CN105535511A - Stomach harmonizing and pain relieving granule and preparation method thereof - Google Patents

Stomach harmonizing and pain relieving granule and preparation method thereof Download PDF

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Publication number
CN105535511A
CN105535511A CN201610067923.8A CN201610067923A CN105535511A CN 105535511 A CN105535511 A CN 105535511A CN 201610067923 A CN201610067923 A CN 201610067923A CN 105535511 A CN105535511 A CN 105535511A
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weight portion
parts
stomach
rhizoma
granule
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况晓文
曹凤霞
阚晓晴
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JIAOZHOU PEOPLE'S TRADITIONAL CHINESE MEDICINE HOSPITAL
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JIAOZHOU PEOPLE'S TRADITIONAL CHINESE MEDICINE HOSPITAL
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The invention discloses a stomach harmonizing and pain relieving granule which is characterized by being prepared from the following components in part by weight: 2 to 3 parts of fructus evodiae, 6 to 8 parts of prepared rhizoma coptidis with rhizoma zingiberis recens juice, 6 to 8 parts of tuber of pinellia ternate, 6 to 8 parts of stir-baked cortex magnolia officinalils with rhizoma zingiberis recens juice, 3 to 5 part of dandelion, 3 to 5 parts of cuttlebone, 3 to 5 parts of root of rhodiola, 3 to 5 parts of herba cistanches, 3 to 5 parts of tuber of bletilla striata, 3 to 5 parts of poria cocos, 3 to 5 parts of lindera aggregata, 3 to 5 parts of zhebeinine, 3 to 5 parts of caulis perllae, 3 to 5 parts of fructus citri sarcodactyli, 6 to 8 parts of calcined concha arcae and 2 to 3 parts of liquorice. The stomach harmonizing and pain relieving granule disclosed by the invention is strict in compatibility and precise in assistant and guide, and has the efficacy of clearing liver, harmonizing stomach, regulating qi-flowing and eliminating phlegm; the granule is prepared by pure Chinese herbs, so that toxic and side effects are avoided; the formula is reasonable; the formula is small but the efficacy is special; the price is low; the clinical effects are remarkable.

Description

A kind of and stomach and alleviating pain granule and preparation method
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of and stomach and alleviating pain granule and preparation method.
Background technology
Traditional Chinese medical science traditional theory is thought, liver controlling conveyance and dispersion, unhappyly can affect transporting and transforming function of the spleen and stomach, functional activity of QI being not smooth, and phlegm-damp condenses, stagnation of QI and blood may bring about pain, and because gastric qi drops to suitable with unobstructed, controlling should soothing liver-QI stomach function regulating, and activating QI to eliminate phlegm, so-called mechanism of qi bar reaches, and general rule is not bitterly.
Doctor trained in Western medicine thinks that stomachache is common in stomach neurosis, acute or chronic gastritis and peptic ulcer etc., and doctor trained in Western medicine mainly gives the medicines such as proton pump inhibitor, NSAID (non-steroidal anti-inflammatory drug), gastric mucosa protective agent, but the normal recurrent exerbation of stomachache symptom, need Long-term taking medicine to treat.Long-term western medicine not only spends mint of money, and some patient often shows unsatisfactory curative effect.
The Chinese patent medicine of current clinical treatment gastropathy has a lot, after clinical practice, effect is very unobvious, and the most important thing is to treat now the administration times such as stomach neurosis, acute or chronic gastritis and peptic ulcer long, cure rate is low, expensive, bring great misery to patient.As SANJIU WEITAI, we get the first character of Chinese medicine three bifurcation hardship, Folium Et Cacumen Murrayae, therefore named " three nine-day periods after the winter solstice ".The bitter heat-clearing and toxic substances removing of three bifurcations, expelling wind and removing dampness; Folium Et Cacumen Murrayae promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis.Radix Zanthoxyli, Radix Aucklandiae (Radix Vladimiriae) warming middle-JIAO for easing the stomach, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain.Poria promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach.Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, relieving spasm to stop pain.Radix Rehmanniae heat clearing and blood cooling, nourishing the stomach to promote the production of body fluid.Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle.For the basic lesion such as the hyperemia of chronic gastritis gastroscope finding, edema, erosion, atrophy and epigastric distending pain, belch, poor appetite, the cardinal symptom such as weak, Chinese medical discrimination belongs to " the stagnation of liver-QI with deficiency of the spleen folder wet folder stasis of blood ".Special curative effect is not had to diseases such as stomach neurosis, acute or chronic gastritis and peptic ulcers.And western medicine produces serious untoward reaction, if omeprazole main adverse reaction is nauseating, flatulence, diarrhoea, constipation, upper abdominal pain etc.Erythra, ALT and bilirubin raise also has generation, is generally slight and of short duration, scarcely affects treatment.Can feel abnormal, dizzy, headache, drowsiness, insomnia and peripheral nervous of nervous system is scorching etc.The performance of atrophic gastritis is can be observed in the body of stomach biopsy specimen of life-time service this product patient.Life-time service may cause hypergastrinemia, also may cause vitamin B12 deficiency.Zoopery shows that this product can cause stomach bottom and body of stomach enterochromaffin cell to increase, and stomach carcinoid may occur long-term prescription.
Summary of the invention
The object of the invention is to overcome above-mentioned technical problem and provide a kind of soothing liver-QI stomach function regulating, cheap, have no side effect, evident in efficacy with stomach and alleviating pain granule.
Another object of the present invention is to provide this preparation method with stomach and alleviating pain granule.
