CN102579846A - Chinese patent medicament wind-calming and pain-relieving granules for treating migraine and preparation method thereof - Google Patents
Chinese patent medicament wind-calming and pain-relieving granules for treating migraine and preparation method thereof Download PDFInfo
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Abstract
The invention provides Chinese patent medicament wind-calming and pain-relieving granules for treating migraine and a preparation method thereof. The granules are prepared by finishing Chinese angelica, hemlock parsley, white peony root, gastrodia elata, dahurian angelica root, paniculate swallowwort root, corydalis tuber and rhizoma cyperi. In the prescription, the Chinese angelica, the hemlock parsley, the dahurian angelica root and the corydalis tuber are common Chinese medicaments for treating migraine, and years of application prove that the granules have an excellent curative effect. The whole prescription of the granules has effects of activating blood, removing wind and relieving pains. The wind-calming and pain-relieving granules are suitable for patients with stubborn migraine, and have the characteristics of convenience for administration, reasonable administration route, high bioavailability, stable product quality and the like. The preparation method is easy and practical.
Description
One, technical field:
The present invention relates to a kind of Chinese patent medicine granule and preparation method thereof, the migrainous Chinese patent medicine of particularly a kind of treatment-endogenous wind stopping pain relieving granule and preparation method thereof.
Two, background technology:
Migraine is a kind of common disease of nervous system, and in general crowd, this sick sickness rate is 5%.The women is slightly more than the male.Migraine is that a kind of ictal head portion vasomotoricity instability adds the headache that the temporary change of some humoral substance causes.Still not fully aware of to migrainous pathogenesis at present, but migraine influences people's orthobiosis and work.
The migrainous medicine of treatment has products such as ZHENGTIAN WAN, Toutongning capsule for headache, YANGXUE QINGNAO KELI, ibuprofen class now.Treat migraine at present in the world and still do not have special means and medicine.
Three, summary of the invention:
The object of the invention, be a kind of compatibility of invention proper, have invigorate blood circulation, dispel the wind, analgesic effect and can give full play to the migrainous Chinese patent medicine of treatment-endogenous wind stopping pain relieving granule of drug effect and preparation method thereof.
The present invention treats migrainous Chinese patent medicine-endogenous wind stopping pain relieving granule; Mainly be by Radix Angelicae Sinensis 266-400g, Rhizoma Chuanxiong 214-320g, Radix Paeoniae Alba 266-400g, Rhizoma Gastrodiae 160-240g, Radix Angelicae Dahuricae 266-400g, Radix Cynanchi Paniculati 214-320g, Rhizoma Corydalis 266-400g, Rhizoma Cyperi 214-320g, process the 800-1200g granule through polish.
The optimum weight of each main component is during preparation 1000g granule: Radix Angelicae Sinensis 333g, Rhizoma Chuanxiong 267g, Radix Paeoniae Alba 333g, Rhizoma Gastrodiae 200g, Radix Angelicae Dahuricae 333g, Radix Cynanchi Paniculati 267g, Rhizoma Corydalis 333g, Rhizoma Cyperi 267g.
We adopt the Chinese medicine of nourishing blood for calming endogenous wind, promoting blood circulation to remove obstruction in the collateral according to the medication characteristics of Chinese medicine, make migraine " stagnation of QI and blood may bring about pain " replacement " general rule is not bitterly ", reach the migrainous purpose of radical cure.Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Rhizoma Corydalis are treatment wind syndrome of head headache conventional Chinese medicines in the side, through utilization for many years, migraine are had good efficacy.Full side all invigorates blood circulation, dispels the wind, the analgesic effect.Be applicable to the prolonged patient of not healing of headache.
