CN113748099A - 一种三苯基氯甲烷的制备方法 - Google Patents

一种三苯基氯甲烷的制备方法 Download PDF

Info

Publication number
CN113748099A
CN113748099A CN202080031514.7A CN202080031514A CN113748099A CN 113748099 A CN113748099 A CN 113748099A CN 202080031514 A CN202080031514 A CN 202080031514A CN 113748099 A CN113748099 A CN 113748099A
Authority
CN
China
Prior art keywords
triphenylchloromethane
acetate
hydrochloric acid
production method
ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202080031514.7A
Other languages
English (en)
Other versions
CN113748099B (zh
Inventor
张露
涂国良
许建跃
靳和平
王甦
胡奇
杨森
刘恒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Linhai Huanan Chemical Co ltd
Zhejiang Huahai Pharmaceutical Co Ltd
Original Assignee
Linhai Huanan Chemical Co ltd
Zhejiang Huahai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Linhai Huanan Chemical Co ltd, Zhejiang Huahai Pharmaceutical Co Ltd filed Critical Linhai Huanan Chemical Co ltd
Publication of CN113748099A publication Critical patent/CN113748099A/zh
Application granted granted Critical
Publication of CN113748099B publication Critical patent/CN113748099B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/04—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

涉及一种三苯基氯甲烷的制备方法，其包括以下步骤：向三苯基甲醇和有机溶剂的混合液中加入盐酸或盐酸与路易斯酸的混合物，在搅拌条件下反应，反应结束后去除水层，得到含有三苯基氯甲烷的有机溶液；所述方法中，三苯基甲醇的转化率几乎是定量的，高达99％以上，所得产品中，三苯基氯甲烷含量达99％以上；而且操作简便，无废气产生，对环境友好，适合工业化放大，有较好的经济效益。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202080031514.7A 2019-06-05 2020-01-06 一种三苯基氯甲烷的制备方法 Active CN113748099B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910486205.8A CN110204413A (zh) 2019-06-05 2019-06-05 一种制备三苯基氯甲烷循环套用工艺
CN2019104862058 2019-06-05
PCT/CN2020/070510 WO2020244225A1 (zh) 2019-06-05 2020-01-06 一种三苯基氯甲烷的制备方法

Publications (2)

Publication Number Publication Date
CN113748099A true CN113748099A (zh) 2021-12-03
CN113748099B CN113748099B (zh) 2024-07-05

Family

ID=67791059

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201910486205.8A Pending CN110204413A (zh) 2019-06-05 2019-06-05 一种制备三苯基氯甲烷循环套用工艺
CN202080031514.7A Active CN113748099B (zh) 2019-06-05 2020-01-06 一种三苯基氯甲烷的制备方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201910486205.8A Pending CN110204413A (zh) 2019-06-05 2019-06-05 一种制备三苯基氯甲烷循环套用工艺

Country Status (4)

Country Link
US (1) US12091375B2 (zh)
EP (1) EP3981753A4 (zh)
CN (2) CN110204413A (zh)
WO (1) WO2020244225A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116730798A (zh) * 2023-01-29 2023-09-12 江苏飞宇医药科技股份有限公司 一种三苯基氯甲烷的合成方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110204413A (zh) * 2019-06-05 2019-09-06 临海市华南化工有限公司 一种制备三苯基氯甲烷循环套用工艺
CN112979411A (zh) * 2021-03-09 2021-06-18 江西华飞医药科技有限公司 一种制备三苯基氯甲烷的工艺

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102718624A (zh) * 2012-06-21 2012-10-10 台州市华南医化有限公司 一种三苯基氯甲烷的合成方法
CN110204413A (zh) * 2019-06-05 2019-09-06 临海市华南化工有限公司 一种制备三苯基氯甲烷循环套用工艺

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102718624A (zh) * 2012-06-21 2012-10-10 台州市华南医化有限公司 一种三苯基氯甲烷的合成方法
CN110204413A (zh) * 2019-06-05 2019-09-06 临海市华南化工有限公司 一种制备三苯基氯甲烷循环套用工艺

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
R.H.CLARK等: "A Systematic Study of the Preparation of Alkyl Chlorides from the Corresponding Alcohols", 《THE ROYAL SOCIETY OF CANADA》, pages 77 - 89 *
TAKAYOSHI YAMAUCHJ ET AL.: "Selenium and Tellurium Tetrachlorides as Reagents for the Conversion of Alcohols to Alkyl Chlorides and Tellurium Tetrachloride as a Lewis Acid Catalyst for Aromatic Alkylation", vol. 59, pages 3617 - 3620, XP055765675 *
晏日安等: "由三苯甲醇高效制备三苯基氯甲烷", no. 9, pages 502 - 503 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116730798A (zh) * 2023-01-29 2023-09-12 江苏飞宇医药科技股份有限公司 一种三苯基氯甲烷的合成方法
CN116730798B (zh) * 2023-01-29 2024-03-19 江苏飞宇医药科技股份有限公司 一种三苯基氯甲烷的合成方法

Also Published As

Publication number Publication date
CN110204413A (zh) 2019-09-06
CN113748099B (zh) 2024-07-05
US12091375B2 (en) 2024-09-17
WO2020244225A1 (zh) 2020-12-10
EP3981753A1 (en) 2022-04-13
EP3981753A4 (en) 2022-07-27
US20220234970A1 (en) 2022-07-28

Similar Documents

Publication Publication Date Title
CN113748099A (zh) 一种三苯基氯甲烷的制备方法
CN104402909B (zh) 一种头孢西丁酸的合成方法
WO2010021409A1 (en) Methods for the production of 2-halo-4-nitroimidazole and intermediates thereof
CN110903163A (zh) 一种三溴新戊醇的制备方法
CN108689952B (zh) 一种丙硫菌唑的制备方法
CN115838346B (zh) 一种一锅法合成n,n′-二烃基-3,3′-二硫代二丙酰胺的方法
CN111099975A (zh) 一种5-溴-2-氯-4’-乙氧基二苯甲酮的制备方法
CN101362730B (zh) 一种制备沙坦侧链化合物的方法
CN111269121B (zh) 一种8-氧代-3,7-二甲基-2,6-辛二烯基羧酸酯化合物的纯化方法
CN113956204A (zh) 鹅肌肽的合成方法
CN112645801A (zh) 一锅法制备邻氟苯酚的方法
CN110903188A (zh) 一种制备三溴新戊醇乙酸酯的方法
CN110903182A (zh) 简单环保的4-氟-2-甲基苯甲酸的化学合成方法
CN108164431B (zh) 2-羟基-5-(2,3,5,6-四氟-4-三氟甲基苄氨基)苯甲酸及其制备方法
CN115260066B (zh) 一种超临界二氧化碳制备肟酯类化合物的方法
WO2022126388A1 (zh) 一种合成5-溴-1h-3-氨基-1,2,4-三氮唑的方法
CN117263788A (zh) 由苯乙酮一步法合成对苄基苯乙酮
CN116813508A (zh) 高选择性合成5-卤代-2-甲基苯甲酸的方法
CN1322710A (zh) 三苯胺衍生物的制备方法
CA2068612C (en) Method of producing alkali metal azides
EP1191010B1 (en) Production of adamantanediols
CN117946039A (zh) 一种恩格列净中间体的手性合成工艺
CN117285411A (zh) 一种2′-溴代邻氟苯乙酮的制备方法
CN116041194A (zh) 去甲肾上腺酮盐酸盐的合成方法
JPH06293712A (ja) モノｐ−ニトロベンジルマロネートの製造方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant