CN110693749A - Cosmetic composition containing tomato extract and preparation method of tomato extract - Google Patents
Cosmetic composition containing tomato extract and preparation method of tomato extract Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
A cosmetic composition containing tomato extract and its preparation method of tomato extract, wherein the tomato extract has better effects of keeping moisture, the active ingredient is a water-soluble component, very suitable for the preparation method of the facial mask, the active ingredient has good effects of resisting aging, resisting inflammation, resisting oxidation, improving the local microcirculation of the skin, the water-soluble extract of tomato comes from daily food, the security is high, the extraction process is good, the advantage of definite effect, have the safety, have effects of resisting inflammation, improving the microcirculation of the skin, whitening, preventing pox, have effects of resisting oxidation, scavenging oxygen free radical at the same time, prevent skin aging and moisturize the advantage of keeping young.
Description
Technical Field
The invention specifically relates to the technical field of cosmetics, and specifically relates to a cosmetic composition containing a tomato extract and a preparation method of the tomato extract.
Background
Tomato (Lycopersicon esculentum) contains a variety of ingredients beneficial to human health, including vitamin E, flavonoids, phytosterols, carotenoids, various water-soluble vitamins and minerals. The tomato water soluble concentrate is extracted and concentrated from mature tomato, and contains various natural anti-inflammatory, antioxidant and antiplatelet compounds, such as nucleoside compounds, polyphenol compounds, flavonoid compounds and the like. Tomato water soluble extracts have become the first European approved healthy product to help maintain normal platelet activity to maintain healthy blood flow according to European statement of health regulations, clause 13 (5). Research reports that the water-soluble extract of tomato can influence the activity of platelets in and out of human body. Administration of tomato extract reduced ADP-induced platelet aggregation by 20.0 ± 4.9% in healthy subjects. Integrin alpha inhibiting effect on multiple aggregation processes from water soluble tomato extractsIIβ3(GPIIb/IIIa) activity, which also shows the efficacy of various water soluble extracts of tomato. Proteomics experiments research the influence of water soluble tomato extract on platelet signal path, and the results show that the water soluble tomato extract can changeA variety of platelet functions, including regulation of platelet structure, coagulation and redox status.
Disclosure of Invention
In order to solve the technical defects in the prior art, the invention provides a cosmetic composition containing a tomato extract and a preparation method of the tomato extract.
The technical solution adopted by the invention is as follows: a cosmetic composition containing tomato extract comprises the following components:
a phase material: polyol, xanthan gum or carbomer, hyaluronic acid;
b phase material: PEG-40 hydrogenated castor oil water, and tomato essence;
c phase material: deionized water, d-panthenol;
d phase material: deionized water;
e phase material: allantoin, disodium ethylenediaminetetraacetate (EDTA-2 NA);
and F phase material: polyhydric alcohol and p-hydroxyacetophenone preservative;
g phase material: water soluble extract of tomato.
A cosmetic composition containing tomato extract comprises the following components in percentage by mass:
a phase material: 4-8% of polyalcohol, 0.1-0.5% of xanthan gum or carbomer and 0.1-0.5% of hyaluronic acid;
b phase material: 0.04-0.08% of PEG-40 hydrogenated castor oil water, 0.02-0.05% of tomato essence;
c phase material: 4-8% of deionized water and 0.8-2% of d-panthenol;
d phase material: 52-78% deionized water;
e phase material: 0.1-0.2% of allantoin, 0.02-0.1% of disodium ethylenediaminetetraacetate (EDTA-2 NA);
and F phase material: 4-8% of polyhydric alcohol and 0.25-0.5% of p-hydroxyacetophenone preservative;
g phase material: 1.0-4.0% of water soluble extract of tomato.
The polyalcohol is one or more of butanediol, propylene glycol, polyethylene glycol-32, 1, 2-hexanediol and 1, 2-pentanediol.
The tomato water-soluble extract comprises phenolic compounds, flavonoid compounds and adenosine compounds which are mixed according to different proportions.