For achieving the above object, the present invention adopts following technical scheme: a kind of and stomach and alleviating pain granule, comprises following component by weight: Fructus Evodiae 2-3 weight portion, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice 6-8 weight portion, Rhizoma Pinelliae 6-8 weight portion, Cortex Magnoliae Officinalis(processed with ginger) 6-8 weight portion, Herba Taraxaci 3-5 weight portion, Endoconcha Sepiae 3-5 weight portion, Radix Rhodiolae 3-5 weight portion, Herba Cistanches 3-5 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-5 weight portion, Poria 3-5 weight portion, Radix Linderae 3-5 weight portion, Bulbus Fritillariae Thunbergii 3-5 weight portion, Caulis Perillae 3-5 weight portion, finger citron sliced 3-5 weight portion, Concha Arcae (calcined) 6-8 weight portion, Radix Glycyrrhizae 2-3 weight portion.
A kind of preparation method of and stomach and alleviating pain granule, comprise the following steps: (1) takes each medicine according to prescription, get Fructus Evodiae, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, the Radix Linderae, Herba Cistanches, Bulbus Fritillariae Thunbergii be ground into coarse powder, secondary is extracted with 5-6 times of weight portion 50% alcohol heating reflux, each 1 hour, filter, merging filtrate, reclaim ethanol and be condensed into thick paste, medicinal residues are for subsequent use;
(2) Caulis Perillae, Fructus Citri Sarcodactylis add 6-8 times of weight parts water, soak 2 hours, distillation extraction 1.5-2 hour, and collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and debris are separately deposited;
(3) medicinal residues of step 1, step 2 and the Rhizoma Pinelliae, Cortex Magnoliae Officinalis(processed with ginger), Herba Taraxaci, Endoconcha Sepiae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Concha Arcae (calcined), Radix Glycyrrhizae are added 6-8 times of weight parts water, soak 2 hours, decoct twice, 2 hours first times, second time 1 hour, collecting decoction, adding 95% ethanol, to be adjusted to concentration of alcohol be 45%-55%, places 24 hours, filters and to obtain alcohol precipitation, decompression recycling ethanol, being concentrated into relative density is 1.25-1.35(60 DEG C) thick paste;
(4) thick paste of step 3 and step 1 thick paste are merged, be dried and crushed into fine powder, add beta-schardinger dextrin-and make clathrate, add 3 parts by weight of sucrose and the mixing of 1 weight portion dextrin again, add 85% ethanol and make soft material and cross a sieve, granule processed, 60 DEG C of oven dry, granulate, obtains 1000 grams.After the sterilizing of epoxy hexane, place 7-10 days, be distributed into bag (15g/ bag) after the assay was approved, obtain final product.
This perfect square compatibility is rigorous, and monarch is clear and definite, has effect of soothing liver-QI stomach function regulating, activating QI to eliminate phlegm, and we are pure Chinese medicinal preparation, have no side effect, and reasonable recipe, the little medicine in side are special, and cheap, clinical effectiveness is remarkable.
Function cures mainly: the present invention is directed to because feelings will is unsuccessful, caused depression of liver-QI, phlegm resistance causes the stomachache of hyperactive liver-QI attacking the stomach, phlegm-damp internal resistance type, stomach neurosis, acute or chronic gastritis and peptic ulcer.
Indication: epigastric distension and distress pain, belch, noisy acid regurgitation, being irritable and getting angry easily, red tongue with thin and yellow fur, wiry and frequent pulse.
The rule for the treatment of: soothing liver-QI stomach function regulating, activating QI to eliminate phlegm.
The stomachache controlled of we, all because feelings will is smooth, disorder of movement of QI, the stagnation of QI then expectorant is coagulated, therefore can occur gastralgia, fullly vexedly not to relax, and food is rear glutted, belch etc.With stomach and alleviating pain granule, Rhizoma Pinelliae drying dampness to eliminate phlegm in side, dissolving lump and resolving mass, Cortex Magnoliae Officinalis(processed with ginger) dampness is except full, therapeutic method to keep the adverse QI flowing downwards removing food stagnancy, and it is stronger that this two medicine share drying dampness to eliminate phlegm power.Fructus Evodiae warming middle-JIAO, pain relieving, regulates the flow of vital energy, dampness, headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, abdominal pain during menstruation; Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, the two conjunction both can be regulated the flow of vital energy by warming middle-JIAO, again can heat clearing and damp drying, again can soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.Papillary can be rated as the good medicine controlling stomach; Herba Taraxaci heat-clearing and toxic substances removing, diuresis eliminating stagnation.Enter liver and enter stomach, the key medicine of antipyretic removing heat from blood, good to the antiinflammation of gastritis.Concha Arcae (calcined), Endoconcha Sepiae astringing to arrest bleeding, relieving leukorrhea by astringents, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.The lung heat clearing of Radix Rhodiolae QI invigorating, Fructus Alpiniae Oxyphyllae are nourished heart, hemostasis with astringents, dissipating blood stasis for subsidence of swelling; Herba Cistanches kidney-replenishing, benefiting essence-blood, intestine moistening road; Both share strengthening the body resistance, supporing yang warm in, hemostasis with astringents, benefiting essence-blood, invigorating the spleen and replenishing QI be effective, the Pseudobulbus Bletillae (Rhizoma Bletillae), Poria promoting diuresis to eliminate damp pathogen, spleen invigorating, for insufficiency of the spleen can not transmitting and distributing the fluids, the disease stopping the raw phlegm retention of dimerization is rather effective.Folium Perillae promoting the circulation of QI to alleviate the stagnation in middle-JIAO, orderly and clearly mechanism of qi.The Radix Linderae " dissipating depression of QI gas; attacked by pestiferous factors is suffered from abdominal pain, except chest and diaphragm distension ", promoting the circulation of QI to relieve pain, Bulbus Fritillariae Thunbergii sending down the abnormal ascending QI eliminating stagnation, two medicines share, and strengthen relieving gastric hyperacidity to alleviate stomachache effect, and Caulis Perillae, both finger citron sliceds share the drug of first choice surely belonging to treatment gastritis, both all have effect of relieving QI stagnancy in the stomach, the symptoms such as patient's flatulence, belch can be eliminated, Radix Glycyrrhizae relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.And do not treat hyperactive liver-QI attacking the stomach in Chinese patent medicine existing on the market, the medicine of phlegm-damp internal resistance type stomachache, and stomach and alleviating pain granule solves a treatment difficult problem for this kind of stomachache well, clinical practice is easy, evident in efficacy.
