the treatment period. The first defecation time, bowel sound recovery time, the number of hospitalization days and the cost of the two groups of patients are counted, data analysis is carried out by SPSS17.0 statistical software, the results are expressed by mean +/-standard deviation, and the P value is calculated. The first defecation time refers to the first defecation time from the beginning of treatment of a patient, and the bowel sound recovery time refers to the time from the beginning of treatment of the patient to the recovery of the bowel sound of the patient. The cost refers to the cost of the patient from the time of starting treatment to the time of discharge of the patient for a cure.

The results show that: in all patients with acute pancreatitis, the powder group for improving gastrointestinal function and the mosapride group have significant difference in the first defecation time (4.28 + -1.98 days vs 5.34 + -2.12 days, P ═ 0.036) and the bowel sound recovery time (3.67 + -1.80 days vs 4.84 + -2.13 days, P ═ 0.016); in patients with mild acute pancreatitis, the powder group for improving gastrointestinal function and the mosapride group have significant differences in the time of first defecation (6.23 ± 1.59 days in vs 3.86 ± 2.14 days, P ═ 0.003), the number of hospitalization days (9.60 ± 2.61 days in vs 7.53 ± 1.69 days, P ═ 0.016 days) and the cost (13080.33 ± 3041.94-membered vs 17716.33 ± 7248.95-membered, P ═ 0.041); in patients with moderate acute pancreatitis, the powder group for improving gastrointestinal function and the mosapride group have significant difference in bowel sound recovery time (3.83 ± 1.90 days vs 5.28 ± 2.02 days, P ═ 0.025).

The clinical treatment results show that: the powder for improving the gastrointestinal function provided by the invention has a remarkable curative effect on acute pancreatitis accompanied with gastrointestinal dysfunction, and has an important application value.

In conclusion, the raw rhubarb, the immature bitter orange, the magnolia officinalis, the mirabilite, the borneol and the sophora flower honey are creatively combined to form the traditional Chinese medicine composition, and the six medicinal materials in the traditional Chinese medicine composition are mutually matched, so that the traditional Chinese medicine composition has the curative effects of improving abnormal defecation, recovering bowel sound and the like, and has the remarkable synergistic effect in the aspect of improving the gastrointestinal function. The invention takes borneol and sophora flower honey as the leading materials, and greatly improves the efficacy of the traditional Chinese medicine formula in percutaneous insertion. And two points of Tianshu and Shenque are selected for external application, so that the drug effect is greatly improved, and the prepared powder for improving the gastrointestinal function has obvious effects of improving constipation and treating acute pancreatitis with gastrointestinal dysfunction, and has important application value.

The applicant states that the present invention is described by the above embodiments and the application thereof, but the present invention is not limited to the above embodiments, i.e. the present invention is not limited to the above embodiments. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.

The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are within the protective scope of the present invention.

It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the invention is not described in any way for the possible combinations in order to avoid unnecessary repetition.

Claims

1. A Chinese medicinal composition is characterized by comprising raw rhubarb, immature bitter orange, officinal magnolia bark, mirabilite, borneol and sophora flower honey.

2. The traditional Chinese medicine composition as claimed in claim 1, wherein the traditional Chinese medicine composition comprises 7-13 parts by weight of raw rhubarb, 7-13 parts by weight of immature bitter orange, 7-13 parts by weight of magnolia officinalis, 7-13 parts by weight of mirabilite, 3-9 parts by weight of borneol and 15-25 parts by weight of sophora flower honey.

3. The traditional Chinese medicine composition as claimed in claim 1 or 2, wherein the traditional Chinese medicine composition comprises, by weight, 9-11 parts of raw rhubarb, 9-11 parts of immature bitter orange, 9-11 parts of magnolia officinalis, 9-11 parts of mirabilite, 5-7 parts of borneol and 19-21 parts of sophora flower honey.

4. The traditional Chinese medicine composition according to any one of claims 1 to 3, wherein the traditional Chinese medicine composition comprises, by weight, 10 parts of raw rhubarb, 10 parts of immature bitter orange, 10 parts of magnolia officinalis, 10 parts of mirabilite, 6 parts of borneol and 20 parts of sophora flower honey.

5. Use of a Chinese medicinal composition according to any one of claims 1 to 4 in the manufacture of a medicament for the prevention and/or treatment of gastrointestinal disorders.

6. The use of claim 5, wherein the gastrointestinal disorder comprises any one of constipation, acute gastroenteritis, chronic gastroenteritis or acute pancreatitis with gastrointestinal dysfunction.

7. The use according to claim 5, wherein the medicament is in the form of any one of a tablet, decoction, pill, paste, granule, lozenge, syrup or powder, preferably a powder.

8. The use of claim 5, wherein the medicament further comprises a pharmaceutically acceptable excipient;

preferably, the adjuvant comprises any one or a combination of at least two of diluents, flavoring agents, binders, excipients or fillers.

9. A powder for improving gastrointestinal function, which is prepared from the raw materials comprising the Chinese medicinal composition of any one of claims 1 to 4.

10. The method of preparing a powder for improving gastrointestinal function according to claim 9, wherein the powder for improving gastrointestinal function is prepared by grinding radix et rhizoma Rhei, fructus Aurantii Immaturus, cortex Magnolia officinalis, Natrii sulfas and Borneolum Syntheticum into powder, and mixing with Japanese pagodatree flower honey.