The phenolic compounds, the flavonoid compounds and the adenosine compounds in different proportion ratios are respectively adenosine, chlorogenic acid and rutin.
The ratio of the adenosine to the chlorogenic acid to the rutin is as follows: 25-50 parts of: 1-5 parts: 5-25 parts.
The cosmetic composition is one of essence, cosmetic water, cream, hydrogel or facial mask.
The facial mask is in the form of a stick or a patch.
A method for preparing tomato extract in cosmetic composition containing tomato extract comprises the following steps: preparation of tomato extract: taking fresh and mature tomatoes, mechanically polishing the tomatoes to form slurry, centrifuging the tomato slurry at the room temperature of 25 ℃ at 3500rpm for 15 minutes, taking supernatant, passing the supernatant through an ultrafiltration membrane, performing solid-phase extraction by utilizing Styrene Divinylbenzene (SDVB) resin at the pH value of 2.5 to remove soluble sugar components, retaining non-sugar components on a column, eluting the non-sugar components with methanol, and drying the eluted non-sugar substance, namely the tomato extract, to form powder for later use, wherein the tomato extract accounts for 4-6% of dry matter of the water extract.
In the step, substances with the molecular weight less than 1 KDa are obtained by passing through an ultrafiltration membrane.
The invention has the beneficial effects that: the invention provides a cosmetic composition containing a tomato extract and a preparation method of the tomato extract, wherein the tomato extract has a good moisturizing effect, the active ingredient belongs to a water-soluble ingredient, and is very suitable for a production process of a mask, the active ingredient has good anti-aging, anti-inflammatory and antioxidant effects and improves the local microcirculation of skin, the water-soluble tomato extract is from daily food, is high in safety, has the advantages of excellent extraction process and definite effect, is safe, has the effects of resisting inflammation, improving the microcirculation of skin, whitening skin and preventing pox, and has the advantages of resisting oxidation, removing oxygen radicals, preventing skin aging, moisturizing and beautifying.
Drawings
FIG. 1 is a gray scale analysis of gel imaging according to the present invention.
Detailed Description
A cosmetic composition containing tomato extract comprises the following components:
a phase material: a first portion of propylene glycol, xanthan gum or carbomer, hyaluronic acid;
b phase material: PEG-40 hydrogenated castor oil water, and tomato essence;
c phase material: a first portion of deionized water, d-panthenol;
d phase material: a second portion of deionized water;
e phase material: allantoin, disodium ethylenediaminetetraacetate (EDTA-2 NA);
and F phase material: a second part of propylene glycol and p-hydroxyacetophenone preservative;
g phase material: water soluble extract of tomato.
A cosmetic composition containing tomato extract comprises the following components in percentage by mass:
a phase material: 4-8% of polyalcohol, 0.1-0.5% of xanthan gum or carbomer and 0.1-0.5% of hyaluronic acid;
b phase material: 0.04-0.08% of PEG-40 hydrogenated castor oil water, 0.02-0.05% of tomato essence;
c phase material: 4-8% of deionized water and 0.8-2% of d-panthenol;
d phase material: 52-78% deionized water;
e phase material: 0.1-0.2% of allantoin, 0.02-0.1% of disodium ethylenediaminetetraacetate (EDTA-2 NA);
and F phase material: 4-8% of polyhydric alcohol and 0.25-0.5% of p-hydroxyacetophenone preservative;
g phase material: 1.0-4.0% of water soluble extract of tomato.
The polyalcohol is one or more of butanediol, propylene glycol, polyethylene glycol-32, 1, 2-hexanediol and 1, 2-pentanediol.
The tomato water-soluble extract comprises phenolic compounds, flavonoid compounds and adenosine compounds which are mixed according to different proportions.
The phenolic compounds, the flavonoid compounds and the adenosine compounds in different proportion ratios are respectively adenosine, chlorogenic acid and rutin.
The ratio of the adenosine to the chlorogenic acid to the rutin is as follows: 25-50 parts of: 1-5 parts: 5-25 parts.
