CN104306457A - Injection liquid for treating epidemic cerebrospinal meningitis and preparation method thereof - Google Patents

Injection liquid for treating epidemic cerebrospinal meningitis and preparation method thereof Download PDF

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CN104306457A
CN104306457A CN201410653937.9A CN201410653937A CN104306457A CN 104306457 A CN104306457 A CN 104306457A CN 201410653937 A CN201410653937 A CN 201410653937A CN 104306457 A CN104306457 A CN 104306457A
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injection
water
treatment
cerebrospinal meningitis
epidemic cerebrospinal
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郝建友
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Priority to CN201610068054.0A priority Critical patent/CN105616516A/en
Priority to CN201410653937.9A priority patent/CN104306457A/en
Priority to CN201610068053.6A priority patent/CN105521026A/en
Priority to CN201610068051.7A priority patent/CN105616515A/en
Publication of CN104306457A publication Critical patent/CN104306457A/en
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Abstract

The invention discloses injection liquid for treating epidemic cerebrospinal meningitis. The injection liquid is prepared mainly through, by weight, 0.5-1.2 parts of cyrtomium fortunei, 0.4-1.5 parts of fructus forsythiae, 0.8-1.6 parts of isatis roots, 0.3-0.8 part of galinsoga parviflora and 0.6-1.5 parts of rhizoma dioscoreae nipponicae. The injection liquid is manufactured through pure traditional Chinese medicine materials, has the functions of clearing away heat and toxic materials, diminishing inflammation and relieving pain, cost is low, the clinical test verifies that the definite curative effect is achieved on epidemic cerebrospinal meningitis patients, and the curative effect is stable.

Description

Injection for the treatment of epidemic cerebrospinal meningitis and preparation method thereof
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of injection for the treatment of epidemic cerebrospinal meningitis and preparation method thereof.
Background technology
Epidemic cerebrospinal meningitis is called for short epidemic encephalitis, is the purulent meningitis caused by meningococcus.Pathogenic bacterium invade blood circulation by nasopharynx part, form septicemia, are finally confined to meninges and membrane of spinal cord, form suppurative meninges pathological changes.Main clinical manifestation has heating, and the meningeal irritation signs such as headache, vomiting, skin petechia and stiffness of the neck, cerebrospinal fluid is suppurative change.Meningococcus can not be invaded meninges and only show as septicemia, and wherein severe one can the outbreak in fulminant type.Infect and also can betide upper and lower respiratory tract, joint, the position such as pericardium and eye.Primary disease, in distribute or large and small popular, take child morbidity as height.The state of an illness of epidemic encephalitis is complicated and changeable, and weight differs, and generally can show as three Clinical types, i.e. plain edition, fulminant type and chronic septicemia.In addition, still atypical presentation person is had.1 ~ 7 day incubation period, be generally 2 ~ 3 days.1. plain edition accounts for 90% of whole meningococcal infection sequela.By primary disease evolution, upper respiratory tract infection phase, septicemia phase and meningitis phase three phases can be divided into, but be difficult to clinically divide.Sometimes the state of an illness ends at the septicemia phase and occurs without meningitis, and the meningitis phase then has septicemia to exist simultaneously.Even if the medium-sized state of an illness also weight differs.2. fulminant type small number of patients onset is hurried, and patient's condition is dangerous, as rescued not in time, often in 24h, even in 6h, getting final product threat to life, being called fulminant type.3. this kind of is rare for chronic meningococcemia.Comparatively be more common in adult.The course of disease often delays the several months long.Publication number CN 102846811 A(application number 201110176084.0) Chinese patent literature disclose a kind of prescription for the treatment of epidemic cerebrospinal meningitis, make for raw material with Scolopendra, scorpion tail, Radix Gentianae, Herba Tagetis Patulae, Fructus Forsythiae, Bombyx Batryticatus, Pheretima, double hook, Radix Paeoniae