CN111937964A - Formula milk powder for promoting overall development of children and application thereof - Google Patents
Formula milk powder for promoting overall development of children and application thereof Download PDFInfo
- Publication number
- CN111937964A CN111937964A CN202010768330.0A CN202010768330A CN111937964A CN 111937964 A CN111937964 A CN 111937964A CN 202010768330 A CN202010768330 A CN 202010768330A CN 111937964 A CN111937964 A CN 111937964A
- Authority
- CN
- China
- Prior art keywords
- vitamin
- children
- powder
- milk powder
- percent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1522—Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1528—Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/154—Milk preparations; Milk powder or milk powder preparations containing additives containing thickening substances, eggs or cereal preparations; Milk gels
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/156—Flavoured milk preparations ; Addition of fruits, vegetables, sugars, sugar alcohols or sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/158—Milk preparations; Milk powder or milk powder preparations containing additives containing vitamins or antibiotics
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Dairy Products (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention belongs to the technical field of food, comprising: whole milk powder, 90% desalted whey powder, xylitol, erythritol, fructo-oligosaccharide, calcium carbonate, DHA, linolenic acid, bovine colostrum powder, N-acetylneuraminic acid, hydrolyzed yolk powder, lactoferrin, bifidobacterium animalis, vitamin premix, mineral premix and lactase; the formula milk powder combines DHA and N-acetylneuraminic acid to promote brain development of children, lutein, taurine and vitamin A are used for protecting vision of the children, lactoferrin, immunoglobulin and animal bifidobacteria are added to improve immunity of the children and regulate intestinal balance of the children, and the lactoferrin, the immunoglobulin and the animal bifidobacteria are reasonably compatible with substances such as whole milk powder, hydrolyzed yolk powder, multiple vitamins, minerals, dietary fibers and the like, so that the formula milk powder has the effect of promoting the comprehensive development of the brain, vision and body of the children aged 3-15 years, has the advantage of improving obesity of teenagers, is added with erythritol, enriches the mouthfeel of the milk powder, and does not cause caries risk.
Description
Technical Field
The invention relates to the technical field of food, in particular to formula milk powder for promoting overall development of children and application thereof.
Background
The age of 1-5 years is the key period of the growth of children, the digestive system is not completely mature, the immune function is poor, and 400-500 mL of proper formula milk powder needs to be supplemented every day to obtain enough nutrition. The 6 year old children enter the education stage of school, grow and develop rapidly, the demand for energy and nutrient is higher than that of adults, 300-500 ml of milk product is still needed every day, sufficient nutrition can promote normal development of intelligence and physique of children, and immunity is improved. The height and the weight of the children aged 3-7 are steadily increased, and the brain develops into a second peak period. Studies have shown that the brain capacity of a person at 6 months of age is twice that of birth, that of a person at two years of age is three times that of birth, and that at 6 years of age the brain capacity almost reaches that of an adult. The physique of children aged 6-15 years begins to steadily increase, and the intelligence begins to steadily develop. Therefore, the age of 3-15 years is the gold time for the development of children's body and intelligence. Research shows that the optic nervous system develops continuously after birth and gradually matures. Since the development stage of children is also the learning stage, it is easy for the children to have eyestrain and impaired vision due to improper use of eyes. The function of the eyes of the children is basically developed and completed in the age group of 3-15 years, so that the age group is a key period for the eyes to strive for structural reversibility and functional reversibility in a certain range and a key period for healthy development of the vision of the children, and the vision of the children needs to be protected in the age group. During this period, the healthy growth of children requires sufficient energy and various nutrients beneficial to physical and mental development.
With the improvement of social and economic conditions, the supply of nutrient substances is sufficient, the condition of nutrient deficiency of children is obviously improved, but the growth and development of the children are limited due to malnutrition and overnutrition caused by anorexia, monophagia, excessive nourishing and the like in the growth and development process, and the overnutrition increases the load of heart and kidney. Over the past decades, the rate of overweight and obesity in children has risen dramatically worldwide. The obesity problem has seriously affected many aspects of the socio-economic development of children and teenagers, such as physical development, physical and mental health, social adaptation, fertility, labor capacity, disease burden and the like. At this time, nutrition instruction is particularly important for the intake of nutrition by children. The good nutritional status is the necessary guarantee for the growth of the physique and intelligence quotient of the children, can also improve the immunity of the children, and is very important for promoting the growth and the development of the children.
The existing children milk powder has the following defects: (1) the functions are single, and the development is only carried out on a specific function, such as functions of benefiting intelligence, protecting eyesight and the like; (2) high sugar raw materials such as white granulated sugar are added, so that dental caries and obesity of children are easily caused. In conclusion, the children formula milk powder which is rich in nutrition and can promote the comprehensive development of the vision, intelligence, height, immunity and the like of the children is urgently needed to solve the problems in the prior art.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide the formula milk powder for promoting the overall development of children.
The second purpose of the invention is to provide the application of the formula milk powder.