The present invention treats migrainous Chinese patent medicine-particulate method for preparing of endogenous wind stopping pain relieving, and its key step is:
(1) it is subsequent use the five tastes such as Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cynanchi Paniculati, Rhizoma Cyperi to be extracted volatile oil with vapor distillation, and the aqueous solution after distillation device is in addition collected;
(2) three flavors such as the Radix Paeoniae Alba, Rhizoma Gastrodiae, Rhizoma Corydalis add an amount of heating and refluxing extraction secondary of 60% alcoholic solution, and each 3 hours, merge extractive liquid,, subsequent use;
(3) medicinal residues of (2) and the medicinal residues after (1) distillation are merged decocte with water secondary, 10 times of water, 8 times of water for the second time for the first time; Each 1.5 hours, filter, the aqueous solution after filtrating and the above-mentioned distillation merges, and being concentrated into relative density is the clear paste of 1.10～1.13 (80 ℃); Add ethanol and make and contain alcohol amount to 60%, left standstill 24 hours, get supernatant and filter, filtrating merges with the reflux extracting liquid of (2); Reclaim ethanol and be concentrated into the thick paste that relative density is 1.38～1.40 (80 ℃), drying is ground into fine powder;
(4) get beta-schardinger dextrin-in addition, add 12.5 times of water gagings, heating makes dissolving, is cooled to 40 ℃; Process saturated aqueous solution, the volatile oil of getting (1) adds a small amount of dehydrated alcohol dilution, is added drop-wise in the beta-schardinger dextrin-saturated aqueous solution by 1: 100, processes inclusion complex; Leave standstill, filter, drying, subsequent use;
(5) get the dried cream fine powder of (3), add the capacity dextrin, granulate in right amount with 90% ethanol, drying adds the inclusion complex that (4) make, and mixing promptly gets and treats migrainous Chinese patent medicine-endogenous wind stopping pain relieving granule.
Endogenous wind stopping pain relieving granule result of study is following:
1, pharmacodynamic study
Pharmacodynamic study shows that endogenous wind stopping pain relieving granule has the reaction of the mouse writhing of inhibition, improves the mice hot plate threshold of pain and the rat radiant heat threshold of pain, points out these article to have analgesic activity; Endogenous wind stopping pain relieving granule has the mice of improvement meninges microcirculation, rat brain RBF and improves the rat WBV, points out these article to have the microcirculation improvement effect; (the blood plasma PGE is penetrated, improved to β-EP) and neuropeptide tyrosine (NPY) generation to improve 5-hydroxy tryptamine (5-HT) in the mouse brain, beta-endorphin
2(PGE
2) level, point out the analgesic activity of these article maybe be relevant with neurotransmitter in the brain.
Migrainous pathogenesis is not illustrated so far as yet fully, discovers that entocranial artery shrinks, cerebral blood flow descends, and is the main pathological manifestations of migraine tendency phase.The particulate analgesic activity of endogenous wind stopping pain relieving, its influence to cerebrovascular, cerebral blood flow and neurotransmitter metabolism are observed in this test emphatically.
Result of study shows that these article can suppress the mouse writhing reaction, improve the mice hot plate threshold of pain and the rat radiant heat threshold of pain; Improve mice meninges microcirculation, rat brain RBF and reduce the rat WBV; Increase 5-HT in the mouse brain, β-EP and reduce NPY level, raising blood plasma PGE
2Level.These article of prompting have analgesia, improve the effect of neurotransmitter in brain microcirculation and the adjusting brain, can be used for migraine.
2, long term toxicity test
Test period: the long term toxicity test administration time is 6 months.Endogenous wind stopping pain relieving granule is given the rat oral gavage administration with 70.2g, 35.1g and 17.55g medical material/kg/d, continuous 6 months, rat generally in order, body weight gain is normal; Hematological examination, blood biochemical are learned inspection and organ coefficient inspection, and difference does not have the significance meaning between administration group and the matched group.The obvious pathological change that causes because of drug toxicity is not seen by the histopathologic examination of main organs.Above results suggest endogenous wind stopping pain relieving granule should be safe by using dosage, approach and the course of treatment of clinical plan usefulness.
3, stability test
Preliminarily stabilised property test of endogenous wind stopping pain relieving granule and accelerated stability were examined three months continuously; And observed the influence of the packaging material that directly contact to stability of drug products with medicine; The character of three lot sample article, discriminating, inspection, assay are all up to specification; Limit test of microbe is up to specification, and promptly result of the test is up to specification.Show these article under clinical application article terms of packing, the test of preliminarily stabilised property and these article of accelerated stability test prompting are stable in two years.