Alba, Radix Glycyrrhizae Preparata, Caulis Polygoni Multiflori, Fructus Tribuli, the Radix Rehmanniae, Radix Panacis Quinquefolii, Moschus, Calculus Bovis, Cornu Saigae Tataricae.Publication number CN 103830523 A(application number 201410082018.0) Chinese patent literature disclose treatment epidemic cerebrospinal meningitis Chinese medicine composition, raw material consists of Radix Isatidis 10-15g, Radix Scutellariae 3-5g, Cortex Phellodendri 3-5g, Fructus Gardeniae 3-5g, Concha rapanae thomasianae 10-15g, Hirudo 1.5-3g, Corallium Japonicum Kishinouye 9-12g, Radix Glycyrrhizae 5-9g, Rhizoma Anemarrhenae 10-15 gram, Radix Saposhnikoviae 10-15g, Cortex Moutan 10-15 gram, Radix Ginseng Rubra 9-12g, Radix Angelicae Sinensis 9-12g, Rhizoma Atractylodis Macrocephalae 9-12g, Rhizoma Pinelliae 5-9g, Fructus Crataegi 25g, Caulis Akebiae 25g, Rhizoma Cimicifugae 25g, Cinnabaris 3-5g.Notification number CN 104042937 A(application number 201310079495.7) Chinese patent literature disclose a kind of combination of Chinese medicine for the treatment of epidemic cerebrospinal meningitis, be made up of Chinese medicines such as Gypsum Fibrosum, Radix Gentianae, the Rhizoma Anemarrhenae, Radix Glycyrrhizae, Rhizoma Imperatae, Folium Isatidiss.
Current, many this of doctor trained in Western medicine to this disease adopts antibiotic properties treatment, uses sulphonamides, penicillin and chloromycetin and some other Tri-Biocin, and some medicine that to be patient responsive, use rear side reaction large.If the state of an illness is not tightly endangered, this disease of Chinese traditional treatment has more advantage, and the good traditional Chinese medical science formula of this sick effect of Current therapeutic is also few, and especially the research of Chinese medicine injection does not almost have, and therefore, the TCM investigation about this disease for the treatment of requires further study excavation.
Summary of the invention
For the defect of prior art, the object of this invention is to provide a kind of preparation simply and injection of the treatment epidemic cerebrospinal meningitis of stable curative effect and preparation method thereof.This injection determined curative effect and having no side effect.
Technical scheme of the present invention is:
The injection for the treatment of epidemic cerebrospinal meningitis, is prepared from primarily of following bulk drugs, is weight portion: Rhizoma Osmundae 0.5-1.2, Fructus Forsythiae 0.4-1.5, Radix Isatidis 0.8-1.6, Herba galinsogae parviflorae 0.3-0.8, Neoalsomitra integrifoliola (Cogn.) Hucth. 0.6-1.5.
In preferred scheme, Rhizoma Osmundae 0.7-1.0, Fructus Forsythiae 0.8-1.1, Radix Isatidis 1.0-1.4, Herba galinsogae parviflorae 0.4-0.7, Neoalsomitra integrifoliola (Cogn.) Hucth. 0.8-1.3.
Be more preferably, Rhizoma Osmundae 0.85, Fructus Forsythiae 0.95, Radix Isatidis 1.2, Herba galinsogae parviflorae 0.55, Neoalsomitra integrifoliola (Cogn.) Hucth. 1.05.
The preparation method of the injection of described treatment epidemic cerebrospinal meningitis is:
(1) Fructus Forsythiae and Radix Isatidis decontamination are pulverized, with the soak with ethanol of 80%, percolation, collect percolate, residue is for subsequent use;
(2) infiltrated by Neoalsomitra integrifoliola (Cogn.) Hucth. clear water, section, be then placed in pot and fry to black for spending, sprinkling clear water, cools;
(3) soaked by obtained to Rhizoma Osmundae, Herba galinsogae parviflorae and step (2) medical material, with steam distillation, collect distillate, medicinal residues are for subsequent use;
(4) step (3) remaining medicinal residues are placed in marmite together with step (1) remaining residue, decoct with water three times, filter, merge three filtrates, and be concentrated into 1/2nd of original volume;
(5) by step (1), (4) gained percolate and concentrated solution merge, with alcohol settling process three times, it is 55% that first time makes containing amount of alcohol, second time 65%, third time 75%, after abundant stirring, place 8 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, inject the medicinal carbon with water and 0.5%, stirring is placed in water-bath, heat 1 hour, cool, cold preservation 24h, filter, add step (3) gained distillate, stir evenly, by 5% sodium hydroxide solution adjust ph, finally add the glucose solution of liquor capacity 1%, filter, embedding, boiling sterilization (100 DEG C) 30 minutes, obtain injection.
