CN113796419A - Formula sheep milk powder for improving immunity of children and preparation method thereof - Google Patents
Formula sheep milk powder for improving immunity of children and preparation method thereof Download PDFInfo
- Publication number
- CN113796419A CN113796419A CN202110757728.9A CN202110757728A CN113796419A CN 113796419 A CN113796419 A CN 113796419A CN 202110757728 A CN202110757728 A CN 202110757728A CN 113796419 A CN113796419 A CN 113796419A
- Authority
- CN
- China
- Prior art keywords
- milk
- powder
- milk powder
- sheep milk
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000843 powder Substances 0.000 title claims abstract description 108
- 235000020254 sheep milk Nutrition 0.000 title claims abstract description 59
- 230000036039 immunity Effects 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 32
- 102000010445 Lactoferrin Human genes 0.000 claims abstract description 27
- 108010063045 Lactoferrin Proteins 0.000 claims abstract description 27
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 claims abstract description 27
- 229940078795 lactoferrin Drugs 0.000 claims abstract description 27
- 235000021242 lactoferrin Nutrition 0.000 claims abstract description 27
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 claims abstract description 22
- 235000019743 Choline chloride Nutrition 0.000 claims abstract description 22
- 229960003178 choline chloride Drugs 0.000 claims abstract description 22
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 18
- 239000008158 vegetable oil Substances 0.000 claims abstract description 18
- 229960003080 taurine Drugs 0.000 claims abstract description 16
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 claims abstract description 14
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims abstract description 14
- 235000013336 milk Nutrition 0.000 claims description 78
- 239000008267 milk Substances 0.000 claims description 78
- 210000004080 milk Anatomy 0.000 claims description 78
- 230000001954 sterilising effect Effects 0.000 claims description 33
- 235000013350 formula milk Nutrition 0.000 claims description 30
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 28
- 238000004659 sterilization and disinfection Methods 0.000 claims description 27
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 26
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 24
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 24
- 150000001875 compounds Chemical class 0.000 claims description 22
- -1 compound vitamin Chemical class 0.000 claims description 21
- 102000007544 Whey Proteins Human genes 0.000 claims description 19
- 108010046377 Whey Proteins Proteins 0.000 claims description 19
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 16
- 239000003623 enhancer Substances 0.000 claims description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 14
- 235000021342 arachidonic acid Nutrition 0.000 claims description 14
- 229940114079 arachidonic acid Drugs 0.000 claims description 14
- 239000008101 lactose Substances 0.000 claims description 14
- 235000016709 nutrition Nutrition 0.000 claims description 14
- 230000035764 nutrition Effects 0.000 claims description 14
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 13
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 13
- 238000003860 storage Methods 0.000 claims description 13
- 239000002211 L-ascorbic acid Substances 0.000 claims description 12
- 235000000069 L-ascorbic acid Nutrition 0.000 claims description 12
- 229960005070 ascorbic acid Drugs 0.000 claims description 12
- 229940090949 docosahexaenoic acid Drugs 0.000 claims description 12
- 235000019197 fats Nutrition 0.000 claims description 12
- 239000012535 impurity Substances 0.000 claims description 12
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 claims description 11
- 235000021277 colostrum Nutrition 0.000 claims description 11
- 210000003022 colostrum Anatomy 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 11
- 238000004806 packaging method and process Methods 0.000 claims description 11
- 239000000126 substance Substances 0.000 claims description 11
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 10
- 239000005862 Whey Substances 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 10
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 10
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 claims description 10
- 229940088594 vitamin Drugs 0.000 claims description 10
- 229930003231 vitamin Natural products 0.000 claims description 10
- 235000013343 vitamin Nutrition 0.000 claims description 10
- 239000011782 vitamin Substances 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 9
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 239000011707 mineral Substances 0.000 claims description 9
- 235000010755 mineral Nutrition 0.000 claims description 9
- 238000005086 pumping Methods 0.000 claims description 9
- 238000001694 spray drying Methods 0.000 claims description 9
- 235000021119 whey protein Nutrition 0.000 claims description 9
- 238000007789 sealing Methods 0.000 claims description 8
- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 claims description 7
- 238000007580 dry-mixing Methods 0.000 claims description 7
- 238000001704 evaporation Methods 0.000 claims description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- 229910021654 trace metal Inorganic materials 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 5
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 claims description 5
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 claims description 5
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 5
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 5
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 5
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 5
- 238000004140 cleaning Methods 0.000 claims description 5
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims description 5
- 235000000639 cyanocobalamin Nutrition 0.000 claims description 5
- 239000011666 cyanocobalamin Substances 0.000 claims description 5
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 claims description 5
- 239000011790 ferrous sulphate Substances 0.000 claims description 5
- 235000003891 ferrous sulphate Nutrition 0.000 claims description 5
- 229960000304 folic acid Drugs 0.000 claims description 5
- 235000019152 folic acid Nutrition 0.000 claims description 5
- 239000011724 folic acid Substances 0.000 claims description 5
- 235000020251 goat milk Nutrition 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 5
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 5
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 5
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims description 5
- 229960004172 pyridoxine hydrochloride Drugs 0.000 claims description 5
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 claims description 5
- 239000011764 pyridoxine hydrochloride Substances 0.000 claims description 5
- 229960000342 retinol acetate Drugs 0.000 claims description 5
