CN109833417A - The composition and preparation method thereof for treating thyroiditis - Google Patents

Abstract

The invention discloses a kind of compositions and preparation method thereof for treating thyroiditis, it is made of the Chinese medicine material of following parts by weight: 16-20 parts of fritillaria thunbergii, 6-9 parts of campanulaceae, 8-10 parts of radix scrophulariae, 8-10 parts of bombyx batryticatus, 8-10 parts of Lasiosphaera fenzlii, 4-6 parts of dandelion, 10-12 parts of Prunella vulgaris, 4-6 parts of honeysuckle flower, 6-9 parts of Fructus Forsythiae, 6-9 parts of radix paeoniae rubra.With significant in efficacy, preparation is convenient, and patient compliance is good, the advantage having no toxic side effect, and is worth clinical expansion and application.

Description

The composition and preparation method thereof for treating thyroiditis

[technical field]

The invention belongs to technical field of traditional Chinese medicine, and in particular to a kind of composition for treating thyroiditis and its preparation Method.

[background technique]

Thyroid disease, age of onset 20-60 years old in the majority, and female middle-aged disease incidence is high, with change caused after virus infection State reaction is related, with fever, thyroid gland position pain, Thyroid Gland Swell, subtracts etc. with hyperthyroidism, first as main clinical characteristics.In Doctor thinks that this disease belongs to " goiter " scope.Ancient Times in China doctor thinks that the main pathogenesis of goiter is solidifying phlegm, the stagnation of the circulation of vital energy, the tired heap soil or fertilizer over and around the roots knot of blood in neck Before.Part of patient is due to mental disorder pent-upization fire, fire consumption impairment of yin essence, so as to cause fire excess from yin deficiency pathological change.At the beginning of goiter Phase more real examples, day prolonged illness can be changed into asthenic symptoms by real example, especially based on the deficiency of vital energy, the deficiency of Yin, to simulataneous insufficiency and excessive occur Complicated disease.In conjunction with modern traditional Chinese medicine theory of development, from the angle for improving curative effect of medication, reducing side effect, by pair Chinese medicine carries out Chinese materia medica preparation made from screening extraction and/or compatibility, shows unique advantage on treating this disease, can not only make Clinical symptoms obtain rapid recovery, and substantially reduce recurrence rate, improve the quality of life of patient, are worth more deep It is researched and developed.

At present for the treatment of thyroiditis, no matter home and abroad, mostly with hormone therapy on western medical treatment, as it is oral it is strong Pine or application hydrogenation cortisone intravenous drip, what the fever of patient and Thyroid Neoplasms had after medication can control quickly.But The state of an illness is easy exacerbation or goitre pain and develops to the other side from side during hormone decrement, and the course of disease is caused to extend.20%- Disease relapse after 30% patient is discontinued.Hormone, which is used for a long time, there is also other side effects, such as moon shaped face, buffalo hump, sclerotin Loose etc., there are also induce hypertension, diabetes, tuberculosis and Gastrointestinal ulcer during medication.And Chinese medicine exists The advantage for treating thyroiditis seems especially prominent, therefore development efficacy is stable, cheap Chinese materia medica preparation is imperative.

[summary of the invention]

The object of the present invention is to provide a kind of compositions and preparation method thereof for treating thyroiditis, above-mentioned existing to solve The defect of technology.

The invention adopts the following technical scheme:

The beneficial effects of the present invention are: preparation is convenient, and patient compliance is good, and what is had no toxic side effect is excellent with significant in efficacy Gesture is worth clinical expansion and application.

[specific embodiment]

Below by embodiment, technical scheme of the present invention will be described in further detail.

The present invention provides a kind of compositions for treating thyroiditis, are made of the Chinese medicine material of following parts by weight:

One, function of each raw material in this drug and major function:

Fritillaria thunbergii: it is bitter, it trembles with fear.Return lung, the heart channel of Hang-Shaoyin.Heat-clearing dissipating bind, preventing phlegm from forming and stopping coughing, be used for wind-heat affecting lung, phlegm-fire cough, pulmonary abscess, Acute mastitis, scrofula, sore.

Campanulaceae: it is bitter, pungent, it puts down.It is distributed in lung channel.Promoting the dispersing function of the lung, relieving sore-throat, eliminating the phlegm, apocenosis.For coughing with a lot of sputum, chest distress, pharyngalgia, Hoarse voice, lung carbuncle pyemesis, sore purulence is not at bursting.

