CN113797110A - Anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine and application thereof - Google Patents

Anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine and application thereof Download PDF

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CN113797110A
CN113797110A CN202111271953.8A CN202111271953A CN113797110A CN 113797110 A CN113797110 A CN 113797110A CN 202111271953 A CN202111271953 A CN 202111271953A CN 113797110 A CN113797110 A CN 113797110A
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thiotaurine
parts
aging
tetrahydropyrane triol
hydroxypropyl tetrahydropyrane
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王超
陈琳
何珂
周正
郭苗
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Hubei Maishite Biotechnology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
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    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
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    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract

The invention discloses an anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine and application thereof. According to the weight parts, the anti-aging composition comprises 0.1-20 parts of hydroxypropyl tetrahydropyrane triol, 0.1-15 parts of thiotaurine, 0.1-10 parts of glycerol glucoside, 10-30 parts of butanediol and 20-80 parts of deionized water. The anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine can be applied to various skin care formulations such as essence water, essence liquid, emulsion, cream and the like. The anti-aging composition has complementary action mechanisms, and has the anti-aging effects of promoting collagen synthesis, enhancing skin barrier, resisting oxidation and promoting cell regeneration activity by combined application.

Description

Anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine and application thereof
Technical Field
The invention relates to a skin care product and application thereof, belongs to the technical field of daily chemicals, and particularly relates to an anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine and application thereof in the skin care product.
Background
Ancient emperors have acquired 'longevity-promoting and non-aging medicines', and at present, various health care products exist, which are declared to 'keep youth forever and prolong life', and the pursuit of people for youth and longevity is invariable despite the change of times. With the advancement of medical standards and the improvement of living conditions, the life of people is longer and longer in modern society, but there is always an upper limit. Biologically, aging is a spontaneous inevitable process of living things over time, and is a complex natural phenomenon, which is manifested by degeneration of structure and functional decline, and decline of adaptability and resistance, among which aging of skin is most obvious, skin loses elasticity, and obvious wrinkles appear. Aging is an irreversible process, however, we can slow aging by several methods, such as topical anti-aging cosmetics. The general principle of action of anti-aging products is to bring the balance of skin regeneration and degeneration to a normal state, i.e., to increase collagen and elastin synthesis.
There are currently literature summarizing the appearance of skin aging in the epidermis, dermoepidermal junction (DEJ) and dermis, the aging mechanism, and the overall anti-aging pathway. Skin aging occurs from hydration, barrier function, oxidation, DNA damage and repair, energy production, oxygenation, immunity, pigmentation, keratinization of the epidermis, skin aging at the junction of the dermis and epidermis, inflammation of the dermis, microcirculation, and the like.
The existing anti-aging products can only act on one or more anti-aging factors, the anti-aging effect is not particularly obvious, the composition is complex, and the cost is high, so that the search for a composition which has simple components, can play a comprehensive anti-aging role and has a good anti-aging effect is necessary.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides an anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine.
The invention also aims to provide a preparation method of the anti-aging composition containing the hydroxypropyl tetrahydropyrane triol and the thiotaurine, which has the advantages of simple preparation method, production time saving, capability of keeping the stability of active ingredients in the preparation process and obvious anti-aging and wrinkle-removing effects.
The invention further aims to provide application of the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine in skin care products.
The technical scheme adopted by the invention is as follows:
an anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine comprises the following raw materials in parts by weight:
0.1-20 parts by weight of hydroxypropyl tetrahydropyrane triol;
0.1-15 parts of thiotaurine;
0.1-10 parts of glycerol glucoside;
10-30 parts of butanediol;
20-80 parts of deionized water.
Further, the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine is characterized by comprising the following raw materials in parts by weight:
1-10 parts of hydroxypropyl tetrahydropyrane triol;
1-15 parts of thiotaurine;
1-8 parts of glycerol glucoside;
10-20 parts of butanediol;
40-70 parts of deionized water.
In addition, the invention also discloses a preparation method of the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine, which comprises the following steps:
1) dissolving hydroxypropyl tetrahydropyrane triol and butanediol in deionized water, and uniformly stirring to prepare a hydroxypropyl tetrahydropyrane triol solution, namely a component A;
2) and (3) sequentially adding thiotaurine, glycerol glucoside and the component A into deionized water, and uniformly stirring to obtain the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine.