- 235000019173 retinyl acetate Nutrition 0.000 claims description 5
- 239000011770 retinyl acetate Substances 0.000 claims description 5
- 229960002477 riboflavin Drugs 0.000 claims description 5
- 235000019192 riboflavin Nutrition 0.000 claims description 5
- 239000002151 riboflavin Substances 0.000 claims description 5
- 239000011781 sodium selenite Substances 0.000 claims description 5
- 229960001471 sodium selenite Drugs 0.000 claims description 5
- 235000015921 sodium selenite Nutrition 0.000 claims description 5
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 5
- 229960000344 thiamine hydrochloride Drugs 0.000 claims description 5
- 235000019190 thiamine hydrochloride Nutrition 0.000 claims description 5
- 239000011747 thiamine hydrochloride Substances 0.000 claims description 5
- 235000005282 vitamin D3 Nutrition 0.000 claims description 5
- 239000011647 vitamin D3 Substances 0.000 claims description 5
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 5
- 229940021056 vitamin d3 Drugs 0.000 claims description 5
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 5
- 229960001763 zinc sulfate Drugs 0.000 claims description 5
- 229910000368 zinc sulfate Inorganic materials 0.000 claims description 5
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 4
- 239000003240 coconut oil Substances 0.000 claims description 4
- 235000019864 coconut oil Nutrition 0.000 claims description 4
- 239000002285 corn oil Substances 0.000 claims description 4
- 235000005687 corn oil Nutrition 0.000 claims description 4
- 239000000839 emulsion Substances 0.000 claims description 4
- 230000008020 evaporation Effects 0.000 claims description 4
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 4
- 229940042585 tocopherol acetate Drugs 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000001301 oxygen Substances 0.000 claims description 3
- 229910052760 oxygen Inorganic materials 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 229960003563 calcium carbonate Drugs 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims description 2
- 229960001781 ferrous sulfate Drugs 0.000 claims description 2
- 229960001375 lactose Drugs 0.000 claims description 2
- 235000008476 powdered milk Nutrition 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims 4
- ZAKOWWREFLAJOT-UHFFFAOYSA-N DL-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims 1
- 235000019486 Sunflower oil Nutrition 0.000 claims 1
- 239000000828 canola oil Substances 0.000 claims 1
- 235000019519 canola oil Nutrition 0.000 claims 1
- 229940117373 dl-alpha tocopheryl acetate Drugs 0.000 claims 1
- 239000002600 sunflower oil Substances 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 15
- 238000006241 metabolic reaction Methods 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 11
- 210000004027 cell Anatomy 0.000 description 9
- 235000015097 nutrients Nutrition 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 150000001720 carbohydrates Chemical class 0.000 description 4
- 235000014633 carbohydrates Nutrition 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 3
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 3
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 3
- DPUOLQHDNGRHBS-UHFFFAOYSA-N Brassidinsaeure Natural products CCCCCCCCC=CCCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-UHFFFAOYSA-N 0.000 description 3
- URXZXNYJPAJJOQ-UHFFFAOYSA-N Erucic acid Natural products CCCCCCC=CCCCCCCCCCCCC(O)=O URXZXNYJPAJJOQ-UHFFFAOYSA-N 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 239000005642 Oleic acid Substances 0.000 description 3
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 3
- 235000019484 Rapeseed oil Nutrition 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 235000020238 sunflower seed Nutrition 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 235000013325 dietary fiber Nutrition 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 230000037356 lipid metabolism Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 description 1
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 description 1
- 206010065687 Bone loss Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- 206010051606 Necrotising colitis Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000036995 brain health Effects 0.000 description 1
- 229940043430 calcium compound Drugs 0.000 description 1
- 238000009924 canning Methods 0.000 description 1
- 230000023852 carbohydrate metabolic process Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 description 1
- 210000000750 endocrine system Anatomy 0.000 description 1
- 210000003617 erythrocyte membrane Anatomy 0.000 description 1
- 235000020774 essential nutrients Nutrition 0.000 description 1
- 239000011552 falling film Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000003832 immune regulation Effects 0.000 description 1
- 230000010438 iron metabolism Effects 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 208000004995 necrotizing enterocolitis Diseases 0.000 description 1
- 230000030363 nerve development Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000008621 organismal health Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 201000006195 perinatal necrotizing enterocolitis Diseases 0.000 description 1
- 108091008695 photoreceptors Proteins 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 235000020185 raw untreated milk Nutrition 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000014493 regulation of gene expression Effects 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 230000009645 skeletal growth Effects 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000033772 system development Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1522—Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1528—Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/154—Milk preparations; Milk powder or milk powder preparations containing additives containing thickening substances, eggs or cereal preparations; Milk gels
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/156—Flavoured milk preparations ; Addition of fruits, vegetables, sugars, sugar alcohols or sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/158—Milk preparations; Milk powder or milk powder preparations containing additives containing vitamins or antibiotics
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dairy Products (AREA)
Abstract
The invention discloses a formula sheep milk powder for improving children immunity and a preparation method thereof, and relates to the technical field of formula sheep milk powder. According to the invention, lactoferrin is added, and isomaltooligosaccharide, mixed vegetable oil, choline chloride and taurine are matched to promote absorption together, choline chloride and taurine promote fat (mixed vegetable oil) absorption, and the mixed vegetable oil and isomaltooligosaccharide promote lactoferrin absorption due to complex metabolic reaction, so that lactoferrin is effectively absorbed and plays a role in assisting children in establishing immunity.