Medication mechanism:
The Rhizoma Pinelliae: warm in nature; Acrid in the mouth is poisonous.Enter spleen, stomach warp.Water of manageing it wets, lowering the adverse flow of QI, and kind taste damp-phlegm of dispelling.Water is wet to be gone, and the strong and sputum of spleen is from disappearing, and inverse gas falls then harmonization of the stomach and feeling of fullness vomiting from only, therefore is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass.Modern pharmacological research shows: the Rhizoma Pinelliae significantly can suppress the gastric secretion of mice, reduces gastric acidity, can suppress the generation of Stress gastric ulcer.Significantly can increase intestinal peristalsis promoting, but have antagonism, so have regulating action to gastrointestinal function to the intestinal smooth muscle contraction caused by acetylcholine, histamine, barium chloride in intestine in vitro.
Cortex Magnoliae Officinalis(processed with ginger): warm in nature; Bitter in the mouth, pungent.Return spleen, stomach, large intestine channel.Cure mainly stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea, expectorant stops up QI rising in reverse order, fullness in the chest is breathed with cough.Modern pharmacological research shows: magnolol has and prevents the handicapped effect of irritability stomach; There is antiphagin effect; External have inhibitory action to tumor cell.To Cavia porcellus intestinal tube Small Dose Excitement, heavy dose of suppression, has excitation to bronchial smooth muscle.Also has hypotensive effect.The modern function analysis of Cortex Magnoliae Officinalis(processed with ginger) is as follows:
(1) for the gastroenteric tumor of Deficiency and coldness of spleen and stomach, transporting mistake department, phlegm and qi stasis, disease sees breast gastral cavity feeling of distension and oppression, abdominal part dull pain, and borborygmus loose stool is indigestion and loss of appetite, or vomiting sputum etc., the fit applications such as normal and Fructus Aurantii, the Rhizoma Atractylodis Macrocephalae, Poria, Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Lee.
(2) for belly cavity tumor, because abdominal part distension appears in oncothlipsis, flatulence etc., the fit applications such as normal and Pericarpium Arecae, Herba Marsileae Quadrifoliae taro, the Radix Aucklandiae.
(3) in addition, all genus retention of dampness in middle-JIAO, the breast abdominal distention of functional activity of QI being not smooth is vexed, and vomiting singultus and damp-phlegm stop up lung, and cough and asthma etc. all can be applied.
Fructus Evodiae: pungent, bitter, heat; Slightly poisonous.Return liver, spleen, stomach, kidney channel.Dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea." property of medicine opinion ": main trusted subordinate's disease, accumulation of pathogenic cold, stagnation of QI under the heart, chronic infectious disease is pained; Control cramp caused by acute vomiting and diarrhea, cold in the stomach gas, vomiting and diarrhoea stomachache can not win the person of bearing; Treat insensitive impediment all over, cold drinks and snachs does not disappear, and sharp large intestine gathers around gas." Japan hanako materia medica ": spleen invigorating is got round by bribery.Control stomachache, kidney qi, beriberi, edema, blood more than lower puerperal.
Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice: bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, palpitation and uneasiness, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.For conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation." elephant " cloud: eliminating heart-fire, except damp and hot in taste, control and irritated to feel sick, strongly fragrant heat in middle-JIAO, intense nausea, epigastric fullness must medication also.Zhong Jing controls nine kinds of epigastric oppressions, and the XIEXIN TANG such as five all use it.Go to use." medicine class on the analogy of natural things ": eliminating heart-fire, except damp and hot in taste, controls irritated nauseating, strongly fragrant heat in middle-JIAO, intense nausea.Control the heart not feeling of fullness must medication also.Zhong Jing controls nine kinds of epigastric oppressions, and the XIEXIN TANG such as five all use it." book on Chinese herbal medicine is newly organized ": Rhizoma Coptidis, bitter in the mouth, cold, can rise and can fall, the moon is also, nontoxic.Enter the heart and collaterals of the uterus.Most pathogenic fire purging, also can enter liver.Ask to join one greatly the medicine of tying-in, all can enter it, and enter the heart, especially special in also.Emesis profit acid regurgitation, kind solution is thirsty.Control acute catarrhal conjunctivitis very refreshing, can feel at ease, only nocturnal emission, fixed manic, except feeling of fullness, go married woman's vaginal orifice to swell.Control children's's geophagy and make infantile malnutrition, separate summer-heat, damp and hot, hot and suffocating, have special merit in fact.
Herba Taraxaci: bitter, sweet, cold.Return liver, stomach warp.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria." south of the Five Ridges gather medicinal herbs record ": process crisp sustainability, (medicine) to be taken with wine, treats gastric abscess." Chinese herbal medicine is commonly used in Shanghai ": heat-clearing and toxic substances removing, diuresis, cathartic.Cure cold heating, tonsillitis, acute pharyngolaryngitis, and acute bronchus is felt well, erysipelas, lymphadenitis, wind-fire acute conjunctivitis, gastritis, hepatitis, osteomyelitis.
