CN113786436B - Traditional Chinese medicine composition, preparation thereof and application of traditional Chinese medicine composition in treatment of subacute thyroiditis - Google Patents
Traditional Chinese medicine composition, preparation thereof and application of traditional Chinese medicine composition in treatment of subacute thyroiditis Download PDFInfo
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- CN113786436B CN113786436B CN202111179321.9A CN202111179321A CN113786436B CN 113786436 B CN113786436 B CN 113786436B CN 202111179321 A CN202111179321 A CN 202111179321A CN 113786436 B CN113786436 B CN 113786436B
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Abstract
The invention discloses a traditional Chinese medicine composition, a preparation thereof and application thereof in treating subacute thyroiditis, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 25-35 parts of honeysuckle, 15-25 parts of barbed skullcap herb, 2-8 parts of weeping forsythia, 5-10 parts of figwort root, 7-15 parts of selfheal, 10-20 parts of dandelion, 10-20 parts of dyers woad leaf, 7-15 parts of oriental wormwood, 5-10 parts of mulberry leaf, 7-15 parts of salvia miltiorrhiza and 7-15 parts of liquorice. The traditional Chinese medicine composition provided by the invention has an obvious improvement effect on symptoms such as pain and fever caused by subacute thyroiditis, is beneficial to recovery of thyroid function indexes, and has a wide market application prospect.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition, a preparation thereof and application thereof in treating subacute thyroiditis.
Background
Subacute thyroiditis (SAT), also known as Subacute granulomatous thyroiditis, (pseudo) giant cell thyroiditis, noninfective thyroiditis, transitional thyroiditis, viral thyroiditis, DeQuervain thyroiditis, granulomatous thyroiditis or giant cell thyroiditis, etc., was first reported by DeQuervain in 1904. In recent years, the disease is gradually increased, the clinical changes are complex, misdiagnosis and missed diagnosis can occur, and the disease is easy to recur, which leads to the reduction of the health level. Subacute thyroiditis is present in particular: systemic symptoms of acute inflammation; the thyroid gland is mild, moderate, heavy, medium and hard, and has obvious tenderness; in the early stage, symptoms such as fever, general malaise, sore throat, hyperhidrosis, and trembling hand can be manifested, and hyperthyroidism is suggested by thyroid function examination.
Subacute thyroiditis is self-limiting, corresponding specific medicines are not available in western medicine at present, treatment is generally not available in clinic, patients with obvious symptoms are treated symptomatically, patients mainly have fever, pain and heart rate acceleration and weakness caused by temporary hyperthyroidism, and patients with light symptoms are preferably selected from nonsteroidal anti-inflammatory medicines with antipyretic and analgesic effects, such as fenbier and aspirin; glucocorticoid can be selected by people with severe high fever and pain to quickly relieve symptoms, but glucocorticoid can not prevent the development process of methyleneitis and can not prevent the occurrence of hypothyroidism, and pathophysiology evidence shows that glucocorticoid has the functions of inhibiting inflammatory cell infiltration and reducing the formation of granulation tissues, but oral administration of glucocorticoid can easily cause larger side effects, such as osteoporosis, acne and the like.
Disclosure of Invention
The purpose of the invention is as follows: the invention aims to provide a traditional Chinese medicine composition and application thereof in preparation of medicines for treating subacute thyroiditis. The invention also aims to provide a preparation of the traditional Chinese medicine composition.
The technical scheme is as follows: the traditional Chinese medicine composition comprises the following raw materials in parts by weight:
25-35 parts of honeysuckle, 15-25 parts of barbed skullcap herb, 2-8 parts of weeping forsythia, 5-10 parts of figwort root, 7-15 parts of selfheal, 10-20 parts of dandelion, 10-20 parts of dyers woad leaf, 7-15 parts of oriental wormwood, 5-10 parts of mulberry leaf, 7-15 parts of salvia miltiorrhiza and 7-15 parts of liquorice.
