CN103191322A - Traditional Chinese medicine for treating severe acute pancreatitis - Google Patents
Traditional Chinese medicine for treating severe acute pancreatitis Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for treating severe acute pancreatitis. The traditional Chinese medicine is prepared from the following medicinal raw material by weight: 10-15g of rheum officinale, 8-12g of salvia miltiorrhiza, 8-12g of pinellia ternate, 10-16g of liquorice, 10-12g of costustoot, 12-18g of aloe, 8-12g of angelica sinensis, 8-12g of cortex magnoliae officinalis, 4-8g of radix bupleuri, 2-6g of goldthread, 14-20g of mirabilite (watering), 5-10g of radix paeoniae alba, 12-18g of capillary artemisia, 4-8g of bamboo shavings and 5-10g of cattail pollen. The traditional Chinese medicine has wide sources, is low in price, simple and reasonable in preparation and good in curative effect and has the effects of relaxing the bowels, purging intense heat, clearing away heat and removing toxicity. Meanwhile, by utilizing the traditional Chinese medicine, secretion of digestive juice and the activity of trypsin are inhibited so that pancreatic tissue inflammation is relieved and the severe acute pancreatitis can be effectively treated.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically a kind of Chinese medicine for the treatment of Severe Acute Pancreatitis SAP.
Background technology
Acute pancreatitis is Gastroenterology dept.'s common disease, divide light-duty and heavy, at present higher to the cure rate of light-duty patients with acute pancreatitis, and Severe Acute Pancreatitis SAP, because it is fallen ill suddenly, the state of an illness is heavy, complication is many, mortality rate is high, and most of patients is died from multiple organ failure, MOF and severe infections, and the cure rate, the reduction mortality rate that how to improve Severe Acute Pancreatitis SAP are focus and the difficult point of clinical research always.The main pathophysiological basis of Severe Acute Pancreatitis SAP be pancreatin in the pancreatic juice to the autodigestion of pancreas and peripancreatic tissue, cause downright bad and concurrent part (pseudocyst, pancreatic abscess etc.) and the whole body complication (systemic inflammatory response syndrome and multiple organ dysfunction syndrome) of pancreas essence or peripancreatic tissue.The factor that influences pancreatic secretion comprises: have basic phase, a phase, stomach phase and duodenum under (1) exocrine pancreas amount normal condition mutually, the food analyte stimulates the span pylorus of intestinal mucosa release Pancreozymin more far away more few.(2) Pancreozymin of duodenal mucosa release is the major hormone that stimulates the pancreatin secretion, and short cholecystokinin stimulates gallbladder contraction secretion of bile simultaneously, and the effect that activates pancreatic lipase is arranged.The most most important link for the treatment of acute pancreatitis is to reduce pancreatic secretion, improves the cure rate of Severe Acute Pancreatitis SAP.
Summary of the invention
The objective of the invention is in order to solve the deficiency of above-mentioned technology, provide a kind of good effect, expense is low, cure rate is high, and have no side effect, can effectively treat the Chinese medicine of Severe Acute Pancreatitis SAP.
For achieving the above object, a kind of Chinese medicine for the treatment of Severe Acute Pancreatitis SAP is characterized in that it is made by the following raw materials in weight drug ratio: Radix Et Rhizoma Rhei 10-15g, Radix Salviae Miltiorrhizae 8-12g, Rhizoma Pinelliae 8-12g, Radix Glycyrrhizae 10-16g, Radix Aucklandiae 10-12g, Aloe 12-18g, Radix Angelicae Sinensis 8-12g, Cortex Magnoliae Officinalis 8-12g, Radix Bupleuri 4-8g, Rhizoma Coptidis 2-6g, Natrii Sulfas 14-20g (dashing), Radix Paeoniae Alba 5-10g, Herba Artemisiae Scopariae 12-18g, Caulis Bambusae In Taenia 4-8g, Pollen Typhae 5-10g.