The cosmetic composition is one of essence, cosmetic water, cream, hydrogel or facial mask.
The facial mask is in the form of a stick or a patch.
A method for preparing tomato extract in cosmetic composition containing tomato extract comprises the following steps: taking fresh ripe tomatoes, mechanically polishing the tomatoes to be pulpy, centrifuging the tomatoes at room temperature and 25 ℃ at 3500rpm for 15 minutes, taking supernate, and passing the supernate through an ultrafiltration membrane (obtaining a substance with the molecular weight of less than 1 KDa). The soluble sugar components were removed by solid phase extraction using Styrene Divinylbenzene (SDVB) resin (pH 2.5) and the non-sugar components were retained on the column and eluted with methanol. The non-saccharide substances obtained by elution account for 4-6% of the dry matter of the water extract. Drying into powder for later use. The water soluble extract in fructus Lycopersici Esculenti contains phenolic compounds, flavonoids compounds, adenosine compounds, etc., and its representative components are chlorogenic acid, rutin and adenosine. The chlorogenic acid and rutin can remove free radicals generated in cell metabolism, reduce damage to cells, and improve skin local microcirculation. Adenosine is a well-known anti-aging component, has no limitation in use in the morning and evening, and also has the functions of promoting collagen synthesis and resisting inflammation.
The water-soluble tomato extract is used for facial masks according to the following steps:
the facial mask prepared from the tomato water-soluble extract has a good moisturizing effect, the active ingredients belong to water-soluble ingredients, the production process of the facial mask is very suitable, and the active ingredients have good effects of resisting aging, inflammation and oxidation and improving local microcirculation of skin. The tomato water-soluble extract is derived from daily food, and has the advantages of high safety, excellent extraction process and exact efficacy.
Adding water-soluble extract of fructus Lycopersici Esculenti into water phase, and instantly experiencing feeling mainly on gum, selecting xanthan gum or carbomer; the humectant is characterized in that the humectant is selected from butanediol, propylene glycol, polyethylene glycol-32, 1, 2-hexanediol, 1, 2-pentanediol and other polyols, and has the effects of moisturizing, cooling and preserving. By adding sodium hyaluronate or carnosine instead of glycerol. The water soluble extract of tomato has tomato flavor, but may not smell at a low concentration of 1-4%, so tomato essence is used as the aromatic substance.
Protein Disulfide Isomerase (PDI) is an oxidoreductase, has a function of catalyzing the formation and isomerization of disulfide bonds, and is a key factor in thrombus formation. Several in vivo thrombosis models have shown that blocking PDI activity inhibits platelet activation processes, including aggregation, release, and fibrinogen binding. The common flavonoid quercetin-3-rutin glycoside (rutin) is considered a natural inhibitor of PDI. Rutin is also one of the main components in the water-soluble extract of tomato. PDI can reduce and reoxidize disulfide bonds in hair cross-linking proteins, and thus is used for permanent waving; PDI plays an important role in redox balance regulation, and continuous imbalance of redox processes can cause aging and related diseases, so that regulation of protein disulfide isomerase is of great significance for the homeostasis of skin cells. In the present air pollution, the mask with the effect of inhibiting protein disulfide isomerase has a good prevention effect.
During the research process, the water-soluble tomato extract has obvious improvement effect on skin microcirculation. And has certain anti-inflammatory and antioxidant injury effects. In addition to at least one of the above mentioned compounds or extracts, the cosmetic composition may also comprise one or more other cosmetic or dermatological active agents in the form of purified molecules or plant extracts having a cosmetic effect similar and/or complementary to that of the compounds.