The present invention treats that the full side of migrainous Chinese patent medicine-endogenous wind stopping pain relieving granule all invigorates blood circulation, dispels the wind, the analgesic effect.Be applicable to the prolonged patient of not healing of headache.And method for preparing is simple and easy to do, and medication is convenient, route of administration is reasonable, bioavailability is high, constant product quality.
Four, the specific embodiment:
Embodiment 1
Main component: Radix Angelicae Sinensis 333g, Rhizoma Chuanxiong 267g, Radix Paeoniae Alba 333g, Rhizoma Gastrodiae 200g, Radix Angelicae Dahuricae 333g, Radix Cynanchi Paniculati 267g, Rhizoma Corydalis 333g, Rhizoma Cyperi 267g.
(1) it is subsequent use the five tastes such as Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cynanchi Paniculati, Rhizoma Cyperi to be extracted volatile oil with vapor distillation, and the aqueous solution after distillation device is in addition collected;
(2) three flavors such as the Radix Paeoniae Alba, Rhizoma Gastrodiae, Rhizoma Corydalis add an amount of heating and refluxing extraction secondary of 60% alcoholic solution, and each 3 hours, merge extractive liquid,, subsequent use;
(3) medicinal residues of (2) and the medicinal residues after (1) distillation are merged decocte with water secondary, 10 times of water, 8 times of water for the second time for the first time; Each 1.5 hours, filter, the aqueous solution after filtrating and the above-mentioned distillation merges, and being concentrated into relative density is the clear paste of 1.10～1.13 (80 ℃); Add ethanol and make and contain alcohol amount to 60%, left standstill 24 hours, get supernatant and filter, filtrating merges with the reflux extracting liquid of (2); Reclaim ethanol and be concentrated into the thick paste that relative density is 1.38～1.40 (80 ℃), drying is ground into fine powder;
(4) get beta-schardinger dextrin-in addition, add 12.5 times of water gagings, heating makes dissolving, is cooled to 40 ℃; Process saturated aqueous solution, the volatile oil of getting (1) adds a small amount of dehydrated alcohol dilution, is added drop-wise in the beta-schardinger dextrin-saturated aqueous solution by 1: 100, processes inclusion complex; Leave standstill, filter, drying, subsequent use;
(5) get the dried cream fine powder of (3), add the capacity dextrin, granulate in right amount with 90% ethanol, drying adds the inclusion complex that (4) make, and mixing promptly gets 1000g and treats migrainous Chinese patent medicine-endogenous wind stopping pain relieving granule.
Embodiment 2
Main component: Radix Angelicae Sinensis 266g, Rhizoma Chuanxiong 214g, Radix Paeoniae Alba 266g, Rhizoma Gastrodiae 160g, Radix Angelicae Dahuricae 266g, Radix Cynanchi Paniculati 214g, Rhizoma Corydalis 266g, Rhizoma Cyperi 214g.
(1) it is subsequent use the five tastes such as Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cynanchi Paniculati, Rhizoma Cyperi to be extracted volatile oil with vapor distillation, and the aqueous solution after distillation device is in addition collected;
(2) three flavors such as the Radix Paeoniae Alba, Rhizoma Gastrodiae, Rhizoma Corydalis add an amount of heating and refluxing extraction secondary of 60% alcoholic solution, and each 3 hours, merge extractive liquid,, subsequent use;
(3) medicinal residues of (2) and the medicinal residues after (1) distillation are merged decocte with water secondary, 10 times of water, 8 times of water for the second time for the first time; Each 1.5 hours, filter, the aqueous solution after filtrating and the above-mentioned distillation merges, and being concentrated into relative density is the clear paste of 1.10～1.13 (80 ℃); Add ethanol and make and contain alcohol amount to 60%, left standstill 24 hours, get supernatant and filter, filtrating merges with the reflux extracting liquid of (2); Reclaim ethanol and be concentrated into the thick paste that relative density is 1.38～1.40 (80 ℃), drying is ground into fine powder;
(4) get beta-schardinger dextrin-in addition, add 12.5 times of water gagings, heating makes dissolving, is cooled to 40 ℃; Process saturated aqueous solution, the volatile oil of getting (1) adds a small amount of dehydrated alcohol dilution, is added drop-wise in the beta-schardinger dextrin-saturated aqueous solution by 1: 100, processes inclusion complex; Leave standstill, filter, drying, subsequent use;
(5) get the dried cream fine powder of (3), add the capacity dextrin, granulate in right amount with 90% ethanol, drying adds the inclusion complex that (4) make, and mixing promptly gets 800g and treats migrainous Chinese patent medicine-endogenous wind stopping pain relieving granule.