The principal agent Radix Et Rhizoma Rhei of Chinese medicine of the present invention is the root and rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.Anthracene derivative is active component main in the Radix Et Rhizoma Rhei.Anthracene derivative comprises effective ingredient such as anthraquinone class emodin, chrysophanic acid, chrysophanol, physcione, aloe-emodin and chrysaron; Radix Et Rhizoma Rhei also contains glycoside that Radix Et Rhizoma Rhei anthracene derivative and glucose be combined into and anthrone class such as Sennoside A, B, C, D, E, F etc., and other glycosides, the matter of trampling on, compound of polysaccharide, organic compound and inorganic matter etc.The conjunction type anthra-glucoside has the diarrhea inducing effect in the Radix Et Rhizoma Rhei, and is the strongest with the Sennoside A effect, and site of action is at colon, and mechanism mainly is to increase intestinal tension force and wriggling, reduces moisture absorption etc.; Can suppress pancreatic secretion, lower capillary permeability, improve its fragility, and can increase platelet content, promote blood coagulation, internally external haemorrhage has tangible anastalsis; Radix Et Rhizoma Rhei has effect for reducing blood fat, and its water decoction comprises that to multiple pathogen antibacterial, virus, fungus, ameba, trichomonas vaginitis and schistosomicide have inhibitory action in various degree; Radix Et Rhizoma Rhei can promote bile secretion, increases bile acid and bilirubinic content in the bile, and Radix Et Rhizoma Rhei has hepatoprotective effect; Chrysophanic acid and Radix Et Rhizoma Rhei have tangible diuresis; Chrysophanic acid, emodin and aloe-emodin have tangible antiinflammatory action.Shennong's Herbal meaning: " Radix Et Rhizoma Rhei can be cleansed gastrointestinal, captures pathogenic fire purging, heat-clearing and toxic substances removing, push away Chen Zhixin, peace and the five internal organs ".Modern medicine study proves, Radix Et Rhizoma Rhei has blood circulation promoting and blood stasis dispelling, improves microcirculation, promotes enterokinesia, protection intestinal mucosa, eliminate the inflammation medium and endotoxin, infection, antitumor, antioxidation, hypertension and hyperlipemia, adjusting immunity, regulate effects such as clotting mechanism.Radix Salviae Miltiorrhizae: cold nature, bitter in the mouth, GUIXIN, Liver Channel, but promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, the removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind cures mainly menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.The Rhizoma Pinelliae: warm in nature, acrid in the mouth is gone into spleen, stomach warp, and the water of manageing it is wet, lowering the adverse flow of QI, and the kind taste damp-phlegm of dispelling can suppress glandular secretion simultaneously, suppresses tryptic activity, press down and tell.Radix Glycyrrhizae: property is flat, and sweet in the mouth is gone into spleen, stomach, lung meridian, detoxifcation is arranged, eliminates the phlegm, pain relieving, spasmolytic be so that pharmacological action such as anticancer; On the traditional Chinese medical science, the Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving cough and moistening lung, emergency detoxifcation is in harmonious proportion hundred medicines; Radix Glycyrrhizae has the effect of similar adrenocortical hormone sample, and the gastroxia that histamine is caused has inhibitory action.The Radix Aucklandiae: warm in nature, bitter in the mouth, suffering are returned spleen, stomach, large intestine, gallbladder meridian, are the promoting the circulation of QI to relieve pain key medicine, and kind opening stopped up intestinal stasis relieving, all gas of lifting, Tongli three warmers and especially in the row taste gas that stagnates, and have that a surname stagnates in the accent, the functions of promoting the circulation of QI to relieve pain; Mainly contain volatile oil, saussurine, resin, glucose, stigmasterol, betulin etc., can be by effect makes large intestine excitement, contractility strengthen, wriggle and accelerate to get rid of gas to vagus nerve.Aloe: cold in nature, bitter in the mouth is returned liver, large intestine channel, and function cures mainly: removing heat from the liver, and relieving constipation is used for constipation, infantile malnutrition, infantile convulsion; The external treatment exudative dermatitis.Radix Angelicae Sinensis: warm in nature, sweet in the mouth, suffering are returned liver, the heart, spleen channel, and function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Cortex Magnoliae Officinalis: warm in nature, bitter in the mouth, suffering are returned spleen, stomach, lung, large intestine channel, and function cures mainly: the dampness expectorant, the therapeutic method to keep the adverse QI flowing downwards is breathed with cough for humidity hysteresis damaging the spleen and