Description
Technical Field
The invention relates to the technical field of formula sheep milk powder, and particularly relates to formula sheep milk powder for improving children immunity and a preparation method thereof.
Background
In the process of children growing up, the problem which is concerned by parents is how to improve the immunity of children, and lactoferrin is usually added into the main milk powder in the market as a means for improving the immunity of children. Lactoferrin, also known as "milk transfer protein" or "hemoglobin", is a globulin present in mammalian whey. The biological functions of lactoferrin include participation in iron metabolism, participation in body antibacterial, anti-inflammatory and immune regulation, regulation of gene expression, intervention in cell reproduction, antioxidation, and the like. As a broad-spectrum antimicrobial agent, lactoferrin inhibits both iron-requiring gram-negative bacteria such as escherichia coli and salmonella, and gram-positive bacteria. Lactoferrin has positive effects in promoting infant growth, and preventing and treating common diseases of infants such as diarrhea, neonatal necrotizing enterocolitis, neonatal septicemia, respiratory diseases, etc. In addition, lactoferrin has important significance for promoting the skeletal growth of infants, slowing down the bone loss of women in menopause and improving osteoporosis of old people.
However, the ingredients added in the milk powder can not be absorbed by human bodies, the absorption of corresponding substances can be influenced due to different compatibility of different formula proportions, the absorption rate of each effective ingredient can be directly influenced by the selection of compatible substances, and the formula milk can not achieve the alleged effect due to the absorption rate even if lactoferrin is added in the existing formula milk. Therefore, there is a need to develop a formula which can effectively improve the immunity of children.
Disclosure of Invention
The invention aims to provide the formula sheep milk powder for improving the immunity of children, which effectively helps the children to build the immunity by improving the absorptivity of immune substances.
In addition, the invention also provides a preparation method of the formula sheep milk powder for improving the immunity of children, the formula sheep milk powder is processed by adopting a dry-wet method composite process, and the food nutrition enhancer in the formula is added by adopting a wet method and a dry method according to the characteristics of raw materials, so that the components of the product are uniformly distributed while the functionality of the product is ensured.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows: the formula sheep milk powder comprises raw sheep milk, desalted whey powder, full-fat sheep milk powder, isomaltooligosaccharide, concentrated whey protein powder, mixed vegetable oil, arachidonic acid, docosahexaenoic acid, lactoferrin, colostrum basic protein, potassium hydroxide and a compound nutrition enhancer, wherein the compound nutrition enhancer comprises choline chloride, taurine, L-ascorbic acid, dl-alpha-tocopherol acetate, D-calcium pantothenate, nicotinamide, retinyl acetate, riboflavin, thiamine hydrochloride, pyridoxine hydrochloride, folic acid, cholecalciferol, cyanocobalamine, calcium carbonate, ferrous sulfate, zinc sulfate, sodium selenite and lactose.
Preferably, the mixed vegetable oil is prepared by mixing corn oil, low erucic acid rapeseed oil, coconut oil and high oleic acid sunflower seed oil.
Preferably, the formula sheep milk powder consists of 993Kg of base powder prepared by a wet method and 5.72Kg of dry formula powder calculated by 998.72Kg of finished formula milk, and the addition amount of each component for preparing the base powder is as follows calculated by 1 ton of base powder prepared by the wet method: 400Kg of raw sheep milk, 400Kg of desalted whey powder, 300Kg of full-fat sheep milk powder, 100Kg of isomaltose hypgather, 75Kg of concentrated whey protein powder with the content of 34 percent, 25Kg of mixed vegetable oil, 1Kg of potassium hydroxide and 12Kg of compound nutrition enhancer; the arachidonic acid powder prepared by the dry method consists of 3.1Kg, 2.2Kg of docosahexaenoic acid, 0.22Kg of lactoferrin and 0.2Kg of colostrum basic protein.
Further, the compound nutrition enhancer consists of the following components: 2Kg of compound vitamin, 1Kg of compound mineral substance, 8Kg of compound calcium carbonate and 1Kg of compound choline chloride.
More preferably, the compound vitamin comprises the following components: 700g of L-ascorbic acid, 134.1g of dl-alpha-tocopherol acetate, 24.4g of D-calcium pantothenate, 43g of nicotinamide, 66.6g of retinyl acetate, 85g of riboflavin, 11g of thiamine hydrochloride, 119.5g of pyridoxine hydrochloride, 23g of folic acid, 40g of cholecalciferol, 2.0g of cyanocobalamine, 320g of taurine and 431.4g of lactose.
More preferably, the compound mineral comprises the following components: 391.5g of ferrous sulfate, 285.7g of zinc sulfate, 31.1g of sodium selenite and 291.7g of lactose.
More preferably, the compound calcium carbonate consists of the following components: 7999g of calcium carbonate, 0.5g of L-ascorbic acid and 0.5g of lactose.
More preferably, the compound choline chloride consists of the following components: 999g of choline chloride, 0.5g of L-ascorbic acid and 0.5g of lactose.