Endoconcha Sepiae: salty in the mouth, puckery, warm in nature.Return spleen, kidney channel.Astringing to arrest bleeding, relieving leukorrhea by astringents, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.For hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation; External treatment bleeding due to trauma, eczema eczema, ulcer being unable to heal." modern Practical Chinese medicinal ": " be antacid, effective to hyperchlorhydria, gastric ulcer." " not Lu ": ", frightened gas enters abdomen, stomachache ring umbilicus, edema due to cold pathogen in the moon (one does " swell and ache in husband's the moon "), only the many pus of skin ulcer are not dry again." current research: based on Os Sepiae, coordinate other drug take orally, to Peptic Ulcers and cause hemorrhage, perforation, all have good therapeutic effect.(i) cuttlefish bone meal 85%, Bulbus Fritillariae Thunbergii powder 15%, mixing.Often take 2 ~ 5 grams, every day 3 taking medicine before meal.Or in above-mentioned powder, add Radix Et Rhizoma Rhei 10% again, to correct the side effect that Os Sepiae easily causes constipation.Also can use Os Sepiae 30 grams of parchings to brown, mixing ground into powder by the compatibility Rhizoma Pinelliae 3 grams.Usage is the same.The effects such as antacid, hemostasis, pain relieving are had for Peptic Ulcers.Within after generally taking medicine 3 ~ 5 days, namely come into effect, appetite amelioration, acid regurgitation and epigastrium pain relief or disappearance, stool reverts to yellow.Most of patients symptom, sign after treatment in 1 ~ 3 month all disappear or show and improve, and x-ray check alcove disappears or makes progress.(ii) cuttlefish bone meal and Pseudobulbus Bletillae (Rhizoma Bletillae) powder mixed in equal amounts, every day 3 ~ 4 times, each 3 ~ 5 grams, warm water is taken after mixing with liquid.For ulcer haemorrhage, observe, generally in 3 ~ 7 days, namely receive haemostatic effect: hematemesis stops according to tens of example, just color recovers normal, and fecal occult blood testing the moon turns.Once tried out merge esophageal varices bleeding in portal hypertension, esophagus diverticulum merges the single cases such as hemorrhage, intestinal hemorrhage of typhoid fever, also all obtains certain effect.(iii) Os Sepiae, each 1 money 5 points of Pseudobulbus Bletillae (Rhizoma Bletillae) powder, gel aluminum hydroxide 25 milliliters.Take for 1 time with cold boiled water after mix and blend, every day 3 ~ 4 times.Coordinate the measures such as gastrointestinal decompression, anti-inflammation, fasting simultaneously, in order to treat taste-blindness rate perforation 31 example, result cures 29 examples, 1 example that takes a turn for the better (original a large amount of ascites merges perforation), dead 1 example (women, old, bore a hole on a full stomach, be admitted to hospital late, viewing duration is suffered a shock, make kposthesis again, postoperative death).Through above-mentioned treatment, except indivedual with except acupuncture pain relieving, generally do not need to use narcotic analgesics.Pain is many obviously to be alleviated after the treatment for 3 ~ 5 hours, within 24 ~ 48 hours, disappears, Average of hospital stay 6 ~ 7 days.Cure case there is not diaphragm under and abdominal cavity residual abscess and the slight intestinal adhesion person of other complication 1 only 1 routine; Without recurrence borer.There is very high toughness after above-listed three medicine mixing, form gluey film at gastric, closed pore and protection gastric mucosa can be helped, gastric acidic liquid is neutralized, stops excessive, create favorable conditions for omentum majus etc. covers perforation; Even if gastric holds excessive, the severe pain that chemical irritation causes also can alleviate.But this therapy has its certain indication, the Operation in early stage (see " Pseudobulbus Bletillae (Rhizoma Bletillae) " bar) of perforated ulcer can not be replaced completely.All one of following situations that meets all should consider operation early: perforated ulcer diagnoses inadequate yea-sayer; Have by the state of an illness after this therapy and worsen tendency person; Preoperative barium meal is diagnosed as gastric cancer, ulcer malignant change or is suspected to have carcinous borer; Have eating and drinking too much at one meal before perforation, abdominal distention after perforation, peritonitis are serious, and there is a large amount of hydrops in abdominal cavity, estimate that perforation is large and the person that is difficult to closed pore; Serious shock is had, through the shock person of failing to respond to any medical treatment when being admitted to hospital.
Radix Rhodiolae: cold, sweet, puckery.Lung meridian.: there is QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae is nourished heart, effect of hemostasis with astringents, dissipating blood stasis for subsidence of swelling.Cure mainly deficiency of vital energy and physically weak, after being ill fear of cold, shortness of breath and fatigue, cough due to lung-heat, spitting of blood, leucorrhea diarrhoea, traumatic injury etc.Radix Rhodiolae energy improving water flood, blood-enriching and blood-promoting circulation, anti-cerebral anoxia, resisting fatigue, promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, change become silted up detumescence, antipyreticly to bring down a fever, nourish the effects such as vigour; Be used for the treatment of traumatic injury and burn and scald outward." modern practical book on Chinese herbal medicine " says that its effect has seven, namely " one, central inhibitory action.Two, antifatigue effect.Three, cardiotonic.Four, antiinflammatory action.Five, blood glucose rising effect is suppressed.Six, Hardy dwarfing.Seven, resisting microwave radiation effect "." acid of Herba hylotelephii erythrosticti bitter in the mouth is flat, nontoxic for supplement to Thousand Golden Prescriptions speech.Main large hot large carbuncle(disease), fever of the body is tired of, evil gas, all diseases due to noxious agents produced by various parasites crust arranges, cold and heat migratory arthralgia, and various symptoms and signs of deficiency, spends main woman's whitish metrorrhagia, clear body improving eyesight, and the logical god of clothes is not old for a long time.”
