CA3091782A1 - 2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene] hydrazide polymorphs and method of making the same - Google Patents

2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene] hydrazide polymorphs and method of making the same Download PDF

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Publication number
CA3091782A1
CA3091782A1 CA3091782A CA3091782A CA3091782A1 CA 3091782 A1 CA3091782 A1 CA 3091782A1 CA 3091782 A CA3091782 A CA 3091782A CA 3091782 A CA3091782 A CA 3091782A CA 3091782 A1 CA3091782 A1 CA 3091782A1
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CA
Canada
Prior art keywords
solvent
amorphous
trifluoroacetic acid
water
crystalline form
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Pending
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CA3091782A
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English (en)
French (fr)
Inventor
Michael O'neill
Barbara KIDON
William A. Janz
Hongqiao Wu
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Oneil Michael
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Individual
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Publication of CA3091782A1 publication Critical patent/CA3091782A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/16—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3091782A 2018-02-21 2019-02-20 2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene] hydrazide polymorphs and method of making the same Pending CA3091782A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862633441P 2018-02-21 2018-02-21
US62/633,441 2018-02-21
PCT/US2019/018835 WO2019164997A1 (en) 2018-02-21 2019-02-20 2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene] hydrazide polymorphs and method of making the same

Publications (1)

Publication Number Publication Date
CA3091782A1 true CA3091782A1 (en) 2019-08-29

Family

ID=67686904

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3091782A Pending CA3091782A1 (en) 2018-02-21 2019-02-20 2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene] hydrazide polymorphs and method of making the same

Country Status (6)

Country Link
US (2) US10968167B2 (cg-RX-API-DMAC10.html)
EP (1) EP3755316A4 (cg-RX-API-DMAC10.html)
JP (2) JP7883832B2 (cg-RX-API-DMAC10.html)
CN (1) CN113747892A (cg-RX-API-DMAC10.html)
CA (1) CA3091782A1 (cg-RX-API-DMAC10.html)
WO (1) WO2019164997A1 (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3755316A4 (en) * 2018-02-21 2022-05-25 Abrexa Pharmaceuticals, Inc. 2,2,2-TRIFLUOROACETIC ACID 1-(2,4-DIMETHYLPHENYL)-2-[(3-METHOXYPHENYL)-METHYLENE]HYDRAZIDE POLYMORPHS AND PROCESS FOR THEIR PREPARATION
WO2021222438A1 (en) * 2020-04-28 2021-11-04 Abrexa Pharmaceuticals, Inc. Compounds for prevention and treatment of post-intensive care cognitive dysfunction and cognitive dysfunction resulting from respiratory distress
JP2026518142A (ja) * 2023-05-26 2026-06-04 アブレキサ ファーマスーティカルズ，インコーポレイテッド 臓器保存および臓器移植に使用するための化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8779002B2 (en) 2007-10-15 2014-07-15 Salk Institute For Biological Studies Methods for treating a variety of diseases and conditions, and compounds useful therefor
CN105801496B (zh) * 2014-12-31 2018-03-13 广州喜鹊医药有限公司 三氟乙酰肼类化合物及其制备方法和在制药中的应用
WO2017015660A1 (en) * 2015-07-23 2017-01-26 Salk Institute For Biological Studies Prevention and treatment of aging and neurodegenerative diseases
EP3755316A4 (en) * 2018-02-21 2022-05-25 Abrexa Pharmaceuticals, Inc. 2,2,2-TRIFLUOROACETIC ACID 1-(2,4-DIMETHYLPHENYL)-2-[(3-METHOXYPHENYL)-METHYLENE]HYDRAZIDE POLYMORPHS AND PROCESS FOR THEIR PREPARATION

Also Published As

Publication number Publication date
US10968167B2 (en) 2021-04-06
US11584711B2 (en) 2023-02-21
WO2019164997A1 (en) 2019-08-29
JP7883832B2 (ja) 2026-07-02
US20200399205A1 (en) 2020-12-24
CN113747892A (zh) 2021-12-03
JP2024038090A (ja) 2024-03-19
EP3755316A4 (en) 2022-05-25
JP2021525275A (ja) 2021-09-24
EP3755316A1 (en) 2020-12-30
US20210139416A1 (en) 2021-05-13

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