The preparation method of the formula sheep milk powder for improving the immunity of children comprises the following steps:
(1) and (3) filtering and removing impurities: measuring and filtering raw sheep milk qualified by acceptance, and removing mechanical impurities in fresh milk;
(2) and (3) cold storage: cooling the filtered raw sheep milk and refrigerating for later use;
(3) cleaning milk: cleaning raw sheep milk, removing impurities in the sheep milk, and ensuring that the impurity degree is less than or equal to 2.0 mg/kg;
(4) and (3) sterilization: sterilizing the raw sheep milk after milk purification, and then storing;
(5) standardizing ingredients: mixing the stored raw sheep milk with desalted whey powder, full-fat sheep milk powder, isomaltose hypgather, concentrated whey protein powder, mixed vegetable oil, compound nutrition enhancer and potassium hydroxide according to the proportion, and carrying out standardized burdening and dissolving at 50-60 ℃ to obtain feed liquid;
(6) homogenizing: homogenizing the feed liquid in a high-pressure homogenizer at a temperature not higher than 60 deg.C under a homogenizing pressure of 10-14Mpa to break fat particles in the feed liquid into smaller fat balls, and uniformly dispersing in milk;
(7) concentration and evaporation and high-temperature sterilization: concentrating and evaporating the emulsion to remove water to form concentrated milk; and sterilizing the concentrated milk at high temperature;
(8) spray drying: pumping the concentrated milk into a sterile milk storage tank through a discharge pump, filtering the concentrated milk by using a filter screen before pumping the concentrated milk into the milk storage tank, and pumping the concentrated milk into a drying tower by using a high-pressure pump for spray drying; wherein: the air inlet temperature during spray drying is 170-185 ℃, the air exhaust temperature is 80-92 ℃, the negative pressure in the tower is-20-35 water column mmH 2O, and the temperature in the tower is 60-92 ℃;
(9) cooling: cooling the dried concentrated milk by a fluidized bed to obtain wet milk powder, and then introducing the wet milk powder into a dry mixing room by a closed conveying system;
(10) dry mixing: according to the proportion, arachidonic acid, docosahexaenoic acid, lactoferrin and colostrum basic protein are added into the dry mixing room after tunnel sterilization;
(11) metering and mixing: mixing the sterilized arachidonic acid, docosahexaenoic acid, lactoferrin and colostrum basic protein with the dried milk powder according to the proportion;
(12) and (3) detecting trace metal elements: detecting trace metal elements of the mixed milk powder;
(13) packaging and warehousing: sieving the qualified milk powder, and then performing film-covering nitrogen-filling packaging, external packaging, code spraying, boxing and warehousing according to the required specification; the nitrogen is filled for packaging, the nitrogen pressure is more than or equal to 0.5MPa, and the residual oxygen is less than or equal to 3.0 percent; the transverse sealing temperature of the adult formula milk powder is 175-185 ℃, and the longitudinal sealing temperature is 160-180 ℃.
Compared with the prior art, the invention has the following beneficial effects:
(1) according to the invention, lactoferrin is added, and isomaltooligosaccharide, mixed vegetable oil, choline chloride and taurine are matched to promote absorption together, choline chloride and taurine promote fat (mixed vegetable oil) absorption, and the mixed vegetable oil and isomaltooligosaccharide promote lactoferrin absorption due to complex metabolic reaction, so that lactoferrin is effectively absorbed and plays a role in assisting children in establishing immunity.
(2) The invention is beneficial to the absorption of various nutrients such as lactoferrin, AA, DHA and the like by children by reasonably adjusting the composition of protein, fat and carbohydrate, and meets the basic requirements of body health: the raw sheep milk, the desalted whey powder, the whole goat milk powder and the concentrated whey protein powder are added to supplement all protein, partial fat, carbohydrate, vitamins and mineral substances, so that the protein content in the product reaches 19.0g/100 g; the mixed vegetable oil (corn oil, low erucic acid rapeseed oil, coconut oil and high oleic acid sunflower seed oil) is added to mainly supplement fat and adjust fatty acid composition, so that the fat content in the product reaches 15.0g/100g, and the absorption of vitamins and lactoferrin is facilitated; the isomaltose hypgather is mainly used for supplementing carbohydrate and is a main source substance of dietary fiber, and the carbohydrate content in the product is 52.8g/100g, wherein the dietary fiber content is 4.2g/100 g.
(3) The added compound nutrition enhancer consists of compound vitamins, compound mineral substances, compound calcium carbonate and compound choline chloride, wherein the choline chloride not only participates in lipid metabolism, but also can prevent fat and sterol from accumulating on the arterial wall or gall bladder to cause liver injury, and also has important functions of participating in the construction of a biological membrane, maintaining the normal structure of cells, participating in information transmission, regulating and controlling apoptosis of cells, influencing the movement ability and the like; the vitamins are essential nutrients for regulating various metabolism of human body and maintaining life and health of organism, in which taurine has several functions of visual development, nerve development, detoxication, calcium flow regulation, bile acid combination, osmotic pressure regulation and cell membrane stabilization, and especially for infant period, taurine can obviously promote abrupt differentiation and cell proliferation of human brain nerve cell, its capacity for enriching taurine in brain is far higher than that of adult, and its important action in visual system development is about 50% of total amino acid in retina, and is an important nutrient factor for photoreceptor development, and taurine also has protective action on immune cell, and the content of taurine in lymphocyte is 50% of total free amino acid, and can affect lipid metabolism, and can help fat absorption by conjugation with choline chloride, meanwhile, the taurine has an adjusting effect on an endocrine system, can influence glycometabolism, can promote the absorption of intestinal tracts to various nutrient substances, and increases the stability of erythrocyte membranes. The mineral is an indispensable nutrient element in human tissues and can meet the requirements of human growth and development; meanwhile, the L-ascorbic acid (vitamin C) also participates in the preparation of the compound calcium carbonate and the compound choline chloride, so that the biological activity of the calcium and the choline chloride is ensured, and the absorption of substances is facilitated; due to the compatibility of different components, the grouped component absorption in the invention is maximized, and the due effect of each component is realized.