The traditional Chinese medicine composition comprises the following raw materials in parts by weight:
27-32 parts of honeysuckle, 18-22 parts of barbed skullcap herb, 3-7 parts of weeping forsythia, 7-9 parts of figwort root, 8-12 parts of selfheal, 12-18 parts of dandelion, 12-18 parts of dyers woad leaf, 8-12 parts of oriental wormwood, 7-9 parts of mulberry leaf, 8-12 parts of salvia miltiorrhiza and 8-12 parts of liquorice; preferably, 30 parts of honeysuckle, 20 parts of barbed skullcap herb, 5 parts of weeping forsythia, 8 parts of figwort root, 10 parts of selfheal, 15 parts of dandelion, 15 parts of dyers woad leaf, 10 parts of oriental wormwood, 8 parts of mulberry leaf, 10 parts of salvia miltiorrhiza and 10 parts of liquorice.
The Chinese medicinal preparation is prepared by adding or not adding auxiliary materials into a decoction obtained by decocting and filtering the Chinese medicinal composition in water.
The preparation can be in the form of decoction, oral liquid, paste, granule or capsule.
The application of the traditional Chinese medicine composition in preparing a medicine for treating subacute thyroiditis.
The traditional Chinese medicine preparation is applied to preparing medicines for treating subacute thyroiditis.
The details of the materials in the present invention are as follows:
honeysuckle, also known as honeysuckle, is derived from dried buds or flowers with early blossoming flowers of honeysuckle, a Caprifoliaceae plant, and is not only a beautiful ornamental flower but also an important traditional Chinese medicine. Honeysuckle has a long medicinal history in China, and has the effects of clearing heat, removing toxicity and dispelling wind and heat.
Scutellaria barbata, cold in nature, pungent and bitter in flavor; it enters lung, liver and kidney meridians. Can be used for treating furuncle, swelling and pain of throat, traumatic injury, edema, jaundice, and snake and insect bite.
Fructus forsythiae is plant of deciduous shrub of Forsythia of Oleaceae, and is used as medicine with fruit. It is slightly cold in nature and bitter in taste, enters lung, heart and gallbladder meridians, and has the effects of clearing away heat and toxic materials, relieving swelling, resolving hard mass, and dispelling pathogenic wind and heat. It is commonly used for treating acute wind-heat type common cold, carbuncle, swelling, sore, scrofula, urinary tract infection, etc., and the Chinese medicine is called as "sore house saint drug".
Radix scrophulariae is dried root tuber of radix scrophulariae belonging to Scrophulariaceae, and is a common traditional Chinese medicine; it is sweet, bitter, salty and slightly cold in nature, and has effects of cooling blood, nourishing yin, purging pathogenic fire and removing toxic substance. It is recorded in Shen nong Ben Cao Jing, named as Yuan Shen, listed as the middle-grade product. Radix scrophulariae is a specialty in China, and is mainly distributed in Zhejiang, Jiangsu, Sichuan, Hubei, Anhui and other places; the Zhejiang radix scrophulariae is also called Zhejiang radix scrophulariae because it is a genuine herb. The traditional Chinese medicine composition is mainly used for fever polydipsia, macula, gingivitis, tonsillitis, acute lymphadenitis and the like in clinic.
Spica Prunellae is one of the common traditional Chinese medicines, is recorded in Shennong Ben Cao Jing, 15 kinds of Chinese herbs in the world, is widely distributed in the European and subambic regions and tropical mountain regions, is also distributed in the northern part of Africa and the North America, and is mainly produced in Hunan, Anhui, Zhejiang and Jiangsu in China. The prunella vulgaris collected in the Chinese pharmacopoeia is the dried cluster of the prunella vulgaris of the labiatae family. Has effects of clearing pathogenic fire, improving eyesight, resolving hard mass, and relieving swelling.