Embodiment 3
Main component: Radix Angelicae Sinensis 400g, Rhizoma Chuanxiong 320g, Radix Paeoniae Alba 400g, Rhizoma Gastrodiae 240g, Radix Angelicae Dahuricae 400g, Radix Cynanchi Paniculati 320g, Rhizoma Corydalis 400g, Rhizoma Cyperi 320g.
(1) it is subsequent use the five tastes such as Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cynanchi Paniculati, Rhizoma Cyperi to be extracted volatile oil with vapor distillation, and the aqueous solution after distillation device is in addition collected;
(2) three flavors such as the Radix Paeoniae Alba, Rhizoma Gastrodiae, Rhizoma Corydalis add an amount of heating and refluxing extraction secondary of 60% alcoholic solution, and each 3 hours, merge extractive liquid,, subsequent use;
(3) medicinal residues of (2) and the medicinal residues after (1) distillation are merged decocte with water secondary, 10 times of water, 8 times of water for the second time for the first time; Each 1.5 hours, filter, the aqueous solution after filtrating and the above-mentioned distillation merges, and being concentrated into relative density is the clear paste of 1.10～1.13 (80 ℃); Add ethanol and make and contain alcohol amount to 60%, left standstill 24 hours, get supernatant and filter, filtrating merges with the reflux extracting liquid of (2); Reclaim ethanol and be concentrated into the thick paste that relative density is 1.38～1.40 (80 ℃), drying is ground into fine powder;
(4) get beta-schardinger dextrin-in addition, add 12.5 times of water gagings, heating makes dissolving, is cooled to 40 ℃; Process saturated aqueous solution, the volatile oil of getting (1) adds a small amount of dehydrated alcohol dilution, is added drop-wise in the beta-schardinger dextrin-saturated aqueous solution by 1: 100, processes inclusion complex; Leave standstill, filter, drying, subsequent use;
(5) get the dried cream fine powder of (3), add the capacity dextrin, granulate in right amount with 90% ethanol, drying adds the inclusion complex that (4) make, and mixing promptly gets 1200g and treats migrainous Chinese patent medicine-endogenous wind stopping pain relieving granule.
During suitability for industrialized production, can enlarge by proportioning and produce.
Claims (3)
1. treat migrainous Chinese patent medicine-endogenous wind stopping pain relieving granule for one kind; It is characterized in that it mainly is by Radix Angelicae Sinensis 266-400g, Rhizoma Chuanxiong 214-320g, Radix Paeoniae Alba 266-400g, Rhizoma Gastrodiae 160-240g, Radix Angelicae Dahuricae 266-400g, Radix Cynanchi Paniculati 214-320g, Rhizoma Corydalis 266-400g, Rhizoma Cyperi 214-320g, processes the 800-1200g granule through polish.
2. the migrainous Chinese patent medicine of treatment according to claim 1-endogenous wind stopping pain relieving granule, the optimum weight of each main component is when it is characterized in that preparing the 1000g granule: Radix Angelicae Sinensis 333g, Rhizoma Chuanxiong 267g, Radix Paeoniae Alba 333g, Rhizoma Gastrodiae 200g, Radix Angelicae Dahuricae 333g, Radix Cynanchi Paniculati 267g, Rhizoma Corydalis 333g, Rhizoma Cyperi 267g.