Further, in the step 1), the stirring speed is 20-80r/min, and in the step 2), the stirring speed is 30-100 r/min.
Further, in the step 2), the mass ratio of the total mass of the 3 raw materials of the hydroxypropyl tetrahydropyrane triol, the thiotaurine and the glycerol glucoside to the mass of the water is 1: 0.5-2.5.
Further, in the step 2), the mass ratio of the total mass of the 3 raw materials of the hydroxypropyl tetrahydropyrane triol, the thiotaurine and the glycerol glucoside to the mass of the water is 1: 2.4.
An anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine is applied to a skin care product, and the skin care product contains 10-40% of the anti-aging composition according to the total weight of the skin care product; and 60-90% of conventional auxiliary materials in the field of skin care products.
Further, the conventional auxiliary materials comprise a surfactant, a thickening agent, a conditioning agent, a humectant, a preservative, a chelating agent, essence and deionized water.
Further, the skin care product is prepared into various dosage forms of toner, smoothing toner, firming toner, nourishing cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, facial mask, pressed powder, body lotion, body cream, body oil, body lotion and body essence.
Further, the skin care product is prepared into anti-aging wrinkle-lightening essence which comprises the following raw material components:
Figure BDA0003328262900000031
the anti-aging wrinkle-lightening essence is prepared by the following steps:
1) mixing deionized water, sodium hyaluronate, xanthan gum and allantoin raw materials, heating at 85 deg.C for 30min, and stirring at 50r/min for 10min to obtain phase A raw material;
2) cooling the phase A raw material to below 40 ℃, adding an anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine, an oat extract and a preservative into the phase A raw material, stirring the mixture for 5min at a speed of 70r/min, cooling the mixture to below 35 ℃, and subpackaging the mixture to obtain the anti-aging wrinkle-lightening essence.
The antiseptic is selected from polyols such as hexanediol and phenoxyethanol.
Compared with the prior art, the invention has the beneficial effects that:
1) the anti-aging composition provided by the invention simultaneously contains hydroxypropyl tetrahydropyrane triol, thiotaurine, glycerol glucoside and the like, the action mechanisms of the hydroxypropyl tetrahydropyrane triol, the thiotaurine, the glycerol glucoside and the like are complementary, and the anti-aging and wrinkle-removing effects of the anti-aging composition are better when the anti-aging composition is combined.
2) The anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine provided by the invention has the advantages of simple preparation method, production time saving, capability of keeping the stability of active ingredients in the preparation process and obvious anti-aging and wrinkle-removing effects.
3) The invention is safe and non-irritant, and is easy to be added into the formulation systems of various formulations of cosmetics, thereby having important practical significance and wide market prospect.
Drawings
FIG. 1 is a production process of glycerol glucoside in the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine provided by the invention.
Fig. 2 is a graph showing wrinkle improvement effects of the anti-wrinkle essence obtained in example 1 according to the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
The invention discloses an anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine, which is prepared by combining hydroxypropyl tetrahydropyrane triol, thiotaurine, glycerol glucoside and butanediol serving as raw materials according to a proper weight ratio.
The technical effects of the raw material components are described below.
(iii) hydroxypropyl Tetrahydropyranetriol
Hydroxypropyl tetrahydropyrane triol, a xylose derivative derived from western european beech wood, was an anti-aging active ingredient first developed by the lancome laboratory, has the efficacy of promoting the synthesis of collagen and glycosaminoglycan, and helps the dermis maintain elasticity by targeting at the junction DEJ of the epidermis and the dermis.
②thiotaurine
The thiotaurine is an endogenous substance derived from deep-sea hydrothermal-jet mussels, cystoceles and tubificans, can resist pollution to skin stratum corneum damage, and enhances the skin barrier function. The thiotaurine can effectively increase the content of reduced GSH in vivo, capture free radicals and strengthen the antioxidant system in vivo. Has excellent oxidation resistance in human body, and also has the effects of detoxification, anti-inflammation and repair.