The dandelion is bitter, sweet and cold in taste, enters liver and stomach channels, and has the efficacies of clearing heat and removing toxicity, eliminating carbuncle and dissipating stagnation, and promoting diuresis and relaxing bowels. It enters liver and stomach meridians. Has the functions of clearing away heat and toxic material, eliminating stagnation, eliminating swelling and promoting urination.
Folium Isatidis is located in liver, heart, stomach and spleen meridians. Is the dry leaf of Isatis tinctoria of Cruciferae, and the commercial product also adopts Polygonum tinctoria of Polygonaceae, Strobilanthes cusia of Acanthaceae and Ardisia serrulata of Verbenaceae as substitute of folium Isatidis. The medicinal plants have the effects of clearing away heat and toxic materials, cooling blood and removing ecchymoses, and can be used for treating warm pathogen invasion, hyperpyrexia and coma, macula and eruption, jaundice and dysentery, mumps, pharyngitis, erysipelas and carbuncle swelling. It is used clinically to treat viral influenza, epidemic parotitis, viral hepatitis and other infectious diseases.
Herba Artemisiae Scopariae is dry aerial part of herba Artemisiae Scopariae or herba Artemisiae Scopariae of Compositae. Mainly produced in Shaanxi, Shanxi, Anhui, etc., and is prepared by harvesting seedlings in spring with the height of 6-10cm or harvesting and cutting buds in autumn when the buds grow, removing impurities and old stems, and drying in the sun. Collected in spring is called capillary wormwood herb, collected in autumn is called capillary wormwood herb, and collected in autumn is called capillary wormwood herb, which has the main effects of clearing damp-heat and eliminating jaundice for a long time, so that the traditional Chinese medicine is the essential medicine for treating jaundice.
The folium Mori is dry leaf of Morus alba L of Moraceae. The silkworm breeding method is distributed in most regions in China, and the yield of silkworm breeding regions in south China such as Jiangsu and Zhejiang is high. Bitter and sweet in taste and cold in nature, enters lung and liver meridians, and has the functions of dispelling wind and heat, clearing lung-heat, moistening dryness, clearing liver and improving vision.
Salvia miltiorrhiza, root and rhizome of the perennial herb Salvia miltiorrhiza of the family Labiatae. Because the root is purple red, it is named Dan Shen or Zi Dan Shen. The Shen nong Ben Cao Jing (Shen nong's herbal Jing) ranks it as the top grade, and is said to treat heart and abdomen pathogenic qi, borborborygmus like getting water, accumulation of cold and heat, broken scar and removing abdominal mass, stopping restlessness and fullness, and tonifying qi. "Ming Yi Bie Lu" means that it can nourish blood, and is mainly for the aeipathia of heart and abdomen, stagnation of qi, strong waist and back, arthralgia of the foot, and dispel wind-evil and retain heat.
The liquorice has the effects of tonifying spleen and qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing the drugs. It is indicated for spleen and stomach deficiency, lassitude and hypodynamia, palpitation and shortness of breath, cough with profuse sputum, spasm and pain of abdomen and limbs, carbuncle and sore, and to relieve toxicity and strong action of drugs.
Wherein, the honeysuckle is a monarch drug for dispelling wind and heat and clearing away heat and toxic materials; the barbed skullcap herb, the weeping forsythia, the dandelion and the common selfheal fruit-spike are used as ministerial drugs for clearing heat and purging fire, and dispersing accumulation and detoxifying; radix scrophulariae, folium Isatidis, herba Artemisiae Scopariae, folium Mori, and radix Salviae Miltiorrhizae can dispel wind-heat, relieve sore throat, remove toxic materials, promote blood circulation, nourish yin, dissipate stagnation, and cool blood. The medicines are combined to play the effects of clearing away heat and toxic materials, reducing phlegm and swelling, tonifying qi and nourishing yin, and are used as adjuvant medicines. Licorice root, radix Glycyrrhizae acts as a guiding drug, has the effects of soothing the liver and spleen, relieving spasm and pain, and harmonizing the effects of the other drugs in the recipe.