The injection of described treatment epidemic cerebrospinal meningitis, the amount of step (1) percolation 80% alcoholic solution used is that the 4-7 of medical material weight is doubly (preferred, the amount of percolation 80% alcoholic solution used is 5-6 times of medical material weight, be more preferably, the amount of percolation 80% alcoholic solution used is 5.5 times of medical material weight).
The injection of described treatment epidemic cerebrospinal meningitis, step (3) amount of water is the 4-6 of medical material weight doubly (preferred, amount of water is 5 times of medical material weight).
The injection of described treatment epidemic cerebrospinal meningitis, step (4) decocts three times, each decoction 20-50 minute (preferred, to decoct 30-40 minute at every turn, be more preferably, each decoction 35 minutes).
The injection of described treatment epidemic cerebrospinal meningitis, step (4) amount of water was not for have medical material 2cm to be as the criterion.
The injection of described treatment epidemic cerebrospinal meningitis, step (5) water-bath temperature is 95-100 DEG C (preferred, water-bath temperature is 96-99 DEG C, is more preferably, and water-bath temperature is 98 DEG C).
The injection of described treatment epidemic cerebrospinal meningitis, step (5) adjust ph is preferred to 7.0-7.8(, and adjust ph, to 7.2-7.6, is more preferably, adjust ph to 7.4).
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Rhizoma Osmundae: base is former: be Dryopteridaceae plant dryopteris crassirhizoma, Athyriaceae plant lunathyrium acrostichoidesChing, ball Pteridiaceae plant Matteuccia strthiopteris, Osmundaceae plant osmund, the rhizome of Blechnaceae plant Blechnum orientale Linn., Brainea insignis, Rhizoma Osmundae etc.Nature and flavor: bitter, cool.Gui Jing: enter liver, stomach warp.Function cures mainly: kill ascarid, silk ribbon, pinworm, heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control anemopyretic cold.Warm macule, spits blood, epistaxis, discharging fresh blood stool, dysentery, metrorrhagia, leukorrhagia, skin infection, hematuria, menorrhagia, and knife injury is hemorrhage, ascarid, rich worm, taeniasis, artificial abortion, postpartum hemorrhage.
Fructus Forsythiae: base is former: be the fruit of Oleaceae plants Fructus Forsythiae.Nature and flavor: bitter, are slightly cold.Gui Jing: return lung, the heart, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warm people battalion, high hot excessive thirst, coma sends out speckle, the puckery pain of pyretic stranguria.
Radix Isatidis: nature and flavor: bitter in the mouth, cold in nature.Gui Jing: GUIXIN warp; Stomach warp.Effect: heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.Cure mainly: control influenza, epidemic encephalitis, encephalitis b, pneumonia, erysipelas, pyretic toxicity sends out speckle, and coma tells nosebleed, pharyngeal swelling, mumps, acute catarrhal conjunctivitis, skin ulcer rash, and crimson tongue is purple dark, sore throat, scarlet fever, major part pestilence, carbuncle; Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.
Herba galinsogae parviflorae: base is former: be the herb of feverfew Herba galinsogae parviflorae.Nature and flavor: light are flat.Function cures mainly: hemostasis, antiinflammatory.Cure mainly tonsillitis, pharyngolaryngitis, acute icterohepatitis; Wound hemorrhage is controlled in external.