Radix scrophulariae: it is sweet, bitter, salty, it is slightly cold.Return lung, stomach, kidney channel.Cool blood enriching yin, purging fire for removing toxin.For consumption of YIN caused by febrile disease, tongue is deep red tired Yearningly, febrile virulent maculae, Tianjin hinder constipation, hectic fever due to yin labor is coughed, hot eyes, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.

Bombyx batryticatus: it is salty, pungent, it puts down.Return liver, lung, stomach meridian.Dispelling wind and relieving convulsion, reducing phlegm and resolving masses.For convulsion, abscess of throat, skin Skin itch, submandibular lymph nodes is scorching, facioplegia.

Lasiosphaera fenzlii: it is pungent, it puts down.It is distributed in lung channel.Removing heat from the lung and relieving sorethroat, hemostasis.For the strongly fragrant lung pharyngalgia of wind-heat, cough, hoarse voice；Nosebleed epistaxis is controlled outside, Wound hemorrhage.

Dandelion: taste sweet and neutral, it is nontoxic.It is clearing heat and detoxicating, diuresis dissipating bind.

Prunella vulgaris: it is pungent, bitter, it trembles with fear.Return liver, gallbladder channel.It relieves inflammation or internal heat, improving eyesight, dissipating bind, detumescence.For red eye, swell pain, eyeball night pain, Headache and dizziness, scrofula, goiter, acute mastitis swelling and pain；Thyroid Gland Swell, scrofula, the proliferation of mammary gland, hypertension.

Honeysuckle flower: nature and flavor are sweet；It is cold.It is clearing heat and detoxicating, fry charcoal cooling blood and hemostasis.

Fructus Forsythiae: it is bitter, it is slightly cold.Return lung, the heart, small intestinl channel.It is clearing heat and detoxicating, dispersing swelling and dissipating binds.For ulcer, scrofula, acute mastitis is red Poison, anemopyretic cold, warm disease is from the beginning of warm is joined the army, hyperpyrexia polydipsia, coma macular eruption, heat gonorrhea renal shutdown.

Radix paeoniae rubra: it is bitter, it is slightly cold.Return liver warp.Clearing heat and cooling blood, removing blood stasis and acesodyne.For febrile virulent maculae, hematemesis and epistaxis, red eye, swell pain, Liver-depressed hypochondrium pain, amenorrhea and algomenorrhea , abdominal mass and abdominal pain, injury from falling down, carbuncle swells sore.

Two, preparation method and usage and dosage

The preparation method of decoction of the present invention, specifically follows the steps below:

Step 1 weighs 16-20 parts of fritillaria thunbergii respectively by weight, and 6-9 parts of campanulaceae, 8-10 parts of radix scrophulariae, 8-10 parts of bombyx batryticatus, 8-10 parts of Lasiosphaera fenzlii, 4-6 parts of dandelion, 10-12 parts of Prunella vulgaris, 4-6 parts of honeysuckle flower, 6-9 parts of Fructus Forsythiae, 6-9 parts of radix paeoniae rubra, and by bulk pharmaceutical chemicals It is placed in suitable container, the 4-10 times of water measured is added as solvent and submerges bulk pharmaceutical chemicals, is heated to boiling, holding is micro-, and to rise 1-3 small When after filter out decocting liquid, decoct again, merge fried liquid；Above all medicines are to clean and shine dry-cure by removing impurity；

The fried liquid merged in step 1 is concentrated into 70-90 DEG C of relative density as 1.35 clear cream by step 2；It adds Appropriate dextrin, granulation are crossed 14-16 mesh, are dried in vacuo at 70-90 DEG C, whole grain, dispense.

The usage and dosage of the traditional chinese medicine composition of the invention:

Every bag of granule is equivalent to 8 grams of crude drug, once a bag, once in the morning and once at night.

Embodiment 1

Step 1 weighs 20 parts of fritillaria thunbergii respectively by weight, and 9 parts of campanulaceae, 10 parts of radix scrophulariae, 10 parts of bombyx batryticatus, 10 parts of Lasiosphaera fenzlii, 6 parts of dandelion, 12 parts of Prunella vulgaris, 6 parts of honeysuckle flower, 9 parts of Fructus Forsythiae, 9 parts of radix paeoniae rubra.Bulk pharmaceutical chemicals are placed in suitable container, are added 4 times The water of amount as solvent submerge bulk pharmaceutical chemicals, be heated to boiling, keep it is micro- rise 1 hour after filter out decocting liquid, decoct again, merge it is fried Liquid；Above all medicines are to clean and shine dry-cure by removing impurity；

The fried liquid merged in step 1 is concentrated into 70 DEG C of relative density as 1.35 clear cream by step 2；It adds suitable Dextrin is measured, granulation is crossed 14 meshes, is dried in vacuo at 70 DEG C, whole grain, dispenses.