Herba Cistanches: sweet in the mouth, salty, warm in nature, returns kidney, large intestine channel.Kidney-replenishing; Benefiting essence-blood; Intestine moistening road.Main kidney yang deficiency; The sexual impotence of asthenia of essence and blood; Seminal emission; Nebulousurine; The frequent micturition heeltap; Lumbago flaccidity of the lower limbs; Tinnitus order flower; Menstruation is spread out the phase; Infertility; Dryness of the intestine constipation.Modern pharmacological research: Herba Cistanches has anti-aging effects, adjustment endocrine, promotion metabolism and strong effect, immune effect." Bencao Jingshu ": Herba Cistanches, the key medicine of nourishing kidney replenishing vital essence and blood, this tepor of gas, thinks that hot person by mistake also according to legend.The invigorating middle warmer of sweet energy heat extraction, acid can enter liver, the nourishing kidney of salty energy, and kidney liver is cloudy, and cloudy gas is grown, then the consumptive fever of the five internal organs is from moving back, the spontaneous recovery of penis invasion by pathogenic cold burning pain.Kidney liver foot, then essence and blood day contains, and essence and blood is contained then how sub.Gynecological mass in abdomen, the disease appearing in blood system, blood exuberant then OK, capable then lump in the abdomen disappears certainly.Bladder is empty, then evil visitor, must to mend then that pathogen is from loose, and lumbago is from stopping.Clothes of a specified duration are then fertile strong and make light of one's life by commiting suicide, and the effect of kidney tonifying liver replenishing vital essence and blood also, controls dysentery if say, sliding with the meaning of intestinal stasis relieving, this also can not say also." beautiful Chinese catalpa medicine solution ": Herba Cistanches, warm waist knee joint, strong kindred, nourishing kidney extractum hepatis blood, intestine moistening stomach knot is dry.All faecal pellet heavily fortified points are little, and shape is as sheep dung, and the wet wood of this soil is strongly fragrant, the event of occlusion of the lower orifices.Paddy dregs at stomach, must not along under, sporadicly transmit, breaking falls does not join, Li Yangming large intestine dry, is smelt granule, and secret puckery difficulty is led to, and total edge wind wood is withered, and catharsis is also not all right.One takes Radix Rehmanniae, Colla Plastri Testudinis, and anti-benefit soil is wet, and middle gas more loses.Herba Cistanches grows wooden fresh breeze, blood enriching and dryness moistening, and kind sliding large intestine, and lower knot excrement, its property is calm and unhurried, does not lose spleen to taste is wet, and non-all demulcens are comparable.Side's book claims its vital essence replenishing and marrow benifiting, and happy color is prolonged life, and reason man absolutely sun is out of fashion, and woman is exhausted, and the moon does not produce, non-praising.
The Pseudobulbus Bletillae (Rhizoma Bletillae): bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Astringing to arrest bleeding, detumescence and promoting granulation.For spitting of blood, spit blood, traumatic hemorrhage, sore swollen toxin, chapped skin.[attention] should not with Radix Aconiti, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii, Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Lateralis Preparata with using.
Current research: 1, anastalsis: it is active that the Pseudobulbus Bletillae (Rhizoma Bletillae) can strengthen platelet factor III, significantly shortens clotting time and thrombinogen formation time, suppresses plasmin enzymatic activity, has anastalsis to local hemorrhage.
2, gastric mucosa is protected: 1% Pseudobulbus Bletillae (Rhizoma Bletillae) decoct gavage, has protective effect to the rat pipe film injury that hydrochloric acid causes; To the experimental Stomach duodenum perforation of anesthetized dog, there is therapeutical effect.[precious jade medicine] Gei be not idle: tuber controls gastric ulcer, pulmonary tuberculosis, cough, and spitting of blood is spitted blood " osmanthus medicine volume ".
Poria: property is put down, sweet in the mouth, light.GUIXIN, spleen, lung, kidney channel.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, is reached by strong activating the spleen pulmonary function.Modern pharmacological research shows: Poria has lax gastrointestinal smooth muscle, the effect of gastric acid secretion inhibiting.
Folium Perillae: warm in nature, acrid in the mouth.Return lung, spleen channel.Folium Perillae can diaphoresis cold expelling to separate pathogenic factor in the exterior, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, resolving depression preventing or arresting vomiting, for diseases such as stagnation of QI in spleen and stomach, uncomfortable in chest, vomiting and nausea.
The Radix Linderae: warm in nature, acrid in the mouth.Return stomach, kidney channel.There is the function of promoting the circulation of QI to relieve pain.Modern pharmacological research shows, the Radix Linderae can increase the secretion of Digestive system, can also resist the stomachache that clinical practice Radix Et Rhizoma Rhei causes.Radix Linderae decocting liquid has excited and strengthens the effect of the stomach motion rhythm and pace of moving things, also significantly can suppress the formation of ulcer, have cytoprotection.
Bulbus Fritillariae Thunbergii: cold in nature; Bitter in the mouth.Return lung, heart channel.There is removing heat-phlegm, sending down the abnormal ascending QI cough-relieving, effect of mass dissipating and swelling eliminating.Say in " Shandong Chinese herbal medicine handbook ": " removing heat from the lung and dissipating phlegm, antacid, removing toxic substances.Cure cold cough, and stomachache acid regurgitation, carbuncle poison swells and ache.”
Caulis Perillae: pungent, temperature.Return lung, spleen channel.Regulating the flow of QI to ease the stomach, pain relieving, antiabortive.Vexed for chest and diaphragm painful abdominal mass, gastralgia, belch is vomitted, frequent fetal movement.Stalk as taste, be good at circulation of qi promoting with in, regulate the flow of vital energy antiabortive.Therefore commonly used by cough due to wind and cold, stagnation of QI in spleen and stomach, promoting the circulation of QI to alleviate the stagnation in middle-JIAO (Caulis Perillae): for stagnation of QI in spleen and stomach, vomiting uncomfortable in chest.This product is promoting the circulation of QI to alleviate the stagnation in middle-JIAO, and activating QI to stop vomiting good medicine has antiabortive merit of regulating the flow of vital energy concurrently." book on Chinese herbal medicine is high former ": " main alleviating distention in middle-JIAO circulation of qi promoting, disappear diet, and reduce phlegm saliva.Control dysphagia and regurgitation, only cardiac and abdominal pain." " must join book on Chinese herbal medicine ": " is soothing the liver, and sharp lung, regulates the flow of vital energy, and blood, resolving depression, and pain relieving is coughed surely, antiabortive."