The purpose of the invention is realized by the following technical scheme:
the formula milk powder for promoting the overall development of children comprises the following components in percentage by mass: 62-66% of full-cream milk powder, 18-22% of 90% desalted whey powder, 1-3% of xylitol, 6-10% of erythritol, 2-4% of fructo-oligosaccharide, 0.5-1% of calcium carbonate, 0.1-0.3% of DHA (docosahexaenoic acid), 0.05-0.06% of linolenic acid, 0.01-0.1% of bovine colostrum powder, 0.01-0.05% of N-acetylneuraminic acid, 0.01-0.1% of hydrolyzed yolk powder, 0.01-0.03% of lactoferrin, 0.01-0.06% of animal bifidobacterium, 0.1-0.3% of vitamin premix, 0.1-0.3% of mineral premix and 0.01-0.1% of lactase;
wherein the vitamin premix comprises the following components: vitamin C, taurine, lutein, vitamin A, vitamin D, nicotinic acid, vitamin K and vitamin B1; the mineral premix comprises the following components: magnesium, iron, zinc.
Preferably, the magnesium is derived from magnesium oxide, magnesium sulfate, magnesium carbonate; the iron is selected from ferric pyrophosphate, ferrous sulfate, and ferrous gluconate; the zinc is selected from zinc oxide, zinc gluconate, zinc citrate, zinc carbonate, zinc sulfate, and zinc chloride.
The formula milk powder disclosed by the invention is prepared by combining DHA and N-acetylneuraminic acid to promote the brain development of children, protecting the vision of children by lutein, taurine and vitamin A, and adding lactoferrin, immunoglobulin lgG and animal bifidobacteria Bb-12 to improve the immunity of children and regulate the intestinal balance of children, and the formula milk powder is reasonably compatible with whole milk powder, hydrolyzed yolk powder, multiple vitamins, mineral substances (high calcium, iron and zinc), dietary fibers (fructo-oligosaccharide) and other substances to play a synergistic effect, has the effect of promoting the comprehensive development of the brain, vision and body of children of 3-15 years old, has the advantage of improving the obesity of teenagers, is added with erythritol to enrich the milk powder, and has the taste of the milk powder without causing dental caries risk.
Docosahexaenoic acid (DHA) is an important structural component of central nervous system and retina, and can be used for regulating and aggregating in infant brain tissue and retina, promoting vision development, and improving cognitive ability.
N-acetylneuraminic acid (cubilose acid) can promote information transmission speed of brain nerve cells, promote development of memory and intelligence, and play an important role in intelligence development of children.
It has effects in improving brain, protecting vision, improving sleep, and reducing blood lipid. Linolenic acid has effects in improving intelligence of children, strengthening brain, promoting growth and development of children, improving memory, protecting eyesight, and improving sleep.
Lactoferrin is a multifunctional protein, participates in iron metabolism, promotes iron absorption, promotes hematopoiesis and effectively prevents iron-deficiency anemia; can regulate the growth of bone marrow cells and promote the growth of cells; and can regulate immunity and enhance disease resistance.
In the compound mineral, iron is an essential element for forming red blood cells, and zinc is an essential element for growth and development of children; calcium is a main component of human bones and teeth, participates in a plurality of physiological functions of human bodies, and has important significance for maintaining the health of the human bodies and ensuring the normal growth and development of the human bodies.
Vitamins have very important functions in human bodies, and the lack of certain vitamins or the excess of certain vitamins in the human bodies are harmful to health and have corresponding pathological symptoms. The children meet the daily vitamins required by the growth and development of the children by fully strengthening various vitamins; taurine and lutein have important effects on the development of vision.
The fructo-oligosaccharide has effects in regulating intestinal flora, proliferating Bacillus bifidus, promoting calcium absorption, regulating blood lipid, regulating immunity, and resisting dental caries.
The animal bifidobacterium has the functions of promoting the balance of intestinal flora, improving the immunity and improving the resistance of the organism to common respiratory tract infection.
The bovine colostrum not only contains rich nutrient substances, but also contains a large amount of immune factors and growth factors, such as immunoglobulin, lactoferrin, lysozyme, insulin-like growth factors, epidermal growth factors and the like, and has a series of physiological activity functions of regulating immunity, improving gastrointestinal tracts, promoting growth and development, improving aging symptoms, inhibiting various pathogenic microorganisms and the like, so the bovine colostrum is known as health-care food in the 21 st century.
The hydrolyzed yolk powder can increase the number of osteoblasts, promote the generation of bones and teeth, activate the motive power of the bones and promote the elongation of the bones; promote the calcium deposition of the skeleton and strengthen the toughness of the skeleton; inhibit the growth of osteoclast and maintain the balance of bone components.
Calcium is a basic material for skeletal development, directly affects body height, and has other important physiological functions in vivo. These functions play an important role in maintaining the health of organisms and ensuring the smooth progress of normal growth and development. Calcium can promote the activity of certain enzymes in vivo and regulate the activity of the enzymes; involved in nerve, muscle activity and neurotransmitter release; regulate the secretion of hormones. Calcium is also required for blood coagulation, cell adhesion, and muscle contraction. Calcium also has effects in regulating heart rhythm, reducing cardiovascular permeability, controlling inflammation and edema, and maintaining acid-base balance. The product is enriched with calcium, and can meet the need of children in development process.