stomach, the vomiting and diarrhoea of gastral cavity painful abdominal mass, stagnation of QI due to dyspepsia, abdominal distention constipation, phlegm retention except full.Radix Bupleuri: cold nature, bitter in the mouth, suffering, return Liver Channel, gallbladder meridian, tool depressed liver-energy dispersing and function of gallbladder promoting, thin gas resolving depression, the effect of fire function of loosing: expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, the elevate a turnable ladder yang-energy, cure mainly cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, the uterus comes off, and menoxenia also can be treated hyperlipemia.Rhizoma Coptidis: cold in nature, bitter in the mouth, GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel, the tool heat clearing and damp drying, the effect of eliminating fire and detoxication is used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, and the carbuncle furuncle is quenched one's thirst in toothache.Natrii Sulfas: cold in nature, salty in the mouth, hardship are returned stomach warp, lung meridian, spleen channel, kidney channel, small intestine meridian, tri-jiao channel, large intestine channel, and function cures mainly: purging heat to relax the bowels, and moistening for dryness and softening hard mass, the detumescence of relieving inflammation or internal heat is used for the excess-heat constipation, constipation due to dry stool, stagnant stomachache, acute appendicitis swells and ache.The Radix Paeoniae Alba: cool in nature, liver, spleen channel are gone in bitter in the mouth, acid, and function cures mainly: nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant, is used for the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.Herba Artemisiae Scopariae: cold nature; bitter in the mouth, suffering; return spleen, stomach, liver, gallbladder meridian; the effect of tool clearing away heat-damp and promoting diuresis, jaundice eliminating; cure mainly: jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis etc., pharmaceutical research have effects such as function of gallbladder promoting, liver function protecting, analgesic, antiinflammatory, blood fat reducing, blood pressure lowering, coronary dilating.Caulis Bambusae In Taenia: cold nature, sweet in the mouth is gone into lung, stomach, gallbladder meridian, the tool clearing away heat to stop vomiting, the effect of clearing away phlegm dissipating depression of QI, function cures mainly: clearing away phlegm dissipating depression of QI, clearing away heat to stop vomiting, clearing heat and relieving fidgetness.Pollen Typhae: property is flat, sweet in the mouth, little suffering, return liver, the heart, spleen channel, function cures mainly: hemostasis, blood stasis dispelling, diuresis, be used for haematemesis, spitting of blood, epistaxis, be equipped with dysentery, have blood in stool, metrorrhagia, traumatic hemorrhage, trusted subordinate's pain, amenorrhea stomachache, puerperal stasis of blood pain, dysmenorrhea, tumbling and swelling, blood strangury and dry pain, leukorrhagia, congenital deformity of the tongue, aphtha, Ting ear, uncontrolled urination itch, Pollen Typhae has reduction serum cholesterol, coagulant blood and antiinflammatory action.
The auxiliary Radix Et Rhizoma Rhei of above medicine strengthens capturing the effect of pathogenic fire purging, heat-clearing and toxic substances removing, suppresses secretion of digestive juice simultaneously, suppresses tryptic activity, to alleviate the pancreatic tissue inflammation.
Preparation method of Chinese medicine of the present invention is: take by weighing above-mentioned Radix Et Rhizoma Rhei, Radix Salviae Miltiorrhizae, the Rhizoma Pinelliae, Radix Glycyrrhizae, the Radix Aucklandiae, Aloe, Radix Angelicae Sinensis, Cortex Magnoliae Officinalis, Radix Bupleuri, Rhizoma Coptidis, the Radix Paeoniae Alba, Herba Artemisiae Scopariae, Caulis Bambusae In Taenia, Pollen Typhae material medicine by weight, clean, roguing, dry; Be ground into granule, put in the multi-function extractor, decoct with water twice, the decocting that adds up 10 times of amounts of medical material for the first time boiled 2 hours, got filtrate, and the decocting that adds up 7 times of amounts of medical material for the second time boiled 1 hour; Get twice decocting liquid and mix, filter, in the heat-sealing bag, every bag of 200ml, 100 ℃ of high temperature sterilizes, packing is namely.When taking, at first get Natrii Sulfas and put in the drug filtrate, taking then.
The administering mode of Chinese medicine of the present invention also can be: insert Nasal cavity intestinal tube down through the gastroscope direct-view at first for the patient, confirm further that through abdominal X-ray slotting Nasal cavity intestinal tube end is positioned at jejunum, per nasal jejunum tube feed is gone into herb liquid then, one time one bag, one twice-daily, ten days is a course for the treatment of.