Finger citron sliced: pungent, bitter, sour, temperature.Return liver, spleen, lung meridian; Depressed liver-energy dispersing and QI regulating, and stomach and alleviating pain, drying dampness to eliminate phlegm.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted, cough with copious phlegm.Current research: have activating QI to eliminate phlegm, preventing or arresting vomiting relieving distension, the liver soothing and the spleen invigorating, the more kinds of medicinal function of stomach function regulating.Obvious mitigation is had to the tracheitis of old people, asthma; Vexed to the dyspepsia of common people, breast abdominal distention, there is more significant curative effect.Fructus Citri Sarcodactylis can be made into several kinds of Chinese medicinal materials, and clothes have the effect of health-care for a long time.
Salty, flat.Return lung, stomach, Liver Channel.
Concha Arcae (calcined): expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache.For the long-pending knot of pertinacious phlegm, sticky difficulty is coughed up, goiter, scrofula ， mass in the abdomen mass in the abdomen, stomachache pantothenic acid.Concha Arcae (calcined) taste walks blood system and softening the hard mass, therefore can repercussive blood, removing obstruction for relieving pain, resolving phlegm and softening hard masses.Fan WEIJIA mass in the abdomen, old expectorant heavily fortified point is long-pending, and stomachache pantothenic acid and goiter, scrofula etc. all can control it." ten thousand stir-fry sides of clan ": control all Qi Xue WEIJIA, expectorant; Concha Arcae is forged, with quench in vinegar three degree, bury make bad, vinegar cream ball.
Radix Glycyrrhizae: property is put down, sweet in the mouth.GUIXIN, spleen, lung, stomach warp.There is invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, heat-clearing and toxic substances removing, alleviate pain relieving, relax effect of the property of medicine.Modern pharmacological research shows, Radix Glycyrrhizae has antiulcer, antiinflammatory, convulsion, antitumor, anti AIDS virus, antiallergic action, removing toxic substances, antitussive, analgesia, spasmolytic, reduction cholesterolemia, increases the pharmacological actions such as bile secretion.
Rhizoma Pinelliae dissipating phlegm and resolving masses in side, Fructus Evodiae dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice heat clearing and damp drying, eliminating fire and detoxication is monarch drug, Endoconcha Sepiae astringing to arrest bleeding, relieving gastric hyperacidity to alleviate stomachache, the Cortex Magnoliae Officinalis(processed with ginger) therapeutic method to keep the adverse QI flowing downwards is except full, the Rhizoma Pinelliae is helped to reduce phlegm as ministerial drug, Concha Arcae (calcined), finger citron sliced and stomach and alleviating pain, Pseudobulbus Bletillae (Rhizoma Bletillae) convergence only, blood Herba Taraxaci heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, the sweet light eliminating dampness by diuresis spleen invigorating of Poria, the Rhizoma Pinelliae is helped to reduce phlegm, Folium Perillae, lac encrusted twig reason lung soothing liver-QI, help Cortex Magnoliae Officinalis promoting QI circulation for relieving depression, promoting the circulation of QI to relieve pain that the Radix Linderae is soothing the liver, Bulbus Fritillariae Thunbergii dissipating phlegm and resolving masses, Radix Rhodiolae hemostasis with astringents, dissipating blood stasis for subsidence of swelling, Herba Cistanches kidney yang, benefiting essence-blood is adjuvant drug altogether.Radix Glycyrrhizae relieving spasm to stop pain, again can coordinating the actions of various ingredients in a prescription, for making medicine.Full side plays soothing liver-QI stomach function regulating altogether, effect of activating QI to eliminate phlegm.Modern pharmacological research proves, originally can gastric acid secretion inhibiting, and shrinking intestinal smooth muscle has antagonism, so have regulating action to gastrointestinal function.
Detailed description of the invention
Below, in conjunction with example, substantive distinguishing features of the present invention and advantage are further described, but the present invention is not limited to listed embodiment.
Embodiment 1
One and stomach and alleviating pain granule, comprise following component by weight: Fructus Evodiae 2-3 weight portion, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice 6 weight portion, the Rhizoma Pinelliae 6 weight portion, Cortex Magnoliae Officinalis(processed with ginger) 6 weight portion, Herba Taraxaci 3 weight portion, Endoconcha Sepiae 3 weight portion, Radix Rhodiolae 3 weight portion, Herba Cistanches 3 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3 weight portion, Poria 3 weight portion, the Radix Linderae 3 weight portion, Bulbus Fritillariae Thunbergii 3 weight portion, Caulis Perillae 3 weight portion, finger citron sliced 3 weight portion, Concha Arcae (calcined) 6 weight portion, Radix Glycyrrhizae 2 weight portion.