(4) Arachidonic Acid (AA) and docosahexaenoic acid (DHA) are added, and the components are matched with each other to promote brain health.
Detailed Description
Example 1
The embodiment provides a formula sheep milk powder for improving immunity of children, which is calculated by 998.72Kg of formula milk finished products, and consists of 993Kg of base powder prepared by a wet method and 5.72Kg of dry formula powder, wherein the addition amount of each component for preparing the base powder is calculated by 1 ton of base powder prepared by the wet method as follows: 400Kg of raw sheep milk, 400Kg of desalted whey powder, 300Kg of full-fat sheep milk powder, 100Kg of isomaltose hypgather, 75Kg of concentrated whey protein powder with the content of 34 percent, 25Kg of mixed vegetable oil (prepared by mixing corn oil, low erucic acid rapeseed oil, coconut oil and high oleic acid sunflower seed oil in the mass ratio of 1: 1), 1Kg of potassium hydroxide and 12Kg of compound nutrition enhancer; the arachidonic acid powder prepared by the dry method consists of 3.1Kg, 2.2Kg of docosahexaenoic acid, 0.22Kg of lactoferrin and 0.2Kg of colostrum basic protein. The compound nutrient enhancer consists of the following components: 2Kg of compound vitamin, 1Kg of compound mineral substance, 8Kg of compound calcium carbonate and 1Kg of compound choline chloride. The compound vitamin comprises the following components: 700g of L-ascorbic acid, 134.1g of dl-alpha-tocopherol acetate, 24.4g of D-calcium pantothenate, 43g of nicotinamide, 66.6g of retinyl acetate, 85g of riboflavin, 11g of thiamine hydrochloride, 119.5g of pyridoxine hydrochloride, 23g of folic acid, 40g of cholecalciferol, 2.0g of cyanocobalamine, 320g of taurine and 431.4g of lactose. The compound mineral comprises the following components: 391.5g of ferrous sulfate, 285.7g of zinc sulfate, 31.1g of sodium selenite and 291.7g of lactose. The compound calcium carbonate consists of the following components: 7999g of calcium carbonate, 0.5g of L-ascorbic acid and 0.5g of lactose. The compound choline chloride comprises the following components: 999g of choline chloride, 0.5g of L-ascorbic acid and 0.5g of lactose.
The embodiment also provides a preparation process of the milk powder, which comprises the following steps:
acceptance of raw sheep milk
The method comprises the steps of purchasing from a specified qualified milk station, monitoring by a stationer for milking and refrigerating, then transporting back to a company, carrying out batch-by-batch sampling inspection by a raw sheep milk inspector after entering a factory according to standards, executing detection items and results according to GB19301-2010 raw milk standard, and inspecting and accepting only when the raw sheep milk is qualified (each factory can also customize respective further inspection and acceptance standards on the basis of the standards and requires that only the raw sheep milk meets two standards simultaneously).
Second, filtration
And (3) filtering the raw sheep milk qualified by acceptance through a 80-mesh or 120-mesh nylon filter screen after metering, and removing mechanical impurities in the fresh milk.
Cold storage
Cooling the filtered raw sheep milk by a plate heat exchanger and storing the cooled raw sheep milk in a refrigeration tank for later use; the temperature is controlled at 0-4 deg.C and the acidity is controlled at 6-130T during storage, and the temperature and acidity are checked periodically to determine whether they meet the requirements.
Fourth, cleaning milk
The raw sheep milk is cleaned by a separator, impurities in the raw sheep milk are removed, slag is discharged in time according to the impurity condition after the milk is cleaned, and the impurity degree is required to be less than or equal to 2.0 mg/kg.
Fifth, sterilizing and storing
The raw sheep milk is pre-sterilized by a plate type sterilization machine, enters a degassing tank, is treated by a spore separator and returns to the plate type sterilization machine to kill part of microorganisms in the fresh milk. In the embodiment, when the adopted sterilization machine is a 25-ton sterilization machine, the temperature is 80-85 ℃, and the sterilization time is 15 s; when the adopted sterilization machine is a 30-ton sterilization machine, the temperature is 90-110 ℃, and the sterilization time is 4 s. And (4) after sterilization, storing the raw sheep milk.
Sixthly, standardized ingredients (from here on, the preparation of the goat milk powder)
Adding auxiliary materials into the stored raw sheep milk according to the formula, and carrying out standardized material mixing and dissolving at 50-60 ℃ to obtain feed liquid. The auxiliary materials described in this embodiment, namely the desalted whey powder, the full-fat goat milk powder, the isomaltooligosaccharide, the concentrated whey protein powder, the mixed vegetable oil, the compound nutrition enhancer and the potassium hydroxide, comprise the steps of weighing, preheating, dissolving (35-45 ℃), metering and the like.
Seven, homogenizing
Homogenizing the feed liquid at a temperature not higher than 60 deg.C in a high-pressure homogenizer under a homogenizing pressure of 10-14Mpa, pulverizing fat particles into smaller fat balls, and uniformly dispersing in the emulsion.
Eighth, concentration and evaporation
And sterilizing the emulsion again by a sterilizer through a falling film evaporation system, concentrating and evaporating by a separator to remove water to form concentrated milk, wherein the discharge density after concentration is 1.090-1.155.