Thus, the composition may comprise, inter alia, a water-soluble extract of tomato, or a solution prepared from an extract of tomato, the extract being advantageously obtained by extraction with a method commonly used by the person skilled in the art, more particularly by extraction with a polar solvent or a mixture of polar solvents, the polar solvent advantageously being selected from water, a C1-C4 alcohol or ethylene glycol. The other active agent or dermatological active agent may be selected from the following: a substance having anti-aging activity; substances having depigmenting or whitening activity on the skin; substances with weight-reducing activity; a substance having moisturizing activity; substances with sedative, soothing or relaxing activity; substances which stimulate the microcirculation of the skin and thus improve the radiance of the complexion, in particular of the face; substances with sebum-regulating activity for greasy skin care; substances used to clean or cleanse the skin; and a substance having a radical scavenging activity. The composition also comprises at least one cosmetically or dermatologically acceptable excipient which may be chosen in particular from pigments, colorants, polymers, surfactants, rheological agents, fragrances (fragrances), electrolytes, pH regulators, antioxidants and preservatives, and mixtures thereof. Advantageously, the cosmetic or dermatological composition is in the form of a serum (serum), lotion (position), cream (cream) or hydrogel, in particular a mask, or in the form of a stick (stick) or patch (patch).
The present invention also relates to the use of at least one composition comprising such a tomato water-soluble extract, advantageously any of the variants and embodiments described above, as an active agent in a cosmetic or dermatological composition for combating skin ageing, in particular for reducing or delaying the effects of skin ageing, for restructuring the epidermis, for firming the skin, and/or for promoting the reduction or resorption of wrinkles and the protective properties of the epidermis, and/or for maintaining or improving skin moisturization and/or for promoting skin healing; the tomato extract has the following effects: inhibit Protein Disulfide Isomerase (PDI), improve skin microcirculation, and reduce the generation of oxygen free radicals.
Experiment on inhibition effect of tomato water-soluble concentrate on human immortalized epidermal cell HaCaT cell disulfide isomerase (PDI)
Culturing HaCaT cells in 10% fetal bovine serum RPMI 1640 medium (Gibco), digesting with trypsin when the cells reach 90% fusion, inoculating 5000 cells/well into 6-well plate, culturing overnight in 5% CO2 incubator at 37 deg.C, adding water soluble concentrate of tomato with concentration of 6.00, 0.60, 0.06g/L on the second day, treating with 60 μ M rutin as positive control for 3 hr, removing culture medium, washing with precooled PBS solution twice, adding RIPA cell lysate containing 1mM PMSF, lysing cells on ice for 15min, collecting cell lysate, and 12000 r.min at 4 deg.C-1Centrifuging for 5min, sucking supernatant, freezing and storing at-20 ℃ for Western blot protein electrophoresis analysis. Determining the protein concentration by adopting a BCA method, transferring the protein concentration to a PVDF membrane by a wet transfer method after SDS-PAGE electrophoresis, and sealing the PVDF membrane for 2 hours at room temperature by using 5% skimmed milk powder; PDI antibody was added separately, incubated overnight at 4 ℃ and TBS-T (100 mmol.L-1 Tris, 100 mmol.L-1 NaCl, 0.1% Tween) was rinsed 3 times for 5min each. Adding a horseradish peroxidase-labeled secondary antibody, and incubating for 2 h at room temperature. TBS-T was washed 3 times for 5min each. And dripping ECL luminous liquid, and scanning and imaging by using a gel imaging system. Image J software was used for grayscale analysis, as shown in FIG. 1.
Experiment on improving effect of oral administration of water-soluble concentrate of tomato on carrageenan-induced microcirculation lesion of skin
The method comprises the following steps of orally administering water-soluble tomato extracts to rats for 21 days, injecting 1mg/kg carrageenan to rat tail veins to cause inflammation and skin microcirculation disturbance models on the 22 th day, anesthetizing the rats with 0.3% pentobarbital sodium on the 23 th day, placing the rats on a 37 ℃ small animal constant temperature blanket, fully exposing skins (thighs, soles and tails) of tested parts, locally coating tomato extract gel for 30min, and measuring the blood flow perfusion of the thighs, the soles and the tails (the same area of black tail boundaries is taken for each group) of rats by using a laser Doppler speckle instrument. Analyzing the blood perfusion amount of the femoral, plantar and caudal skins of different groups of rats.