Has the advantages that: compared with the prior art, the traditional Chinese medicine composition treats subacute thyroiditis based on syndrome differentiation from the aspect of traditional Chinese medicine, adopts a big method of clearing heat and removing toxicity, and has the effect of relieving pain.
Detailed Description
The technical solution of the present invention is further described in detail by the following specific examples.
Example 1
Preparation of decoction
The medicine comprises the following components: 30g of honeysuckle, 20g of barbed skullcap herb, 5g of weeping forsythia, 8g of figwort root, 10g of selfheal, 15g of dandelion, 15g of dyers woad leaf, 10g of oriental wormwood, 8g of mulberry leaf, 10g of salvia miltiorrhiza and 10g of liquorice.
The preparation method comprises the following steps: weighing the raw materials in parts by weight, adding 500mL of water for decoction, cooling, filtering and removing residues to obtain the traditional Chinese medicine.
Example 2
Preparation of oral liquid
The medicine comprises the following components: 28g of honeysuckle, 18g of barbed skullcap herb, 6g of weeping forsythia, 9g of figwort root, 12g of selfheal, 18g of dandelion, 18g of dyers woad leaf, 12g of oriental wormwood, 9g of mulberry leaf, 12g of salvia miltiorrhiza and 12g of liquorice.
The preparation method comprises the following steps: weighing the raw materials in parts by weight, adding 500mL of water for decocting, cooling, filtering, removing residues, and adding modified starch, sodium carboxymethylcellulose, stevioside, and potassium sorbate.
Example 3
Preparation of Yinlian detoxification paste
The medicine comprises the following components: 30g of honeysuckle, 20g of barbed skullcap herb, 5g of weeping forsythia, 8g of figwort root, 10g of selfheal, 15g of dandelion, 15g of dyers woad leaf, 10g of oriental wormwood, 8g of mulberry leaf, 10g of salvia miltiorrhiza and 10g of liquorice.
The preparation method comprises the following steps: the preparation method comprises the following steps: weighing the raw materials in parts by weight, adding 500mL of water for decocting, cooling, filtering, removing residues, adding 100mL of honey, and evaporating the solution under reduced pressure to form a paste.
Example 4
Preparation of Yinlian granules
The medicine comprises the following components: 32g of honeysuckle, 22g of sculellaria barbata, 5g of fructus forsythiae, 8g of radix scrophulariae, 7g of selfheal, 15g of dandelion, 15g of folium isatidis, 10g of oriental wormwood, 8g of folium mori, 10g of salvia miltiorrhiza and 7g of liquorice.
The preparation method comprises the following steps: weighing the raw materials in parts by weight, adding 500mL of water for decoction, cooling, filtering, removing residues, adding 100mL of honey, evaporating the solution under reduced pressure to form a paste, adding a certain amount of soluble starch, dextrin and mannitol, wetting with 40% ethanol to prepare a soft material, extruding, granulating and drying.
Example 5
Preparation of capsules
The medicine comprises the following components: 32g of honeysuckle, 22g of barbed skullcap herb, 5g of weeping forsythia, 8g of figwort root, 7g of selfheal, 15g of dandelion, 15g of dyers woad leaf, 10g of oriental wormwood, 8g of mulberry leaf, 10g of salvia miltiorrhiza and 7g of liquorice.
The preparation method comprises the following steps: the granules obtained in example 4 were encapsulated to prepare capsules.
Example 6
27 patients with subacute thyroiditis were selected and the decoction of example 1 was administered 3 times daily.