3. according to claim 1 or the migrainous Chinese patent medicine of 2 said treatments-particulate method for preparing of endogenous wind stopping pain relieving, it is characterized in that its key step is:
(1) it is subsequent use the five tastes such as Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Radix Cynanchi Paniculati, Rhizoma Cyperi to be extracted volatile oil with vapor distillation, and the aqueous solution after distillation device is in addition collected;
(2) three flavors such as the Radix Paeoniae Alba, Rhizoma Gastrodiae, Rhizoma Corydalis add an amount of heating and refluxing extraction secondary of 60% alcoholic solution, and each 3 hours, merge extractive liquid,, subsequent use;
(3) medicinal residues of (2) and the medicinal residues after (1) distillation are merged decocte with water secondary, 10 times of water, 8 times of water for the second time for the first time; Each 1.5 hours, filter, the aqueous solution after filtrating is distilled with (1) merges, and being concentrated into relative density is the clear paste of 1.10～1.13 (80 ℃); Add ethanol and make and contain alcohol amount to 60%, left standstill 24 hours, get supernatant and filter, filtrating merges with the reflux extracting liquid of (2); Reclaim ethanol and be concentrated into the thick paste that relative density is 1.38～1.40 (80 ℃), drying is ground into fine powder;
(4) get beta-schardinger dextrin-in addition, add 12.5 times of water gagings, heating makes dissolving, is cooled to 40 ℃; Process saturated aqueous solution, the volatile oil of getting (1) adds a small amount of dehydrated alcohol dilution, is added drop-wise in the beta-schardinger dextrin-saturated aqueous solution by 1: 100, processes inclusion complex; Leave standstill, filter, drying, subsequent use;
(5) get the dried cream fine powder of (3), add the capacity dextrin, granulate in right amount with 90% ethanol, drying adds the inclusion complex that (4) make, and mixing promptly gets and treats migrainous Chinese patent medicine-endogenous wind stopping pain relieving granule.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491759A (en) * | 2015-01-15 | 2015-04-08 | 张士红 | Traditional Chinese medicine composition for treating cephalagra and preparation method thereof |
| CN104740183A (en) * | 2015-04-18 | 2015-07-01 | 青岛辰达生物科技有限公司 | Pharmaceutical composition for treating migraine |
| CN105343409A (en) * | 2014-08-21 | 2016-02-24 | 李新民 | Formula for treating migraine |
| CN105535511A (en) * | 2016-02-01 | 2016-05-04 | 胶州市人民中医医院 | Stomach harmonizing and pain relieving granule and preparation method thereof |
Citations (3)
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| CN1943689A (en) * | 2005-10-08 | 2007-04-11 | 刘国飞 | A Chinese traditional medicinal composition for treatment of wind-heat type common cold and its preparation method |
| CN1943708A (en) * | 2005-10-08 | 2007-04-11 | 刘国飞 | A Chinese traditional medicinal composition and its preparation method |
| CN101167817A (en) * | 2007-10-20 | 2008-04-30 | 刘衍 | Traditional Chinese medicine for treating migraine |
-
2012
- 2012-03-09 CN CN 201210061770 patent/CN102579846B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943689A (en) * | 2005-10-08 | 2007-04-11 | 刘国飞 | A Chinese traditional medicinal composition for treatment of wind-heat type common cold and its preparation method |
| CN1943708A (en) * | 2005-10-08 | 2007-04-11 | 刘国飞 | A Chinese traditional medicinal composition and its preparation method |
| CN101167817A (en) * | 2007-10-20 | 2008-04-30 | 刘衍 | Traditional Chinese medicine for treating migraine |
Non-Patent Citations (1)
| Title |
|---|
| 罗涛: "息风止痛颗粒治疗偏头痛（血虚风动证）的临床有效性及安全性观察", 《中国优秀硕士论文全文数据库（医药卫生科技辑）》, no. 5, 31 May 2011 (2011-05-31) * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343409A (en) * | 2014-08-21 | 2016-02-24 | 李新民 | Formula for treating migraine |
| CN104491759A (en) * | 2015-01-15 | 2015-04-08 | 张士红 | Traditional Chinese medicine composition for treating cephalagra and preparation method thereof |
| CN104491759B (en) * | 2015-01-15 | 2017-12-19 | 张士红 | A kind of Chinese medicine composition for treating antimigraine and preparation method thereof |
| CN104740183A (en) * | 2015-04-18 | 2015-07-01 | 青岛辰达生物科技有限公司 | Pharmaceutical composition for treating migraine |
| CN105535511A (en) * | 2016-02-01 | 2016-05-04 | 胶州市人民中医医院 | Stomach harmonizing and pain relieving granule and preparation method thereof |
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