Embodiment 2

Step 1 weighs 16 parts of fritillaria thunbergii respectively by weight, and 6 parts of campanulaceae, 8 parts of radix scrophulariae, 8 parts of bombyx batryticatus, 8 parts of Lasiosphaera fenzlii, Pu Gong 4 parts of English, 10 parts of Prunella vulgaris, 4 parts of honeysuckle flower, 6 parts of Fructus Forsythiae, 6 parts of radix paeoniae rubra.Bulk pharmaceutical chemicals are placed in suitable container, 10 times of amounts are added Water as solvent submerge bulk pharmaceutical chemicals, be heated to boiling, keep it is micro- rise 3 hours after filter out decocting liquid, decoct again, merge it is fried Liquid；Above all medicines are to clean and shine dry-cure by removing impurity；

The fried liquid merged in step 1 is concentrated into 90 DEG C of relative density as 1.35 clear cream by step 2；It adds suitable Dextrin is measured, granulation is crossed 16 meshes, is dried in vacuo at 90 DEG C, whole grain, dispenses.

Embodiment 3

Step 1 weighs 18 parts of fritillaria thunbergii respectively by weight, and 7.5 parts of campanulaceae, 9 parts of radix scrophulariae, 9 parts of bombyx batryticatus, 9 parts of Lasiosphaera fenzlii, Pu 5 parts of public English, 11 parts of Prunella vulgaris, 5 parts of honeysuckle flower, 7.5 parts of Fructus Forsythiae, 7.5 parts of radix paeoniae rubra.Bulk pharmaceutical chemicals are placed in suitable container, are added 7 The water of times amount submerges bulk pharmaceutical chemicals as solvent, is heated to boiling, and filters out decocting liquid after keeping micro- and rising 2 hours, decocts, merge pan-fried again Liquid out；Above all medicines are to clean and shine dry-cure by removing impurity；

The fried liquid merged in step 1 is concentrated into 80 DEG C of relative density as 1.35 clear cream by step 2；It adds suitable Dextrin is measured, granulation is crossed 15 meshes, is dried in vacuo at 80 DEG C, whole grain, dispenses.

Three, Clinic Case

1, case-data: selection hospital outpatient thyroiditis patient 80 is divided into treatment group and right using parallel control method According to group, every group 40.

Treatment group male 13, female 27, the age 18~50 years old, 34.56 ± 6.32 years old, course of disease 3-50d average, average course of disease 18.25±5.53d。

Control group male 12, women 28；It is age 20 years old~50 years old, 35.55 ± 6.43 years old, course of disease 1-55d average, it puts down 18.60 ± 6.33d of the equal course of disease.

Through statistical analysis, two groups of patient ages, gender, courses of disease etc. have comparable without significant difference (P > 0.05) Property.

2, case diagnosis standard

It is before the onset of 1. to have infection of the upper respiratory tract history or parotitis medical history more；2. thyroid gland pain enlargement, obvious with tenderness, can There is radiating pain, part can swell in diffusivity without redness or nodositas is swollen；3. have pharyngalgia, headache, fever, chilly, it is out of strength, Hidrosis, or have neck constriction, hoarseness；4. free triiodothyronine (FT3), free thyroxine (FT4) rise Height, thyroid-stimulating hormone (TSH) reduce；5. erythrocyte sedimentation rate (ESR) (ESR) is obviously speeded；6. thyroid gland Color Doppler ultrasound shows first Two leaf anthorisma of shape gland, interior echo are unevenly distributed, and the low echo of sheet, color doppler flow imaging (CDFI) shows low time Sound area blood flow signal reduces or nothing, and perilesional can visit and more rich blood flow signal.

Wind-heat phlegm resistance card CM syndrome differentiation criterion.Primary symptom: fever, chilly, headache, pharyngalgia, throat enlargement, pain, tenderness can have pressure Compel sense or radiating pain；Minor symptom: hoarseness, red tongue body, thin white fur of tongue or thin Huang, superficial and rapid pulse or sliding number.

3, treatment method

Treatment group: bagged granules prepared by oral pharmaceutical composition embodiment 1 of the present invention, once a bag, once in the morning and once at night. 4 weeks are 1 course for the treatment of, continuously treat 2 courses for the treatment of.

Control group: prednisone, each 30mg take orally one time a day.It is reduced after body temperature, ESR are normal, subtract 5 weekly~ 10mg, until being kept to daily 5mg and being gradually discontinued.One week for a course for the treatment of, the course for the treatment of are no more than 9 weeks.