Neoalsomitra integrifoliola (Cogn.) Hucth.: base is former: the tuber of cucurbitaceous plant Neoalsomitra integrifoliola (Cogn.) Hucth..Nature and flavor: bitter in the mouth; Puckery; Cold in nature.Function cures mainly: heat-clearing and toxic substances removing; Pain relieving.Main bacillary dysentery; Intestinal is scorching; Gastritis; Pharyngolaryngitis; Parotitis; Periodontitis; Epidemic hemorrhagic conjunctivitis; Tonsillitis; High heat; Urinary tract infection.
Not only curative effect is high for the injection for the treatment of epidemic cerebrospinal meningitis provided by the invention, and side effect is little, and in addition, excellent results of the present invention also shows:
1, selected materials is Chinese medicine material, and cost of manufacture is low;
2, this prescription meets Chinese medicine principle, for epidemic cerebrospinal meningitis pathogeny and clinical symptoms, develops;
3, through clinical trial, the present invention proves that popularity cerebrospinal meningitis patient has good curative effect, and stable curative effect.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the injection for the treatment of epidemic cerebrospinal meningitis, is prepared from primarily of following bulk drugs: Rhizoma Osmundae 50g, Fructus Forsythiae 40g, Radix Isatidis 80g, Herba galinsogae parviflorae 30g, Neoalsomitra integrifoliola (Cogn.) Hucth. 60g.
The preparation method of the injection of above-mentioned treatment epidemic cerebrospinal meningitis is:
(1) Fructus Forsythiae and Radix Isatidis decontamination are pulverized, with the soak with ethanol of 80% of medical material weight 4 times, percolation, collect percolate, residue is for subsequent use;
(2) infiltrated by Neoalsomitra integrifoliola (Cogn.) Hucth. clear water, section, be then placed in pot and fry to black for spending, sprinkling clear water, cools;
(3) soaked (water weight is 4 times of medical material weight) by obtained to Rhizoma Osmundae, Herba galinsogae parviflorae and step (2) medical material, with steam distillation, collect distillate, medicinal residues are for subsequent use;
(4) step (3) remaining medicinal residues are placed in marmite together with step (1) remaining residue, add water and do not have medical material 2cm, decoct three times, each decoction 20 minutes, filters, merges three filtrates, and be concentrated into 1/2nd of original volume;
(5) by step (1), (4) gained percolate and concentrated solution merge, with alcohol settling process three times, it is 55% that first time makes containing amount of alcohol, second time 65%, third time 75%, after abundant stirring, place 8 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, inject the medicinal carbon with water and 0.5%, stirring is placed in the water-bath of 95 DEG C, heat 1 hour, cool, cold preservation 24h, filter, add step (3) gained distillate, stir evenly, by 5% sodium hydroxide solution adjust ph to 7.0, finally add the glucose solution of liquor capacity 1%, filter, embedding, boiling sterilization (100 DEG C) 30 minutes, obtain injection.
embodiment 2the injection for the treatment of epidemic cerebrospinal meningitis, is prepared from primarily of following bulk drugs: Rhizoma Osmundae 12g, Fructus Forsythiae 15g, Radix Isatidis 16g, Herba galinsogae parviflorae 8g, Neoalsomitra integrifoliola (Cogn.) Hucth. 15g.
The preparation method of the injection for the treatment of epidemic cerebrospinal meningitis is:
(1) Fructus Forsythiae and Radix Isatidis decontamination are pulverized, with the soak with ethanol of 80% of medical material weight 7 times, percolation, collect percolate, residue is for subsequent use;
(2) infiltrated by Neoalsomitra integrifoliola (Cogn.) Hucth. clear water, section, be then placed in pot and fry to black for spending, sprinkling clear water, cools;
(3) soaked (water weight is 6 times of medical material weight) by obtained to Rhizoma Osmundae, Herba galinsogae parviflorae and step (2) medical material, with steam distillation, collect distillate, medicinal residues are for subsequent use;
(4) step (3) remaining medicinal residues are placed in marmite together with step (1) remaining residue, add water and do not have medical material 2cm, decoct three times, each decoction 50 minutes, filters, merges three filtrates, and be concentrated into 1/2nd of original volume;
(5) by step (1), (4) gained percolate and concentrated solution merge, with alcohol settling process three times, it is 55% that first time makes containing amount of alcohol, second time 65%, third time 75%, after abundant stirring, place 8 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, inject the medicinal carbon with water and 0.5%, stirring is placed in the water-bath of 100 DEG C, heat 1 hour, cool, cold preservation 24h, filter, add step (3) gained distillate, stir evenly, by 5% sodium hydroxide solution adjust ph to 7.8, finally add the glucose solution of liquor capacity 1%, filter, embedding, boiling sterilization (100 DEG C) 30 minutes, obtain injection.
