JP7883832B2 - ２，２，２－トリフルオロ酢酸１－（２，４－ジメチルフェニル）－２－［（３－メトキシフェニル）メチレン］ ヒドラジド多形体およびその製造方法 - Google Patents

２，２，２－トリフルオロ酢酸１－（２，４－ジメチルフェニル）－２－［（３－メトキシフェニル）メチレン］ ヒドラジド多形体およびその製造方法

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Publication number
JP7883832B2
JP7883832B2 JP2020567741A JP2020567741A JP7883832B2 JP 7883832 B2 JP7883832 B2 JP 7883832B2 JP 2020567741 A JP2020567741 A JP 2020567741A JP 2020567741 A JP2020567741 A JP 2020567741A JP 7883832 B2 JP7883832 B2 JP 7883832B2
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JP
Japan
Prior art keywords
solvent
hydrazide
dimethylphenyl
methoxyphenyl
methylene
Prior art date
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Active
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JP2020567741A
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English (en)
Japanese (ja)
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JP2021525275A5 (cg-RX-API-DMAC10.html
JP2021525275A (ja
Inventor
オニール，マイケル
キドン，バーバラ
ジャンズ，ビル
ウー，ホンチアオ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abrexa Pharmaceuticals Inc
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Abrexa Pharmaceuticals Inc
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Application filed by Abrexa Pharmaceuticals Inc filed Critical Abrexa Pharmaceuticals Inc
Publication of JP2021525275A publication Critical patent/JP2021525275A/ja
Publication of JP2021525275A5 publication Critical patent/JP2021525275A5/ja
Priority to JP2023218036A priority Critical patent/JP2024038090A/ja
Application granted granted Critical
Publication of JP7883832B2 publication Critical patent/JP7883832B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/16—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C07C251/86—Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020567741A 2018-02-21 2019-02-20 ２，２，２－トリフルオロ酢酸１－（２，４－ジメチルフェニル）－２－［（３－メトキシフェニル）メチレン］ ヒドラジド多形体およびその製造方法 Active JP7883832B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023218036A JP2024038090A (ja) 2018-02-21 2023-12-25 ２，２，２－トリフルオロ酢酸１－（２，４－ジメチルフェニル）－２－［（３－メトキシフェニル）メチレン］ ヒドラジド多形体およびその製造方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862633441P 2018-02-21 2018-02-21
US62/633,441 2018-02-21
PCT/US2019/018835 WO2019164997A1 (en) 2018-02-21 2019-02-20 2,2,2-trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl) methylene] hydrazide polymorphs and method of making the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023218036A Division JP2024038090A (ja) 2018-02-21 2023-12-25 ２，２，２－トリフルオロ酢酸１－（２，４－ジメチルフェニル）－２－［（３－メトキシフェニル）メチレン］ ヒドラジド多形体およびその製造方法

Publications (3)

Publication Number Publication Date
JP2021525275A JP2021525275A (ja) 2021-09-24
JP2021525275A5 JP2021525275A5 (cg-RX-API-DMAC10.html) 2022-03-02
JP7883832B2 true JP7883832B2 (ja) 2026-07-02

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JP2020567741A Active JP7883832B2 (ja) 2018-02-21 2019-02-20 ２，２，２－トリフルオロ酢酸１－（２，４－ジメチルフェニル）－２－［（３－メトキシフェニル）メチレン］ ヒドラジド多形体およびその製造方法
JP2023218036A Pending JP2024038090A (ja) 2018-02-21 2023-12-25 ２，２，２－トリフルオロ酢酸１－（２，４－ジメチルフェニル）－２－［（３－メトキシフェニル）メチレン］ ヒドラジド多形体およびその製造方法

Family Applications After (1)

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JP2023218036A Pending JP2024038090A (ja) 2018-02-21 2023-12-25 ２，２，２－トリフルオロ酢酸１－（２，４－ジメチルフェニル）－２－［（３－メトキシフェニル）メチレン］ ヒドラジド多形体およびその製造方法

Country Status (6)

Country Link
US (2) US10968167B2 (cg-RX-API-DMAC10.html)
EP (1) EP3755316A4 (cg-RX-API-DMAC10.html)
JP (2) JP7883832B2 (cg-RX-API-DMAC10.html)
CN (1) CN113747892A (cg-RX-API-DMAC10.html)
CA (1) CA3091782A1 (cg-RX-API-DMAC10.html)
WO (1) WO2019164997A1 (cg-RX-API-DMAC10.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3755316A4 (en) * 2018-02-21 2022-05-25 Abrexa Pharmaceuticals, Inc. 2,2,2-TRIFLUOROACETIC ACID 1-(2,4-DIMETHYLPHENYL)-2-[(3-METHOXYPHENYL)-METHYLENE]HYDRAZIDE POLYMORPHS AND PROCESS FOR THEIR PREPARATION
WO2021222438A1 (en) * 2020-04-28 2021-11-04 Abrexa Pharmaceuticals, Inc. Compounds for prevention and treatment of post-intensive care cognitive dysfunction and cognitive dysfunction resulting from respiratory distress
JP2026518142A (ja) * 2023-05-26 2026-06-04 アブレキサ ファーマスーティカルズ，インコーポレイテッド 臓器保存および臓器移植に使用するための化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8779002B2 (en) 2007-10-15 2014-07-15 Salk Institute For Biological Studies Methods for treating a variety of diseases and conditions, and compounds useful therefor
CN105801496B (zh) * 2014-12-31 2018-03-13 广州喜鹊医药有限公司 三氟乙酰肼类化合物及其制备方法和在制药中的应用
WO2017015660A1 (en) * 2015-07-23 2017-01-26 Salk Institute For Biological Studies Prevention and treatment of aging and neurodegenerative diseases
EP3755316A4 (en) * 2018-02-21 2022-05-25 Abrexa Pharmaceuticals, Inc. 2,2,2-TRIFLUOROACETIC ACID 1-(2,4-DIMETHYLPHENYL)-2-[(3-METHOXYPHENYL)-METHYLENE]HYDRAZIDE POLYMORPHS AND PROCESS FOR THEIR PREPARATION

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Alzheimer's research & therapy, 2013, 5(25), pp.1-19
PLoS One, 2011, 6(12), pp.1-17
実験化学講座（続）２ 分離と精製, 丸善株式会社, 1967年01月25日, pp.159-162,184-193
平山令明, 有機化合物結晶作製ハンドブック, 2008, pp. 17-23,37-40,45-51,57-65

Also Published As

Publication number Publication date
US10968167B2 (en) 2021-04-06
CA3091782A1 (en) 2019-08-29
US11584711B2 (en) 2023-02-21
WO2019164997A1 (en) 2019-08-29
US20200399205A1 (en) 2020-12-24
CN113747892A (zh) 2021-12-03
JP2024038090A (ja) 2024-03-19
EP3755316A4 (en) 2022-05-25
JP2021525275A (ja) 2021-09-24
EP3755316A1 (en) 2020-12-30
US20210139416A1 (en) 2021-05-13

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