③ Glycerol glucoside
The glycerol glucoside can effectively lock water and preserve moisture, improve the expression of aquaporins, increase the transdermal absorption of epidermis, promote the cell regeneration activity, delay cell aging and slow down aging. The glyceroglucoside also has the physiological effects of promoting wound healing, tissue repair and the like. The biotransformation process for the production of glycerol glucoside is shown in FIG. 1.
The anti-aging composition containing the hydroxypropyl tetrahydropyrane triol and the thiotaurine finally prepared has the effects of promoting collagen synthesis, enhancing skin barrier, resisting oxidation and promoting cell regeneration activity by virtue of different action mechanisms of the components, the enhancement of the permeability of the anti-aging composition containing the hydroxypropyl tetrahydropyrane triol and the thiotaurine by virtue of the cooperation of the components and the synergistic effect of the components.
In the following examples, the unit of parts by weight may be g or kg.
All the raw material components of the invention are commercial products. Hydroxypropyl tetrahydropyran triol is available from shanghai ketjen technologies ltd; thiotaurine was purchased from shanghai shinwen biotechnology limited; the glycerol glucoside is purchased from Kazuku scientific Biotech development Co., Ltd in Qingdao; oat extract was purchased from demi. The glycerol glucoside is obtained by obtaining hypotonic extract rich in GG through blue algae, membrane filtration for decolorization, resin adsorption for decolorization, membrane filtration for desalination, and finally dehydration and concentration.
Example 1
The embodiment provides an anti-aging wrinkle-lightening essence which comprises the following raw material components in parts by weight:
57.4 parts by weight of deionized water;
40 parts by weight of an anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine;
0.15 part by weight of sodium hyaluronate;
0.15 part by weight of xanthan gum;
0.3 part by weight of allantoin;
1 part by weight of oat extract;
1 part by weight of phenoxyethanol;
the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine comprises the following raw material components:
10 parts by weight of hydroxypropyl tetrahydropyrane triol;
10 parts of thiotaurine;
5 parts of glycerol glucoside;
15 parts of butanediol;
60 parts of deionized water;
the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine is prepared by the following method:
1) dissolving hydroxypropyl tetrahydropyrane triol and butanediol in deionized water, and uniformly stirring at the stirring speed of 50r/min to prepare a hydroxypropyl tetrahydropyrane triol solution, namely a component A;
2) and (3) sequentially adding thiotaurine, glycerol glucoside and the component A into deionized water, and uniformly stirring at the stirring speed of 40r/min to obtain the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine.
The preparation method of the anti-aging wrinkle-lightening essence comprises the following steps:
1) mixing deionized water, sodium hyaluronate, xanthan gum and allantoin raw materials, heating at 85 deg.C for 30min, and stirring at 50r/min for 10min to obtain phase A raw material;
2) cooling the phase A raw material to below 40 ℃, adding an anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine, an oat extract and a preservative into the phase A raw material, stirring the mixture for 5min at a speed of 70r/min, cooling the mixture to below 35 ℃, and subpackaging the mixture to obtain the anti-aging wrinkle-lightening essence.
Example 2
The embodiment provides an anti-aging wrinkle-lightening essence which comprises the following raw material components in parts by weight:
67.4 parts by weight of deionized water;
30 parts by weight of an anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine;
0.15 part by weight of sodium hyaluronate;
0.15 part by weight of xanthan gum;
0.3 part by weight of allantoin;
1 part by weight of oat extract;
1 part by weight of phenoxyethanol;
the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine comprises the following raw material components:
10 parts by weight of hydroxypropyl tetrahydropyrane triol;
10 parts of thiotaurine;
5 parts of glycerol glucoside;
15 parts of butanediol;
60 parts of deionized water;
the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine is prepared by the following method:
1) dissolving hydroxypropyl tetrahydropyrane triol and butanediol in deionized water, and uniformly stirring at the stirring speed of 50r/min to prepare a hydroxypropyl tetrahydropyrane triol solution, namely a component A;
2) and (3) sequentially adding thiotaurine, glycerol glucoside and the component A into deionized water, and uniformly stirring at the stirring speed of 40r/min to obtain the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine.