Model case: xxx, female, 12 years old.Before 4 days, generate heat suddenly in the evening, thinks flu of catching a cold, take febrifuge, body temperature is in a slight decrease, after recover again, the next morning occur headache, nausea and vomiting, household extremely worries, then medical, time medical, lip cyanosis, have more visible ecchymosis with it, wear through waist, hemoculture, rabat etc. inspection is diagnosed as epidemic cerebrospinal encephalitis.
Skin test finds that patient is irritated to cephalo-type antibiolics, carries out penicillin transfusion, DeGrain after 4 days of infusing, symptom has no improvement, so use the injection of the present embodiment gained treatment epidemic cerebrospinal meningitis, every day 1 time, each 10ml, intramuscular injection, 7 days courses for the treatment of.Inject after 2 days, temperature recovery is normal, and headache obviously alleviates, and after 4 days, nausea and vomiting disappears, and appetite becomes good, and after injecting one week, all malaise symptoms of patient all disappear, and continues injection 3 days consolidate curative effect again, and patient fully recovers.
embodiment 3the injection for the treatment of epidemic cerebrospinal meningitis, is prepared from primarily of following bulk drugs: Rhizoma Osmundae 70g, Fructus Forsythiae 80g, Radix Isatidis 100g, Herba galinsogae parviflorae 40g, Neoalsomitra integrifoliola (Cogn.) Hucth. 80g.
The preparation method of the injection for the treatment of epidemic cerebrospinal meningitis is:
(1) Fructus Forsythiae and Radix Isatidis decontamination are pulverized, with the soak with ethanol of 80% of medical material weight 5 times, percolation, collect percolate, residue is for subsequent use;
(2) infiltrated by Neoalsomitra integrifoliola (Cogn.) Hucth. clear water, section, be then placed in pot and fry to black for spending, sprinkling clear water, cools;
(3) soaked (water weight is 4 times of medical material weight) by obtained to Rhizoma Osmundae, Herba galinsogae parviflorae and step (2) medical material, with steam distillation, collect distillate, medicinal residues are for subsequent use;
(4) step (3) remaining medicinal residues are placed in marmite together with step (1) remaining residue, add water and do not have medical material 2cm, decoct three times, each decoction 30 minutes, filters, merges three filtrates, and be concentrated into 1/2nd of original volume;
(5) by step (1), (4) gained percolate and concentrated solution merge, with alcohol settling process three times, it is 55% that first time makes containing amount of alcohol, second time 65%, third time 75%, after abundant stirring, place 8 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, inject the medicinal carbon with water and 0.5%, stirring is placed in the water-bath of 96 DEG C, heat 1 hour, cool, cold preservation 24h, filter, add step (3) gained distillate, stir evenly, by 5% sodium hydroxide solution adjust ph to 7.2, finally add the glucose solution of liquor capacity 1%, filter, embedding, boiling sterilization (100 DEG C) 30 minutes, obtain injection.
Model case: xxx, man, 61 years old.During morning exercises, prominent sense is uncomfortable, dizzy weak, and neighbours are sent back home rests, soon occur again vomitting, because it suffers from hypertension, dare not arbitrarily medication, and just control so be sent to hospital emergency.Time medical, obnubilation, restlessness, spirit is not good enough, dizzy, and vomiting, skin has speckle not of uniform size, through multiple inspection, be finally diagnosed as epidemic cerebrospinal meningitis.