Erythritol belongs to a novel functional sugar alcohol food sweetening agent and has low calorific value. Erythritol has a calorific value of about 1/10 that of sucrose, belongs to non-metabolizable low-calorie sugar alcohol, and has a small molecular weight so that it can be absorbed without decomposition in the small intestine and then excreted with urine without affecting body fat during the metabolizing process. In addition, since erythritol cannot be metabolized by the body's enzyme system, does not cause changes in the body's blood sugar and insulin levels, and has no influence on sugar metabolism, it can be used for developing foods suitable for patients with obesity and diabetes. And the erythritol also has the advantages of resisting decayed teeth, promoting the proliferation of probiotics, resisting oxidation and having high tolerance.
The xylitol has sweetness equivalent to that of sucrose at normal temperature, 1.2 times of that of sucrose at low temperature, but is not fermented and utilized by bacteria in oral cavity, and can inhibit bacterial growth and acid generation and prevent dental caries.
Lactase can decompose excessive lactose in human body into glucose and galactose. Glucose is an energy source for metabolism of each part of a human body, galactose is structural sugar necessary for metabolism of human brain and mucous membrane tissues, is an essential tissue for development of infant brain, and is closely related to rapid growth of infant brain. In addition, lactase can generate oligosaccharides in a human body through transglycosylation, and the oligosaccharides are low-molecular-weight and non-sticky water-soluble dietary fibers which are used as multiplication factors only by bifidobacterium and not used by putrefying bacteria in intestinal tracts, so that the generation of harmful toxins in the intestinal tracts can be greatly reduced, and the lactase has an important effect on preventing constipation and diarrhea. And lactose intolerance can be relieved to a certain extent by adding lactase.
In the formula milk powder, the whole milk powder and the 90% desalted whey powder are used together to provide protein and fat required by children, and the bovine colostrum contains a large amount of immune factors and growth factors and is beneficial to immune regulation.
Preferably, the formula milk powder for promoting the overall development of children comprises the following components in percentage by mass: 64.75 percent of full-cream milk powder, 20 percent of 90 percent desalted whey powder, 2 percent of xylitol, 8 percent of erythritol, 3.5 percent of fructo-oligosaccharide, 0.85 percent of calcium carbonate, 0.2 percent of DHA, 0.056 percent of linolenic acid, 0.05 percent of bovine colostrum powder, 0.022 percent of N-acetylneuraminic acid, 0.06 percent of hydrolyzed yolk powder, 0.012 percent of lactoferrin, 0.05 percent of animal bifidobacterium, 0.2 percent of vitamin premix, 0.2 percent of mineral premix and 0.05 percent of lactase.
Preferably, the vitamin premix comprises the following components in percentage by mass: 19.12-25.87% of vitamin C, 17-23% of taurine, 9.95-13.46% of lutein, 1.54-2.09% of vitamin A, 1.17-1.95% of vitamin D, 1.20-1.62% of nicotinic acid, 0.46-0.62% of vitamin K, 0.20-0.28% of vitamin B1 and 31.11-49.36% of maltodextrin.
The vitamin dosage design refers to the recommended nutrient intake of children in Chinese resident diet, meets the nutritional requirements of the children in the growth and development process, and meets the requirements of GB14880 national standard for food safety food nutrition enhancer use standard on the allowable compound source and allowable usage amount of the milk powder nutrition enhancer for the children. The selection of the nutrient formulation fully considers the solubility, the effective component content, the inherent characteristics and the absorption, transformation and metabolism condition of each substance in human body.
The mineral premix comprises the following components in percentage by mass: 12.54-15.34% of iron, 25.07-30.64% of magnesium, 3.64-4.45% of zinc and 49.57-58.75% of maltodextrin.
The invention also provides application of the formula milk powder for promoting the overall development of children in obesity improvement.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a formula milk powder for promoting the overall development of children, which comprises the following components: whole milk powder, 90% desalted whey powder, xylitol, erythritol, fructo-oligosaccharide, calcium carbonate, DHA, linolenic acid, bovine colostrum powder, N-acetylneuraminic acid, hydrolyzed yolk powder, lactoferrin, bifidobacterium animalis, vitamin premix, mineral premix and lactase; wherein the vitamin premix comprises the following components: vitamin C, taurine, lutein, vitamin A, vitamin D, nicotinic acid, vitamin K and vitamin B1; the mineral premix comprises the following components: magnesium, iron, zinc.
The formula milk powder disclosed by the invention is prepared by combining DHA and N-acetylneuraminic acid to promote the brain development of children, protecting the vision of children by lutein, taurine and vitamin A, and adding lactoferrin, immunoglobulin lgG and animal bifidobacteria Bb-12 to improve the immunity of children and regulate the intestinal balance of children, and the formula milk powder is reasonably compatible with whole milk powder, hydrolyzed yolk powder, multiple vitamins, mineral substances (high calcium, iron and zinc), dietary fibers (fructo-oligosaccharide) and other substances to play a synergistic effect, has the effect of promoting the comprehensive development of the brain, vision and body of children of 3-15 years old, has the advantage of improving the obesity of teenagers, is added with erythritol to enrich the milk powder, and has the taste of the milk powder without causing dental caries risk.
Drawings
FIG. 1 is a production flow chart of the formula milk powder of the present invention.