The preparation method of the anti-aging wrinkle-lightening essence comprises the following steps:
1) mixing deionized water, sodium hyaluronate, xanthan gum and allantoin raw materials, heating at 85 deg.C for 30min, and stirring at 50r/min for 10min to obtain phase A raw material;
2) cooling the phase A raw material to below 40 ℃, adding an anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine, an oat extract and a preservative into the phase A raw material, stirring the mixture for 5min at a speed of 70r/min, cooling the mixture to below 35 ℃, and subpackaging the mixture to obtain the anti-aging wrinkle-lightening essence.
Example 3
The embodiment provides an anti-aging wrinkle-lightening essence which comprises the following raw material components in parts by weight:
87.4 parts by weight of deionized water;
10 parts by weight of an anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine;
0.15 part by weight of sodium hyaluronate;
0.15 part by weight of xanthan gum;
0.3 part by weight of allantoin;
1 part by weight of oat extract;
1 part by weight of hexanediol;
the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine comprises the following raw material components:
10 parts by weight of hydroxypropyl tetrahydropyrane triol;
10 parts of thiotaurine;
5 parts of glycerol glucoside;
15 parts of butanediol;
60 parts of deionized water;
the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine is prepared by the following method:
1) dissolving hydroxypropyl tetrahydropyrane triol and butanediol in deionized water, and uniformly stirring at the stirring speed of 50r/min to prepare a hydroxypropyl tetrahydropyrane triol solution, namely a component A;
2) and (3) sequentially adding thiotaurine, glycerol glucoside and the component A into deionized water, and uniformly stirring at the stirring speed of 40r/min to obtain the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine.
The preparation method of the anti-aging wrinkle-lightening essence comprises the following steps:
1) mixing deionized water, sodium hyaluronate, xanthan gum and allantoin raw materials, heating at 85 deg.C for 30min, and stirring at 50r/min for 10min to obtain phase A raw material;
2) cooling the phase A raw material to below 40 ℃, adding an anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine, an oat extract and a preservative into the phase A raw material, stirring the mixture for 5min at a speed of 70r/min, cooling the mixture to below 35 ℃, and subpackaging the mixture to obtain the anti-aging wrinkle-lightening essence.
Blank example 1
The blank example 1 is different from the example 1 only in the raw material components of the anti-wrinkle essence, the anti-wrinkle essence in the blank example 1 does not contain the anti-aging composition of hydroxypropyl tetrahydropyrane triol and thiotaurine, and the other operations are the same as those in the example 1.
Test example for Effect verification
First, safety test-Patch test
Test subjects: the anti-aging wrinkle-lightening essence obtained in examples 1-3 and the anti-aging wrinkle-lightening essence obtained in blank example 1.
The number of the tested persons is as follows: 150, male and female halves, and the age between 20 and 55 years, all meet the subject criteria.
The test process comprises the following steps: the test population of 150 persons meeting the standard of the test subjects is randomly divided into 5 groups, and the groups respectively correspond to the anti-aging wrinkle essence obtained in the examples 1-3, the anti-aging wrinkle essence obtained in the blank example 1 and a control group of 30 persons in each group of the test subjects; respectively placing the anti-aging and wrinkle-lightening essence in the test object into the small chambers of the spot tester, wherein the dosage is about 0.020mL-0.025mL, and no substance is placed in the control holes; the spot tester with the test substance is applied to the back or the forearm curvature of the subject with hypoallergenic tape (manufacturer: Shanghai medical apparatus and instruments (group) Co., Ltd., hygienic materials factory, product number of spot test tape: 09000251116), and is applied to the skin with palm gently for 24 h; skin reactions were observed at 30min, 24h, and 48h after removal of the test article blotter according to the criteria shown in table 1 and the observations were recorded, with the ranking criteria shown in table 1 and the test results shown in table 2.
TABLE 1 skin occlusion Patch test skin response grading Standard
Figure BDA0003328262900000091
TABLE 2 test results of the skin patches on human body of examples 1-3 and blank example 1 of the present invention
Figure BDA0003328262900000092
As can be seen from Table 2, the anti-aging wrinkle-lightening essence obtained in examples 1-3 and blank example 1 of the present invention is non-irritating to the skin.