Chinese medicine of the present invention source is wide, cheap, and preparation is simple, reasonable, and good effect is easy to use, without any side effects, the cure rate height.
The present invention verifies through clinical practice, after in the patient of Severe Acute Pancreatitis SAP, having used this Therapeutic Method, find that patient's gastrointestinal functions resumed shortens, blood amylase is active to be reduced, numeration of leukocyte reduces, the APACHEII reduction of marking, multiple organ dysfunction syndrome's incidence rate and mortality rate reduce, total effective rate improves, point out this therapy by improving Severe Acute Pancreatitis SAP patient's gastrointestinal function, suppress secretion of digestive juice, suppress tryptic activity, thereby alleviate the pancreatic tissue inflammation, reduce the order of severity of the state of an illness, the control multiple organ dysfunction syndrome finally reaches the purpose that improves salvage success rate.The former medicine convenient sources of the present invention, cheap is introduced into Severe Acute Pancreatitis SAP treatment field. brought into play the advantage of motherland's traditional medicine, for new approach has been opened up in critical patient's treatment.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1: a kind of Chinese medicine for the treatment of Severe Acute Pancreatitis SAP, and composition and the content of its preparation are: with Radix Et Rhizoma Rhei 15g, Radix Salviae Miltiorrhizae 12g, Rhizoma Pinelliae 12g, Radix Glycyrrhizae 16g, Radix Aucklandiae 12g, Aloe 18g, Radix Angelicae Sinensis 12g, Cortex Magnoliae Officinalis 12g, Radix Bupleuri 8g, Rhizoma Coptidis 6g, Natrii Sulfas 20g (dashing), Radix Paeoniae Alba 10g, Caulis Bambusae In Taenia 8g, Herba Artemisiae Scopariae 18g, Pollen Typhae 10g makes decocting liquid according to a conventional method, one twice-daily is once taken 200ml, and ten days is a course for the treatment of.
Embodiment 2: a kind of Chinese medicine for the treatment of Severe Acute Pancreatitis SAP, and composition and the content of its preparation are: with Radix Et Rhizoma Rhei 10g, Radix Salviae Miltiorrhizae 8g, Rhizoma Pinelliae 8g, Radix Glycyrrhizae 10g, Radix Aucklandiae 10g, Aloe 12g, Radix Angelicae Sinensis 8g, Cortex Magnoliae Officinalis 8g, Radix Bupleuri 4g, Rhizoma Coptidis 2g, Natrii Sulfas 14g (dashing), Radix Paeoniae Alba 5g, Caulis Bambusae In Taenia 4g, Herba Artemisiae Scopariae 12g, Pollen Typhae 5g makes decocting liquid according to a conventional method, one twice-daily is once taken 200ml, and ten days is a course for the treatment of.
A kind of Chinese medicine clinical observation on the therapeutic effect data for the treatment of Severe Acute Pancreatitis SAP
1. clinical data
1.1 physical data: Severe Acute Pancreatitis SAP patient 144 examples of selecting accept for medical treatment during in the December, 2012 in 2010 01 month to are divided into treatment group A, treatment group B and matched group according to contrasting principle at random.Treatment group A patient 48 examples, male 25 examples, women 23 examples, 18～76 years old age, average 43.35 ± 16.03 years old, pathogenic factor: gallbladder source property 12 examples, ethanol 16 examples, eating and drinking too much at one meal 11 examples, hyperlipemia 9 examples, morbidity is to consultation time 9h～2d, blood amylase activity 300～5630U/L when being admitted to hospital, average 2396 ± 451U/L, APACHE II scoring is 22～38 minutes when being admitted to hospital, average 31 ± 5 minutes.Treatment group B patient 48 examples, male 24 examples, women 24 examples, 19～77 years old age, average 43.94 ± 16.77 years old, pathogenic factor: gallbladder source property 11 examples, ethanol 17 examples, eating and drinking too much at one meal 10 examples, hyperlipemia 10 examples, morbidity is to consultation time 8h～2d, blood amylase activity 330～5430U/L when being admitted to hospital, average 2401 ± 438U/L, APACHE II scoring is 20～37 minutes when being admitted to hospital, average 30 ± 5 minutes.Matched group patient 48 examples, male 26 examples, women 22 examples, 21～78 years old age, average 44.57 ± 15.78 years old, pathogenic factor: gallbladder source property 13 examples, ethanol 16 examples, eating and drinking too much at one meal 12 examples, hyperlipemia 7 examples, morbidity is to consultation time 6h～2d, blood amylase activity 320～5580U/L when being admitted to hospital, average 2367 ± 483U/L, APACHE II scoring is 21～38 minutes when being admitted to hospital, average 30 ± 6 minutes.Three groups of statistics are learned comparing difference is not had significance (P＞0.05), has comparability.