High temperature sterilization
The concentrated milk is sterilized by the plate heat exchanger, so that most of bacteria in the feed liquid are killed. In this embodiment, the high-temperature sterilization mainly has two modes: the method is characterized in that the high-temperature sterilization of the south China and the VTIS (tetra-basic ethylene glycol-vinyl acetate copolymer) is realized, a VTIS sterilization mode is usually adopted, and the south China equipment is adopted for sterilization when VTIS sterilization equipment fails or small-batch production (1-3 tons) is carried out. Specifically, the plate heat exchanger is of a Nanhua brand, the used high-temperature sterilization is 89-96 ℃, and the sterilization time is 10 s; or the plate heat exchanger brand is VTIS, the used high-temperature sterilization is performed at the temperature of 110-120 ℃, and the sterilization time is 0.33 s.
Ten, spray drying
Pumping the concentrated milk into a sterile milk storage tank through a discharge pump, filtering the concentrated milk by using a filter screen before pumping the concentrated milk into the milk storage tank, and pumping the concentrated milk into a drying tower by using a high-pressure pump for spray drying. In the embodiment, the air inlet temperature during spray drying is 170-185 ℃, the air outlet temperature is 80-92 ℃, the negative pressure in the tower is-20-35 water column mmH 2O, and the temperature in the tower is 60-92 ℃.
Eleven, fluidized bed cooling and temporary storage
And (3) sequentially cooling the dried concentrated milk for three times by a fluidized bed to obtain milk powder, and then temporarily storing the milk powder in a closed conveying system (or carrying out large packaging on 25KG perilla formula goat milk powder base powder). The air inlet temperature of the tertiary cooling is 15-35 ℃.
Twelve, tunnel sterilization
According to the proportion, arachidonic acid, docosahexaenoic acid, lactoferrin and colostrum basic protein are added into the dry mixing room after tunnel sterilization.
Thirteen, metering and mixing
Mixing the above arachidonic acid, docosahexaenoic acid, lactoferrin, and colostrum basic protein with the milk powder.
Fourteen, trace metal element detection
And a metal detector is installed on the formula milk powder production line, and trace metal element detection is carried out on the mixed milk powder. In this embodiment, the metal detector is calibrated by sequentially using 1.0mm iron balls, 1.2mm non-iron balls and 1.5mm stainless steel balls before use, so as to ensure accurate detection results.
Fifteen, nitrogen-filled package
Sieving the qualified milk powder through a vibrating screen, then conveying to a quantitative packaging machine, and performing film-covering nitrogen-filling packaging and sealing according to the required specification. The parameters of the film-covered nitrogen-filled package in the embodiment are as follows:
the nitrogen pressure is more than or equal to 0.5MPa, and the residual oxygen content is less than or equal to 3.0 percent;
the transverse sealing temperature of the adult formula milk powder is 175-185 ℃, and the longitudinal sealing temperature is 160-180 ℃.
Sixthly, external package
Canning or boxing according to the product variety requirement, sealing, spraying code, and finally boxing.
Seventeen, warehousing
And stacking the packaged finished products in a finished product warehouse according to the requirement for storage, wherein the products must be stacked on a tray and keep a certain distance from the wall surface, and stacking the products respectively according to the production date/batch number and the variety/specification to make marks. Keeping the warehouse clean and sanitary, cool, dry and ventilated, and keeping the rat-proof, dust-proof, damp-proof and fireproof facilities intact.
Eighteen, inspecting and leaving factory
And (4) inspecting the milk powder put in storage, wherein an inspection qualified report can be issued when the milk powder is qualified, and then the milk powder leaves the factory, and the milk powder returns for additional treatment when the milk powder is not qualified.
Comparative example
Providing the formula and the production process provided according to the embodiment 1, canceling one additive, and producing the control group milk powder, wherein the formula comprises the following specific steps: preparing control group milk powder A without adding lactoferrin; the addition of mixed vegetable oil is cancelled, and the control group milk powder B is prepared; the isomaltose hypgather is not added, and the control group milk powder C is prepared; preparing milk powder D of a control group without adding taurine; preparing control group milk powder E without adding choline chloride; choline chloride was added directly without compounding to prepare control group milk powder F.
Control test
A small amount of serum of a mouse is extracted, escherichia coli is added into the mouse, cell mass is formed after the specific combination of the antibody and the bacteria, the cell mass number under a microscope is recorded, 8 mice with the same number are selected, the 8 mice are respectively fed with the milk powder A-G of the example 1 and the control group for half a month, a small amount of serum of the mouse is extracted again, the escherichia coli is added into the mice again, cell mass is formed after the specific combination of the antibody and the bacteria, the cell mass number under the microscope is recorded, and the data are as follows:
| mouse group number | Milk powder combined number | Number of cell clusters under the scope of anterior lens for feeding | Number of cell clusters under the feeding back mirror |
| 1 | Example 1 | 3 | 12 |
| 2 | Control group milk powder A | 3 | 4 |
| 3 | Comparison group milk powder B | 3 | 7 |
| 4 | Control group milk powder C | 3 | 6 |
| 5 | Control group milk powder D | 3 | 9 |
| 6 | Control group milk powder E | 3 | 5 |
| 7 | Control group milk powder F | 3 | 7 |
The above-mentioned embodiment is only one of the preferred embodiments of the present invention, and should not be used to limit the scope of the present invention, but all the insubstantial modifications or changes made within the spirit and scope of the main design of the present invention, which still solve the technical problems consistent with the present invention, should be included in the scope of the present invention.