A kind of preparation method of and stomach and alleviating pain granule, comprise the following steps: (1) takes each medicine according to prescription, get Fructus Evodiae, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, the Radix Linderae, Herba Cistanches, Bulbus Fritillariae Thunbergii be ground into coarse powder, secondary is extracted with 5 times of weight portion 50% alcohol heating reflux, each 1 hour, filter, merging filtrate, reclaim ethanol and be condensed into thick paste, medicinal residues are for subsequent use;
(2) Caulis Perillae, Fructus Citri Sarcodactylis add 6-8 times of weight parts water, soak 2 hours, distillation extraction 1.5 hours, and collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and debris are separately deposited;
(3) medicinal residues of step 1, step 2 and the Rhizoma Pinelliae, Cortex Magnoliae Officinalis(processed with ginger), Herba Taraxaci, Endoconcha Sepiae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Concha Arcae (calcined), Radix Glycyrrhizae are added 6 times of weight parts waters, soak 2 hours, decoct twice, 2 hours first times, second time 1 hour, collecting decoction, adding 95% ethanol, to be adjusted to concentration of alcohol be 45%-55%, places 24 hours, filters and to obtain alcohol precipitation, decompression recycling ethanol, being concentrated into relative density is 1.25-1.35(60 DEG C) thick paste;
(4) thick paste of step 3 and step 1 thick paste are merged, be dried and crushed into fine powder, add beta-schardinger dextrin-and make clathrate, add 3 parts by weight of sucrose and the mixing of 1 weight portion dextrin again, add 85% ethanol and make soft material and cross a sieve, granule processed, 60 DEG C of oven dry, granulate, obtains 1000 grams.After the sterilizing of epoxy hexane, place 7-10 days, be distributed into bag (15g/ bag) after the assay was approved, obtain final product.
Usage and dosage: oral, a 1-2 bag, one day 2-3 time.
Embodiment 2
One and stomach and alleviating pain granule, comprise following component by weight: Fructus Evodiae 2-3 weight portion, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice 8 weight portion, the Rhizoma Pinelliae 8 weight portion, Cortex Magnoliae Officinalis(processed with ginger) 8 weight portion, Herba Taraxaci 5 weight portion, Endoconcha Sepiae 5 weight portion, Radix Rhodiolae 5 weight portion, Herba Cistanches 5 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 weight portion, Poria 5 weight portion, the Radix Linderae 5 weight portion, Bulbus Fritillariae Thunbergii 5 weight portion, Caulis Perillae 5 weight portion, finger citron sliced 5 weight portion, Concha Arcae (calcined) 8 weight portion, 3 parts, Radix Glycyrrhizae.
A kind of preparation method of and stomach and alleviating pain granule, comprise the following steps: (1) takes each medicine according to prescription, get Fructus Evodiae, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, the Radix Linderae, Herba Cistanches, Bulbus Fritillariae Thunbergii be ground into coarse powder, secondary is extracted with 5-6 times of weight portion 50% alcohol heating reflux, each 1 hour, filter, merging filtrate, reclaim ethanol and be condensed into thick paste, medicinal residues are for subsequent use;
(2) Caulis Perillae, Fructus Citri Sarcodactylis add 8 times of weight parts waters, soak 2 hours, distillation extraction 2 hours, and collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and debris are separately deposited;
(3) medicinal residues of step 1, step 2 and the Rhizoma Pinelliae, Cortex Magnoliae Officinalis(processed with ginger), Herba Taraxaci, Endoconcha Sepiae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Concha Arcae (calcined), Radix Glycyrrhizae are added 8 times of weight parts waters, soak 2 hours, decoct twice, 2 hours first times, second time 1 hour, collecting decoction, adding 95% ethanol, to be adjusted to concentration of alcohol be 45%-55%, places 24 hours, filters and to obtain alcohol precipitation, decompression recycling ethanol, being concentrated into relative density is 1.25-1.35(60 DEG C) thick paste;
(4) thick paste of step 3 and step 1 thick paste are merged, be dried and crushed into fine powder, add beta-schardinger dextrin-and make clathrate, add 3 parts by weight of sucrose and the mixing of 1 weight portion dextrin again, add 85% ethanol and make soft material and cross a sieve, granule processed, 60 DEG C of oven dry, granulate, obtains 1000 grams.After the sterilizing of epoxy hexane, place 7-10 days, be distributed into bag (15g/ bag) after the assay was approved, obtain final product.
Usage and dosage: oral, a 1-2 bag, one day 2-3 time.
My seminar of institute is in differential diagnosis in tcm theoretical basis, and in conjunction with pharmacological research in modern age, Chinese medicine and stomach and alleviating pain granule solve this problem, and for hyperactive liver-QI attacking the stomach, phlegm-damp internal resistance type stomachache serves good therapeutic effect.We are made up of medicines such as the Rhizoma Pinelliae, Cortex Magnoliae Officinalis(processed with ginger), Fructus Evodiae, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, Herba Taraxaci, Endoconcha Sepiae, Radix Rhodiolae, Herba Cistanches, the Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Folium Perillae, the Radix Linderae, Bulbus Fritillariae Thunbergii, Caulis Perillae, finger citron sliced, Concha Arcae (calcined), Radix Glycyrrhizaes, there is dispersing the stagnated liver-QI for regulating the stomach, effect of activating QI to eliminate phlegm, safe and effective through clinical verification.
Clinical data
All cases all meets " the tcm internal medicine gastropathy Illnesses Diagnoses standard " that State Administration of Traditional Chinese Medicine formulates.Treatment group 100 example is all stomach neurosis, acute or chronic gastritis and Peptic Ulcers, male example 63 example, female 37 example, 25 ~ 55 years old age, average 36.8 years old, the course of disease 2 first quarter moon sky ~ 12 year, average 4 ~ 5 years.Clinical manifestation is gastral cavity feeling of distension and oppression pain in various degree, belch, noisy acid regurgitation, being irritable and getting angry easily.Syndrome Differentiation of Traditional Chinese Medicine is hyperactive liver-QI attacking the stomach, phlegm-damp internal resistance type, and disease is seen: epigastric distension and distress pain, belch, noisy acid regurgitation, being irritable and getting angry easily, red tongue with thin and yellow fur, wiry and frequent pulse.Matched group 100 example, at the age, sex, symptom, the aspects such as sign, without significant difference, have comparability (P > 0.05) with treatment group (100 example).
