CN113747892A - 2,2,2-三氟乙酸1-(2,4-二甲基苯基)-2-[(3-甲氧基苯基)亚甲基]酰肼多晶型物及其制备方法 - Google Patents

2,2,2-三氟乙酸1-(2,4-二甲基苯基)-2-[(3-甲氧基苯基)亚甲基]酰肼多晶型物及其制备方法 Download PDF

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Publication number
CN113747892A
CN113747892A CN201980025349.1A CN201980025349A CN113747892A CN 113747892 A CN113747892 A CN 113747892A CN 201980025349 A CN201980025349 A CN 201980025349A CN 113747892 A CN113747892 A CN 113747892A
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China
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solvent
hydrazide
dimethylphenyl
trifluoroacetic acid
methoxyphenyl
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Pending
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CN201980025349.1A
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English (en)
Chinese (zh)
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B·基多恩
W·A·詹兹
吴虹桥
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Abraxar Pharmaceuticals
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Abraxar Pharmaceuticals
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/16—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980025349.1A 2018-02-21 2019-02-20 2,2,2-三氟乙酸1-(2,4-二甲基苯基)-2-[(3-甲氧基苯基)亚甲基]酰肼多晶型物及其制备方法 Pending CN113747892A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862633441P 2018-02-21 2018-02-21
US62/633,441 2018-02-21
PCT/US2019/018835 WO2019164997A1 (en) 2018-02-21 2019-02-20 2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene] hydrazide polymorphs and method of making the same

Publications (1)

Publication Number Publication Date
CN113747892A true CN113747892A (zh) 2021-12-03

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CN201980025349.1A Pending CN113747892A (zh) 2018-02-21 2019-02-20 2,2,2-三氟乙酸1-(2,4-二甲基苯基)-2-[(3-甲氧基苯基)亚甲基]酰肼多晶型物及其制备方法

Country Status (6)

Country Link
US (2) US10968167B2 (cg-RX-API-DMAC10.html)
EP (1) EP3755316A4 (cg-RX-API-DMAC10.html)
JP (2) JP7883832B2 (cg-RX-API-DMAC10.html)
CN (1) CN113747892A (cg-RX-API-DMAC10.html)
CA (1) CA3091782A1 (cg-RX-API-DMAC10.html)
WO (1) WO2019164997A1 (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3755316A4 (en) * 2018-02-21 2022-05-25 Abrexa Pharmaceuticals, Inc. 2,2,2-TRIFLUOROACETIC ACID 1-(2,4-DIMETHYLPHENYL)-2-[(3-METHOXYPHENYL)-METHYLENE]HYDRAZIDE POLYMORPHS AND PROCESS FOR THEIR PREPARATION
WO2021222438A1 (en) * 2020-04-28 2021-11-04 Abrexa Pharmaceuticals, Inc. Compounds for prevention and treatment of post-intensive care cognitive dysfunction and cognitive dysfunction resulting from respiratory distress
JP2026518142A (ja) * 2023-05-26 2026-06-04 アブレキサ ファーマスーティカルズ，インコーポレイテッド 臓器保存および臓器移植に使用するための化合物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105801496A (zh) * 2014-12-31 2016-07-27 广州喜鹊医药有限公司 三氟乙酰肼类化合物及其制备方法和在制药中的应用
WO2017015660A1 (en) * 2015-07-23 2017-01-26 Salk Institute For Biological Studies Prevention and treatment of aging and neurodegenerative diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8779002B2 (en) 2007-10-15 2014-07-15 Salk Institute For Biological Studies Methods for treating a variety of diseases and conditions, and compounds useful therefor
EP3755316A4 (en) * 2018-02-21 2022-05-25 Abrexa Pharmaceuticals, Inc. 2,2,2-TRIFLUOROACETIC ACID 1-(2,4-DIMETHYLPHENYL)-2-[(3-METHOXYPHENYL)-METHYLENE]HYDRAZIDE POLYMORPHS AND PROCESS FOR THEIR PREPARATION

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105801496A (zh) * 2014-12-31 2016-07-27 广州喜鹊医药有限公司 三氟乙酰肼类化合物及其制备方法和在制药中的应用
WO2017015660A1 (en) * 2015-07-23 2017-01-26 Salk Institute For Biological Studies Prevention and treatment of aging and neurodegenerative diseases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MARGUERITE PRIOR 等: "The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer’s disease mice", 《ALZHEIMER’S RESEARCH & THERAPY》, vol. 5, no. 25, pages 6 *
QI CHEN 等: "A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer’s Disease", 《PLOS ONE》, vol. 6, no. 12, pages 15 - 16 *

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Publication number Publication date
US10968167B2 (en) 2021-04-06
CA3091782A1 (en) 2019-08-29
US11584711B2 (en) 2023-02-21
WO2019164997A1 (en) 2019-08-29
JP7883832B2 (ja) 2026-07-02
US20200399205A1 (en) 2020-12-24
JP2024038090A (ja) 2024-03-19
EP3755316A4 (en) 2022-05-25
JP2021525275A (ja) 2021-09-24
EP3755316A1 (en) 2020-12-30
US20210139416A1 (en) 2021-05-13

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