1.2 Severe Acute Pancreatitis SAP diagnostic criteria: acute critical pancreatitis clinical diagnosis and the grade scale of organizing proposition according to the pancreas surgery of Society of Surgery of China in 2008: acute pancreatitis is with the organ function obstacle, or local complication persons such as necrosis, abscess or pseudocyst occur, or both have concurrently.Common abdominal part sign has the tangible tenderness of epigastrium, rebound tenderness, muscle tonus, abdominal distention, hypoactive bowel sounds or disappearance etc.Abdominal mass can be arranged, and the subcutaneous ecchymosis of accidental waist flank levies (Grey-Tumer levies) and all subcutaneous ecchymosis of umbilicus are levied (Cullen levies).Can concurrent one or more organ function obstacles, also can be with serious metabolic function disorder, comprise hypocalcemia (blood calcium＜1.87mmoL/L).Enhanced CT is the most effectual way of diagnosis pancreatic necrosis, and B ultrasonic and abdominal paracentesis have certain help to diagnosis.APACHE II scoring 〉=8 minutes.Balthazar CT hierarchy system 〉=II level.
2. clinical experiment method
2.1 experimental drug: Radix Et Rhizoma Rhei 10-15g, Radix Salviae Miltiorrhizae 8-12g, Rhizoma Pinelliae 8-12g, Radix Glycyrrhizae 10-16g, Radix Aucklandiae 10-12g, Aloe 12-18g, Radix Angelicae Sinensis 8-12g, Cortex Magnoliae Officinalis 8-12g, Radix Bupleuri 4-8g, Rhizoma Coptidis 2-6g, Natrii Sulfas 14-20g (dashing), Radix Paeoniae Alba 5-10g, Herba Artemisiae Scopariae 12-18g, Caulis Bambusae In Taenia 4-8g, Pollen Typhae 5-10g.
2.2 medicaments preparation: take by weighing the above-mentioned raw materials medicine by weight, except Natrii Sulfas, other material medicines are cleaned, roguing, dry; Be ground into granule, put in the multi-function extractor, decoct with water twice, the decocting that adds up 10 times of amounts of medical material for the first time boiled 2 hours, got filtrate, and the decocting that adds up 7 times of amounts of medical material for the second time boiled 1 hour; Get twice decocting liquid and mix, filter, in the heat-sealing bag, every bag of 200ml, 100 ℃ of high temperature sterilizes, packing is namely.When taking, at first get Natrii Sulfas and put in the drug filtrate, taking then.
2.3 experimental technique: three groups all give same basic treatment measure, as fasting, gastrointestinal decompression, application somatostatin and antacid medicine, inhibition pancreatin activity, application antibiotic and intravenous hyperalimentation, correction Water-Electrolyte acid base imbalance and symptomatic treatment etc.Treatment group A adds with Chinese medicine decocting liquid 200ml on the basis of above-mentioned treatment and is fed into from Nasal cavity intestinal tube, every day 2 times, is used in conjunction 10 days.Treatment group B adds with Chinese medicine decocting liquid 200ml on the basis of above-mentioned treatment and is fed into from nasogastric tube, every day 2 times, is used in conjunction 10 days.
2.4 clinical indexes: gastrointestinal functions resumed, blood amylase activity, numeration of leukocyte, APACHE II scoring, multiple organ dysfunction syndrome's incidence rate and mortality rate, total effective rate.
2.5 statistical method
Enumeration data is used χ
2Check, measurement data is with mean ± standard deviation
The t check is used in expression.With SPSS12.0 statistics software processes.Be that difference has significance with P＜0.05.