Detailed Description
The following further describes the embodiments of the present invention. It should be noted that the description of the embodiments is provided to help understanding of the present invention, but the present invention is not limited thereto. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
The test methods used in the following experimental examples are all conventional methods unless otherwise specified; the materials, reagents and the like used are, unless otherwise specified, commercially available reagents and materials.
Example 1
Formula milk powder (1000kg) for promoting overall development of children is prepared from the following raw materials:
625kg of full cream milk powder, 220kg of 90% desalted whey powder, 15kg of xylitol, 95kg of erythritol, 30kg of fructo-oligosaccharide, 8.3kg of calcium carbonate, 1kg of DHA (docosahexaenoic acid) algal oil powder (7%), 0.3kg of linolenic acid powder, 0.6kg of bovine colostrum powder, 0.3kg of N-acetylneuraminic acid, 0.8kg of hydrolyzed yolk powder, 0.1kg of lactoferrin, 0.6kg of bifidobacterium animalis Bb-12 powder, 1kg of vitamin premix, 1kg of mineral premix and 1kg of lactase.
The vitamin premix comprises the following components in percentage by weight: 19.12% of vitamin C, 23.00% of taurine, 9.95% of lutein, 2.09% of vitamin A, 1.95% of vitamin D, 1.62% of nicotinic acid, 0.62% of vitamin K, 0.28% of vitamin B1 and the balance of maltodextrin.
Wherein, the mineral premix comprises the following components: 25.07% magnesium (magnesium oxide), 15.34% iron (ferric pyrophosphate), 4.45% zinc (zinc oxide), and the balance maltodextrin.
Example 2
Formula milk powder (1000kg) for promoting overall development of children is prepared from the following raw materials:
647.5kg of full cream milk powder, 200kg of 90% desalted whey powder, 20kg of xylitol, 80kg of erythritol, 35kg of fructo-oligosaccharide, 8.5kg of calcium carbonate, 2kg of DHA algal oil powder (7%), 0.56kg of linolenic acid powder, 0.5kg of bovine colostrum powder, 0.22kg of N-acetylneuraminic acid, 0.6kg of hydrolyzed yolk powder, 0.12kg of lactoferrin, 0.5kg of bifidobacterium animalis Bb-12 powder, 2kg of vitamin premix, 2kg of mineral premix and 0.5kg of lactase.
The vitamin premix comprises the following components in percentage by weight: 22.50% of vitamin C, 20.00% of taurine, 11.70% of lutein, 1.82% of vitamin A, 1.56% of vitamin D, 1.41% of nicotinic acid, 0.54% of vitamin K, 0.23% of vitamin B1 and the balance of maltodextrin.
Wherein, the mineral premix comprises the following components: 27.86% magnesium (magnesium oxide), 13.94% iron (ferric pyrophosphate), 4.05% zinc (zinc oxide), the balance being maltodextrin.
Example 3
Formula milk powder (1000kg) for promoting overall development of children is prepared from the following raw materials:
660kg of full-cream milk powder, 190kg of 90% desalted whey powder, 30kg of xylitol, 68.5kg of erythritol, 28kg of fructo-oligosaccharide, 10kg of calcium carbonate, 3kg of DHA (docosahexaenoic acid) algal oil powder (7%), 0.6kg of linolenic acid powder, 1kg of bovine colostrum powder, 0.5kg of N-acetylneuraminic acid, 1kg of hydrolyzed yolk powder, 0.3kg of lactoferrin, 1kg of bifidobacterium animalis Bb-12 powder, 3kg of vitamin premix, 3kg of mineral premix and 0.1kg of lactase.
The vitamin premix comprises the following components in percentage by weight: 25.87% vitamin C (sodium ascorbate), 17.00% taurine, 13.46% lutein, 1.54% vitamin a (retinyl acetate), 1.17% vitamin D (cholecalciferol), 1.20% niacin (niacinamide), 0.46% vitamin K (phytomenadione), 0.20% vitamin B1 (thiamine hydrochloride), and the balance maltodextrin.
Wherein, the mineral premix comprises the following components: 30.64% magnesium (magnesium oxide), 12.54% iron (ferric pyrophosphate), 3.64% zinc (zinc oxide), and the balance maltodextrin.
Comparative example 1
Unlike example 2, the formula of this comparative example does not contain linolenic acid powder, and the mass of the whole milk powder is 648.06 kg.
Comparative example 2
Unlike example 2, the formula of this comparative example does not contain N-acetylneuraminic acid, and the mass of the whole milk powder is 647.72 kg.
First, bone mineral density experiment
40 SPF female Wistar rats with the weight of about 300g are divided into a control group and an experimental group after being adaptively fed for one week; wherein after the experimental group is fed adaptively, the formula milk powder obtained in examples 1 to 3 and comparative examples 1 to 2 is fed, and the formula milk powder (the formula milk powder given in the specific embodiment in the patent with the publication number of CN 11296577A) is fed to the control group; each group of 10 animals was fed in a single cage, fed freely, dosed with deionized water (to avoid calcium pick-up from drinking), weighed weekly, and the feeding recorded for a 13 week period.