(1) Changes of first function and blood sedimentation before and after treatment of patients with methyleneitis
TABLE 1 the changes in onychomycosis and blood sedimentation before and after treatment
Note: compared with the pretreatment, P is less than 0.01; p is less than 0.05
As a result: post-patient treatment FT 3 The decrease appears, and the difference has statistical significance (P <)0.05); post patient treatment FT 4 Obvious decrease appears, and the difference has statistical significance (P is less than 0.01); TSH of the patients is obviously increased after treatment, and the difference has statistical significance (P is less than 0.01); the ESR of the patients is obviously reduced after treatment, and the difference has statistical significance (P is less than 0.01).
(2) Integration of clinical symptoms before and after treatment in patients with methyleneitis
The treatment effect of the patients is compared, and the evaluation of the curative effect refers to the standard in the clinical research guiding principle of new traditional Chinese medicines.
Thyroid pain score: the subjective pain with tenderness was rated 2, the subjective pain or tenderness 1, the subjective pain or tenderness earlier relieved 0.5, and the no pain 0. Heat generation integration: the body temperature is 3 minutes at the temperature of more than 38 ℃, 2 minutes at the temperature of 37.6-38 ℃, 1 minute at the temperature of 37-37.5 ℃ and 0 minute at the temperature of less than 37 ℃. Changes in clinical scores before and after patient treatment were compared.
TABLE 2 analysis of integral change of clinical symptoms before and after treatment
Note: compared with the pretreatment, P is less than 0.01
As a result: after the patients are treated, the pain and fever symptoms are obviously improved, and the difference has statistical significance (P is less than 0.01).
(3) The treatment effect of the patient is comprehensively evaluated by combining the treatment standards in the clinical research guiding principle of the new traditional Chinese medicine:
the treatment effect of the patients is divided into 3 grades of obvious effect, effective effect and ineffective effect. Wherein the clinical symptoms of the patient disappear and the serological indicators are normally significant; the clinical symptoms and serological indexes of the patients are changed into effective ones; the patient's clinical symptoms did not improve and no improvement in serology index was considered ineffective. The total effective rate is (effective + effective)/the total number of cases is multiplied by 100%.
TABLE 3 analysis of clinical treatment effectiveness [ n (%) ]
As a result: the 27 patients had 3 cases of significant effect, 24 cases of effective effect and 0 case of ineffective effect, and the total effective rate is 100 percent.
Claims (6)
1. A traditional Chinese medicine composition for treating subacute thyroiditis is characterized by comprising the following raw materials in parts by weight:
25-35 parts of honeysuckle, 15-25 parts of barbed skullcap herb, 2-8 parts of weeping forsythia, 5-10 parts of figwort root, 7-15 parts of selfheal, 10-20 parts of dandelion, 10-20 parts of dyers woad leaf, 7-15 parts of oriental wormwood, 5-10 parts of mulberry leaf, 7-15 parts of salvia miltiorrhiza and 7-15 parts of liquorice.
2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight:
27-32 parts of honeysuckle, 18-22 parts of barbed skullcap herb, 3-7 parts of weeping forsythia, 7-9 parts of figwort root, 8-12 parts of selfheal, 12-18 parts of dandelion, 12-18 parts of dyers woad leaf, 8-12 parts of oriental wormwood, 7-9 parts of mulberry leaf, 8-12 parts of salvia miltiorrhiza and 8-12 parts of liquorice.
3. A traditional Chinese medicine preparation for treating subacute thyroiditis, which is characterized in that the traditional Chinese medicine preparation is prepared by adding or not adding auxiliary materials into a decoction obtained by decocting and filtering the traditional Chinese medicine composition according to any one of claims 1-2 in water.
4. The traditional Chinese medicine preparation according to claim 3, wherein the preparation is in the form of decoction, oral liquid, paste, granules or capsules.
5. The use of a Chinese medicinal composition as claimed in any one of claims 1-2 in the preparation of a medicament for the treatment of subacute thyroiditis.
6. The use of the Chinese medicinal preparation of claim 3 in the preparation of a medicament for the treatment of subacute thyroiditis.
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