4, the standard of curative effect evaluation

Recovery from illness: thyroid gland restores normal, and symptomatology, sign disappear, and serum FT 3, FT4, TSH and ESR are normal, and CDFI is just Often；

Improve: thyroid gland pain disappears, and goitre mitigates I degree or more, and serum FT 3, FT4, TSH, ESR improvement >= 30%；

Invalid: symptom, sign and serum FT 3, FT4, TSH, ESR are not improved after treatment, or improve < before relatively treating 30%.

5, therapeutic effect:

During clinical observation, 80 patients complete clinical observation.Two groups of clinical effectiveness compare, and treatment group's clinic is fullyed recover from an illness More rate 95%, clinical effectiveness is significant；Control group clinical recovery rate 70%.Two groups for the treatment of results compare, in terms for the treatment of group's cure rate Treatment group's clinical effectiveness is more significant.Two groups of body temperature, thyroid gland pain improve the time and total treatment time compares, each side, treatment group In terms of face effect is more significant, and thyroid gland pain improves time and total treatment time and control group has significant difference (P < 0.05).Recovery from illness case follow-up 3 months, treatment group is without recurrence；Control group recurs 10.

Claims (5)

1. the composition for treating thyroiditis, which is characterized in that be made of the Chinese medicine material of following parts by weight: fritillaria thunbergii 16-20 Part, 6-9 parts of campanulaceae, 8-10 parts of radix scrophulariae, 8-10 parts of bombyx batryticatus, 8-10 parts of Lasiosphaera fenzlii, 4-6 parts of dandelion, 10-12 parts of Prunella vulgaris, honeysuckle flower 4-6 parts, 6-9 parts of Fructus Forsythiae, 6-9 parts of radix paeoniae rubra.

2. the composition for the treatment of thyroiditis as described in claim 1, which is characterized in that by the Chinese medicine material of following parts by weight Medicine is made: 20 parts of fritillaria thunbergii, 9 parts of campanulaceae, and 10 parts of radix scrophulariae, 10 parts of bombyx batryticatus, 10 parts of Lasiosphaera fenzlii, 6 parts of dandelion, 12 parts of Prunella vulgaris, silver Spend 6 parts, 9 parts of Fructus Forsythiae, 9 parts of radix paeoniae rubra.

3. the composition for the treatment of thyroiditis as described in claim 1, which is characterized in that by the Chinese medicine material of following parts by weight It is made: 16 parts of fritillaria thunbergii, 6 parts of campanulaceae, 8 parts of radix scrophulariae, 8 parts of bombyx batryticatus, 8 parts of Lasiosphaera fenzlii, 4 parts of dandelion, 10 parts of Prunella vulgaris, 4 parts of honeysuckle flower, 6 parts of Fructus Forsythiae, 6 parts of radix paeoniae rubra.

4. the composition for the treatment of thyroiditis as described in claim 1, which is characterized in that by the Chinese medicine material of following parts by weight It is made: 18 parts of fritillaria thunbergii, 7.5 parts of campanulaceae, 9 parts of radix scrophulariae, 9 parts of bombyx batryticatus, 9 parts of Lasiosphaera fenzlii, 5 parts of dandelion, 11 parts of Prunella vulgaris, honeysuckle flower 5 Part, 7.5 parts of Fructus Forsythiae, 7.5 parts of radix paeoniae rubra.

5. the preparation method of the composition for the treatment of thyroiditis described in a kind of any one of claim 1-4, feature exist In specifically following the steps below:

Step 1 weighs 16-20 parts of fritillaria thunbergii respectively by weight, and 6-9 parts of campanulaceae, 8-10 parts of radix scrophulariae, 8-10 parts of bombyx batryticatus, Lasiosphaera fenzlii 8-10 parts, 4-6 parts of dandelion, 10-12 parts of Prunella vulgaris, 4-6 parts of honeysuckle flower, 6-9 parts of Fructus Forsythiae, 6-9 parts of radix paeoniae rubra, and bulk pharmaceutical chemicals are placed in In suitable container, the 4-10 times of water measured is added as solvent and submerges bulk pharmaceutical chemicals, is heated to boiling, holding is micro- rise 1-3 hours after Decocting liquid is filtered out, is decocted again, fried liquid is merged；Above all medicines are to clean and shine dry-cure by removing impurity；

The fried liquid merged in step 1 is concentrated into 70-90 DEG C of relative density as 1.35 clear cream by step 2；It adds appropriate Dextrin, granulation are crossed 14-16 mesh, are dried in vacuo at 70-90 DEG C, whole grain, dispense.