The results show that the average blood perfusion of the thigh, the sole and the tail of the rats in the normal group are 91.88 +/-27.00, 43.23 +/-17.64 and 24.17 +/-6.26 PU respectively; compared with the normal group, the average blood perfusion of the skin of the thigh, the sole and the tail of the rat in the model group is obviously increased (P is less than 0.01); the dose group in tomato aqueous extract showed an effect of improving femoral skin microcirculation (P = 0.07); tomato aqueous extracts reduced tail mean perfusion and showed anti-inflammatory and microcirculation improving effects, see table 1.
TABLE 1 Effect of Neocoid on the amount of microcirculation-induced blood Perfusion (PU) in the skin of different sites of carrageenan-induced thrombosis in rats
| Grouping | n | Thigh part | Sole of foot | Tail part |
| Is normal | 10 | 91.88±27.00 | 43.23±17.64 | 24.17±6.26 |
| Model (model) | 10 | 114.98±21.44** | 84.62±21.96** | 50.11±14.60** |
| Low dose of neolysin | 10 | 101.60±21.61 | 71.34±29.31 | 35.41±8.01& |
| Middle dosage of neoludin | 10 | 96.59±10.92& | 76.30±22.58 | 39.00±15.43 |
| High dose of neolysin | 10 | 105.88±33.27 | 78.57±24.22 | 38.69±9.40& |
Note: compared with the normal groupP<0.05，**P<0.01; in comparison to the set of models,# P<0.05，## P<0.01, compared to the model set,& P<0.10
and (4) experimental conclusion: under the action of carrageenan, the hemodynamics of rats are changed, and pathological symptoms such as hyperemia, microthrombus and the like are easy to appear on superficial skin, particularly tail blood vessels. Improving the microcirculation of the skin is considered to be one of the important matters for improving the health status of the skin.
Tomato water-soluble extract mask experimental data
The efficacy of the tomato water-soluble extract mask was verified by a random crossover test:
subjects with acne or chloasma on their skin were recruited 20, aged 18-45 years, 4 of men and 16 of women. 20 patients are randomly divided into two groups, namely 10 tomato aqueous extract facial mask groups and 10 facial mask matrix groups, and the ages, the sexes, the disease courses and the like of the two groups of patients have no statistical difference and are comparable. The subjects had not systemically applied antibiotics and other acne treatment medications for 2 weeks.
The use method of the facial mask comprises the following steps:
tomato aqueous extract mask group: cleaning face, applying the tomato water extract facial mask paste on face, washing off with clear water after 30min, 1 time every other day, and 2 weeks as 1 treatment course. The application method of the facial mask matrix group is the same as that of the test article group.
After 1 treatment course, 7 days are taken as an elution period, two groups of subjects are exchanged, and a trial test of 2 weeks is carried out after 1 treatment course.
The curative effect standard is as follows:
2 weeks is 1 course of treatment, and the curative effect is determined after 2 courses of treatment.
① has obvious curative effect index of 60-95%, ② has effective curative effect index of 20-59%, and ③ has no effect index of 20%.
After 2 treatment courses, the tomato water-soluble extract facial mask treatment group shows 25 persons; 9 persons in effect; 6 people were not effective; the effective rate is 85.0%.
Mask base control group: 7 persons with obvious effect; effective 6 persons; 27 persons who were not effective; the effective rate is 32.5%.
Examples
Plum women, 45 years old, had a small amount of chloasma, dullness, fine lines and sometimes redness on the face before using the tomato extract mask. After cleansing, tomato extract facial mask was applied for 4 weeks, 1 time every other day, for 14 times. The elasticity and color of the facial skin are obviously improved, fine wrinkles are obviously reduced, the chloasma symptom is relieved, and the skin is glossy.
In conclusion, the facial mask prepared from the tomato water-soluble extract has a good moisturizing effect, the active ingredients belong to water-soluble ingredients, the production process of the facial mask is very suitable, and the active ingredients have good effects of resisting aging, inflammation and oxidation and improving local microcirculation of skin.