Claims (9)
1. The formula sheep milk powder for improving the immunity of children is characterized by consisting of raw sheep milk, desalted whey powder, full-fat sheep milk powder, isomaltooligosaccharide, concentrated whey protein powder, mixed vegetable oil, arachidonic acid, docosahexaenoic acid, lactoferrin, colostrum basic protein, potassium hydroxide and a compound nutrition enhancer, wherein the compound nutrition enhancer consists of choline chloride, taurine, L-ascorbic acid, dl-alpha-tocopheryl acetate, D-calcium pantothenate, nicotinamide, retinyl acetate, riboflavin, thiamine hydrochloride, pyridoxine hydrochloride, folic acid, cholecalciferol, cyanocobalamine, calcium carbonate, ferrous sulfate, zinc sulfate, sodium selenite and lactose.
2. The children's immunity enhancing formulated sheep milk powder of claim 1, wherein said blended vegetable oil is a blend of corn oil, canola oil, coconut oil, and high oleic sunflower oil.
3. The formulated sheep milk powder for improving children immunity according to claim 1, wherein the formulated goat milk consists of 993Kg of base powder prepared by a wet method and 5.72Kg of dry formula powder, calculated as 998.72Kg of finished formulated milk product, and the addition amount of each component for preparing the base powder is as follows, calculated as 1 ton of base powder prepared by the wet method: 400Kg of raw sheep milk, 400Kg of desalted whey powder, 300Kg of full-fat sheep milk powder, 100Kg of isomaltose hypgather, 75Kg of concentrated whey protein powder with the content of 34 percent, 25Kg of mixed vegetable oil, 1Kg of potassium hydroxide and 12Kg of compound nutrition enhancer; the arachidonic acid powder prepared by the dry method consists of 3.1Kg, 2.2Kg of docosahexaenoic acid, 0.22Kg of lactoferrin and 0.2Kg of colostrum basic protein.
4. The formulated sheep milk powder for improving immunity of children as claimed in claim 3, wherein the compound nutrition enhancer is composed of the following components: 2Kg of compound vitamin, 1Kg of compound mineral substance, 8Kg of compound calcium carbonate and 1Kg of compound choline chloride.
5. The children immunity enhancing formulated sheep milk powder of claim 4, wherein said compounded vitamins consist of: 700g of L-ascorbic acid, 134.1g of dl-alpha-tocopherol acetate, 24.4g of D-calcium pantothenate, 43g of nicotinamide, 66.6g of retinyl acetate, 85g of riboflavin, 11g of thiamine hydrochloride, 119.5g of pyridoxine hydrochloride, 23g of folic acid, 40g of cholecalciferol, 2.0g of cyanocobalamine, 320g of taurine and 431.4g of lactose.
6. The children immunity enhancing formulated sheep milk powder of claim 4, wherein the compound minerals consist of: 391.5g of ferrous sulfate, 285.7g of zinc sulfate, 31.1g of sodium selenite and 291.7g of lactose.
7. The formulated sheep milk for improving immunity of children according to claim 4, wherein the compound calcium carbonate is composed of the following components: 7999g of calcium carbonate, 0.5g of L-ascorbic acid and 0.5g of lactose.
8. The children immunity enhancing formulated sheep milk powder of claim 4, wherein the compound choline chloride is composed of the following components: 999g of choline chloride, 0.5g of L-ascorbic acid and 0.5g of lactose.
9. The preparation method of the formula sheep milk powder for improving the immunity of children as claimed in any one of claims 1 to 8, comprising the following steps:
(1) and (3) filtering and removing impurities: measuring and filtering raw sheep milk qualified by acceptance, and removing mechanical impurities in fresh milk;
(2) and (3) cold storage: cooling the filtered raw sheep milk and refrigerating for later use;
(3) cleaning milk: cleaning raw sheep milk, removing impurities in the sheep milk, and ensuring that the impurity degree is less than or equal to 2.0 mg/kg;
(4) and (3) sterilization: sterilizing the raw sheep milk after milk purification, and then storing;
(5) standardizing ingredients: mixing the stored raw sheep milk with desalted whey powder, full-fat sheep milk powder, isomaltose hypgather, concentrated whey protein powder, mixed vegetable oil, compound nutrition enhancer and potassium hydroxide according to the proportion, and carrying out standardized burdening and dissolving at 50-60 ℃ to obtain feed liquid;
(6) homogenizing: homogenizing the feed liquid in a high-pressure homogenizer at a temperature not higher than 60 deg.C under a homogenizing pressure of 10-14Mpa to break fat particles in the feed liquid into smaller fat balls, and uniformly dispersing in milk;
(7) concentration and evaporation and high-temperature sterilization: concentrating and evaporating the emulsion to remove water to form concentrated milk; and sterilizing the concentrated milk at high temperature;
(8) spray drying: pumping the concentrated milk into a sterile milk storage tank through a discharge pump, filtering the concentrated milk by using a filter screen before pumping the concentrated milk into the milk storage tank, and pumping the concentrated milk into a drying tower by using a high-pressure pump for spray drying; wherein: the air inlet temperature during spray drying is 170-185 ℃, the air exhaust temperature is 80-92 ℃, the negative pressure in the tower is-20-35 water column mmH 2O, and the temperature in the tower is 60-92 ℃;
(9) cooling: cooling the dried concentrated milk by a fluidized bed to obtain wet milk powder, and then introducing the wet milk powder into a dry mixing room by a closed conveying system;
(10) dry mixing: according to the proportion, arachidonic acid, docosahexaenoic acid, lactoferrin and colostrum basic protein are added into the dry mixing room after tunnel sterilization;