Animals were sacrificed after 13 weeks feeding, one side of the femur was peeled off, baked in an oven at 105 ℃ to constant weight, and the dry weight and length of the bones were weighed; measuring the bone density of the key point of the femur and the distal end of the femur by using a single photon bone densitometer; roasting thighbones on one side of a rat to constant weight, and then digesting the whole body by a wet method; the calcium content was determined by atomic absorption spectrophotometry (GB/T5009.92-2003).
Table 1 shows the effect of formula on rat body weight
Table 2 shows the effect of formula on femur length, femur weight and calcium content in rats
| Group of | Femur length (cm) | Femur weight (g) | Calcium content of femur (mg/g) |
| Example 1 | 3.577±0.065 | 0.669±0.057 | 395±27 |
| Example 2 | 3.579±0.069 | 0.666±0.059 | 391±31 |
| Example 3 | 3.575±0.063 | 0.665±0.061 | 392±29 |
| Comparative example 1 | 3.554±0.046 | 0.651±0.036 | 383±41 |
| Comparative example 2 | 3.551±0.051 | 0.653±0.039 | 385±39 |
| Control group | 3.569±0.035 | 0.655±0.038 | 381±38 |
Table 1 shows the effect of the formula milk powder on the body weight of rats, and it can be seen from table 1 that the formula milk powder of examples 1 to 3 of the present invention is selected to significantly increase the body weight of rats compared to the commercially available formula milk powder, and the lack of linolenic acid or N-acetylneuraminic acid has no significant effect on the body weight; table 2 shows the effect of the formula milk powder on the calcium content of the femur and femur of a rat, and it can be seen from table 2 that, compared with the formula of the commercially available milk powder, the milk powder of the present invention selected from the examples 1 to 3 can significantly improve the femur length, the femur weight and the calcium content of the femur of a rat, and the lack of linolenic acid or N-acetylneuraminic acid has no significant effect on the bone development of a mouse, thereby demonstrating that the formula milk powder of the present invention can significantly improve the height and the weight of a rat, and the sufficient calcium content in vivo can meet the requirement of the body development.
Water maze experiment
C57BL/6 mice were purchased 6 weeks old, acclimatized for 12 days, and then subjected to the water maze experiment.
The mouse Morris water maze online detection system consists of a stainless steel plastic-sprayed cylindrical water pool and an image acquisition and analysis system, wherein the diameter of the water pool is 100cm, the height of the water pool is 38cm, and the diameter of a platform is 6cm, and the height of the platform is 14 cm. The pool is divided into 4 quadrants (NE, SE, SW and NW) according to four directions of southeast, west and north, the middle point of the circular arc of the wall of the quadrant pool is an optional animal water inlet point, and the platform can be arranged in the center of any quadrant. The image acquisition and analysis system records animal swimming track data for index extraction and analysis.
Spatial search experiments: the NW quadrant is selected as the entry quadrant, and the spatial memory of the animal is evaluated by the number of times the animal passes through the original platform position within 60s, the original platform quadrant run length ratio and the time ratio (namely the ratio of the run length and time of the animal in the original platform quadrant to the total run length and total time).
TABLE 3 Water maze test results (space search)
Table 3 shows the results of the water maze test on mice, the effect of the milk powder on the mice is significantly different in different groups, the platform crossing times of the mice fed with the formula milk powder of examples 1 to 3 are significantly higher than those of the control group, and the quadrant run rate and time rate of the original platform are significantly higher than those of the control group, the difference is significant, which suggests that the spatial position memory ability of the mice fed with the formula milk powder of examples 1 to 3 is stronger than that of the control group, and in addition, as can be seen from comparative examples 1 and 2, the lack of linolenic acid or/and N-acetylneuraminic acid significantly affects the cognition of the mice.
Third, improving the fat blood of fat mice
The experimental process comprises the following steps: c57BL/6J mice are adaptively fed for about 8d, except for the control group mice which are fed with common feed, other mice are fed with high-fat feed for 3 months; after the model building is successful (the increase of the physical quality is more than 20 percent of that of a control group), mice fed with high-fat feed are randomly divided into an example 1 group, an example 2 group and an example 3 group according to the physical quality, 20 mice are fed with the formula milk powder of the example 1, the example 2 and the example 3 respectively for 2 months, the control group is fed with the same volume of commercial milk powder, the animal body quality and the food intake are monitored every week, and the mental state, the hair color, the diet, the drinking water, the activity and the like of the mice are observed.
And (3) detecting the state of the obese mouse: the results of the tests on the relative body mass growth rate and waist circumference (60d) of each group of mice are shown in table 4. from table 4, it can be seen that the formulas of examples 1 to 3 can significantly reduce the body mass growth rate and waist circumference of the mice relative to the control group.
Serological index detection: at 1d prior to testing, the pad was changed and the mice were fasted overnight. 2d, collecting plasma, standing for 2h at room temperature, centrifuging, subpackaging in a refrigerator at-80 ℃ for storage, and respectively detecting the levels of Triacylglycerol (TG) and Total Cholesterol (TC) in the serum, wherein the results are shown in Table 5, and as can be seen from the table 5, compared with a control group, the levels of TG and TC in the serum of the mice fed by the formula milk powder of the examples 1 to 3 are obviously reduced, which shows that the formula milk powder of the invention can improve the dyslipidemia of obese mice.