The skilled person should understand that: although the invention has been described in terms of the above specific embodiments, the inventive concept is not limited thereto and any modification applying the inventive concept is intended to be included within the scope of the patent claims.
The above description is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.
Claims (10)
1. A cosmetic composition containing tomato extract, characterized by consisting of:
a phase material: polyol, xanthan gum or carbomer, hyaluronic acid;
b phase material: PEG-40 hydrogenated castor oil water, and tomato essence;
c phase material: deionized water, d-panthenol;
d phase material: deionized water;
e phase material: allantoin, disodium ethylenediaminetetraacetate (EDTA-2 NA);
and F phase material: polyhydric alcohol and p-hydroxyacetophenone preservative;
g phase material: water soluble extract of tomato.
2. The cosmetic composition containing the tomato extract as claimed in claim 1, which is characterized by comprising the following components by mass percent:
a phase material: 4-8% of polyalcohol, 0.1-0.5% of xanthan gum or carbomer and 0.1-0.5% of hyaluronic acid;
b phase material: 0.04-0.08% of PEG-40 hydrogenated castor oil water, 0.02-0.05% of tomato essence;
c phase material: 4-8% of deionized water and 0.8-2% of d-panthenol;
d phase material: 52-78% deionized water;
e phase material: 0.1-0.2% of allantoin, 0.02-0.1% of disodium ethylenediaminetetraacetate (EDTA-2 NA);
and F phase material: 4-8% of polyhydric alcohol and 0.25-0.5% of p-hydroxyacetophenone preservative;
g phase material: 1.0-4.0% of water soluble extract of tomato.
3. The cosmetic composition containing tomato extract as claimed in claim 2, wherein the polyol is one or more selected from butylene glycol, propylene glycol, polyethylene glycol-32, 1, 2-hexanediol, and 1, 2-pentanediol.
4. The cosmetic composition containing the tomato extract as claimed in claim 1, wherein the tomato water-soluble extract comprises phenolic compounds, flavonoid compounds and adenosine compounds in different proportions.
5. The cosmetic composition containing the tomato extract as claimed in claim 4, wherein the phenolic compounds, flavonoid compounds and adenosine compounds in different proportions are adenosine, chlorogenic acid and rutin, respectively.
6. The cosmetic composition containing tomato extract as claimed in claim 5, wherein the ratio of adenosine, chlorogenic acid and rutin is: 25-50 parts of: 1-5 parts: 5-25 parts.
7. The cosmetic composition containing tomato extract as claimed in claim 1, wherein the cosmetic composition is one of essence, lotion, cream, hydrogel or facial mask.
8. The cosmetic composition comprising tomato extract as claimed in claim 7, wherein the mask is in the form of stick or patch.
9. A method for preparing a tomato extract in a cosmetic composition comprising the tomato extract as set forth in claim 1, comprising the steps of: preparation of tomato extract: taking fresh and mature tomatoes, mechanically polishing the tomatoes to form slurry, centrifuging the tomato slurry at the room temperature of 25 ℃ at 3500rpm for 15 minutes, taking supernatant, passing the supernatant through an ultrafiltration membrane, performing solid-phase extraction by utilizing Styrene Divinylbenzene (SDVB) resin at the pH value of 2.5 to remove soluble sugar components, retaining non-sugar components on a column, eluting the non-sugar components with methanol, and drying the eluted non-sugar substance, namely the tomato extract, to form powder for later use, wherein the tomato extract accounts for 4-6% of dry matter of the water extract.
10. The method for preparing tomato extract as claimed in claim 9, wherein the step of passing through ultrafiltration membrane to obtain substance with molecular weight less than 1 KDa.
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| CN116803404A (en) * | 2023-08-24 | 2023-09-26 | 汤臣倍健股份有限公司 | Application of water-soluble tomato concentrate in preparation of hair loss reducing and hair growing products |
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