(11) metering and mixing: mixing the sterilized arachidonic acid, docosahexaenoic acid, lactoferrin and colostrum basic protein with the dried milk powder according to the proportion;
(12) and (3) detecting trace metal elements: detecting trace metal elements of the mixed milk powder;
(13) packaging and warehousing: sieving the qualified milk powder, and then performing film-covering nitrogen-filling packaging, external packaging, code spraying, boxing and warehousing according to the required specification; the nitrogen is filled for packaging, the nitrogen pressure is more than or equal to 0.5MPa, and the residual oxygen is less than or equal to 3.0 percent; the transverse sealing temperature of the adult formula milk powder is 175-185 ℃, and the longitudinal sealing temperature is 160-180 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110757728.9A CN113796419A (en) | 2021-07-05 | 2021-07-05 | Formula sheep milk powder for improving immunity of children and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110757728.9A CN113796419A (en) | 2021-07-05 | 2021-07-05 | Formula sheep milk powder for improving immunity of children and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113796419A true CN113796419A (en) | 2021-12-17 |
Family
ID=78893056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110757728.9A Pending CN113796419A (en) | 2021-07-05 | 2021-07-05 | Formula sheep milk powder for improving immunity of children and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113796419A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106615146A (en) * | 2016-09-01 | 2017-05-10 | 西安银桥乳业（集团）有限公司 | Infant formula added with combined prebiotics and preparation method thereof |
| CN109362895A (en) * | 2018-09-11 | 2019-02-22 | 内蒙古欧世蒙牛乳制品有限责任公司 | A kind of baby formula milk powder and preparation method thereof containing lactoferrin |
| AU2020101887A4 (en) * | 2020-08-19 | 2020-09-24 | Little Umbrella Limited | Milk powder for young children and preparation method thereof |
| CN111758774A (en) * | 2020-08-07 | 2020-10-13 | 西安百跃羊乳集团有限公司 | Perilla frutescens formula goat milk powder and preparation method thereof |
-
2021
- 2021-07-05 CN CN202110757728.9A patent/CN113796419A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106615146A (en) * | 2016-09-01 | 2017-05-10 | 西安银桥乳业（集团）有限公司 | Infant formula added with combined prebiotics and preparation method thereof |
| CN109362895A (en) * | 2018-09-11 | 2019-02-22 | 内蒙古欧世蒙牛乳制品有限责任公司 | A kind of baby formula milk powder and preparation method thereof containing lactoferrin |
| CN111758774A (en) * | 2020-08-07 | 2020-10-13 | 西安百跃羊乳集团有限公司 | Perilla frutescens formula goat milk powder and preparation method thereof |
| AU2020101887A4 (en) * | 2020-08-19 | 2020-09-24 | Little Umbrella Limited | Milk powder for young children and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111990462A (en) | Infant formula containing protein composition and preparation method thereof | |
| CN108522655A (en) | The baby milk and preparation method of micro functional active components in a kind of across-the-board regulation formula | |
| CN110786388A (en) | Milk powder for promoting growth of children and preparation method thereof | |
| CN110074188A (en) | A kind of baby formula milk powder and preparation method thereof adding human milk oligosaccharides | |
| CN111758774A (en) | Perilla frutescens formula goat milk powder and preparation method thereof | |
| CN116172191B (en) | Nutritional composition and its application in preparing anti-inflammatory products | |
| CN114223728B (en) | Premature/low birth weight infant formula containing prebiotics and probiotics | |
| CN109169916A (en) | A kind of puerpera's nutriment and its production technology | |
| CN114223729B (en) | Application of bifidobacterium longum subspecies infantis and breast milk oligosaccharide composition in formula milk powder | |
| CN109430382A (en) | It is a kind of to have effects that adjust the formula food and preparation method thereof of blood glucose | |
| CN111937964A (en) | Formula milk powder for promoting overall development of children and application thereof | |
| CN109077123A (en) | A kind of infant formula goat milk powder produced using concentrating and desalinating sheep whey liquid | |
| CN113331256A (en) | Formula sheep milk powder capable of promoting sleep and preparation method thereof | |
| CN112167360A (en) | Low-sensitization infant formula goat milk powder | |
| CN112772722A (en) | Formula and production method of milk powder for helping skeleton and height development of children | |
| CN111067104A (en) | Composite probiotic infant formula milk powder and preparation method thereof | |
| CN104381782A (en) | Bovine colostrum calcium citrate chewable tablet and preparation method thereof | |
| CN113142306A (en) | Preparation method of infant formula milk powder | |
| CN114208893B (en) | Formula milk powder capable of improving intestinal microenvironment health and preparation method and application thereof | |
| CN113841740A (en) | Sialic acid-containing infant formula milk powder and preparation method thereof | |
| CN112056404A (en) | Formula milk powder for pregnant women and preparation method thereof | |
| CN112715672A (en) | Oligosaccharide mother-emulsified infant formula milk and preparation method thereof | |
| CN107927198A (en) | One kind drinks milk powder and preparation method thereof for premature | |
| CN111642566A (en) | Goat milk powder beneficial to children's height and intelligence development | |
| CN113796419A (en) | Formula sheep milk powder for improving immunity of children and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20211217 |