The injection of injection the present embodiment gained treatment epidemic cerebrospinal meningitis, adopts once a day, each 10ml, intramuscular injection, 7 days courses for the treatment of.Inject after 3 days, dizzy, symptoms of emesis disappears, and spirit is improved, and appetite becomes good, continues injection after one week, and ecchymosis disappears and loses with it, and patient mental is good, and each side reaction is good, and patient fully recovers, and has no recurrence in later six months.
embodiment 4the injection for the treatment of epidemic cerebrospinal meningitis, is prepared from primarily of following bulk drugs: Rhizoma Osmundae 10g, Fructus Forsythiae 11g, Radix Isatidis 14g, Herba galinsogae parviflorae 7g, Neoalsomitra integrifoliola (Cogn.) Hucth. 13g.
The preparation method of the injection for the treatment of epidemic cerebrospinal meningitis is:
(1) Fructus Forsythiae and Radix Isatidis decontamination are pulverized, with the soak with ethanol of 80% of medical material weight 6 times, percolation, collect percolate, residue is for subsequent use;
(2) infiltrated by Neoalsomitra integrifoliola (Cogn.) Hucth. clear water, section, be then placed in pot and fry to black for spending, sprinkling clear water, cools;
(3) soaked (water weight is 6 times of medical material weight) by obtained to Rhizoma Osmundae, Herba galinsogae parviflorae and step (2) medical material, with steam distillation, collect distillate, medicinal residues are for subsequent use;
(4) step (3) remaining medicinal residues are placed in marmite together with step (1) remaining residue, add water and do not have medical material 2cm, decoct three times, each decoction 40 minutes, filters, merges three filtrates, and be concentrated into 1/2nd of original volume;
(5) by step (1), (4) gained percolate and concentrated solution merge, with alcohol settling process three times, it is 55% that first time makes containing amount of alcohol, second time 65%, third time 75%, after abundant stirring, place 8 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, inject the medicinal carbon with water and 0.5%, stirring is placed in the water-bath of 99 DEG C, heat 1 hour, cool, cold preservation 24h, filter, add step (3) gained distillate, stir evenly, by 5% sodium hydroxide solution adjust ph to 7.6, finally add the glucose solution of liquor capacity 1%, filter, embedding, boiling sterilization (100 DEG C) 30 minutes, obtain injection.
embodiment 5the injection for the treatment of epidemic cerebrospinal meningitis, is prepared from primarily of following bulk drugs: Rhizoma Osmundae 85g, Fructus Forsythiae 95g, Radix Isatidis 120g, Herba galinsogae parviflorae 55g, Neoalsomitra integrifoliola (Cogn.) Hucth. 105g.
The preparation method of the injection for the treatment of epidemic cerebrospinal meningitis is:
(1) Fructus Forsythiae and Radix Isatidis decontamination are pulverized, with the soak with ethanol of 80% of medical material weight 5.5 times, percolation, collect percolate, residue is for subsequent use;
(2) infiltrated by Neoalsomitra integrifoliola (Cogn.) Hucth. clear water, section, be then placed in pot and fry to black for spending, sprinkling clear water, cools;
(3) soaked (water weight is 5 times of medical material weight) by obtained to Rhizoma Osmundae, Herba galinsogae parviflorae and step (2) medical material, with steam distillation, collect distillate, medicinal residues are for subsequent use;
(4) step (3) remaining medicinal residues are placed in marmite together with step (1) remaining residue, add water and do not have medical material 2cm, decoct three times, each decoction 35 minutes, filters, merges three filtrates, and be concentrated into 1/2nd of original volume;
(5) by step (1), (4) gained percolate and concentrated solution merge, with alcohol settling process three times, it is 55% that first time makes containing amount of alcohol, second time 65%, third time 75%, after abundant stirring, place 8 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, inject the medicinal carbon with water and 0.5%, stirring is placed in the water-bath of 98 DEG C, heat 1 hour, cool, cold preservation 24h, filter, add step (3) gained distillate, stir evenly, by 5% sodium hydroxide solution adjust ph to 7.4, finally add the glucose solution of liquor capacity 1%, filter, embedding, boiling sterilization (100 DEG C) 30 minutes, obtain injection.