Second, efficacy test
Test subjects: the antiaging composition of example 1 contains hydroxypropyl tetrahydropyrane triol and thiotaurine. The anti-aging wrinkle-lightening essence obtained in examples 1-3 and the anti-aging wrinkle-lightening essence obtained in blank example 1.
1) Percent oxygen radical inhibition test
The photon energy of ultraviolet rays is absorbed by atoms or molecules of cells, causing the state of the electronic energy level of the atoms to change, generating a large amount of free radicals, which can hinder the normal development of the cells, interfere with the metabolism of the cells, destroy mitochondria in the cells, and the like.
The test method comprises the following steps: using Organotypical skin model
Figure BDA0003328262900000101
The skin model is pretreated by the anti-aging wrinkle-lightening essence of the invention, Ve and Vc are control groups, and ultraviolet irradiation with different intensities (0-30 mJ/cm)2UVB intensity), the percent oxygen radical inhibition was measured and the results are shown in table 3.
TABLE 3 test results
Figure BDA0003328262900000102
As can be seen from Table 3, the anti-aging wrinkle-lightening essence obtained in examples 1-3 of the invention is effective in resisting oxidation; the anti-aging wrinkle-lightening essence obtained in the blank example 1 has weak oxidation resistance. The anti-aging composition containing the hydroxypropyl tetrahydropyrane triol and the thiotaurine can effectively resist oxidation.
2) Experiment for promoting proliferation of human keratinocyte (hacat cell)
When people study body aging and skin aging, people mostly stress the aging of skin fibroblasts. In recent years, it has been gradually recognized that keratinocytes also play a very important role in skin aging. With age, skin aging is manifested by a slowing of epidermal turnover, a diminished barrier function, and a diminished keratinocyte viability.
The test method comprises the following steps: establishing a keratinocyte in-vitro cytology model, culturing Hacat cells in a 24-well plate, adding 0.1 percent, 0.3 percent and 0.5 percent of the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and polypeptide protein in example 1, and adding hoechst3342 nucleic acid dye after 24 hours. Incubate for 15 minutes and then take pictures. The results are shown in Table 4.
TABLE 4 test results
Figure BDA0003328262900000111
As can be seen from table 4, 0.1%, 0.3%, 0.5% of the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine obtained in example 1 of the present invention can effectively promote the proliferation of hacat cells and promote cell regeneration activity.
Third, synergistic Experimental example
Comparative examples 1 to 6
The proportion of the raw materials of comparative examples 1-6 of the anti-aging wrinkle-lightening essence is shown in the following table 5.
TABLE 5 raw material composition ratio (% by weight) of comparative examples 1 to 6
Figure BDA0003328262900000112
Figure BDA0003328262900000121
The preparation process was as described in example 1 above.
The anti-wrinkle effect test was performed on example 1 and comparative examples 1 to 6, and the test results after one month are shown in table 4.
TABLE 6 test results
Figure BDA0003328262900000122
As can be seen from the test data in Table 6, the anti-wrinkle effect is ranked as example 1> comparative examples 4, 5, 6> comparative examples 1, 2, 3, and it is demonstrated that the composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine has better anti-wrinkle effect than the composition containing one or two components alone through the synergistic effect between the components.
Third, human body trial evaluation experiment
Test subjects: the anti-aging wrinkle-lightening essence obtained in examples 1-3 and the anti-aging wrinkle-lightening essence obtained in blank example 1. The essence is adopted for testing: the test persons are 100 persons, each group of 25 persons is numbered 1-25, and the test persons are used for 2 times in 1 day for 3 weeks continuously. Filling a trial effect evaluation table according to the sensory evaluation (a volunteer evaluation scoring system is adopted, wherein the highest score is 2 to indicate satisfaction, the highest score is 1 to indicate generality, and the highest score is 0 to indicate dissatisfaction). The wrinkle, tightness, speckle and skin stability maintaining effects are measured by a skin detector, specifically a Visia skin detector. Experimental results statistics of human trial evaluation results are shown in table 7.
TABLE 7 test results
Figure BDA0003328262900000123
Figure BDA0003328262900000131
As can be seen from the test data in table 7, the anti-wrinkle essence obtained in examples 1 to 3 of the present invention can effectively lighten wrinkles, improve skin elasticity, reduce spots, and enhance skin barrier, and has an effect superior to that of the anti-wrinkle essence of blank example 1. The wrinkle-improving effect of the anti-wrinkle essence obtained in example 1 is shown in fig. 2.
In conclusion, the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine disclosed by the invention can promote collagen synthesis, enhance skin barrier, resist oxidation, promote cell regeneration activity and fade skin wrinkles.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims (10)

1. An anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine is characterized in that: the anti-aging composition comprises the following raw material components in parts by weight:
0.1-20 parts by weight of hydroxypropyl tetrahydropyrane triol;
0.1-15 parts of thiotaurine;
0.1-10 parts of glycerol glucoside;
10-30 parts of butanediol;
20-80 parts of deionized water.
2. The anti-aging composition comprising hydroxypropyl tetrahydropyrane triol and thiotaurine according to claim 1, characterized in that: the anti-aging composition comprises the following raw material components in parts by weight:
1-10 parts of hydroxypropyl tetrahydropyrane triol;
1-15 parts of thiotaurine;
1-8 parts of glycerol glucoside;
10-20 parts of butanediol;
40-70 parts of deionized water.
3. The method for preparing an antiaging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine as set forth in claim 1 or 2, characterized by comprising the steps of:
1) dissolving hydroxypropyl tetrahydropyrane triol and butanediol in deionized water, and uniformly stirring to prepare a hydroxypropyl tetrahydropyrane triol solution, namely a component A;
2) and (3) sequentially adding thiotaurine, glycerol glucoside and the component A into deionized water, and uniformly stirring to obtain the anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine.
4. The production method according to claim 3, characterized in that: in the step 1), the stirring speed is 20-80r/min, and in the step 2), the stirring speed is 30-100 r/min.
5. The production method according to claim 3, characterized in that: in the step 2), the mass ratio of the total mass of the 3 raw materials of the hydroxypropyl tetrahydropyrane triol, the thiotaurine and the glycerol glucoside to the mass of the water is 1: 0.5-2.5.
6. The method of claim 5, wherein: in the step 2), the mass ratio of the total mass of the 3 raw materials of the hydroxypropyl tetrahydropyrane triol, the thiotaurine and the glycerol glucoside to the mass of the water is 1: 2.4.
7. Use of an anti-aging composition comprising hydroxypropyl tetrahydropyrane triol and thiotaurine according to claim 1 or 2 in skin care products, characterized in that: the skin care product comprises 10-40% of the anti-aging composition by total weight of the skin care product; and 60-90% of conventional auxiliary materials in the field of skin care products.
8. The use of an anti-aging composition comprising hydroxypropyl tetrahydropyrane triol and thiotaurine according to claim 7 in a skin care product, wherein:
the conventional auxiliary materials comprise a surfactant, a thickening agent, a conditioning agent, a humectant, a preservative, a chelating agent, essence and deionized water.
9. The use of an anti-aging composition comprising hydroxypropyl tetrahydropyrane triol and thiotaurine according to claim 7 in a skin care product, wherein:
the skin care product is prepared into various dosage forms of toner, smoothing toner, firming toner, nourishing cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, facial mask, pressed powder, body lotion, body cream, body oil, body lotion and body essence.
10. The use of an anti-aging composition comprising hydroxypropyl tetrahydropyrane triol and thiotaurine according to claim 7 in a skin care product, wherein:
the skin care product is prepared into anti-aging wrinkle-lightening essence which comprises the following raw material components:
Figure FDA0003328262890000021
the anti-aging wrinkle-lightening essence is prepared by the following steps:
1) mixing deionized water, sodium hyaluronate, xanthan gum and allantoin raw materials, heating at 85 deg.C for 30min, and stirring at 50r/min for 10min to obtain phase A raw material;
2) cooling the phase A raw material to below 40 ℃, adding an anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine, an oat extract and a preservative into the phase A raw material, stirring the mixture for 5min at a speed of 70r/min, cooling the mixture to below 35 ℃, and subpackaging the mixture to obtain the anti-aging wrinkle-lightening essence.
CN202111271953.8A 2021-10-29 2021-10-29 Anti-aging composition containing hydroxypropyl tetrahydropyrane triol and thiotaurine and application thereof Pending CN113797110A (en)

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