TABLE 4
TABLE 5
| Group of | TG(mmol/L) | TC(mmol/L) |
| Example 1 | 0.6±0.2 | 3.3±0.3 |
| Example 2 | 0.6±0.3 | 3.6±0.2 |
| Example 3 | 0.7±0.1 | 3.5±0.3 |
| Control group | 1.4±0.2 | 4.8±0.6 |
Example 4
The production flow of the formula of example 1, example 2 and example 3 comprises the following steps:
(1) checking and accepting raw materials and auxiliary materials: all the used raw and auxiliary materials come from a supplier qualified by evaluation, products produced by enterprises obtaining production licenses must be selected, and the products have certification, imported raw materials must provide certification materials of entry and exit inspection and quarantine departments, quality departments and inspection departments inspect and accept the raw materials according to the inspection standards of companies, and the raw materials can be put into use after being qualified; all packing materials related to the production of the formula milk powder come from suppliers qualified by evaluation, all packing materials are required to be checked and accepted according to corresponding checking and accepting standards, the packing materials meet the checking and accepting standards of the packing materials specified by companies, and qualified packing materials can be put into use.
(2) Preparing materials: all raw and auxiliary materials are received and prepared according to the requirements of a production plan, and the names, specifications, production dates, batch numbers, quality guarantee periods, quantities, whether the raw and auxiliary materials are qualified, whether the external packages are pollution-free and the like of the raw and auxiliary materials are confirmed.
(3) Removing the outer package: the raw materials are taken off from the outer bag in a feeding workshop, before feeding, whether the variety and the quantity of various raw and auxiliary materials used conform to a production plan list is confirmed again, and the outer bag and the sealing line are stored in a centralized way.
(4) Dedusting and sterilizing the inner bag: after the outer package is removed, the inner package and the appearance of the content of the raw and auxiliary materials are checked to confirm that the inner package of the raw and auxiliary materials used in the production is intact. The inner package needs to be cleaned by a method of wiping 75 +/-1 percent (vol% at 20 ℃) of alcohol on the surface for disinfection;
sterilizing raw materials and auxiliary materials: adopt the tunnel that disinfects to disinfect, tunnel conveyer belt frequency: less than or equal to 30Hz, and the sterilization time is more than or equal to 60 s. Ultraviolet intensity is more than or equal to 70 mu w/cm2。
(5) And (3) metering the ingredients: the batching personnel accurately weigh various raw materials and auxiliary materials by using the calibrated electronic scale according to the requirements of the formula table of the product, marks (names and quantities) are made on the various raw materials and the auxiliary materials, the raw materials and the auxiliary materials are conveyed to a goods shelf to be placed in order for the next procedure to use, and meanwhile, the records of batching and weighing are made.
(6) Premixing: pre-stirring calcium carbonate, DHA algae oil powder (7%), linolenic acid powder, N-acetylneuraminic acid (cubilose acid), hydrolyzed yolk powder, lactoferrin, animal bifidobacterium Bb-12, vitamin premix, mineral premix, bovine colostrum powder, lactase and the like. The obtained mixed powder is filled in a big sterilized inner bag, and a mark is made for standby.
(7) Feeding and sieving: checking the mixed powder information and the raw material information according to a production work order and a formula table, removing an inner package after confirming the correctness, putting the inner package into a vibrating sieving machine, carrying out physical sieving, and conveying the sieved mixture to a suspended weighing bin through a feed opening and a sealed pipeline.
(8) Final mixing: dry-mixing the premix with whole milk powder, fructo-oligosaccharide, xylitol, erythritol, 90% desalted whey powder and the like, fully stirring in a dry-mixing stirring cylinder to fully mix the materials uniformly, and conveying the mixed formula powder to a full-automatic packaging machine for quantitative packaging after passing through a vibrating screen and a filter screen.
(9) Metal detection: and the finished product materials to be packaged completely pass through a blanking pipeline provided with a metal detector before entering the filling machine. Before production, the standard block is used for verifying the equipment; in the production process, if the metal detector has an alarm, whether metal foreign matters exist or not is checked in time and the metal foreign matters are cleaned, so that the metal foreign matters are prevented from entering a product, and the detection limit of the metal detector is as follows: limit of iron detection:
nonferrous detection limit:
stainless steel detection limit:
(10) dedusting and sterilizing packing materials:
iron can: transport through the conveyer belt, the process sweeps the empty can through compressed air, gets rid of the foreign matter, disinfects again through the tunnel and gets into between the inner packing, tunnel conveyer belt frequency disinfects: not more than 25Hz, sterilization time not less than 10s, ultraviolet intensity not less than 70 μ w/cm2。
Bottom cover, inner membrane bag: ozone sterilization is adopted, the ozone sterilization concentration is more than or equal to 10ppm, and the sterilization time is more than or equal to 60 min.
(11) Filling, vacuum nitrogen filling and packaging: the parameters of a filling machine and the net content of the product are set before starting production, the packing material is automatically supplied by equipment, and the semi-finished milk powder is continuously stirred by a spiral stirring paddle and filled into an iron can one by one. And conveying the semi-finished product to a can sealing machine through a conveying belt, automatically vacuumizing through the can sealing machine, and filling nitrogen. The pressure of the sealed tank is more than or equal to 0.2 MPa. When 800g and 400g of product are produced, the evacuation pressure P1 is set to be between-80 Kpa and-95 Kpa, and the vacuum degree P2 after nitrogen charging is set to be between-15 Kpa and-30 Kpa. When 85g and 50g of products are produced, the vacuum pressure P1 is set to be between-50 Kpa and-70 Kpa, and the vacuum degree P2 after nitrogen filling is set to be between-5 Kpa and-20 Kpa. Packaging requirements of canned products: the residual oxygen content is less than or equal to 3 percent, and the air leakage (vacuum pressure of-70 KPa, 30 s) cannot occur in the sealing property.
(12) Labeling, code spraying and boxing: and the canned product enters an outer packaging workshop through a conveyer belt, and is labeled and coded according to requirements. The code spraying should be clear and accurate. And (5) boxing according to the product requirements, printing the production date on the outer package of the box package according to the requirements, and checking whether the production date is correct or not.
(13) And (6) inspection and warehousing: and all finished products are inspected according to the product execution standard, and qualified inspection report sheets are issued after the finished products are inspected to be qualified and then are stored according to the finished product management regulations of the company.
It will be appreciated by those skilled in the art that the use of the present invention is not limited to the specific applications described above. The invention is also not limited to the preferred embodiments thereof with respect to the specific elements and/or features described or depicted herein. It should be understood that the invention is not limited to the disclosed embodiment or embodiments, but is capable of numerous rearrangements, modifications and substitutions without departing from the scope of the invention as set forth and defined by the following claims.
Claims (4)
1. The formula milk powder for promoting the overall development of children is characterized by comprising the following components in percentage by mass: 62-66% of full-cream milk powder, 18-22% of 90% desalted whey powder, 1-3% of xylitol, 6-10% of erythritol, 2-4% of fructo-oligosaccharide, 0.5-1% of calcium carbonate, 0.1-0.3% of DHA (docosahexaenoic acid), 0.05-0.06% of linolenic acid, 0.01-0.1% of bovine colostrum powder, 0.01-0.05% of N-acetylneuraminic acid, 0.01-0.1% of hydrolyzed yolk powder, 0.01-0.03% of lactoferrin, 0.01-0.06% of animal bifidobacterium, 0.1-0.3% of vitamin premix, 0.1-0.3% of mineral premix and 0.01-0.1% of lactase;
wherein the vitamin premix comprises the following components: vitamin C, taurine, lutein, vitamin A, vitamin D, nicotinic acid, vitamin K and vitamin B1; the mineral premix comprises the following components: magnesium, iron, zinc.
2. The formula milk powder for promoting the overall development of children according to claim 1, wherein the formula milk powder comprises the following components in percentage by mass: 64.75 percent of full-cream milk powder, 20 percent of 90 percent desalted whey powder, 2 percent of xylitol, 8 percent of erythritol, 3.5 percent of fructo-oligosaccharide, 0.85 percent of calcium carbonate, 0.2 percent of DHA, 0.056 percent of linolenic acid, 0.05 percent of bovine colostrum powder, 0.022 percent of N-acetylneuraminic acid, 0.06 percent of hydrolyzed yolk powder, 0.012 percent of lactoferrin, 0.05 percent of animal bifidobacterium, 0.2 percent of vitamin premix, 0.2 percent of mineral premix and 0.05 percent of lactase.
3. The formula milk powder for promoting the overall development of children according to claim 2, wherein the vitamin premix comprises the following components in percentage by mass: 19.12-25.87% of vitamin C, 17-23% of taurine, 9.95-13.46% of lutein, 1.54-2.09% of vitamin A, 1.17-1.95% of vitamin D, 1.20-1.62% of nicotinic acid, 0.46-0.62% of vitamin K, 0.20-0.28% of vitamin B1 and 31.11-49.36% of maltodextrin.
The mineral premix comprises the following components in percentage by mass: 12.54-15.34% of iron, 25.07-30.64% of magnesium, 3.64-4.45% of zinc and 49.57-58.75% of maltodextrin.
4. Use of a formula for promoting the overall development of children according to any one of claims 1 to 3 for improving obesity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010768330.0A CN111937964A (en) | 2020-08-03 | 2020-08-03 | Formula milk powder for promoting overall development of children and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010768330.0A CN111937964A (en) | 2020-08-03 | 2020-08-03 | Formula milk powder for promoting overall development of children and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111937964A true CN111937964A (en) | 2020-11-17 |
Family
ID=73339392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010768330.0A Withdrawn CN111937964A (en) | 2020-08-03 | 2020-08-03 | Formula milk powder for promoting overall development of children and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111937964A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112889930A (en) * | 2021-03-08 | 2021-06-04 | 湖南欧比佳营养食品有限公司 | Formula of milk powder for promoting children immunity and bone growth and preparation method thereof |
| CN112889929A (en) * | 2021-02-26 | 2021-06-04 | 广州麦乐生物科技有限公司 | Preparation method and formula of milk powder for promoting height development of children |
| CN115025105A (en) * | 2022-06-07 | 2022-09-09 | 嘉必优生物技术（武汉）股份有限公司 | Use of sialic acid for reducing weight and inhibiting weight gain |
| CN116725141A (en) * | 2023-06-14 | 2023-09-12 | 深圳市小元圈科技有限公司 | Nutritional milk powder and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105831254A (en) * | 2016-03-31 | 2016-08-10 | 东北农业大学 | Lactose intolerance and protein allergy preventing formula milk powder for children of 12-36 months |
| CN111264632A (en) * | 2020-02-27 | 2020-06-12 | 青岛索康食品有限公司 | Children formula milk powder for promoting calcium growth and preparation method thereof |
| CN111296577A (en) * | 2020-03-20 | 2020-06-19 | 湖南康诺优品健康产业有限公司 | Milk powder formula and preparation method |
| CN111418664A (en) * | 2020-04-20 | 2020-07-17 | 石家庄君乐宝乳业有限公司 | Modified milk powder for promoting bone growth and protecting eyesight and preparation method thereof |
-
2020
- 2020-08-03 CN CN202010768330.0A patent/CN111937964A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105831254A (en) * | 2016-03-31 | 2016-08-10 | 东北农业大学 | Lactose intolerance and protein allergy preventing formula milk powder for children of 12-36 months |
| CN111264632A (en) * | 2020-02-27 | 2020-06-12 | 青岛索康食品有限公司 | Children formula milk powder for promoting calcium growth and preparation method thereof |
| CN111296577A (en) * | 2020-03-20 | 2020-06-19 | 湖南康诺优品健康产业有限公司 | Milk powder formula and preparation method |
| CN111418664A (en) * | 2020-04-20 | 2020-07-17 | 石家庄君乐宝乳业有限公司 | Modified milk powder for promoting bone growth and protecting eyesight and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112889929A (en) * | 2021-02-26 | 2021-06-04 | 广州麦乐生物科技有限公司 | Preparation method and formula of milk powder for promoting height development of children |
| EP4049544A1 (en) * | 2021-02-26 | 2022-08-31 | Guangzhou Maile Biotech Co., Ltd. | Milk powder preparation method and formula to increase the children's height |
| CN112889930A (en) * | 2021-03-08 | 2021-06-04 | 湖南欧比佳营养食品有限公司 | Formula of milk powder for promoting children immunity and bone growth and preparation method thereof |
| CN115025105A (en) * | 2022-06-07 | 2022-09-09 | 嘉必优生物技术（武汉）股份有限公司 | Use of sialic acid for reducing weight and inhibiting weight gain |
| CN115025105B (en) * | 2022-06-07 | 2024-03-01 | 嘉必优生物技术（武汉）股份有限公司 | Use of sialic acid for weight loss and weight gain inhibition |
| CN116725141A (en) * | 2023-06-14 | 2023-09-12 | 深圳市小元圈科技有限公司 | Nutritional milk powder and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111937964A (en) | Formula milk powder for promoting overall development of children and application thereof | |
| CN112042751A (en) | Child formula goat milk powder and preparation method thereof, dairy product and application | |
| WO2012135499A1 (en) | Probiotic sports nutrition compositions | |
| CN109042893A (en) | A kind of probiotics vegetable protein powder solid beverage | |
| CN103168839B (en) | Preparation process of infant formula milk powder | |
| CN109156535A (en) | A kind of maternal nutritional product and its production technology | |
| CN109169916A (en) | A kind of puerpera's nutriment and its production technology | |
| CN102228136A (en) | Production method of nutritious target-functional eggs | |
| CN107173816A (en) | A kind of aid digestion infant nutrient of strengthen immunity packs agent | |
| CN101142940A (en) | Lactic acid bacteria beverage containing probiotics microcapsule and its production method | |
| CN105532890A (en) | Modified milk powder made from yak milk for pregnant women and preparation method | |
| CN102415447B (en) | Calcium supplement electuary for infants and preparation process thereof | |
| CN111280257A (en) | Immunoglobulin formula goat milk powder | |
| CN102885138A (en) | Powder composition with cholesterol-removing cardiovascular-dredging function formula and preparation method thereof | |
| CN107821597A (en) | Very sub- seed flavored fermented milk of a kind of normal temperature quinoa and preparation method thereof | |
| CN116172191A (en) | Nutritional composition and its application in preparing anti-inflammatory products | |
| CN106720369A (en) | A kind of neonate's prescription emulsifiable powder and preparation method thereof | |
| CN110115327A (en) | A kind of drink and preparation method thereof containing walnut ox bone peptide | |
| US20230227771A1 (en) | Pre-conditioning of l.reuteri | |
| CN108720024A (en) | A kind of activity multienzyme vitamin cell nutrient solution | |
| CN113729211A (en) | Composition and preparation method and application thereof | |
| KR20000065465A (en) | Nutritional Drink of Containing Extracts of Oyster Shell and Method of Manufacturing Thereof | |
| O'Hare et al. | Stated versus actual lipase activity in pancreatic enzyme supplements: implications for clinical use | |
| CN112006289A (en) | Compound food composition for assisting in regulating gastrointestinal tract and preparation method thereof | |
| CN108850156A (en) | A kind of probiotics solid beverage and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20201117 |
|
| WW01 | Invention patent application withdrawn after publication |