test example 1the clinical practice of injection of embodiment 5 gained treatment epidemic cerebrospinal meningitis: in JIUYUE, 2011 in June ,-2013,248 routine common epidemic cerebrospinal meningitis out-patients are screened in 6 hospitals, wherein women 118 example, male 130 example, oldest 18 years old, minimal ages 1 years old, 9.5 years old mean age.Diagnostic criteria:: (1), how in spring and summer and morbidity early autumn, often has virus infection history.(2) heating is had, headache, vomiting, diarrhoea, disturbance of consciousness, even the symptoms such as stupor of fainting from fear.Infant bregma is full.(3) meningeal irritation sign is positive, sometimes can draw pathologic reflex.(4) cerebrospinal fluid outward appearance is limpid or micro-muddy, and pressure slightly increases, and cell number is mostly between 10 ~ 500/mm3, and lymphocyte occupies the majority.Albumen slightly increases, sugar and chloride normal.Minority case cerebrospinal fluid is without obvious change.The person of having ready conditions can make virus purification and Serological testing.(5) electroencephalogram: often occur diffused inactive echoes.
Patient is divided into two groups at random, experimental group 168 example and matched group 80 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Experimental group takes embodiment 5 products obtained therefrom, and once, intramuscular injection, each 10m1(adjusts to some extent depending on concrete condition in injection every day), 7 days courses for the treatment of, matched group injects other medicine conventional medication such as () sulfadiazine, benzylpenicillin, ampicillin.Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect situation criterion: cure: clinical symptoms all disappears, physical and chemical index inspection is normal, observes and within three months, has no repeatedly; Effective: clinical symptom relief, the state of an illness is controlled, physical and chemical index inspection improvement or normal; Invalid: clinical symptoms is without being clearly better or increasing the weight of.Result is as shown in table 1.
Table 1 liang group patient treatment outcome
As shown in Table 1: during treatment, the experimental group patient of the injection of injection embodiment 5 gained treatment epidemic cerebrospinal meningitis, cures and effective number of cases is respectively 105 and 55, and the total effective rate of experimental group is 95.2%.The total effective rate of matched group is 90%, experimental group is suitable with treatment of control group effect, and experimental group is a shade better, and untoward reaction does not appear in treatments period experimental group patient, matched group has patient to occur untoward reaction to medicament, and the comparatively conventional Western medicine of visible experimental group injection is safer.
Rhizoma Osmundae selected in the present invention's injection, Fructus Forsythiae have the effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens, also have Radix Isatidis, Herba galinsogae parviflorae, Neoalsomitra integrifoliola (Cogn.) Hucth., removing heat from blood, antiinflammatory, pain relieving, several medicine synergism popularity cerebrospinal meningitis shows good therapeutic effect, pure natural medical material is made, ensure safety, side effect is almost nil.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. treat the injection of epidemic cerebrospinal meningitis, it is characterized in that, be prepared from primarily of following bulk drugs, be weight portion: Rhizoma Osmundae 0.5-1.2, Fructus Forsythiae 0.4-1.5, Radix Isatidis 0.8-1.6, Herba galinsogae parviflorae 0.3-0.8, Neoalsomitra integrifoliola (Cogn.) Hucth. 0.6-1.5.
2. the injection for the treatment of epidemic cerebrospinal meningitis as claimed in claim 1, is characterized in that, Rhizoma Osmundae 0.7-1.0, Fructus Forsythiae 0.8-1.1, Radix Isatidis 1.0-1.4, Herba galinsogae parviflorae 0.4-0.7, Neoalsomitra integrifoliola (Cogn.) Hucth. 0.8-1.3.
3. the injection for the treatment of epidemic cerebrospinal meningitis as claimed in claim 1, is characterized in that, Rhizoma Osmundae 0.85, Fructus Forsythiae 0.95, Radix Isatidis 1.2, Herba galinsogae parviflorae 0.55, Neoalsomitra integrifoliola (Cogn.) Hucth. 1.05.
4. the injection of the treatment epidemic cerebrospinal meningitis as described in as arbitrary in claim 1-3, it is characterized in that, the preparation method of described injection is:
(1) Fructus Forsythiae and Radix Isatidis decontamination are pulverized, with the soak with ethanol of 80%, percolation, collect percolate, residue is for subsequent use;
(2) infiltrated by Neoalsomitra integrifoliola (Cogn.) Hucth. clear water, section, be then placed in pot and fry to black for spending, sprinkling clear water, cools;
(3) soaked by obtained to Rhizoma Osmundae, Herba galinsogae parviflorae and step (2) medical material, with steam distillation, collect distillate, medicinal residues are for subsequent use;
(4) step (3) remaining medicinal residues are placed in marmite together with step (1) remaining residue, decoct with water three times, filter, merge three filtrates, and be concentrated into 1/2nd of original volume;
(5) by step (1), (4) gained percolate and concentrated solution merge, with alcohol settling process three times, it is 55% that first time makes containing amount of alcohol, second time 65%, third time 75%, after abundant stirring, place 8 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, inject the medicinal carbon with water and 0.5%, stirring is placed in water-bath, heat 1 hour, cool, cold preservation 24h, filter, add step (3) gained distillate, stir evenly, by 5% sodium hydroxide solution adjust ph, finally add the glucose solution of liquor capacity 1%, filter, embedding, boiling sterilization (100 DEG C) 30 minutes, obtain injection.
5. the injection for the treatment of epidemic cerebrospinal meningitis as claimed in claim 4, it is characterized in that, the amount of step (1) percolation 80% alcoholic solution used is that the 4-7 of medical material weight is doubly (preferred, the amount of percolation 80% alcoholic solution used is 5-6 times of medical material weight, be more preferably, the amount of percolation 80% alcoholic solution used is 5.5 times of medical material weight).
6. the injection for the treatment of epidemic cerebrospinal meningitis as claimed in claim 4, is characterized in that, step (3) amount of water is the 4-6 of medical material weight doubly (preferred, amount of water is 5 times of medical material weight).
7. the injection for the treatment of epidemic cerebrospinal meningitis as claimed in claim 4, is characterized in that, step (4) decoction three times, each decoction 20-50 minute (preferred, each decoction 30-40 minute, is more preferably, each decoction 35 minutes).
8. the injection for the treatment of epidemic cerebrospinal meningitis as claimed in claim 4, it is characterized in that, step (4) amount of water was not for have medical material 2cm to be as the criterion.
9. the injection for the treatment of epidemic cerebrospinal meningitis as claimed in claim 4, is characterized in that, step (5) water-bath temperature is 95-100 DEG C (preferred, water-bath temperature is 96-99 DEG C, is more preferably, and water-bath temperature is 98 DEG C).
10. the injection for the treatment of epidemic cerebrospinal meningitis as claimed in claim 4, it is characterized in that, step (5) adjust ph is preferred to 7.0-7.8(, and adjust ph, to 7.2-7.6, is more preferably, adjust ph to 7.4).
CN201410653937.9A 2014-11-18 2014-11-18 Injection liquid for treating epidemic cerebrospinal meningitis and preparation method thereof Pending CN104306457A (en)

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Publication number Priority date Publication date Assignee Title
CN106309877A (en) * 2016-09-30 2017-01-11 毛华养 Drug for preventing and treating porcine hemagglutinating encephalomyelitis viruses

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101637574A (en) * 2008-07-30 2010-02-03 张在文 Chinese medicinal composition for treating cold
CN103479902A (en) * 2013-07-22 2014-01-01 郝振荣 Proved prescription used for treating epidemic cerebrospinal meningitis

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CN103830523A (en) * 2014-03-07 2014-06-04 王玉芳 Traditional Chinese medicine composition for treating epidemic cerebrospinal meningitis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101637574A (en) * 2008-07-30 2010-02-03 张在文 Chinese medicinal composition for treating cold
CN103479902A (en) * 2013-07-22 2014-01-01 郝振荣 Proved prescription used for treating epidemic cerebrospinal meningitis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106309877A (en) * 2016-09-30 2017-01-11 毛华养 Drug for preventing and treating porcine hemagglutinating encephalomyelitis viruses

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Application publication date: 20150128