Therapeutic Method
Treatment group is used and stomach and alleviating pain granule, oral: a 1-2 bag, one day 2-3 time, warm water is taken after dissolving.
Matched group omeprazole adds amoxicillin, omeprazole: oral, 20mg (a time 1), 1 ~ 2 time on the one.Rise morning every day swallow or sooner or later each once, amoxicillin: oral, people 0.5g, every 6 ~ 8 hours 1 time, a daily dose is no more than 4g.Equal 7 days is a course for the treatment of.
Criterion of therapeutical effect and result
Main detection epigastric distension and distress pain, belch, noisy acid regurgitation, the cardinal symptoms such as being irritable and getting angry easily, by light, in, score as parameters for observation on effect heavily respectively.1 course for the treatment of is observed patients clinical performance in two groups of medications again, and carries out training inspection, according in " People's Republic of China's traditional Chinese medical science industry standard ", evaluates about traditional Chinese medical science stomach section disease criterion of therapeutical effect, according to its integration, be divided into effective, take a turn for the better, invalid 3 kinds.
Treatment group 100 example, effective 83 examples (83 ﹪), 14 examples that take a turn for the better (14 ﹪), invalid 3 examples (3 ﹪), total effective rate is 97 ﹪.
Matched group 100 example, effective 63 examples (63 ﹪), 19 examples that take a turn for the better (19 ﹪), invalid 18 examples (18 ﹪), total effective rate is 82 ﹪.
Compare for two groups, total effective rate has significant difference (P < 0.01), over the course for the treatment of, finds no toxic and side effects, and anaphylaxis.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.

Claims (2)

1. one kind and stomach and alleviating pain granule, it is characterized in that, comprise following component by weight: Fructus Evodiae 2-3 weight portion, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice 6-8 weight portion, Rhizoma Pinelliae 6-8 weight portion, Cortex Magnoliae Officinalis(processed with ginger) 6-8 weight portion, Herba Taraxaci 3-5 weight portion, Endoconcha Sepiae 3-5 weight portion, Radix Rhodiolae 3-5 weight portion, Herba Cistanches 3-5 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-5 weight portion, Poria 3-5 weight portion, Radix Linderae 3-5 weight portion, Bulbus Fritillariae Thunbergii 3-5 weight portion, Caulis Perillae 3-5 weight portion, finger citron sliced 3-5 weight portion, Concha Arcae (calcined) 6-8 weight portion, Radix Glycyrrhizae 2-3 weight portion.
2. described in a claim 1 and the preparation method of stomach and alleviating pain granule, it is characterized in that, comprise the following steps: (1) takes each medicine according to prescription, get Fructus Evodiae, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, the Radix Linderae, Herba Cistanches, Bulbus Fritillariae Thunbergii be ground into coarse powder, extract secondary with 5-6 times of weight portion 50% alcohol heating reflux, each 1 hour, filter, merging filtrate, reclaim ethanol and be condensed into thick paste, medicinal residues are for subsequent use;
(2) Caulis Perillae, Fructus Citri Sarcodactylis add 6-8 times of weight parts water, soak 2 hours, distillation extraction 1.5-2 hour, and collect volatile oil, add appropriate beta-schardinger dextrin-and make clathrate, the medicinal residues after distillation and debris are separately deposited;
(3) medicinal residues of step 1, step 2 and the Rhizoma Pinelliae, Cortex Magnoliae Officinalis(processed with ginger), Herba Taraxaci, Endoconcha Sepiae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Poria, Concha Arcae (calcined), Radix Glycyrrhizae are added 6-8 times of weight parts water, soak 2 hours, decoct twice, 2 hours first times, second time 1 hour, collecting decoction, adding 95% ethanol, to be adjusted to concentration of alcohol be 45%-55%, places 24 hours, filters and to obtain alcohol precipitation, decompression recycling ethanol, being concentrated into relative density is 1.25-1.35(60 DEG C) thick paste;
(4) thick paste of step 3 and step 1 thick paste are merged, be dried and crushed into fine powder, add beta-schardinger dextrin-and make clathrate, add 3 parts by weight of sucrose and the mixing of 1 weight portion dextrin again, add 85% ethanol and make soft material and cross a sieve, granule processed, 60 DEG C of oven dry, granulate, obtains 1000 grams;
After the sterilizing of epoxy hexane, place 7-10 days, be distributed into bag (15g/ bag) after the assay was approved, obtain final product.
CN201610067923.8A 2016-02-01 2016-02-01 Stomach harmonizing and pain relieving granule and preparation method thereof Pending CN105535511A (en)

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CN106038887A (en) * 2016-07-05 2016-10-26 山西忻州兴华皮肤病专科医院 Traditional Chinese medicine for treating stomach disease with middle-jiao cold and dampness and upper-jiao fire syndrome
US11083764B1 (en) * 2020-09-21 2021-08-10 Babry Oren Pharmaceutical composition based on plant raw materials
CN116211953A (en) * 2023-02-09 2023-06-06 北京中医药大学东方医院 Traditional Chinese medicine composition for treating upper abdominal pain syndrome, preparation method and application

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CN102579846A (en) * 2012-03-09 2012-07-18 广西强寿药业集团有限公司 Chinese patent medicament wind-calming and pain-relieving granules for treating migraine and preparation method thereof
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Cited By (3)

* Cited by examiner, † Cited by third party
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CN106038887A (en) * 2016-07-05 2016-10-26 山西忻州兴华皮肤病专科医院 Traditional Chinese medicine for treating stomach disease with middle-jiao cold and dampness and upper-jiao fire syndrome
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CN116211953A (en) * 2023-02-09 2023-06-06 北京中医药大学东方医院 Traditional Chinese medicine composition for treating upper abdominal pain syndrome, preparation method and application

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