3. result
3.1 observe three groups of patient's gastrointestinal functions resumed (seeing Table 1):
Gastrointestinal functions resumed shortened after the patient of Severe Acute Pancreatitis SAP used this Therapeutic Method: treatment group A gastrointestinal functions resumed is 36.77 ± 11.56h (comparing P all＜0.05 with treatment group B and matched group), and treatment group B gastrointestinal functions resumed is 47.33 ± 12.05h (comparing P＜0.05 with matched group), and the matched group gastrointestinal functions resumed is 56.58 ± 10.43.
Three groups of patient's gastrointestinal functions resumed of table 1
Annotate: compare with matched group
aCompare with treatment group B P＜0.05
cP＜0.05
3.2 observe three groups of patient's blood amylase activity change (seeing Table 2):
The blood amylase activity reduced after the patient of Severe Acute Pancreatitis SAP used this Therapeutic Method: treatment group A 2d, 4d, 6d, the blood amylase activity of 8d is respectively 1839 ± 405U/L, 1393 ± 388U/L (comparing P＜0.05 with matched group), 831 ± 396U/L (compares P＜0.01 with matched group, compare P＜0.05 with treatment group B), 213 ± 64U/L (compares P＜0.01 with matched group, compare P＜0.05 with treatment group B), and treatment group B 2d, 4d, 6d, the blood amylase activity of 8d is respectively 1942 ± 411U/L, 1724 ± 404U/L, 1256 ± 390U/L (comparing P＜0.05 with matched group), 707 ± 128U/L (comparing P＜0.05 with matched group), matched group 2d, 4d, 6d, the blood amylase activity of 8d is respectively 2030 ± 393U/L, 1862 ± 411U/L, 1531 ± 387U/L, 1113 ± 342U/L.
Three groups of patient's blood amylases of table 2 activity change
Annotate: the active normal value of blood amylase is that 30～110U/L and matched group compare
aP＜0.05
bCompare with treatment group B P＜0.01
cP＜0.05
Change (seeing Table 3) 3.3 observe three groups of patient's numeration of leukocyte:
The blood leukocytes counting reduced after the patient of Severe Acute Pancreatitis SAP used this Therapeutic Method: the numeration of leukocyte for the treatment of group A 2d, 4d, 6d, 8d is respectively 16.19 ± 4.44 * 10
9/ L (comparing P all＜0.05 with treatment group B and matched group), 12.83 ± 2.92 * 10
9/ L (comparing P all＜0.05 with treatment group B and matched group), 10.88 ± 2.17 * 10
9/ L (comparing P all＜0.05 with treatment group B and matched group), 8.83 ± 1.87 * 10
9/ L (comparing P all＜0.05 with treatment group B and matched group), and the numeration of leukocyte for the treatment of group B 2d, 4d, 6d, 8d is respectively 18.31 ± 5.04 * 10
9/ L, 16.38 ± 3.88 * 10
9/ L, 12.53 ± 2.54 * 10
9/ L (comparing P＜0.05 with matched group), 10.45 ± 1.99 * 10
9/ L (comparing P＜0.05 with matched group), the numeration of leukocyte of matched group 2d, 4d, 6d, 8d is respectively 18.77 ± 5.87 * 10
9/ L, 17.26 ± 4.84 * 10
9/ L, 14.19 ± 3.88 * 10
9/ L, 12.18 ± 2.21 * 10
9/ L.
Three groups of patient's numeration of leukocyte of table 3 change
Annotate: the numeration of leukocyte normal value is 4.0～10.0 * 10
9/ L and matched group are relatively
aCompare with treatment group B P＜0.05
cP＜0.05
Change (seeing Table 4) 3.4 observe three groups of patient APACHE II scorings:
APACHE II scoring reduced after the patient of Severe Acute Pancreatitis SAP used this Therapeutic Method: treatment group A 2d, 4d, 6d, the APACHE II of 8d was respectively 28 ± 6 fens, 24 ± 5 minutes (comparing P all＜0.05 with treatment group B and matched group), (compared P＜0.01 with matched group in 20 ± 4 minutes, compare P＜0.05 with treatment group B), (compared P＜0.01 with matched group in 16 ± 5 minutes, compare P＜0.05 with treatment group B), and treatment group B 2d, 4d, 6d, the APACHE II of 8d was respectively 29 ± 6 fens, 27 ± 5 minutes, 23 ± 4 minutes (comparing P＜0.05 with matched group), 20 ± 5 minutes (comparing P＜0.05 with matched group), matched group 2d, 4d, 6d, the APACHE II of 8d was respectively 30 ± 5 fens, 28 ± 6 minutes, 26 ± 4 minutes, 24 ± 4 minutes.
Three groups of patient APACHE of table 4 II variation of marking
Annotate: compare with matched group
aP＜0.05
bCompare with treatment group B P＜0.01
cP＜0.05
3.5 observe three groups of patient multiple organ dysfunction syndrome (MODS) incidence rates and mortality rate (seeing Table 5):
The patient of Severe Acute Pancreatitis SAP uses that MODS incidence rate and mortality rate all reduce behind this Therapeutic Method, treatment group A MODS incidence rate is that 10.42% (comparing P all＜0.05 with treatment group B and matched group), mortality rate were 20.0% (comparing P all＜0.05 with treatment group B and matched group), and treatment group B MODS incidence rate is 25.00%, mortality rate is 25.00%, matched group MODS incidence rate 27.08%, mortality rate 30.77%.
Three groups of patient MODS of table 5 incidence rate, mortality rate
Annotate: compare with matched group
aCompare with treatment group B P＜0.05
cP＜0.05
3.6 observe three groups of patient's total effective rates (seeing Table 6)
Total effective rate improved after the patient of Severe Acute Pancreatitis SAP used this Therapeutic Method, treatment group A total effective rate was 83.33% (comparing P all＜0.05 with treatment group B and matched group), and treatment group B total effective rate was 70.83% (comparing P＜0.05 with matched group), matched group total effective rate 58.83%.
Three groups of patient's total effective rates of table 6
Annotate: compare with matched group
aCompare with treatment group B P＜0.05
cP＜0.05.
Claims (1)
1. Chinese medicine for the treatment of Severe Acute Pancreatitis SAP is characterized in that it is made by the following raw materials in weight drug ratio: Radix Et Rhizoma Rhei 10-15g, Radix Salviae Miltiorrhizae 8-12g, Rhizoma Pinelliae 8-12g, Radix Glycyrrhizae 10-16g, Radix Aucklandiae 10-12g, Aloe 12-18g, Radix Angelicae Sinensis 8-12g, Cortex Magnoliae Officinalis 8-12g, Radix Bupleuri 4-8g, Rhizoma Coptidis 2-6g, Natrii Sulfas 14-20g (dashing), Radix Paeoniae Alba 5-10g, Herba Artemisiae Scopariae 12-18g, Caulis Bambusae In Taenia 4-8g, Pollen Typhae 5-10g.
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| CN103933468A (en) * | 2014-03-22 | 2014-07-23 | 苑丕吉 | Traditional Chinese medicine for treating acute pancreatitis |
| CN104984107A (en) * | 2015-06-30 | 2015-10-21 | 卞永兴 | Traditional Chinese medicine enema for treating severe acute pancreatitis |
| CN105233135A (en) * | 2015-10-20 | 2016-01-13 | 河南中医学院第一附属医院 | Medicine for treating pancreatic pseudocyst after severe acute pancreatitis and preparation method of medicine |
| CN107088209A (en) * | 2017-06-22 | 2017-08-25 | 贵州省安顺市黔艺贝纺织有限公司 | A kind of seedling medicine for treating pancreatitis |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103933468A (en) * | 2014-03-22 | 2014-07-23 | 苑丕吉 | Traditional Chinese medicine for treating acute pancreatitis |
| CN104984107A (en) * | 2015-06-30 | 2015-10-21 | 卞永兴 | Traditional Chinese medicine enema for treating severe acute pancreatitis |
| CN105233135A (en) * | 2015-10-20 | 2016-01-13 | 河南中医学院第一附属医院 | Medicine for treating pancreatic pseudocyst after severe acute pancreatitis and preparation method of medicine |
| CN105233135B (en) * | 2015-10-20 | 2019-03-29 | 河南中医学院第一附属医院 | The drug and preparation method thereof for treating Pancreatic Psoudocyst after Severe Acute Pancreatitis SAP |
| CN107088209A (en) * | 2017-06-22 | 2017-08-25 | 贵州省安顺市黔艺贝纺织有限公司 | A kind of seedling medicine for treating pancreatitis |
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Application publication date: 20130710 |